UA64693C2 - Novel staphylokinase derivatives, a method for the preparation thereof and pharmaceutical composition - Google Patents
Novel staphylokinase derivatives, a method for the preparation thereof and pharmaceutical composition Download PDFInfo
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- UA64693C2 UA64693C2 UA97073590A UA97073590A UA64693C2 UA 64693 C2 UA64693 C2 UA 64693C2 UA 97073590 A UA97073590 A UA 97073590A UA 97073590 A UA97073590 A UA 97073590A UA 64693 C2 UA64693 C2 UA 64693C2
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- Prior art keywords
- staphylokinase
- amino acid
- amino acids
- alanine
- replaced
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95200023A EP0721982A1 (de) | 1995-01-06 | 1995-01-06 | Neue staphylokinase Derivative |
| PCT/EP1996/000081 WO1996021016A2 (en) | 1995-01-06 | 1996-01-03 | New staphylokinase derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA64693C2 true UA64693C2 (en) | 2004-03-15 |
Family
ID=8219945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA97073590A UA64693C2 (en) | 1995-01-06 | 1996-03-01 | Novel staphylokinase derivatives, a method for the preparation thereof and pharmaceutical composition |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5695754A (de) |
| EP (1) | EP0721982A1 (de) |
| UA (1) | UA64693C2 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5951980A (en) * | 1995-01-06 | 1999-09-14 | Leuven Research & Development Vzw | Identification, production and use of new staphylokinase derivatives with reduced immunogenicity |
| EP0721013B1 (de) * | 1995-01-06 | 2005-03-09 | Leuven Research & Development VZW | Neue staphylokinase Derivate |
| US6383483B1 (en) | 1995-01-06 | 2002-05-07 | Désiré José Collen | Staphylokinase derivatives with cysteine substitutions |
| WO1999040198A2 (en) * | 1998-02-04 | 1999-08-12 | Thromb-X N.V. | Identification, production and use of staphylokinase derivatives with reduced immunogenicity and/or reduced clearance |
| ATE352559T1 (de) * | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| US20040101920A1 (en) * | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE139570T1 (de) * | 1991-12-30 | 1996-07-15 | Medac Klinische Spezialpraep | Expression signalpeptid-freier staphylokinasen |
-
1995
- 1995-01-06 EP EP95200023A patent/EP0721982A1/de not_active Withdrawn
- 1995-01-11 US US08/371,505 patent/US5695754A/en not_active Expired - Lifetime
-
1996
- 1996-03-01 UA UA97073590A patent/UA64693C2/uk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5695754A (en) | 1997-12-09 |
| EP0721982A1 (de) | 1996-07-17 |
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