UA125793U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

Diagnostic method for the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR C677T, eNOS T786C gene polymorphism in serum, endothelin content, CMP, IL-6, IL-6, IL-6, IL-6 TT, 786-CC, endothelin levels> 10 ng / ml, COMP> 595 ng / ml, IL-6> 10 ng / l, SRP> 6 mg / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. - M.: Med. lit., 2003. - Vol. 6. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow early diagnosis of atherosclerosis.

The task is solved by the fact that along with the study of low- and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the genes methylenetetrahydrofolate reductase (MITNEV Сб677Т), nitric oxide synthase (emoОо5 17860), the content of endothelin, cartilage oligomeric matrix protein (СОМР), interleukin 6 (IL-b6), C-reactive protein (CRP), homocysteine. At homozygous carriers of 677-TT, 786-SS, levels of endothelin 210 ng/ml, SOMR »595 ng/ml, IL-6 »10 ng/l, SRP »6 mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphisms of the MITNEV C677tT, emMO5 T786C genes are determined in blood serum, the endothelin content is determined by the immunoenzymatic method,

SOMR, IL-6, SRP, homocysteine. At homozygous carriers of 677-TT, 786-SS, levels of endothelin 210 ng/ml, SOMR »595 ng/ml, IL-b6 »10 ng/l, SRP »6b mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient V., 46 years old, was hospitalized in the clinic with a diagnosis of rheumatoid arthritis.

Examined Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. No signs of atherosclerosis were detected. The polymorphism of MTNEV S677T and emMo5 T7860 genes was determined in blood serum. The content of endothelin, SOMP, IL-6, SRP, and homocysteine was determined by immunoenzymatic method. Homozygous carriers of 677-111 and 786-

SS. Levels of endothelin - 14 ng/ml, SOMR - 595 ng/ml, IL-6 - 21 ng/l, PSA - 14 mg/l, homocysteine - 32 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic confirmation of the diagnosis was obtained only after 14 months.

Thus, the proposed method makes it possible to establish a diagnosis at the early stages of the development of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, determination of MTNEV C677T, eMmo5 T786C gene polymorphisms in blood serum, endothelin content, SOMR, IL-b6, PSA, homocysteine, which differs in that with homozygous carriers of 677-TT, 786-SS , levels of endothelin 210 ng/ml, SMR »595 ng/ml, IL-6 »10 ng/l, SRP »b mg/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.