UA105034C2 - Фармацевтична комбінація 5-фторурацилу і похідного 1,4-дигідропіридину та її застосування в лікуванні раку - Google Patents

Фармацевтична комбінація 5-фторурацилу і похідного 1,4-дигідропіридину та її застосування в лікуванні раку

Info

Publication number
UA105034C2
UA105034C2 UAA201110839A UAA201110839A UA105034C2 UA 105034 C2 UA105034 C2 UA 105034C2 UA A201110839 A UAA201110839 A UA A201110839A UA A201110839 A UAA201110839 A UA A201110839A UA 105034 C2 UA105034 C2 UA 105034C2
Authority
UA
Ukraine
Prior art keywords
fluorouracil
derivate
dihydropyridine
cancer
treatment
Prior art date
Application number
UAA201110839A
Other languages
English (en)
Russian (ru)
Inventor
Егілс Бісініекс
Гунарс Дубурс
Ілмарс Стонанс
Original Assignee
Гріндекс, Е Джоінт Сток Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гріндекс, Е Джоінт Сток Компані filed Critical Гріндекс, Е Джоінт Сток Компані
Publication of UA105034C2 publication Critical patent/UA105034C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Нові сполуки типу ефіру 2,6-диметил-1,4-дигідропіридин-3,5-дикарбонової кислоти загальної формули (І), де R - це нижча алкільна група, що є метилом або етилом, a R1 і R2 - це натрію карбоксилат-метиловий ефір, які дають синергічний цитотоксичний ефект в комбінації з 5-фторурацилом.
UAA201110839A 2009-03-11 2010-03-11 Фармацевтична комбінація 5-фторурацилу і похідного 1,4-дигідропіридину та її застосування в лікуванні раку UA105034C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09154872 2009-03-11
EP09159197 2009-04-30
EP09173816A EP2228365A1 (en) 2009-03-11 2009-10-22 Pharmaceutical combination of 5-fluorouracil and derivative of 1,4-dihydropyridine and its use in the treatment of cancer
PCT/EP2010/053094 WO2010103067A1 (en) 2009-03-11 2010-03-11 Pharmaceutical combination of 5-fluorouracil and derivate of 1,4-dihydropyridine and its use in the treatment of cancer

Publications (1)

Publication Number Publication Date
UA105034C2 true UA105034C2 (uk) 2014-04-10

Family

ID=41396245

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201110839A UA105034C2 (uk) 2009-03-11 2010-03-11 Фармацевтична комбінація 5-фторурацилу і похідного 1,4-дигідропіридину та її застосування в лікуванні раку

Country Status (8)

Country Link
US (1) US8492413B2 (uk)
EP (2) EP2228365A1 (uk)
JP (1) JP2012520264A (uk)
CN (1) CN102348685A (uk)
EA (1) EA018566B1 (uk)
GE (1) GEP20135897B (uk)
UA (1) UA105034C2 (uk)
WO (1) WO2010103067A1 (uk)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2578218A1 (en) * 2011-10-06 2013-04-10 Grindeks, A Joint Stock Company Antiviral efficacy of disodium 2,6-dimethyl-1,4-dihydropyridine-3,5-bis(carbonyloxyacetate) and its derivatives
CN114349687B (zh) * 2020-10-13 2023-11-17 中山奕安泰医药科技有限公司 3,5-二羧酸酯-1,4-二氢吡啶类氢化试剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE439980B (sv) 1978-06-02 1985-07-08 United Stirling Ab & Co Forfarande och anordning for reglering av luft/brensleblandning vid brennare av den typ som er utformade med ett evaporatorror
SU725406A1 (ru) 1978-08-08 1981-07-30 Ордена Трудового Красного Знамениинститут Органического Синтеза Ah Латвий-Ской Ccp Эфиры диметил дигидропиридин диКАРбОНОВОй КиСлОТы,ОблАдАющиЕ АНТи-МЕТАСТАТичЕСКОй АКТиВНОСТью

Also Published As

Publication number Publication date
JP2012520264A (ja) 2012-09-06
EA018566B1 (ru) 2013-08-30
EA201101175A1 (ru) 2012-03-30
GEP20135897B (en) 2013-08-12
EP2228365A1 (en) 2010-09-15
EP2406218A1 (en) 2012-01-18
US20120022088A1 (en) 2012-01-26
CN102348685A (zh) 2012-02-08
WO2010103067A1 (en) 2010-09-16
US8492413B2 (en) 2013-07-23

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