UA103034C2 - Picolinamide derivatives as kinase inhibitors - Google Patents
Picolinamide derivatives as kinase inhibitors Download PDFInfo
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- UA103034C2 UA103034C2 UAA201101618A UAA201101618A UA103034C2 UA 103034 C2 UA103034 C2 UA 103034C2 UA A201101618 A UAA201101618 A UA A201101618A UA A201101618 A UAA201101618 A UA A201101618A UA 103034 C2 UA103034 C2 UA 103034C2
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- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title abstract description 54
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract description 150
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- 238000000034 method Methods 0.000 abstract description 96
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- 201000011510 cancer Diseases 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 17
- 241001465754 Metazoa Species 0.000 abstract description 16
- 239000003795 chemical substances by application Substances 0.000 abstract description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 12
- 102100036077 Serine/threonine-protein kinase pim-1 Human genes 0.000 abstract description 4
- 230000005764 inhibitory process Effects 0.000 abstract description 4
- 230000001404 mediated effect Effects 0.000 abstract description 3
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
В заявке описаны новые соединения, композиции и способы ингибирования активности провирусной интеграции киназы Мелони (киназы PIM), связанные с онкогенезом у человека или животного.В некоторых вариантах осуществления соединения и композиции эффективны для ингибирования активности по меньшей мере одной киназы PIM.Новые соединения и композиции можно использовать отдельно или в комбинации по меньшей мере с одним дополнительным средством, предназначенным для лечения нарушения, опосредованного серин/треонинкиназой или рецепторной тирозинкиназой, такого как рак.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9366608P | 2008-09-02 | 2008-09-02 | |
| PCT/EP2009/061205 WO2010026124A1 (en) | 2008-09-02 | 2009-08-31 | Picolinamide derivatives as kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA103034C2 true UA103034C2 (en) | 2013-09-10 |
Family
ID=43566735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201101618A UA103034C2 (en) | 2008-09-02 | 2009-08-31 | Picolinamide derivatives as kinase inhibitors |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR073474A1 (ru) |
| JO (1) | JO3055B1 (ru) |
| UA (1) | UA103034C2 (ru) |
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2009
- 2009-08-31 UA UAA201101618A patent/UA103034C2/uk unknown
- 2009-09-01 JO JOP/2009/0326A patent/JO3055B1/ar active
- 2009-09-01 AR ARP090103346 patent/AR073474A1/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AR073474A1 (es) | 2010-11-10 |
| JO3055B1 (ar) | 2017-03-15 |
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