UA73155C2 - Substituted by piperidine and piperazine n-hydroxyformamides as metalloproteinase inhibitors - Google Patents
Substituted by piperidine and piperazine n-hydroxyformamides as metalloproteinase inhibitors Download PDFInfo
- Publication number
- UA73155C2 UA73155C2 UA2002075698A UA2002075698A UA73155C2 UA 73155 C2 UA73155 C2 UA 73155C2 UA 2002075698 A UA2002075698 A UA 2002075698A UA 2002075698 A UA2002075698 A UA 2002075698A UA 73155 C2 UA73155 C2 UA 73155C2
- Authority
- UA
- Ukraine
- Prior art keywords
- compound
- formula
- pyridyl
- pharmaceutically acceptable
- methyl
- Prior art date
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title claims description 39
- 239000003475 metalloproteinase inhibitor Substances 0.000 title abstract description 4
- 125000003386 piperidinyl group Chemical group 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 126
- -1 2-pyridyloxyl group Chemical group 0.000 claims description 46
- 150000003839 salts Chemical class 0.000 claims description 33
- 150000002148 esters Chemical class 0.000 claims description 32
- 229910052736 halogen Inorganic materials 0.000 claims description 29
- 238000006243 chemical reaction Methods 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 22
- 150000002367 halogens Chemical class 0.000 claims description 21
- 241000282414 Homo sapiens Species 0.000 claims description 18
- 230000007062 hydrolysis Effects 0.000 claims description 18
- 238000006460 hydrolysis reaction Methods 0.000 claims description 18
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 102000005741 Metalloproteases Human genes 0.000 claims description 16
- 108010006035 Metalloproteases Proteins 0.000 claims description 16
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 16
- 102000004190 Enzymes Human genes 0.000 claims description 15
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
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- ZHNUHDYFZUAESO-UHFFFAOYSA-N formamide Substances NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 10
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
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- AVJKDKWRVSSJPK-UHFFFAOYSA-N 1-(4-fluorophenyl)piperazine Chemical compound C1=CC(F)=CC=C1N1CCNCC1 AVJKDKWRVSSJPK-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
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- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 3
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- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 2
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- XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims 1
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00400467 | 2000-02-21 | ||
| PCT/GB2001/000624 WO2001062742A1 (en) | 2000-02-21 | 2001-02-15 | Piperidine- and piperazine substituted n-hydroxyformamides as inhibitors of metalloproteinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA73155C2 true UA73155C2 (en) | 2005-06-15 |
Family
ID=8173564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA2002075698A UA73155C2 (en) | 2000-02-21 | 2001-02-15 | Substituted by piperidine and piperazine n-hydroxyformamides as metalloproteinase inhibitors |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US6734183B2 (es) |
| EP (1) | EP1261590B1 (es) |
| JP (1) | JP4256095B2 (es) |
| KR (1) | KR20020073594A (es) |
| CN (1) | CN1247547C (es) |
| AR (1) | AR029657A1 (es) |
| AT (1) | ATE553097T1 (es) |
| AU (1) | AU783284B2 (es) |
| BG (1) | BG65276B1 (es) |
| BR (1) | BR0108501A (es) |
| CA (1) | CA2396965C (es) |
| CO (1) | CO5241356A1 (es) |
| CZ (1) | CZ20022828A3 (es) |
| EE (1) | EE200200462A (es) |
| HU (1) | HUP0302723A3 (es) |
| IL (1) | IL150806A0 (es) |
| IS (1) | IS6507A (es) |
| MX (1) | MXPA02008111A (es) |
| MY (1) | MY128164A (es) |
| NO (1) | NO323765B1 (es) |
| NZ (1) | NZ520104A (es) |
| PL (1) | PL365909A1 (es) |
| RU (1) | RU2283306C2 (es) |
| SA (1) | SA01220167B1 (es) |
| SG (1) | SG127737A1 (es) |
| SK (1) | SK287071B6 (es) |
| TW (1) | TWI276632B (es) |
| UA (1) | UA73155C2 (es) |
| WO (1) | WO2001062742A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0119473D0 (en) * | 2001-08-09 | 2001-10-03 | Astrazeneca | Compounds |
| GB0119474D0 (en) * | 2001-08-09 | 2001-10-03 | Astrazeneca Ab | Compounds |
| GB0119472D0 (en) * | 2001-08-09 | 2001-10-03 | Astrazeneca Ab | Compounds |
| US7511144B2 (en) | 2001-09-07 | 2009-03-31 | Kaken Pharmaceutical Co., Ltd. | Reverse hydroxamic acid derivatives |
| SE0301922D0 (sv) * | 2003-06-27 | 2003-06-27 | Astrazeneca Ab | Novel compounds |
| JP4866610B2 (ja) | 2003-08-18 | 2012-02-01 | 富士フイルムファインケミカルズ株式会社 | ピリジルテトラヒドロピリジン類およびピリジルピペリジン類 |
| GB0427403D0 (en) | 2004-12-15 | 2005-01-19 | Astrazeneca Ab | Novel compounds I |
| WO2007060132A1 (en) * | 2005-11-24 | 2007-05-31 | Laboratoires Serono S.A. | N-hydroxyamide derivatives and use thereof |
| GB0617367D0 (en) * | 2006-09-02 | 2006-10-11 | Astrazeneca Ab | Novel process |
| CA2722658C (en) | 2008-04-28 | 2018-09-18 | Richard L. Watson | Compositions and methods for treating multiple sclerosis |
| JP5808743B2 (ja) * | 2010-07-08 | 2015-11-10 | 科研製薬株式会社 | Ｎ−ヒドロキシホルムアミド誘導体およびそれを含有する医薬 |
| US10287255B2 (en) | 2014-03-12 | 2019-05-14 | Chong Kun Dang Pharmaceutical Corp. | Compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same |
| JP2022512584A (ja) | 2018-10-04 | 2022-02-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 角皮症を処置するためのｅｇｆｒインヒビター |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998016514A1 (en) | 1996-10-16 | 1998-04-23 | American Cyanamid Company | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| US6376506B1 (en) | 1997-01-23 | 2002-04-23 | Syntex (U.S.A.) Llc | Sulfamide-metalloprotease inhibitors |
| EA002810B1 (ru) * | 1997-01-23 | 2002-10-31 | Ф.Хоффманн-Ля Рош Аг | Сульфамидные ингибиторы металлопротеаз |
| ZA98376B (en) | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
| US6482827B1 (en) | 1997-07-10 | 2002-11-19 | Pharmacia & Upjohn S.P.A. | Matrix metalloproteinase inhibitors |
| AU8858398A (en) * | 1997-07-10 | 1999-02-08 | Pharmacia & Upjohn S.P.A. | Matrix metalloproteinase inhibitors |
| US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
| US6130220A (en) | 1997-10-16 | 2000-10-10 | Syntex (Usa) Inc. | Sulfamide-metalloprotease inhibitors |
| EP1051395B1 (en) | 1998-01-30 | 2006-11-22 | Darwin Discovery Limited | N-hydroxyformamide derivatives |
| WO2000012477A1 (en) | 1998-08-29 | 2000-03-09 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as proteinase inhibitors |
| GB9919776D0 (en) * | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
-
2001
- 2001-02-15 RU RU2002118301/04A patent/RU2283306C2/ru not_active IP Right Cessation
- 2001-02-15 BR BR0108501-8A patent/BR0108501A/pt not_active Application Discontinuation
- 2001-02-15 EE EEP200200462A patent/EE200200462A/xx unknown
- 2001-02-15 MX MXPA02008111A patent/MXPA02008111A/es active IP Right Grant
- 2001-02-15 KR KR1020027010762A patent/KR20020073594A/ko active Search and Examination
- 2001-02-15 PL PL01365909A patent/PL365909A1/xx not_active Application Discontinuation
- 2001-02-15 SG SG200404773A patent/SG127737A1/en unknown
- 2001-02-15 JP JP2001562524A patent/JP4256095B2/ja not_active Expired - Fee Related
- 2001-02-15 WO PCT/GB2001/000624 patent/WO2001062742A1/en active IP Right Grant
- 2001-02-15 SK SK1197-2002A patent/SK287071B6/sk not_active IP Right Cessation
- 2001-02-15 NZ NZ520104A patent/NZ520104A/en unknown
- 2001-02-15 CN CNB018053920A patent/CN1247547C/zh not_active Expired - Fee Related
- 2001-02-15 HU HU0302723A patent/HUP0302723A3/hu unknown
- 2001-02-15 EP EP01905885A patent/EP1261590B1/en not_active Expired - Lifetime
- 2001-02-15 AT AT01905885T patent/ATE553097T1/de active
- 2001-02-15 CZ CZ20022828A patent/CZ20022828A3/cs unknown
- 2001-02-15 AU AU33855/01A patent/AU783284B2/en not_active Ceased
- 2001-02-15 IL IL15080601A patent/IL150806A0/xx not_active IP Right Cessation
- 2001-02-15 UA UA2002075698A patent/UA73155C2/uk unknown
- 2001-02-15 CA CA2396965A patent/CA2396965C/en not_active Expired - Fee Related
- 2001-02-19 MY MYPI20010723A patent/MY128164A/en unknown
- 2001-02-20 CO CO01013250A patent/CO5241356A1/es not_active Application Discontinuation
- 2001-02-21 AR ARP010100790A patent/AR029657A1/es not_active Application Discontinuation
- 2001-02-21 US US09/788,687 patent/US6734183B2/en not_active Expired - Fee Related
- 2001-02-27 TW TW090104516A patent/TWI276632B/zh not_active IP Right Cessation
- 2001-06-23 SA SA01220167A patent/SA01220167B1/ar unknown
-
2002
- 2002-08-14 BG BG107003A patent/BG65276B1/bg unknown
- 2002-08-16 IS IS6507A patent/IS6507A/is unknown
- 2002-08-20 NO NO20023956A patent/NO323765B1/no not_active IP Right Cessation
-
2004
- 2004-02-26 US US10/787,813 patent/US7122551B2/en not_active Expired - Fee Related
-
2006
- 2006-08-24 US US11/509,490 patent/US20060287338A1/en not_active Abandoned
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