US10274419B2 - Container having a measuring cell - Google Patents

Container having a measuring cell Download PDF

Info

Publication number
US10274419B2
US10274419B2 US16/061,719 US201616061719A US10274419B2 US 10274419 B2 US10274419 B2 US 10274419B2 US 201616061719 A US201616061719 A US 201616061719A US 10274419 B2 US10274419 B2 US 10274419B2
Authority
US
United States
Prior art keywords
container
window
measuring
optical
fiber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US16/061,719
Other languages
English (en)
Other versions
US20180372617A1 (en
Inventor
Marek Hoehse
Christian Grimm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim Biotech GmbH
Original Assignee
Sartorius Stedim Biotech GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sartorius Stedim Biotech GmbH filed Critical Sartorius Stedim Biotech GmbH
Assigned to SARTORIUS STEDIM BIOTECH GMBH reassignment SARTORIUS STEDIM BIOTECH GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GRIMM, CHRISTIAN, HOEHSE, MAREK
Publication of US20180372617A1 publication Critical patent/US20180372617A1/en
Application granted granted Critical
Publication of US10274419B2 publication Critical patent/US10274419B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0321—One time use cells, e.g. integrally moulded
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/02—Mechanical
    • G01N2201/024—Modular construction
    • G01N2201/0245—Modular construction with insertable-removable part

Definitions

  • the invention relates to a container having a measuring-cell housing of an optical measuring cell that protrudes into the container interior of the container, wherein the measuring-cell housing has a measuring gap, which is bounded by two opposite-facing lateral surfaces spaced apart from each other and by a connecting surface that connects the lateral surfaces, wherein the lateral surfaces each have an optical window, and wherein at least one first optical fiber can be arranged before the first window and at least one second optical fiber can be arranged before the second window.
  • DE 10 2008 036 934 B4 discloses a bioreactor (container) having a measuring-cell housing of an optical measuring cell that protrudes into the container interior of the container.
  • the measuring-cell housing is designed as part of a transmission probe that protrudes with its free end into the container interior of the bioreactor and has a first optical window as well as a second optical window arranged at a distance therefrom that delimit a cuvette gap or measuring gap that is filled by the sample volume of the container interior.
  • a first optical fiber is arranged before the first window and a second optical fiber is arranged before the second window.
  • the known bioreactor (container) has the disadvantage that the first optical window is formed by a partial region of a deflecting prism, which is relatively elaborate and cost-intensive—especially for single-use bioreactors.
  • the optical measuring cell is welded in place and jointly sterilized. Different measuring cells must therefore be developed, qualified, validated and welded in place for different types of spectroscopy.
  • the present invention therefore seeks to provide a container, in particular for use as a single-use bioreactor, having an inexpensive optical measuring cell suitable for different types of spectroscopy.
  • the invention relates to a container, such as a bioreactor, having a measuring-cell housing of an optical measuring cell that protrudes into the container interior of the container.
  • the measuring-cell housing has a measuring gap that is bounded by two opposite-facing lateral surfaces spaced apart from each other at a distance and by a connecting surface that connects the lateral surfaces.
  • Each lateral surface has an optical window.
  • At least one first optical fiber can be arranged before the first window and at least one second optical fiber can be arranged before the second window.
  • the measuring-cell housing has receiving channels arranged before the windows for receiving the at least one optical fiber in each case. The optical fibers subsequently can be fit into the receiving channels from the outside, and the measuring-cell housing having the windows and the receiving channels is connected fixedly to the wall of the container interior.
  • the receiving channels subsequently can be fit with the optical fibers, based on the chosen type of spectroscopy.
  • the measuring-cell housing can be built inexpensively into the container and can be used universally for optical measuring cells for different types of spectroscopy.
  • the modular structure enables various optical combinations without any need to change the basic structure. Furthermore, the optical structure of the multifunctional (single-use) measuring cell makes it possible to minimize optical components in the single-use part, with a corresponding reduction of costs.
  • the fibers are light conductors and are not integrated permanently into the probe but rather the fibers can be inserted reversibly into the single-use part of the optical measuring cell via the receiving channels, as required, depending on the type of spectroscopy.
  • Ends of the receiving channels facing toward the windows may be oriented orthogonally to the windows. Orthogonal orientation of the fiber ends following insertion of the fibers is ensured, for example, by a corresponding curvature in the receiving channels.
  • a deflecting prism or deflecting mirror can therefore be dispensed with.
  • the connecting surface of the measuring-cell housing may have a third optical window, with a third receiving channel being arranged before the third optical window. At least one third optical fiber subsequently can be fit in the third receiving channel from the outside.
  • the third window enables light to be directed from the measuring gap to the third optical fiber at an angle of 90°, for example, relative to the first and second fibers. The light can then be directed to a detector via the third fiber.
  • a multi-lens optical imaging device (such as found in a microscope) can also be inserted into the third receiving channel.
  • the single-use part is only the third window or a final lens; all other optical elements can be inserted reversibly into and removed from the third receiving channel.
  • This multi-lens optical device can, for example, be used for Raman spectroscopy as well as for dark-field microscopy.
  • the two other receiving channels do not necessarily also have to be used, but rather can remain blind.
  • a removable third window also enables the third receiving channel to be used for taking samples. This makes it possible to ensure that the sample taken is virtually identical to the sample quantity that was just measured. As a result, inhomogeneities in the container interior cannot affect the samples removed for calibration. Therefore, the third receiving channel optionally can be used for taking samples, detecting a 90° scatter or inserting a multi-lens optical device.
  • Ends of the receiving channels facing away from the windows may have receiving openings with longitudinal axes that extend parallel to one another.
  • the parallel arrangement of the longitudinal axes enables the fibers to be connected to the measuring-cell housing by means of corresponding plug-in, snap-lock or screw connections.
  • the parallel longitudinal axes make it possible also to use a common plug-in connection.
  • the receiving channels of the measuring-cell housing may form a common spatial depression in which the optical fibers are arranged fixedly before the windows by means of brackets. This arrangement enables a rapid and precise orientation of the optical fibers. Brackets also enable the optical fibers to be fixed in the spatial depression such that they are arranged before the windows.
  • the measuring-cell housing along with windows and receiving channels may form a single-use part of the optical measuring cell while the optical fibers, along with connected light sources and/or sensors and evaluation and control electronics, form a reusable part of the optical measuring cell.
  • the optical windows may be lenses, filters or diffusely reflecting surfaces.
  • light from a light source can be conducted via the at least one first fiber in the first receiving channel, through the first window into the measuring gap with a sample volume, and further via the second window and the at least one second fiber arranged in the second receiving channel, to a detector.
  • At least one pinhole aperture can be arranged between the second window or lens and the second fiber arranged in the second receiving channel. The end of the second fiber facing the pinhole aperture can be arranged at a distance from the pinhole aperture.
  • light from a light source can be conducted via a first fiber in the first receiving channel, through the first window into the measuring gap with a sample volume and, as light that has been reflected or scattered by the sample volume, the light can be conducted back via the first window and a second fiber arranged in the first receiving channel, to a detector.
  • fiber bundles can also be used instead of fibers.
  • the detection at least, can be done via fiber bundles (e.g. annularly arranged around the excitation fiber) especially for reflection measurement. This arrangement therefore makes it possible to use the device to perform, relatively easily and inexpensively, an evaluation by means of spectroscopic reflection.
  • light from a light source can be conducted via a first fiber in the first receiving channel, through the first window into the measuring gap with a sample volume, and further via the second window in the second receiving channel onto a diffusely reflecting surface, and the light can be conducted as reflected light back via the first window and a second fiber arranged in the first receiving channel to a detector.
  • the reflecting surface can be arranged at the free end of a dummy fiber (or, e.g. a tubular element) inserted into the second receiving channel.
  • the second window can also be designed as a reflector. This arrangement therefore makes it possible to use the device to perform, relatively easily and inexpensively, an evaluation by means of spectroscopic transflection.
  • Light scattered by the sample volume i.e. light after it has interacted with the sample, can be conducted via the third optical window and the third optical fiber arranged in the third receiving channel, to a detector.
  • the container may be a single-use bioreactor or a single-use mixing bag.
  • FIG. 1 is a cross-sectional lateral and detail view of a container depicted with dotted lines (single-use bioreactor) having a measuring-cell housing with receiving channels and optical windows.
  • FIG. 2 is a cross-sectional view of the measuring-cell housing from FIG. 1 with a first fiber in the first receiving channel and a second fiber in the second receiving channel.
  • FIG. 3 is a cross-sectional view of the measuring-cell housing from FIG. 1 with a first fiber in the first receiving channel, a second fiber in the second receiving channel and a third fiber in the third receiving channel.
  • FIG. 4 is a cross-sectional view of the measuring-cell housing from FIG. 1 with a first fiber and a second fiber in the first receiving channel.
  • FIG. 5 is a cross-sectional view of the measuring-cell housing from FIG. 1 with a first fiber and a second fiber in the first receiving channel and with a dummy fibre with a diffusely reflecting surface in the second receiving channel.
  • FIG. 6 is a cross-sectional lateral and detail view of an additional container (single-use bioreactor) depicted with dotted lines having a measuring cell housing with receiving channels and optical windows.
  • FIG. 7 is a three-dimensional perspective representation of an additional measuring-cell housing, the receiving channels of which are combined to form a common depression.
  • FIG. 8 is a lateral view of the measuring housing from FIG. 7 from Direction VIII.
  • FIG. 9 is a top plan view of the measuring housing from FIG. 8 from Direction IX.
  • FIG. 10 is a lateral view of the measuring housing from FIG. 8 with a cover indicated with dotted lines.
  • a container 1 for example, a single-use bioreactor, essentially comprises a container interior 2 , a wall 3 and an optical measuring cell 4 .
  • the container interior 2 is enclosed by the wall 3 .
  • the measuring cell 4 has a measuring-cell housing 5 that protrudes through the wall 3 , to which it is fixedly connected, into the container interior 2 .
  • the measuring-cell housing 5 On the inner side of the container, the measuring-cell housing 5 has a “U”-shaped cut-out measuring gap 6 to receive a sample volume for analysis.
  • the measuring gap 6 is bordered by two lateral surfaces 8 , 9 facing one another at a distance 7 , and by a connecting surface 10 that connects the lateral surfaces 8 , 9 .
  • the first lateral surface 8 has a first optical window 11
  • the second lateral surface 9 has a second optical window ( 12 )
  • the connecting surface 10 has a third optical window 13 .
  • the measuring-cell housing 5 On its side facing away from the measuring gap 6 , the measuring-cell housing 5 has a first receiving channel 14 arranged before the first window 11 in order to receive at least one first optical fiber 15 . In corresponding fashion, on its side facing away from the measuring gap 6 , the measuring-cell housing 5 has a second receiving channel 16 arranged before the second window 12 in order to receive at least one second optical fiber 17 . Furthermore, on its side facing away from the measuring gap 6 , the measuring-cell housing 5 has a third receiving channel 18 arranged before the third window 13 in order to receive at least one third optical fiber 19 .
  • the receiving channels 14 , 16 , 18 At their ends facing away from the windows 11 , 12 , 13 , the receiving channels 14 , 16 , 18 have receiving openings 26 , 27 , 28 , the longitudinal axes 29 , 30 , 31 of which extend parallel to one another.
  • light from a light source can be conducted via the first optical fiber 15 in the first receiving channel 14 , through the first window 11 into the measuring gap 6 with the sample volume, and further via the second window 12 and the second fiber 17 arranged in the second receiving channel 16 the light can be conducted as transmitted light 21 to a detector (not shown).
  • At least one pinhole aperture can be arranged between the second window 12 and the second fiber 17 arranged in the second receiving channel 16 .
  • reflected light 22 from the sample volume can additionally be conducted via the third optical window 13 and the third optical fiber 19 arranged in the third receiving channel 18 , to a detector (not shown).
  • light from a light source 20 ′ can be conducted via a first optical fiber 15 ′ in the first receiving channel 14 , through the first window 11 into the measuring gap 6 with the sample volume, and it can be conducted back as reflected light 22 ′ from the sample volume, via the first window 11 and a second fiber 17 ′ arranged in the first receiving channel 14 , to a detector.
  • light from a light source 20 ′ can be conducted via the first fiber 15 ′ in the first receiving channel 14 , through the first window 11 into the measuring gap 6 with the sample volume, and further via the second window 12 in the second receiving channel 16 , onto a diffusely reflecting surface 23 , and it is conducted back as reflected light 22 ′′ via the first window 11 and a second fiber 17 ′ arranged in the first receiving channel 14 , to a detector.
  • the reflecting surface 23 can be arranged at the free end of a dummy fiber 25 inserted into the second receiving channel.
  • the receiving channels 14 ′′′, 16 ′′′, 18 ′′′ of the measuring cell 5 ′′′ form a spatial depression 32 in which they merge into each other.
  • the optical fibers 15 , 17 , 19 are fixed in the depression 32 by means of brackets 33 , 34 , 35 of the receiving channels 14 ′′′, 16 ′′′, 18 ′′′ associated with the depression 32 .
  • Possible types of brackets 33 , 34 , 35 include: click closures, bayonet closures and screw closures.
  • the optical fibers 15 , 17 , 19 are fixed in the brackets 33 , 34 , 35 such that, with their free ends, they are arranged before the windows 11 , 12 , 13 on the outside thereof.
  • the brackets 33 , 34 , 35 each have a receiving channel piece 37 , 38 , 39 , the receiving cross-section of each of which forms a channel segment to receive the associated optical fibers 15 , 17 , 19 .
  • the receiving channel pieces 37 , 38 , 39 can each have a longitudinal slot 40 to facilitate fastening of the optical fibres 15 , 17 , 19 .
  • the depression 32 of the measuring cell 5 ′′′ is covered, at least in part, by a cover piece 36 .
  • a fiber bundle (also not shown) can be used instead of the fibers 15 , 15 ′, 17 , 17 ′, 18 , 19 .
  • the fibers 15 , 15 ′, 17 , 17 ′, 18 , 19 or the fiber bundles can be inserted directly into the receiving channels 14 , 16 , 18 before use.
  • the fibers 15 , 15 ′, 17 , 17 ′, 18 , 19 or the fiber bundles can be connected to the measuring-cell housing 5 by means of screws, clamps or other fasteners (not shown). This enables reproducible positioning of the fibers 15 , 15 ′, 17 , 17 ′, 18 , 19 or the fiber bundles.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
US16/061,719 2015-12-23 2016-12-22 Container having a measuring cell Active US10274419B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102015122745 2015-12-23
DE102015122745.2 2015-12-23
DE102015122745.2A DE102015122745B3 (de) 2015-12-23 2015-12-23 Behälter
PCT/EP2016/082436 WO2017109104A1 (de) 2015-12-23 2016-12-22 Behälter mit einem messzelle

Publications (2)

Publication Number Publication Date
US20180372617A1 US20180372617A1 (en) 2018-12-27
US10274419B2 true US10274419B2 (en) 2019-04-30

Family

ID=57630339

Family Applications (1)

Application Number Title Priority Date Filing Date
US16/061,719 Active US10274419B2 (en) 2015-12-23 2016-12-22 Container having a measuring cell

Country Status (4)

Country Link
US (1) US10274419B2 (de)
EP (1) EP3394241B1 (de)
DE (1) DE102015122745B3 (de)
WO (1) WO2017109104A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102017010629A1 (de) 2017-11-16 2019-05-16 Sartorius Stedim Biotech Gmbh Behälter mit Wandungsvorsprung und Sensorbereich
DE102018108325B4 (de) 2018-04-09 2020-07-09 Schott Ag Sensoraufnahme für einen Bioreaktor sowie Bioreaktor mit Sensoraufnahme und Verfahren zur Vermehrung oder Kultivierung biologischen Materials
DE102018108323B4 (de) * 2018-04-09 2020-07-09 Schott Ag Vorrichtung zur Halterung einer bilderfassenden Einrichtung an einem Bioreaktor, Bioreaktor mit Vorrichtung zur Halterung einer bilderfassenden Einrichtung sowie Verfahren zur Vermehrung oder Kultivierung biologischen Materials
DE102018117332A1 (de) * 2018-07-18 2020-01-23 Hamilton Bonaduz Ag Vorrichtung zum Überwachen eines biologischen Prozesses in einem flüssigen Medium
FR3085117B1 (fr) 2018-08-22 2023-11-03 Sartorius Stedim Biotech Gmbh Dispositif à orifice jetable pour relier une unité fonctionnelle à une paroi flexible d'un contenant jetable et procédé de fabrication d'un dispositif à orifice jetable
DE102018008622B4 (de) * 2018-10-31 2020-10-01 Sartorius Stedim Biotech Gmbh Bioprozessbehälter mit optischer Messvorrichtung

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040144163A1 (en) * 2002-11-06 2004-07-29 Kram Mark Lenard Storage tank leak detection system for petroleum products
US20080032389A1 (en) 2006-08-02 2008-02-07 Finesse Solutions, Llc. Disposable bioreactor vessel port
US20090075248A1 (en) * 2007-07-28 2009-03-19 Buglab Llc Particle sensor with wide linear range
US20100035337A1 (en) 2008-08-08 2010-02-11 Sartorius Stedim Biotech Gmbh Bioreactor with window
DE102010007559A1 (de) 2010-02-10 2011-08-11 Sartorius Stedim Biotech GmbH, 37079 Bioreaktorbehälter mit einem optischen Schaumsensor
DE102011101107A1 (de) 2011-05-10 2012-11-15 Sartorius Stedim Biotech Gmbh Einweg-Sensorkopf und Einwegbehälter
US20150330903A1 (en) 2014-05-13 2015-11-19 Asl Analytical, Inc. Near-Infrared Optical Interfaces for Disposable Bioprocessing Vessels

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040144163A1 (en) * 2002-11-06 2004-07-29 Kram Mark Lenard Storage tank leak detection system for petroleum products
US20080032389A1 (en) 2006-08-02 2008-02-07 Finesse Solutions, Llc. Disposable bioreactor vessel port
US20090075248A1 (en) * 2007-07-28 2009-03-19 Buglab Llc Particle sensor with wide linear range
US20100035337A1 (en) 2008-08-08 2010-02-11 Sartorius Stedim Biotech Gmbh Bioreactor with window
DE102008036934A1 (de) 2008-08-08 2010-02-11 Sartorius Stedim Biotech Gmbh Bioreaktor mit Fenster
DE102010007559A1 (de) 2010-02-10 2011-08-11 Sartorius Stedim Biotech GmbH, 37079 Bioreaktorbehälter mit einem optischen Schaumsensor
US20130039810A1 (en) 2010-02-10 2013-02-14 Sartorius Stedim Biotech Gmbh Bioreactor vessel having an optical foam sensor
DE102011101107A1 (de) 2011-05-10 2012-11-15 Sartorius Stedim Biotech Gmbh Einweg-Sensorkopf und Einwegbehälter
US20140054186A1 (en) 2011-05-10 2014-02-27 Sartorius Stedim Biotech Gmbh Disposable sensor head and disposable container
US20150330903A1 (en) 2014-05-13 2015-11-19 Asl Analytical, Inc. Near-Infrared Optical Interfaces for Disposable Bioprocessing Vessels

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
International Search Report dated Apr. 18, 2017.
Translation of International Preliminary Report on Patentability for International Application No. PCT/EP2016/082436 dated Jun. 26, 2018.

Also Published As

Publication number Publication date
US20180372617A1 (en) 2018-12-27
EP3394241B1 (de) 2019-09-25
DE102015122745B3 (de) 2017-01-19
WO2017109104A1 (de) 2017-06-29
EP3394241A1 (de) 2018-10-31
WO2017109104A9 (de) 2017-09-21

Similar Documents

Publication Publication Date Title
US10274419B2 (en) Container having a measuring cell
JP6336710B2 (ja) 試料内の不均質性を検知するための光学装置、特に偏光計
US9400243B2 (en) Disposable sensor head and disposable container
US20220205925A1 (en) Flow Cell System for Optical Fluid Analysis and Bioreactor System
US5347358A (en) Refractometer
US11733500B2 (en) Surface color and liquid contact angle imaging
CN106574866A (zh) 用于反射测量的测量装置
RU2728838C2 (ru) Устройства и способ выполнения измерения поглощения света на испытываемом образце и измерения для установления соответствия на контрольном образце
US20240167937A1 (en) Measuring cell, measuring cell receptacle and measuring device with a measuring cell
US8638433B1 (en) Visual spectrophotometer
CN103796567A (zh) 校准装置和校准方法
CN111025619A (zh) 一种检测柱体内壁缺陷的装置
US8164747B2 (en) Apparatus, system and method for optical spectroscopic measurements
JP2016075509A (ja) 筒状穴内検査用器具、及びこれを用いた筒状穴内検査装置
US11280730B2 (en) Bioprocess container having an optical measuring device
US20200122148A1 (en) Precision cuvette holders and supports for optical characterization and measurements
CN109557046B (zh) 液体试样测定用配件、折射率测定装置及折射率测定方法
EP4276164A1 (de) Bioreaktor für zellkultur mit wiederverwendbarem reaktorgefäss und schnittstelle für optische spektroskopie
CN218823880U (zh) 样品支架及分光光度计
CN219496793U (zh) 一种光学适配模组以及显微拉曼光谱装置
LU102997B1 (en) Optical analyte sensor
US20240210323A1 (en) Measurement chamber extension for spectrophotometric characterization of a sterile liquid in a polymer container by nir- or raman-spectrophotometry
JP3159281U (ja) 試料測定装置
GB2457449A (en) Fibre optic probe reference cell
CN114112904A (zh) 光学过程传感器、测量头、测量系统和校准验证方法

Legal Events

Date Code Title Description
AS Assignment

Owner name: SARTORIUS STEDIM BIOTECH GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HOEHSE, MAREK;GRIMM, CHRISTIAN;SIGNING DATES FROM 20180607 TO 20180608;REEL/FRAME:046067/0953

FEPP Fee payment procedure

Free format text: ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: BIG.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

STPP Information on status: patent application and granting procedure in general

Free format text: PUBLICATIONS -- ISSUE FEE PAYMENT VERIFIED

STCF Information on status: patent grant

Free format text: PATENTED CASE

MAFP Maintenance fee payment

Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1551); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 4