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Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
A process for the preparation of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide involves cyclizing acetoacetamide-N-sulfonic acid in the presence of a water-immiscible, inert organic solvent and, if appropriate, also an inert, inorganic solvent. the 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide obtained in the form of the SO3-adduct is hydrolyzed by adding water or ice. The inert, organic solvent is then removed from the resulting multi-phase mixture by distillation, and the 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is obtained in a pure form from the remaining aqueous sulfuric acid phase by crystallization. Additionally, quite generally, crude 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one 2,2-dioxide is purified by recrystallization from aqueous sulfuric acid.
UA4028042A1986-09-011986-09-01Process for the preparation of 6-methyl-3,4-dihydro-1,2,3-oxathiazin-4-one-2,2-dioxide
UA8331A1
(en)
Institut fur Pharmazeutische Chemie der Universitat Marburg, Marbacher Weg 6, D-3550 Marburg/Lahn, Germany This paper is dedicated to Professor EC Taylor on the occasion of his 70th birthday.