UA87474C2 - Способ получения 6-амино-4-(3-хлоро-4-фторофениламино) )-7-этоксихинолин-3-карбонитрила, промежуточные соединения и способ получения промежуточного соединения - Google Patents
Способ получения 6-амино-4-(3-хлоро-4-фторофениламино) )-7-этоксихинолин-3-карбонитрила, промежуточные соединения и способ получения промежуточного соединенияInfo
- Publication number
- UA87474C2 UA87474C2 UAA200604146A UAA200604146A UA87474C2 UA 87474 C2 UA87474 C2 UA 87474C2 UA A200604146 A UAA200604146 A UA A200604146A UA A200604146 A UAA200604146 A UA A200604146A UA 87474 C2 UA87474 C2 UA 87474C2
- Authority
- UA
- Ukraine
- Prior art keywords
- amino
- carbonitrile
- quinoline
- ethoxy
- prepation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/30—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same unsaturated acyclic carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50310603P | 2003-09-15 | 2003-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA87474C2 true UA87474C2 (ru) | 2009-07-27 |
Family
ID=34375310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA200604146A UA87474C2 (ru) | 2003-09-15 | 2004-09-15 | Способ получения 6-амино-4-(3-хлоро-4-фторофениламино) )-7-этоксихинолин-3-карбонитрила, промежуточные соединения и способ получения промежуточного соединения |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7365203B2 (ru) |
| EP (1) | EP1663951A2 (ru) |
| JP (1) | JP2007505910A (ru) |
| KR (1) | KR20060079217A (ru) |
| CN (2) | CN100395231C (ru) |
| AU (1) | AU2004274450A1 (ru) |
| BR (1) | BRPI0414377A (ru) |
| CA (1) | CA2536439A1 (ru) |
| CO (1) | CO5670368A2 (ru) |
| CR (1) | CR8277A (ru) |
| EC (1) | ECSP066423A (ru) |
| IL (1) | IL173750A0 (ru) |
| MX (1) | MXPA06002796A (ru) |
| NO (1) | NO20060767L (ru) |
| RU (1) | RU2006105263A (ru) |
| SG (1) | SG146645A1 (ru) |
| UA (1) | UA87474C2 (ru) |
| WO (1) | WO2005028421A2 (ru) |
| ZA (1) | ZA200602149B (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200526219A (en) * | 2004-01-16 | 2005-08-16 | Wyeth Corp | Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof |
| CA2609186A1 (en) * | 2005-05-25 | 2006-11-30 | Wyeth | Methods of synthesizing substituted 3-cyanoquinolines and intermediates thereof |
| EP1984325A4 (en) * | 2006-02-03 | 2011-08-10 | Univ Ohio State Res Found | SULFONANILID ANALOGUE AS SELECTIVE AROMATASE MODULATORS |
| JP2008102489A (ja) * | 2006-09-19 | 2008-05-01 | Ricoh Co Ltd | 現像剤搬送装置、現像装置、プロセスユニット及び画像形成装置 |
| CN102070524A (zh) * | 2011-01-12 | 2011-05-25 | 无锡好芳德药业有限公司 | 一种3-氰基-4-卤代喹啉衍生物的制备方法 |
| CN103275002A (zh) * | 2013-06-14 | 2013-09-04 | 苏州明锐医药科技有限公司 | 培利替尼的制备方法 |
| CN108675958A (zh) * | 2018-03-23 | 2018-10-19 | 孙金霞 | 一种抗肿瘤药物培利替尼中间体的清洁生产方法 |
| CN111848581B (zh) * | 2020-08-19 | 2021-08-10 | 昆明学院 | 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6384051B1 (en) * | 2000-03-13 | 2002-05-07 | American Cyanamid Company | Method of treating or inhibiting colonic polyps |
| AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
| ATE370123T1 (de) * | 2001-11-27 | 2007-09-15 | Wyeth Corp | 3-cyanochinoline als inhibitoren von egf-r- und her2-kinasen |
-
2004
- 2004-09-10 US US10/939,008 patent/US7365203B2/en not_active Expired - Fee Related
- 2004-09-15 BR BRPI0414377-9A patent/BRPI0414377A/pt not_active IP Right Cessation
- 2004-09-15 CN CNB2004800262386A patent/CN100395231C/zh not_active Expired - Fee Related
- 2004-09-15 WO PCT/US2004/030219 patent/WO2005028421A2/en active Application Filing
- 2004-09-15 UA UAA200604146A patent/UA87474C2/ru unknown
- 2004-09-15 CA CA002536439A patent/CA2536439A1/en not_active Abandoned
- 2004-09-15 CN CNA2008100961200A patent/CN101318908A/zh active Pending
- 2004-09-15 SG SG200806897-5A patent/SG146645A1/en unknown
- 2004-09-15 MX MXPA06002796A patent/MXPA06002796A/es unknown
- 2004-09-15 RU RU2006105263/04A patent/RU2006105263A/ru not_active Application Discontinuation
- 2004-09-15 JP JP2006527002A patent/JP2007505910A/ja not_active Withdrawn
- 2004-09-15 KR KR1020067005153A patent/KR20060079217A/ko not_active IP Right Cessation
- 2004-09-15 EP EP04784171A patent/EP1663951A2/en not_active Withdrawn
- 2004-09-15 AU AU2004274450A patent/AU2004274450A1/en not_active Withdrawn
-
2006
- 2006-02-15 IL IL173750A patent/IL173750A0/en unknown
- 2006-02-17 NO NO20060767A patent/NO20060767L/no not_active Application Discontinuation
- 2006-03-06 CR CR8277A patent/CR8277A/es not_active Application Discontinuation
- 2006-03-08 CO CO06023402A patent/CO5670368A2/es unknown
- 2006-03-14 ZA ZA200602149A patent/ZA200602149B/xx unknown
- 2006-03-15 EC EC2006006423A patent/ECSP066423A/es unknown
-
2008
- 2008-03-10 US US12/075,227 patent/US20080161575A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06002796A (es) | 2006-06-14 |
| US20080161575A1 (en) | 2008-07-03 |
| NO20060767L (no) | 2006-06-07 |
| SG146645A1 (en) | 2008-10-30 |
| CA2536439A1 (en) | 2005-03-31 |
| RU2006105263A (ru) | 2007-11-10 |
| IL173750A0 (en) | 2006-07-05 |
| CO5670368A2 (es) | 2006-08-31 |
| KR20060079217A (ko) | 2006-07-05 |
| JP2007505910A (ja) | 2007-03-15 |
| CN101318908A (zh) | 2008-12-10 |
| WO2005028421A8 (en) | 2005-06-16 |
| WO2005028421A3 (en) | 2005-05-19 |
| ECSP066423A (es) | 2006-09-18 |
| US20050065181A1 (en) | 2005-03-24 |
| CN1849299A (zh) | 2006-10-18 |
| CN100395231C (zh) | 2008-06-18 |
| BRPI0414377A (pt) | 2007-04-10 |
| ZA200602149B (en) | 2009-09-30 |
| US7365203B2 (en) | 2008-04-29 |
| CR8277A (es) | 2006-07-14 |
| EP1663951A2 (en) | 2006-06-07 |
| WO2005028421A2 (en) | 2005-03-31 |
| AU2004274450A1 (en) | 2005-03-31 |
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