UA24432U - Hepaphyt-1 herbal species - Google Patents

Abstract

The herbal species contains the herb of the stinging nettle, the root of the chicory, the herb of the origanum, the flowers of the thyme, the corn stigmata, the herb of the St.-John's wort, the herb of the common wormwood, the flowers of calendula, and the root of the dandelion.

Description

Description of the invention

The useful model relates to medicine, and in particular to gastroenterology and endocrinology, and can be used both in inpatient and outpatient settings for the treatment of non-alcoholic steatohepatosis and steatohepatitis, which are complications of type II diabetes.

Metabolic syndrome X with excess body weight, hyperinsulinemia, and hyperlipidemia is associated with elevated blood cholesterol and triglycerides, accompanied by impaired liver function and the occurrence of fatty liver dystrophy, the manifestations of which are steatohepatosis and steatohepatitis. Steatohepatitis is a pre-stage of cirrhosis of the liver and its prevalence, as a complication, is from 34 to 9095 in type II diabetes.

Known medicinal products that have a hepatoprotective effect and affect the metabolic syndrome - Legalen,

Silibor, Karsil, the active ingredient of which are flavonoids isolated from the fruits of the spotted thistle | Mashkovsky

M.D. Medicines. Kharkov. Torsing, 1997, T.1.-S.514-516), the well-known hepatoprotective agent Lipofen, 12 containing soy phospholipids, flakumin, vitamins B, Ve, E and soy base. It is recommended to use this drug in complex therapy for liver damage due to diabetes, hepatitis, etc. (Stalemate.

Mo35027A Sha, IPC Ab1KZ35/78,9/66. Publ. Bul. 2001, Mod.

However, when using these drugs, side effects of a weakening effect, allergic reactions are possible.

Collections of medicinal plants that have hepatoprotective, antioxidant, anti-inflammatory and/or hypoglycemic effects are also known. Among them is Hepanorm, which includes the fruits of spotted thistle, sand cumin, burkun grass, calendula flowers, common chicory, corn cobs, peppermint or birch leaves; a tool that contains an extract of corn cobs, peppermint, rosehip, horsetail, dry beetroot juice; collection - Afradepien, containing blueberry sprouts, bean pods, Manchurian aralia root, horsetail, rose hips, St. John's wort, chamomile flowers (Pat. Mob9958А OA, MPK Ab1KZ35/78. Publ. Byul. 2004, Me9;

Stalemate. Mo2122419 C1 KU, IPC AbITKZ5/78. Publ. Bul. 1998, Mo3; Minezhin G.Z Collection of folk medicine and non-traditional methods of treatment. M.: Technozkos, 19911.

Also known is the collection - Lon-1-U, which contains chamomile flowers, peppermint leaves, plantain leaves, nettles, rosehip fruits, chicory root, valerian root, oat seeds, motherwort (Pat. Mo34877А OA, IPC

Ab1KZ35/78. Publ. Bul. 2001, Mo2). This collection is used for the prevention and treatment of diabetes, metabolic polyarthritis, stimulation of the immune system, treatment of liver and kidney diseases. co

However, this collection stimulates gastric secretion, which is undesirable for patients with diabetes and is not suitable for the treatment of steatohepatosis. WITH

The basis of this useful model is the task of expanding the arsenal of medicinal plants for the treatment of steatohepatitis in type II diabetes, by selecting components and optimal quantitative 3o composition, which will provide a wide range of specific activity. high school

The task is achieved by the fact that in the collection, which contains nettle grass, chicory roots, motherwort grass, according to a useful model, cumin flowers, corn cobs with lotions, St. John's wort grass, bitter wormwood grass, calendula flowers, dandelion root, with the following "ratio of components by mass: - 10 centum flowers 10" corn cobs with sockets 15 " bitter wormwood grass 7 motherwort grass 10 nettle grass 8 o chicory roots 25 s" St. John's wort grass 5 calendula flowers 10 sh dandelion root 10. p. 50

The development of this medical collection became possible thanks to the clarification of both its chemical composition and the pharmacological qualities of the components, as well as the pathogenetic mechanisms of the development of non-alcoholic steatohepatosis and steatohepatitis against the background of diabetes, the main of which is the accumulation of free fatty acids in hepatocytes and the strengthening of free radical oxidation processes with the accumulation of peroxide products oxidation of lipids 29 (POL), which lead to a violation of the integrity of cell membranes of hepatocytes and the initiation of a cascade of processes with the formation of fibrous tissue in the liver.

The introduction into the collection of medicinal plants of the flowers of sand sedum, corn cobs with receptacles, bitter wormwood grass, St. John's wort, calendula flowers, dandelion root in this mass ratio of 9o provides the collection with a wide range of specific effects. 60 So, the inflorescence of the sedum contains flavonoid glycosides, flavonoids, essential oil, resinous and bitter substances, ascorbic acid, vitamin K, etc., which helps to increase bile secretion, changes the chemistry of bile, exhibits anti-inflammatory, antibacterial, antispasmodic effects, stimulates the pancreas .

Corn cobs contain saponins, tannins, flavonoids, alkaloids, ascorbic and pantothenic acids, etc. They have choleretic, diuretic, hypoglycemic properties, because they affect lipid metabolism and suppress appetite.

Wormwood herb has amino acids - 13 free and 20 bound, flavonoids, inulin, vitamins C, K, B, B», -D-

carotene, essential oils and normalizes lipid metabolism, has an antidiabetic effect, improves the protein-synthesizing function of the liver, improves reparative processes.

St. John's wort has flavonoids, tannins, choline, etc. It has an anti-atherosclerotic effect, improves metabolic processes in the liver, improves blood circulation, reduces spasm of the sphincter of Oddi.

Calendula flowers contain carotenoids, flavonoids, saponins, resinous and tannic substances, inulin, organic acids, etc. They have anti-inflammatory, antispasmodic, hypotensive properties, increase the metabolic function of the liver.

Dandelion root contains choline, up to 40,905 inulins, organic acids, trace elements and essential amino acids. Promotes oxidation and removal of cholesterol in the form of bile acids, improves water-salt exchange.

The composition of this agent in the given mass.9o was selected by studying antioxidant, hepatoprotective, anti-inflammatory, hypolipidemic and hypoglycemic activity. It has been experimentally proven that this composition of components is optimal and has a potentiating effect.

The authors showed that a decrease in the mass of the components of the collection leads to a decrease in the therapeutic activity of the collection, while an increase can lead to increased bile formation and undesirable consequences.

The tool is prepared and used as follows.

Medicinal plant raw materials collected and dried according to the regulations of the procurement rules are crushed on a special grinder. 1 tablespoon of the crushed mass of the collection is poured with a glass of boiled water at room temperature, closed with a lid and insisted in a boiling water bath for 15 minutes, cooled, filtered. Use 1/2 cup of the infusion 3 times a day through ЗОхв. after meals. It is taken for 1-1.5 months with periodic repetition.

The efficiency of the collection was studied in models of white Wistar rats. A spectrophotometric method of determining the level of metabolites of lipid peroxidation in the liver, the protein-synthesizing function of the liver, indicators of carbohydrate and lipid metabolism in the blood of animals was used for a comprehensive assessment of the effectiveness of the pharmacological action of a mixture of medicinal plants. The antioxidant activity of blood serum, the level of glucose, total protein, and total cholesterol were determined.

Under the influence of this agent, indicators of carbohydrate, protein and lipid metabolism in the body of rats improved. The tool contributed to the normalization of lipoperoxidation processes, which were disturbed during oxidative modification of biomembranes and prevented the development of pathological processes. me)

In this way, specific hepatoprotective, antioxidant, membrane protective, antitoxic, anti-inflammatory, hypolipidemic and hypoglycemic effects have been proven.

The results of preclinical studies were confirmed when clinical studies were conducted on 30 patients. "

Example. with

Patient V. 51 years old, diagnosis: diabetes || type, of average severity, has been ill for 10 years. Takes sugar-lowering drugs against the background of a diet.

Complaints of periodic discomfort in the mesogastric area, a feeling of heaviness, nausea, dry mouth, frostbite of the lower extremities. Glucose content in fasting blood - 8.4 mmol/l. "

Consultation of a gastroenterologist is scheduled. The liver is enlarged by 2 cm from the edge of the costal arch, there is pain on palpation. Laboratory data: total bilirubin 8.0 mmol/l; alanine aminotransferase - 1.1 mmol/l, . aspartate aminotransferase - 0.bOmmol/l, total blood cholesterol - 3.ummol/l, blood triglycerides - 3.0mmol/l, high-density lipoproteins - 0.674mmol/l, low-density lipoproteins - 1.8mmol/l.

Results of ultrasound examination of internal organs: liver - vertical dimension of the right lobe is 7 150 mm, the edge is rounded, the parenchyma is medium-grained, homogeneously compacted, dorsal attenuation of the ultrasound to the potential, the vascular network is expanded. The intrahepatic ducts are not dilated. The diagnosis was made - steatohepatitis. o Treatment with Hepafit-1 collection is prescribed for 28 days. After the treatment, their patient felt a decrease in discomfort in the mesogastric area. Dyspeptic symptoms completely disappeared and general well-being improved - fatigue disappeared, working capacity increased. Biochemical indicators were normalized. The fasting blood glucose level is 5.0 mol/l. Total bilirubin - 104 mmol/l, ALT -

Ge 0.ZOmmol/l, AST - 0.20mmol/l.

It is recommended to repeat the course of treatment after 3-4 weeks.

Thus, the proposed collection of Hepafit-1 increases the effectiveness of treatment - the main clinical manifestations of the disease disappear and are associated with non-alcoholic steatohepatosis and steatohepatitis, the well-being of patients improves. The tool does not cause side effects, allergic reactions and can be used both in inpatient and outpatient settings.

Claims (1)

The formula of the invention A collection of medicinal herbs that contains nettle grass, chicory roots, motherwort grass, which is distinguished by the fact that it additionally includes cumin flowers, corn cobs with receivers, St. John's wort grass, bitter wormwood grass, calendula flowers, dandelion root, in the following ratio 65 components, by mass. 90: cumin flowers 10 corn cobs with receivers 15 wormwood grass 7 motherwort grass 10 nettle grass 8 chicory roots 25 St. John's wort grass B calendula flowers 10 dandelion root 10. Official Bulletin "Industrial Property". Book 1 "Inventions, useful models, topographies of integrated microcircuits", 2007, M 9, 25.06.2007. State Department of Intellectual Property of the Ministry of Education and/5 Science of Ukraine. z z s so « « s - - y? name) Chek" Chek" (95) Ko) 60 b5