US11186622B2 - PAC1 receptor agonists (MAXCAPS) and uses thereof - Google Patents
PAC1 receptor agonists (MAXCAPS) and uses thereof Download PDFInfo
- Publication number
- US11186622B2 US11186622B2 US16/473,240 US201816473240A US11186622B2 US 11186622 B2 US11186622 B2 US 11186622B2 US 201816473240 A US201816473240 A US 201816473240A US 11186622 B2 US11186622 B2 US 11186622B2
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- seq
- amino acid
- acid sequence
- pac1
- pac1 receptor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/473,240 US11186622B2 (en) | 2017-01-05 | 2018-01-04 | PAC1 receptor agonists (MAXCAPS) and uses thereof |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762442906P | 2017-01-05 | 2017-01-05 | |
US16/473,240 US11186622B2 (en) | 2017-01-05 | 2018-01-04 | PAC1 receptor agonists (MAXCAPS) and uses thereof |
PCT/US2018/012405 WO2018129200A2 (fr) | 2017-01-05 | 2018-01-04 | Agonistes du récepteur pac1 (maxcaps) et leurs utilisations |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2018/012405 A-371-Of-International WO2018129200A2 (fr) | 2017-01-05 | 2018-01-04 | Agonistes du récepteur pac1 (maxcaps) et leurs utilisations |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US17/510,090 Continuation US20220251162A1 (en) | 2017-01-05 | 2021-10-25 | Pac1 receptor agonists (maxcaps) and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
US20190322718A1 US20190322718A1 (en) | 2019-10-24 |
US11186622B2 true US11186622B2 (en) | 2021-11-30 |
Family
ID=62791208
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/473,240 Active 2038-01-29 US11186622B2 (en) | 2017-01-05 | 2018-01-04 | PAC1 receptor agonists (MAXCAPS) and uses thereof |
US17/510,090 Pending US20220251162A1 (en) | 2017-01-05 | 2021-10-25 | Pac1 receptor agonists (maxcaps) and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US17/510,090 Pending US20220251162A1 (en) | 2017-01-05 | 2021-10-25 | Pac1 receptor agonists (maxcaps) and uses thereof |
Country Status (8)
Country | Link |
---|---|
US (2) | US11186622B2 (fr) |
EP (1) | EP3565573B1 (fr) |
JP (1) | JP7183164B2 (fr) |
CN (1) | CN110300595A (fr) |
AU (1) | AU2018205458A1 (fr) |
CA (1) | CA3049212A1 (fr) |
MX (1) | MX2019008056A (fr) |
WO (1) | WO2018129200A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10624944B2 (en) * | 2017-06-19 | 2020-04-21 | Creative Bio-Peptides Inc. | Anti-inflammatory peptides for treating non-alcoholic steatohepatitis (NASH) |
CN110747163B (zh) * | 2019-11-13 | 2021-06-11 | 暨南大学 | 一种提高人脂肪间充质干细胞成脂分化的方法及其专用培养基 |
CN111110830B (zh) * | 2020-02-18 | 2023-05-26 | 暨南大学 | 生物活性多肽pacap在制备提高肥胖男性生育力的药物中的应用 |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5480864A (en) | 1993-08-06 | 1996-01-02 | Shiseido Co., Ltd. | Modified maxadilan protein, its preparation and use, and DNA encoding the protein |
US5637309A (en) | 1993-09-20 | 1997-06-10 | Shiseido Company, Ltd. | Physiologically active substance-prolonged releasing-type pharmaceutical preparation |
US5763271A (en) | 1989-06-29 | 1998-06-09 | The President And Fellows Of Harvard College | Vasodilatory and immune suppressant peptides |
US6017533A (en) | 1996-04-25 | 2000-01-25 | Shiseido Company, Ltd. | Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors |
CA2335341A1 (fr) | 1998-07-20 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Analogues peptidiques des pacap |
WO2001085100A2 (fr) | 2000-05-11 | 2001-11-15 | The General Hospital Corporation | Proteines de fusion et conjugues contenant un vasodilatateur et un agent thrombolytique |
US6462016B1 (en) | 1995-10-06 | 2002-10-08 | Shiseido Company, Ltd. | Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method |
US20020182729A1 (en) | 2001-01-11 | 2002-12-05 | Dicicco-Bloom Emanuel | Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo |
WO2003092716A2 (fr) | 2002-05-03 | 2003-11-13 | Neuronova Ab | Role fonctionnel et utilisation therapeutique potentielle de pacap, vip et maxadilan en rapport avec des cellules progenitrices ou souches neuronales chez l'adulte |
US20090030178A1 (en) | 2006-08-02 | 2009-01-29 | Phoenix Pharmaceuticals, Inc. | Cell permeable bioactive peptide conjugates |
US20110268789A1 (en) | 2008-09-25 | 2011-11-03 | Min Li | Use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs as adjunctive treatments with anticancer agents |
US20120309683A1 (en) | 2010-02-05 | 2012-12-06 | The Administrators Of The Tulane Educational Fund | USE OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND PACAP ANALOGS AS ADJUNCTIVE TREATMENTS WITH INHIBITORS OF CALCINEURIN OR INHIBITORS OF THE MAMMALIAN TARGET OF RAPAMYCIN (mTOR) COMPLEXES |
US8916517B2 (en) | 2009-11-02 | 2014-12-23 | The Administrators Of The Tulane Educational Fund | Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use |
US20160122406A1 (en) | 2013-06-07 | 2016-05-05 | The Administrators Of The Tulane Educational Fund | Analogs of pituitary adenylate cyclase-activating polypeptide (pacap) and methods for their use |
US20170343561A1 (en) | 2011-02-01 | 2017-11-30 | The University Of Vermont And State Agricultural College | Diagnostic and therapeutic methods and products related to anxiety disorders |
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-
2018
- 2018-01-04 AU AU2018205458A patent/AU2018205458A1/en not_active Abandoned
- 2018-01-04 CA CA3049212A patent/CA3049212A1/fr active Pending
- 2018-01-04 EP EP18736163.9A patent/EP3565573B1/fr active Active
- 2018-01-04 MX MX2019008056A patent/MX2019008056A/es unknown
- 2018-01-04 CN CN201880005836.7A patent/CN110300595A/zh active Pending
- 2018-01-04 JP JP2019537254A patent/JP7183164B2/ja active Active
- 2018-01-04 WO PCT/US2018/012405 patent/WO2018129200A2/fr unknown
- 2018-01-04 US US16/473,240 patent/US11186622B2/en active Active
-
2021
- 2021-10-25 US US17/510,090 patent/US20220251162A1/en active Pending
Patent Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5763271A (en) | 1989-06-29 | 1998-06-09 | The President And Fellows Of Harvard College | Vasodilatory and immune suppressant peptides |
US5480864A (en) | 1993-08-06 | 1996-01-02 | Shiseido Co., Ltd. | Modified maxadilan protein, its preparation and use, and DNA encoding the protein |
US5637309A (en) | 1993-09-20 | 1997-06-10 | Shiseido Company, Ltd. | Physiologically active substance-prolonged releasing-type pharmaceutical preparation |
US6462016B1 (en) | 1995-10-06 | 2002-10-08 | Shiseido Company, Ltd. | Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method |
US6017533A (en) | 1996-04-25 | 2000-01-25 | Shiseido Company, Ltd. | Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors |
CA2335341A1 (fr) | 1998-07-20 | 2000-02-03 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R | Analogues peptidiques des pacap |
WO2001085100A2 (fr) | 2000-05-11 | 2001-11-15 | The General Hospital Corporation | Proteines de fusion et conjugues contenant un vasodilatateur et un agent thrombolytique |
US20020182729A1 (en) | 2001-01-11 | 2002-12-05 | Dicicco-Bloom Emanuel | Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo |
WO2003092716A2 (fr) | 2002-05-03 | 2003-11-13 | Neuronova Ab | Role fonctionnel et utilisation therapeutique potentielle de pacap, vip et maxadilan en rapport avec des cellules progenitrices ou souches neuronales chez l'adulte |
CA2485216A1 (fr) | 2002-05-03 | 2003-11-13 | Neuronova Ab | Role fonctionnel et utilisation therapeutique potentielle de pacap, vip et maxadilan en rapport avec des cellules progenitrices ou souches neuronales chez l'adulte |
US20040038888A1 (en) | 2002-05-03 | 2004-02-26 | Alex Mercer | Functional role and potential therapeutic use of PACAP, VIP and Maxadilan in relation to adult neural stem or progenitor cells |
US20090030178A1 (en) | 2006-08-02 | 2009-01-29 | Phoenix Pharmaceuticals, Inc. | Cell permeable bioactive peptide conjugates |
US7928186B2 (en) | 2006-08-02 | 2011-04-19 | Phoenix Pharmaceuticals, Inc. | Cell permeable bioactive peptide conjugates |
US20110268789A1 (en) | 2008-09-25 | 2011-11-03 | Min Li | Use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs as adjunctive treatments with anticancer agents |
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US20220251162A1 (en) | 2022-08-11 |
WO2018129200A2 (fr) | 2018-07-12 |
CA3049212A1 (fr) | 2018-07-12 |
CN110300595A (zh) | 2019-10-01 |
EP3565573A2 (fr) | 2019-11-13 |
WO2018129200A3 (fr) | 2018-08-09 |
EP3565573A4 (fr) | 2020-08-12 |
MX2019008056A (es) | 2019-11-21 |
AU2018205458A1 (en) | 2019-07-11 |
JP2020503367A (ja) | 2020-01-30 |
US20190322718A1 (en) | 2019-10-24 |
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