UA95921C2 - Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents - Google Patents

Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents

Info

Publication number
UA95921C2
UA95921C2 UAA200803884A UAA200803884A UA95921C2 UA 95921 C2 UA95921 C2 UA 95921C2 UA A200803884 A UAA200803884 A UA A200803884A UA A200803884 A UAA200803884 A UA A200803884A UA 95921 C2 UA95921 C2 UA 95921C2
Authority
UA
Ukraine
Prior art keywords
compositions
water soluble
poorly water
soluble pharmaceutical
agents
Prior art date
Application number
UAA200803884A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Нейл П. Дисей
Радж Селварадж
Эндрю Янг
Патрик М. Д. Соон-Шионг
Original Assignee
АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи. filed Critical АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи.
Publication of UA95921C2 publication Critical patent/UA95921C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
UAA200803884A 2005-08-31 2006-08-30 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents UA95921C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71286505P 2005-08-31 2005-08-31

Publications (1)

Publication Number Publication Date
UA95921C2 true UA95921C2 (en) 2011-09-26

Family

ID=41449779

Family Applications (3)

Application Number Title Priority Date Filing Date
UAA200803884A UA95921C2 (en) 2005-08-31 2006-08-30 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
UAA201109120A UA108840C2 (en) 2005-08-31 2006-08-30 COMPOSITION AND METHOD OF OBTAINING MEDICINE ON THE BASIS OF DOCETAXEL WITH INCREASED STABILITY
UAA200803886A UA96273C2 (en) 2005-08-31 2006-08-30 Docetaxel and citrate composition for the treatment of cancer

Family Applications After (2)

Application Number Title Priority Date Filing Date
UAA201109120A UA108840C2 (en) 2005-08-31 2006-08-30 COMPOSITION AND METHOD OF OBTAINING MEDICINE ON THE BASIS OF DOCETAXEL WITH INCREASED STABILITY
UAA200803886A UA96273C2 (en) 2005-08-31 2006-08-30 Docetaxel and citrate composition for the treatment of cancer

Country Status (3)

Country Link
NO (1) NO344525B1 (en)
UA (3) UA95921C2 (en)
ZA (1) ZA200802763B (en)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
EP1100494A1 (en) * 1998-07-30 2001-05-23 Novopharm Biotech, Inc. Pharmaceutically composition comprising an aqueous solution of paclitaxel and albumin
SI21222A (en) * 2002-05-28 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Method for preparation of nanoparticles
CN104587479A (en) * 2002-12-09 2015-05-06 阿布拉西斯生物科学有限责任公司 Compositions and methods of delivery of pharmacological agents
CA2551117A1 (en) * 2003-12-23 2005-07-14 Abraxis Bioscience, Inc. Substituted melatonin derivatives, process for their preparation, and methods of use

Also Published As

Publication number Publication date
NO344525B1 (en) 2020-01-27
UA96273C2 (en) 2011-10-25
NO20190306A1 (en) 2008-05-13
UA108840C2 (en) 2015-06-25
ZA200802763B (en) 2009-10-28

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