UA85750C2 - Комбинация лекарственных форм с контролируемым высвобождением опиоидов - Google Patents

Комбинация лекарственных форм с контролируемым высвобождением опиоидов Download PDF

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Publication number
UA85750C2
UA85750C2 UAA200703642A UAA200703642A UA85750C2 UA 85750 C2 UA85750 C2 UA 85750C2 UA A200703642 A UAA200703642 A UA A200703642A UA A200703642 A UAA200703642 A UA A200703642A UA 85750 C2 UA85750 C2 UA 85750C2
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UA
Ukraine
Prior art keywords
dosage form
dose
dosage forms
opioid
dosage
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Application number
UAA200703642A
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English (en)
Ukrainian (uk)
Inventor
Кертис Райт
Роберт Колуччи
Ахмед Эль-Тахтави
Original Assignee
Евро-Селтик С.А.
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Application filed by Евро-Селтик С.А. filed Critical Евро-Селтик С.А.
Publication of UA85750C2 publication Critical patent/UA85750C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Изобретение относится к комбинации лекарственных форм, включающих:a) первую лекарственную форму, содержащую первую эффективную дозу опиоида иb) вторую лекарственную форму, содержащую вторую эффективную дозу опиоида.Вторая эффективная доза выше первой. Обе лекарственные формы являются формами с контролируемым высвобождением, содержащими материал контролируемого высвобождения, который обеспечивает максимальную концентрацию Соднократной дозы второй лекарственной формы меньшую, чем минимальный уровень пропорциональности доз относительно первой лекарственной формы. Изобретение также относится к способу введения таких лекарственных форм пациенту, а также набору, который включает такие лекарственные формы и инструкцию из введения лекарственных форм пациенту.
UAA200703642A 2004-09-01 2005-08-30 Комбинация лекарственных форм с контролируемым высвобождением опиоидов UA85750C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60635404P 2004-09-01 2004-09-01

Publications (1)

Publication Number Publication Date
UA85750C2 true UA85750C2 (ru) 2009-02-25

Family

ID=35759199

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200703642A UA85750C2 (ru) 2004-09-01 2005-08-30 Комбинация лекарственных форм с контролируемым высвобождением опиоидов

Country Status (15)

Country Link
US (2) US9326959B2 (ru)
EP (1) EP1786404A2 (ru)
JP (1) JP4997109B2 (ru)
KR (2) KR20080046751A (ru)
CN (1) CN101010072A (ru)
AU (1) AU2005282784B2 (ru)
BR (1) BRPI0515600A (ru)
CA (1) CA2578540A1 (ru)
EA (1) EA010627B1 (ru)
IL (1) IL181600A0 (ru)
MX (1) MX2007002135A (ru)
NO (1) NO20071352L (ru)
UA (1) UA85750C2 (ru)
WO (1) WO2006028830A2 (ru)
ZA (1) ZA200700620B (ru)

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Also Published As

Publication number Publication date
AU2005282784A1 (en) 2006-03-16
IL181600A0 (en) 2007-07-04
WO2006028830A2 (en) 2006-03-16
MX2007002135A (es) 2007-04-02
EA200700500A1 (ru) 2007-08-31
KR20070048272A (ko) 2007-05-08
US9326959B2 (en) 2016-05-03
US9034377B2 (en) 2015-05-19
ZA200700620B (en) 2008-04-30
JP4997109B2 (ja) 2012-08-08
EA010627B1 (ru) 2008-10-30
CN101010072A (zh) 2007-08-01
BRPI0515600A (pt) 2008-07-29
AU2005282784B2 (en) 2008-06-19
KR20080046751A (ko) 2008-05-27
NO20071352L (no) 2007-05-30
US20140187572A1 (en) 2014-07-03
WO2006028830A3 (en) 2006-05-26
CA2578540A1 (en) 2006-03-16
JP2008511657A (ja) 2008-04-17
EP1786404A2 (en) 2007-05-23
US20080132532A1 (en) 2008-06-05

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