UA118530U - METHOD OF PREVENTION OF OXIPROLINE AND CREATININ HOMEOSTASE DISORDERS IN DOMESTIC CATS - Google Patents

Abstract

Method for the prevention of homeostasis disorders of oxyprolin and creatinine in domestic cats, intended as prevention of disorders of connective tissue, protein, water-salt and mineral metabolism in this species of animals, which includes the use of feed additives with biologically active substances: amino acids, vitamins, vitamins, vitamins trace elements. Apply a collagen-protective amino acid-vitamin-mineral premix to carnivorous animals as part of two sets: a set of vitamins and amino acids and a set of macro- and micro-elements, with the participation of which collagen is synthesized in the body, with the addition of each of these sets to the base 0.5-0.9 g / kg animal weight once a day, alternately every other day for 1-1.5 months, with 2-3 week breaks, to prevent the formation of antivitamins in the body and the accumulation of injected substances.

Description

The useful model belongs to veterinary medicine, namely to auxiliary factors of feed for carnivores, containing ingredients: organic, inorganic and of unknown composition, which can be used for the prevention of disorders of the state of connective tissue, protein, water-salt and mineral metabolism in domestic cats

Analogues of a useful model. Known methods of treatment of glomerulonephritis in domestic cats, when chronic progressive kidney disease is formed by using daily for 7-14 days: - drugs to improve hemodynamics and increase glomerular filtration in the kidneys - furosemide intravenously at 0.5 ml - desensitizing agents - diphenhydramine subcutaneously 1, 5 ml once a day; - vitamin preparations of group B and C - 0.5 ml intravenously; - antibacterial agents - 2.5 ml digitalis intravenously 2 times a day;

Dmytrenko N.I. Glomerulonephritis in domestic cats (pathogenesis, diagnosis and treatment).

Autoref. thesis Ph.D. Vet. of science - Bila Tserkva, 2009. - 20 p.

A known method of treatment of chronic kidney failure on I! stage in domestic cats.

It includes a blood test for the level of creatinine and urea in the animal's blood and, additionally, for the content of oxyproline and uronic acids (to assess the state of connective tissue of different localization).

At the same time, the directions of medical correction include: - improvement of hemodynamics and strengthening of glomerular filtration in the kidneys (solcoseryl 1 ml intramuscularly 2 times a day, 14 days, pentoxifylline 1 ml intramuscularly 1 time a day, 14 days, subcutaneous injection 0, 9 96 sodium chloride solution 40 ml 2 times a day for 5 days and drinking boiled water without restrictions in order to restore violations of water and electrolyte metabolism); - adsorption of metabolic products in the intestines (oral administration of enterosgel per 1 teaspoonful with 2-3 ml of water 1.5-2 hours before or after feeding or other oral adsorbents, a course of 14 days) with subsequent stimulation of the tone and secretion of the gastrointestinal tract tract (ubretide 0.1 ml deep intramuscularly once every 2 days, 8 days); - measures to improve metabolism - mineral, vitamin, carbohydrate, protein and lipid (Katozal 2 ml subcutaneously once a day, 14 days, nephroprotector of plant origin - nephropatin 0.5 ml with water orally 3 times a day, 14 days) ; - kidney and urinary tract infections - 0.5 ml of amoxicillin subcutaneously once a day for 10 days; - diet therapy - Wow! Sapip Repay canned food - strictly according to the recommended dosage scheme.

However, modern studies have proven the connection between the manifestations of chronic renal failure in domestic cats and the degradation of collagen in the event of a violation of the homeostasis of oxyproline (hydroxyproline) - a non-standard amino acid that is part of the main protein of connective tissue - collagen and with the participation of which in the presence of oxygen, ascorbic acid and amino acids lysine and proline, collagen is synthesized. An indicator of a violation of oxyproline homeostasis is its increased level in urine. The latter, respectively, is a signal of an increased level of degradation of collagen and connective tissue, which occurs in pathological conditions.

At the same time, a violation of the homeostasis of creatinine as the final product of protein exchange in the body of warm-blooded animals in the blood serum in the range of lower values indicates insufficient protein content in the diet, and an increased concentration of creatinine in the blood serum above the norm is an indicator of an excessive amount of meat in the diet (if there is also an increased the amount of creatinine in the urine) or kidney failure (if the concentration of creatinine is increased only in the blood).

Morozenko D.V. Chronic renal failure of domestic cats (pathogenesis, diagnosis and treatment). Autoref. thesis Ph.D. Vet. of science Bila Tserkva - 2008. - 22 p. A.V. Lipin, A.V. Sanin, E.V.

Zinchenko. Veterinary directory. Traditional and non-traditional methods of treating cats. 2002. por://teabribv.ip.sa/o5pirki-Koptiepii-K.ozpek. to sweat

Thus, we are talking about a number of widespread and slowly progressing pathologies among carnivorous animals, especially the feline family, which lead a sedentary lifestyle (zoo animals, domestic cats, etc.). Terminologically combined into chronic renal failure (CKD), have irreversible disorders of the excretory, endocrine and metabolic function of the kidneys, progress to bilateral damage to the structure of their tissues in primary and secondary diseases such as: primary and systemic glomerulonephritis, nephritis, chronic pyelonephritis, urolithiasis and other asymptomatic and mildly symptomatic kidney lesions.

The analogues do not take into account that: - Lysine and proline, vitamin C and oxygen are necessary amino acids for the synthesis of collagen of the connective tissue of internal organs. Also, a lack of the amino acid arginine in the diet, which is necessary for the elimination of nitrogen metabolism products, causes the accumulation of toxic ammonia in the blood.

An unbalanced excessive amount of sulfur-containing amino acids in diets can cause metabolic acidosis. - For the normal functioning of the body of animals of this family, the supply of 12 minerals is necessary: calcium, phosphorus, magnesium, potassium, sodium, chlorine, iron, copper, zinc, manganese, selenium and iodine. At the same time, an excess of magnesium, calcium and phosphorus can cause the formation of kidney stones. Therefore, the composition of the ration should not be formed by using a significant content of bone mass, meat and bone meal, it is undesirable to introduce pyrophosphates to encourage animals to use feed.

Almost all cats in captivity suffer from various pathologies caused by vitamin deficiency

It is absorbed in the small intestine, so its amount decreases with duodenitis, nephritis and pneumonia, changes in the microbial symbiosis in the intestines. The composition of cat food, both conventional and professional, does not always satisfy the need of animals in the daily norm of vitamins. The norm is 1 mg per 10 kg of body weight, for pregnant and lactating animals the norm is increased by 25 95.

Also, the body uses the hydroxylating effect of vitamin C to transform harmful compounds, bacterial toxins into harmless ones. Strengthen the effect of vitamin C - synergistic vitamins: P and

E. Finally, vitamin C causes physiological effects, the mechanism of which has not yet been fully elucidated, but their presence has been clearly demonstrated. The most famous is the stimulation of the immune system. It has been shown that interferon production increases in the patient's body with regular intake of vitamin C.

It is also important that vitamin C takes part in the synthesis of steroid hormones in the adrenal glands.

Ascorbynka according to Pauling. pErulymlispet.tvy.5shpivLoshgpaiIv/spetiie/roNpd2a.pIti

Ascorbic acid. Veterinarian. por//azsotbisasia.sot.tsa/arriisayop/ueyeigipatlua. to sweat

Chronic renal failure, as a constantly progressing pathological process, periodically puts the owner of the animal at risk of its premature loss or the need for significantly expensive, often with a pessimistic prognosis, treatment in the clinic. At the same time, the statistics of requests for veterinary help show that in most cases, the owner of the animal brings it to the brink of a neglected state of kidneys and accompanying pathologies of other organs and systems

From the body. In our opinion, timely and affordable prevention of the progression of this disease can prevent this. On this basis.

The basis of a useful model is the development of a method of maintaining the homeostasis of creatinine and oxyproline as indicators of the functional state of the kidneys in order to prevent the development of chronic renal failure and related pathologies.

The task is solved by administering orally with feed biologically active substances in the composition of medicinal substances: amino acids, vitamins, macro- and microelements, and, according to a useful model, using a collagen-protective amino acid-vitamin-mineral premix for carnivores in the composition two sets: a set of vitamins and amino acids and a set of macro- and microelements, with the participation of which collagen synthesis occurs in the body, with the addition of each of these sets to the main diet in a dose of 0.5-0.9 g/kg of animal weight once per day alternately every other day for 1-1.5 months with breaks of 2-3 weeks to prevent the creation of anti-vitamins in the body and accumulation of injected substances.

Application of the method of prevention of violations of the homeostasis of oxyproline and oxyproline in animals provides the following technical result: - the level of creatinine in urine is maintained; - the level of oxyproline in the blood is maintained; - the development of the inflammatory process in the kidneys and adrenal glands is prevented; - water-electrolyte exchange, hemodynamics and glomerular filtration in the kidneys are supported; - the release of metabolic products into the intestines decreases; - the activity of the process decreases in systemic diseases of the connective tissue in the kidneys, liver and other pathologies; - metabolism in the animal's body is activated, which is especially important in case of anemia; - the animal's health is maintained at an acceptable level against the background of a significant reduction in costs for periodic treatment courses in the clinic.

The cause-and-effect relationship of the set of essential features and the technical result that is achieved is the use of positive properties of premixes, which allow regular oral administration of dietary food products together with 60 biologically active substances into the body, thereby influencing collagen homeostasis (in the direction stimulation of its synthesis and prevention of degradation by introducing into the premix the necessary amino acids, macro- and microelements, vitamins) in the structure of the connective tissue of internal organs, kidneys, which allows to maintain their excretory, endocrine and metabolic function and, as a result, prevent the occurrence and progression chronic renal failure and related pathologies.

Confirms the possibility of implementing a useful model - available formulation of "collagen-protective amino acid-vitamin-mineral premix for carnivores" as part of sets: - set of vitamins and amino acids:

Vb 50y5Og1

R 1blnokyuk1

The biological activity of substances included in this premix gives it the following properties: - the amino acid arginine prevents the accumulation of toxic ammonia in the blood; - lysine and proline - indispensable amino acids for collagen synthesis; - potassium iodide with sodium chloride provide a water-salt balance and replenish iodine deficiency, which normalizes the work of the thyroid gland, which promotes collagen synthesis; - iron (II), copper (II), together with zinc, take part in hematopoiesis; - copper also takes part in the metabolism, synthesis of collagen - contributes to the creation of strong frameworks of bones and blood vessels, together with vitamin C, helps to keep the immune system normal; - zinc together with vitamin A is a necessary complex for collagen renewal; - selenium - a powerful antioxidant; - vitamin C provides: synthesis of collagen from procollagen; promotes the removal of bacterial toxins; stimulates the immune system; promotes the formation of interferon; takes part in the synthesis of steroid hormones; (Vitamin (F) in animal husbandry, see:/azsogbisasia.sot.pa/apisIv/23-miiyatip-5-m-2pii moipomoavzime.piti

Zo Vitamin for cats, piEr:/BbeiKamei pgy/airoi/mtatipu-Kozpek. sweat) - vitamins: - Vi (thiamine) - necessary for the regulation of hormones, metabolism, stability of the nervous system, regulates water - salt exchange; - B2 (riboflavin) - an active catalyst of oxygen exchange and transport processes in the body;

- Vie (pyridoxine) - participates in hematopoiesis and synthesis of neurotransmitters. It is also useful for the quality of the skin, promoting the synthesis of nucleic acids.

Specific examples of method application.

Example 1. Collagen-protective amino acid-vitamin-mineral premix for carnivorous animals was added to the feed three times a week every other day of each set of 0.5 g per 1 kg of animal weight to cats and cats of various breeds aged 2-5 years. from CNN. The course lasted for one month, then there was a two-week break, and then the prevention process was repeated.

Example 2 The collagen-protective amino acid-vitamin-mineral premix for carnivores was introduced into the feed three times a week every other day of each set of 0.7 g per 1 kg of animal weight to cats and cats of various breeds aged 2-5 years, with HNN The course lasted for one month, then there was a two-week break, and then the prevention process was repeated.

Example 3. Collagen-protective amino acid-vitamin-mineral premix for carnivores was added to the feed three times a week every other day of each set of 0.9 g per 1 kg of animal weight to cats and cats of various breeds aged 2-5 years, from CNN. The course lasted for one month, then there was a two-week break, and then the prevention process was repeated.

Observations on animals showed a significant increase in the intervals between visits to the doctor, and exacerbations of this pathology were observed with less pronounced clinical manifestations.

During periodic examinations during periods of remission, tests for the level of creatinine in blood plasma and oxyproline in urine in most animals were kept at subthreshold values. At the same time: - in example 1, the results were on the border of satisfactory, - in example 2, the results were satisfactory, - in example C, the results were good.

Conclusion: it is enough to add collagen-protective amino acid-vitamin-mineral premix to feed in a single dose of each set of 0.6-0.9 g per 1 kg of animal weight per day, alternately every other day, for one month with subsequent breaks of two weeks .

Claims (1)

FORMULA OF THE USEFUL MODEL Zo The method of prevention of violations of the homeostasis of oxyproline and creatinine in domestic cats, which is prescribed as a prevention of violations of the state of connective tissue, protein, water-salt and mineral metabolism in this species of animals, which includes the use of feed additives with biologically active substances: amino acids, vitamins , macro- and microelements, which differs in that it uses a collagen-protective amino acid-vitamin-mineral premix for carnivores in two sets: a set of vitamins and amino acids and a set of macro- and microelements, with the participation of which collagen is synthesized in the body, with the addition of each of these sets to the main diet at a dose of 0.5-0.9 g/kg of animal weight once a day, alternately every other day for 1-1.5 months with breaks of 2-3 weeks to prevent the creation of antivitamins and cumulation of injected substances.