TWM621796U - Air-pressure supplying device - Google Patents

Abstract

The present invention provides an air pressure supply device for supplying air pressure to a detection device. The air pressure supply device includes: a main body; a bearing platform disposed on the main body for carrying the detection device; a positive pressure motor disposed in the main body for generating positive pressure; A negative pressure motor arranged on the body to generate negative pressure; a first solenoid valve with two first inlets and a first outlet, wherein the two first inlets are respectively connected with the positive pressure motor and the negative pressure motor to control the positive pressure or negative pressure through; and a second solenoid valve with a second inlet, an atmospheric port and a second outlet, wherein the second inlet is connected to the first outlet of the first solenoid valve for the passage of positive pressure or negative pressure, and the atmospheric port For providing normal pressure passage, the second outlet is connected to the detection device, and the positive pressure, negative pressure or normal pressure is provided to the detection device through the second solenoid valve.

Description

Air pressure supply device

This creation relates to an air pressure supply device for providing air pressure to a detection device, especially an air pressure supply device that can provide micro positive pressure, micro negative pressure, positive pressure, negative pressure or normal pressure.

Circulating tumor cells (CTCs) have been widely used as a potential tool for cancer diagnosis and prognosis because their presence in the blood may suggest metastatic recurrence. To detect rare CTCs in blood samples, automated, fast and sensitive detection devices have been developed that can perform all experimental procedures without any manual intervention. The detection device needs the air pressure supply device to provide air pressure to actuate the pump and valve in the detection device. However, the existing air pressure supply device cannot provide a tiny air pressure, which often causes the membrane of the pump to be damaged and cannot be used. Moreover, the existing air pressure supply device cannot provide normal pressure, so that the membrane of the pump cannot return to a flat state during the inspection process. , resulting in cell damage, so an air pressure supply device that can provide micro-air pressure and normal pressure to the detection device is required.

For this reason, in view of the lack of known technology, the applicant has made careful experiments and researches, and with a spirit of perseverance, finally created the "air pressure supply device" in this case to improve the above-mentioned lack of known technology.

The air pressure supply device of this creation can not only provide a large positive and negative air pressure to control the valve action in the detection device, but also can provide a small positive and negative air pressure through the positive pressure micro-regulating valve and the negative pressure micro-regulating valve, and can pass the solenoid valve. The atmospheric port provides atmospheric pressure to more precisely regulate the pump action in the detection device.

An aspect of the present invention is to provide an air pressure supply device for supplying a positive pressure, a negative pressure or a normal pressure to a microfluidic chip, wherein the microfluidic chip includes a first pump, and the air pressure supply The device includes: a main body; a bearing table, arranged on the main body, for carrying the micro-channel chip; a positive pressure motor, arranged on the main body, to generate the positive pressure; a negative pressure motor, arranged on the The main body is used to generate the negative pressure; a first positive pressure micro-regulating valve is connected to the positive pressure motor to precisely adjust the magnitude of the positive pressure to generate a first micro positive pressure; a first negative pressure A micro-regulating valve, connected with the negative pressure motor, is used to precisely adjust the magnitude of the negative pressure to generate a first micro-negative pressure; a first solenoid valve has two first inlets and a first outlet, wherein the second An inlet is respectively connected with the first positive pressure micro-regulating valve and the first negative pressure micro-regulating valve, for controlling the passage of the first micro-positive pressure or the first micro-negative pressure; and a second solenoid valve having a A second inlet, a first atmospheric port and a second outlet, wherein the second inlet is connected to the first outlet of the first solenoid valve for allowing the first micro-positive pressure or the first micro-negative pressure to pass through , the first atmospheric port is used to provide the normal pressure passage, the second outlet is connected to the first pump of the micro-channel chip, and the first micro-positive pressure, the first The micro-negative pressure or the normal pressure is supplied to the micro-channel chip, and then the first pump is actuated.

Another aspect of the present invention is to provide an air pressure supply device for supplying air pressure to a detection device, comprising: a main body; a bearing platform disposed on the main body to carry the detection device; a positive pressure motor disposed The main body is used to generate a positive pressure; a negative pressure motor is arranged on the main body to generate a negative pressure; a first solenoid valve has two first inlets and a first outlet, wherein the two The first inlet is respectively connected with the positive pressure motor and the negative pressure motor to control the passage of the positive pressure or the negative pressure; and a second solenoid valve, which has a second inlet, an air inlet and a second outlet, The second inlet is connected to the first outlet of the first solenoid valve for allowing the positive pressure or the negative pressure to pass through, the atmospheric port is used to provide a normal pressure to pass through, and the second outlet is connected to the detection device , and the positive pressure, the negative pressure or the normal pressure is supplied to the detection device through the second solenoid valve.

Another aspect of the present invention is to provide an air pressure supply device for supplying air pressure to a detection device, comprising: a main body; a bearing platform disposed on the main body to carry the detection device; a positive pressure motor, provided with on the main body, to generate the positive pressure; a negative pressure motor, arranged on the main body, to generate the negative pressure; a positive pressure micro-regulating valve, connected with the positive pressure motor, to precisely adjust the positive pressure The size of the pressure to generate a micro positive pressure; a negative pressure micro-regulating valve, connected with the negative pressure motor, to precisely adjust the size of the negative pressure to generate a micro negative pressure; and a solenoid valve, with two inlets and a an outlet, wherein the two inlets are respectively connected with the positive pressure micro-regulating valve and the negative pressure micro-regulating valve to control the passage of the micro-positive pressure or the micro-negative pressure, and the outlet is connected with the detection device to provide the The slight positive pressure or the slight negative pressure is applied to the detection device.

In order to make the above and other purposes, features and advantages of this creation more clear It is easy to understand, and a preferred embodiment is given below, which is combined with the accompanying drawings for a detailed description.

10: Detection device

100: Microfluidic chip

110: First Pump

120: Second Pump

130A~130H: Valve

140: Collection area

20, 400: Air pressure supply device

210: Ontology

212: Upper Floor

214: Lower Floor

220: Positive pressure supply source

222: Positive pressure motor

224: Positive pressure gas distribution groove

230: Negative pressure supply source

232: Negative pressure motor

234: Negative pressure gas distribution groove

240: Positive pressure micro-regulating valve

242: The first positive pressure micro-regulating valve

244: The second positive pressure micro-regulating valve

250: Negative pressure micro-regulating valve

252: The first negative pressure micro-regulating valve

254: Second negative pressure micro-regulating valve

260: The first solenoid valve group

262, 264, 266, 411, 421, 431A~431H, 441, 451: The first solenoid valve

270: The second solenoid valve group

272, 274, 276, 412, 422, 432A~432H, 442, 452: The second solenoid valve

273, 275, 277: Atmospheric port

280: carrying platform

282: Heating device

310: Pressure Sensor

312: First pressure sensor

314: Second pressure sensor

320: Collection trough

330: Magnetic Device

340: Fan

350: Controller

[Fig. 1] is a schematic diagram of the configuration of the air pressure supply device of the present invention.

[ FIG. 2 ] is a schematic diagram of an embodiment of the detection device applied to the air pressure supply device of the present invention.

[Fig. 3] is a schematic diagram of an embodiment of the air pressure supply device of the present invention applied to a detection device.

The following describes the various embodiments of the "air pressure supply device" in this case, please refer to the accompanying drawings, but the actual configuration and the adopted method do not necessarily fully conform to the described content, and those skilled in the art should be able to do so without departing from the Various changes and revisions are made within the actual spirit and scope of the case.

The air pressure supply device of the present invention is used to provide air pressure to the detection device. In the example of the present invention, the detection device can be used to detect biological substances (such as circulating tumor cells, fetal microfluidic chips for cells, bacteria, viruses, epithelial cells, endothelial cells, etc.).

Please refer to FIG. 1 , which is a schematic diagram of the configuration of the air pressure supply device of the present invention. The air pressure supply device 20 of the present invention includes a main body 210 , and the main body 210 includes an upper layer 212 and a lower layer 214 . The air pressure supply device 20 further includes a positive pressure supply source 220, a negative pressure supply source 230, a positive pressure micro-regulating valve 240, a negative pressure micro-regulating valve 250, The first solenoid valve group 260 , the second solenoid valve group 270 , and the carrying platform 280 for carrying the detection device 10 . The positive pressure supply source 220 includes a positive pressure motor 222 and a positive pressure air distribution groove 224, which are respectively disposed on the lower layer 214 and the upper layer 212 of the main body 210. The positive pressure motor 222 and the positive pressure air distribution groove 224 are connected by air pipes, and the positive pressure The positive pressure gas generated by the motor 222 is stored in the positive pressure gas distribution tank 224 to provide positive pressure. The negative pressure supply source 230 includes a negative pressure motor 232 and a negative pressure air distribution groove 234, which are respectively disposed on the lower layer 214 and the upper layer 212 of the main body 210. The negative pressure motor 232 and the negative pressure air distribution groove 234 are connected by air pipes, and the negative pressure The vacuum suction force generated by the motor 232 is stored in the negative pressure air distribution groove 234 to provide negative pressure.

The air pressure supply device 20 of the present invention can provide micro positive pressure, micro negative pressure and normal pressure to the detection device 10, and the micro air pressure supply path is from the positive pressure air distribution groove 224 and the negative pressure air distribution groove 234 through the positive pressure micro-regulating valve 240 , the negative pressure micro-regulating valve 250 , the first solenoid valve 262 and the second solenoid valve 272 to the detection device 10 . The positive pressure micro-regulating valve 240 is connected to the positive-pressure gas distribution tank 224 through a gas pipe. When the positive-pressure gas passes through the positive-pressure micro-regulating valve 240, the pressure of the positive pressure gas can be adjusted to 1-6 psi to provide a micro positive pressure. The negative pressure micro-regulating valve 250 is connected to the negative pressure air distribution groove 234 through the trachea. When the vacuum suction passes through the negative pressure micro-regulating valve 250, the pressure of the vacuum suction can be adjusted to -1-6 psi to provide micro negative pressure. The positive pressure micro-regulating valve 240 and the negative pressure micro-regulating valve 250 of the present invention can be accurate to ±0.01psi. The first solenoid valve 262 includes two inlets and one outlet, wherein the two inlets of the first solenoid valve 262 are respectively connected to the positive pressure micro-regulating valve 240 and the negative pressure micro-regulating valve 250 by air pipes, and are disposed on the lower layer 214 of the main body 210 through a gas pipe. The controller 350 of the controller 350 controls which inlet is to be opened, the micro positive pressure generated by the positive pressure micro-regulating valve 240 passes through or the micro-negative pressure generated by the negative pressure micro-regulating valve 250 passes through, and is transported to the outlet of the first solenoid valve 262 mouth. The second solenoid valve 272 includes an inlet, an air port 273 and an outlet, wherein the inlet of the second solenoid valve 272 is connected to the outlet of the first solenoid valve 262 by a gas pipe, so that the slight positive pressure from the first solenoid valve 262 or When the slight negative pressure passes through, the atmospheric port 273 of the second solenoid valve 272 can allow the atmosphere to pass through to provide normal pressure, and the second solenoid valve 272 can control which inlet to be opened through the controller 350 disposed on the lower layer 214 of the main body 210. The pressure or slight negative pressure or normal pressure passes through and is transported to the outlet of the second solenoid valve 272 . The outlet of the second solenoid valve 272 is connected to the detection device 10 by a gas pipe, so as to provide a slight positive pressure, a slight negative pressure or a normal pressure to the detection device 10 . The air pressure supply device 20 of the present invention may further include a pressure sensor 310 disposed on the air pipe between the outlet of the second solenoid valve 272 and the detection device 10 for sensing the magnitude of the micro positive pressure or micro negative pressure, so as to Determine the amount of pressure input to the detection device 10 .

In the present invention, when the air pressure supply device 20 is to provide a micro positive pressure to the detection device 10, it is necessary to open the first solenoid valve 262 connected to the inlet of the positive pressure micro regulator valve 240 and open the second solenoid valve 272 connected to the first electromagnetic valve Inlet to valve 262. When the air pressure supply device 20 is to provide micro negative pressure to the detection device 10 , it is necessary to open the first solenoid valve 262 connected to the inlet of the negative pressure micro-regulating valve 250 and the second solenoid valve 272 to be connected to the inlet of the first solenoid valve 262 . When the air pressure supply device 20 is to provide normal pressure to the detection device 10 , the air port 273 of the second solenoid valve 272 needs to be opened.

The air pressure supply device 20 of the present invention may include multiple sets of positive pressure micro-regulating valves 240 , negative pressure micro-regulating valves 250 , a first solenoid valve 262 and a second solenoid valve 272 for use by different detection devices 10 . That is to say, the air pressure supply device 20 of the present invention may have more than two lines to provide micro positive pressure, micro negative pressure and normal pressure to the detection device 10 .

The air pressure supply device 20 of the present invention can also provide positive pressure, negative pressure and normal pressure to the detection device 10. The air pressure supply path is from the positive pressure air distribution groove 224 and the negative pressure air distribution groove 234 through the first solenoid valve 264 and the first solenoid valve 264. Two solenoid valves 274 to the detection device 10 . Since the air pressure supply path does not pass through the positive pressure micro-regulating valve 240 and the negative pressure micro-regulating valve 250 , the pressures of the provided positive pressure and negative pressure are ±0.1-12 psi. Similarly, the first solenoid valve 264 includes two inlets and one outlet, wherein the two inlets of the first solenoid valve 264 are respectively connected to the positive pressure air distribution groove 224 and the negative pressure air distribution groove 234 by air pipes, and are arranged on the main body through The controller 350 of the lower layer 214 of the 210 controls which inlet to be opened, the positive pressure generated by the positive pressure gas distribution groove 224 passes through or the negative pressure generated by the negative pressure gas distribution groove 234 passes through, and is transported to the outlet of the first solenoid valve 264 . The second solenoid valve 274 includes an inlet, an air port 275 and an outlet, wherein the inlet of the second solenoid valve 274 is connected to the outlet of the first solenoid valve 264 by a gas pipe, which can allow positive or negative pressure from the first solenoid valve 264 The atmospheric port 275 of the second solenoid valve 274 can allow atmospheric pressure to pass through to provide normal pressure, and the second solenoid valve 274 can control which inlet to open through the controller 350 disposed on the lower layer 214 of the main body 210, from positive pressure or negative pressure. The pressure or atmospheric pressure is passed through and delivered to the outlet of the second solenoid valve 274 . The outlet of the second solenoid valve 274 is connected to the detection device 10 by a gas pipe, so as to provide positive pressure or negative pressure or normal pressure to the detection device 10 .

In the present invention, when the air pressure supply device 20 is to provide positive pressure to the detection device 10, it is necessary to open the first solenoid valve 264 connected to the inlet of the positive pressure air distribution groove 224 and open the second solenoid valve 274 to connect to the first solenoid valve 264 entrance. When the air pressure supply device 20 is to provide negative pressure to the detection device 10, it is necessary to open the first solenoid valve 264 connected to the inlet of the negative pressure air distribution groove 234 and the second solenoid valve 274 to be connected to the first solenoid valve 264 entrance. When the air pressure supply device 20 is to provide normal pressure to the detection device 10 , the air port 275 of the second solenoid valve 274 needs to be opened.

The air pressure supply device 20 of the present invention may include multiple sets of the first solenoid valve 264 and the second solenoid valve 274 for use by different detection devices 10 . That is to say, the air pressure supply device 20 of the present invention can have more than two lines to provide positive pressure, negative pressure and normal pressure to the detection device 10 .

The air pressure supply device 20 of the present invention can also only provide negative pressure and normal pressure to the detection device 10 . Since the air pressure supply path does not pass through the positive pressure micro-regulating valve 240 , the negative pressure micro-regulating valve 250 and the positive pressure air distribution groove 224 , the pressure of the provided negative pressure is -0.1-12 psi. Similarly, the first solenoid valve 266 includes two inlets and one outlet, wherein the two inlets of the first solenoid valve 266 are respectively connected to the positive pressure air distribution groove 224 and the negative pressure air distribution groove 234 by air pipes, and are arranged on the main body through air pipes. The controller 350 of the lower layer 214 of the 210 controls the negative pressure generated by the negative pressure air distribution groove 234 to pass through and deliver it to the outlet of the first solenoid valve 264 . The second solenoid valve 276 includes an inlet, an air port 277 and an outlet, wherein the inlet of the second solenoid valve 276 is connected to the outlet of the first solenoid valve 266 by a gas pipe, so that the negative pressure from the first solenoid valve 266 can pass through, The atmospheric port 277 of the second solenoid valve 276 can allow the atmosphere to pass through to provide normal pressure, and the second solenoid valve 276 can control which inlet to open through the controller 350 disposed on the lower layer 214 of the body 210, and the negative pressure or normal pressure can pass through and Delivered to the outlet of the second solenoid valve 276 . The outlet of the second solenoid valve 276 is connected to the detection device 10 by a gas pipe, so as to provide negative pressure or normal pressure to the detection device 10 . The air pressure supply device 20 of the present creation may further include a collection tank 320, which is provided with Between the outlet of the second solenoid valve 276 and the detection device 10 , the waste liquid in the detection device 10 is collected by the negative pressure provided.

In this way, when the air pressure supply device 20 is to provide negative pressure to the detection device 10, it is necessary to open the first solenoid valve 266 to connect to the inlet of the negative pressure air distribution groove 234 and to open the second solenoid valve 276 to connect to the first solenoid valve 266 entrance. When the air pressure supply device 20 is to provide normal pressure to the detection device 10 , the air port 277 of the second solenoid valve 276 needs to be opened.

The air pressure supply device 20 of the present invention delivers the micro positive pressure, micro negative pressure, positive pressure, negative pressure and normal pressure to the detection device 10 through three paths to perform different functions. In addition, the air pressure supply device 20 of the present invention can control the air pressure supply device 20 to operate automatically through a computer or other electronic device.

The air pressure supply device 20 of the present invention further includes a magnetic device 330 , which is disposed on the lower layer 214 of the main body 210 and located below the bearing platform 280 . The magnetic device 330 can generate a magnetic field to attract magnetic substances in the detection device 10 . The magnetic device 330 can be moved to be close to the carrier 280 , or even attached to the bottom of the carrier 280 .

The bottom of the bearing platform 280 of the air pressure supply device 20 of the present invention is a heating device 282 , which can heat the detection device 10 . The air pressure supply device 20 of the present invention further includes at least one fan 340 disposed on the lower layer 214 of the main body 210 to cool the detection device 10 .

Example

In the embodiment of the present invention, the detection device 10 is a micro-channel wafer 100 as shown in FIG. 2 . The lower layer of the microfluidic chip 100 is for the flow of biological fluid samples Liquid channel, the upper layer is a gas channel for gas to pass through. The microfluidic chip 100 includes a first pump 110, a second pump 120, eight valves 130A-130H and a collection area 140, and the gas pressure provided by the gas pressure supply device 400 is supplied to the gas channel of the microfluidic chip 100 to make the first pump 100. The first pump 110, the second pump 120, and the eight valves 130A~130H actuate.

Please refer to FIG. 3 , which is a schematic diagram of an implementation of the air pressure supply device of the present invention applied to the microfluidic chip 100 . Please refer to FIGS. 2-3 , in the embodiment of the present invention, the microfluidic chip 100 is disposed on the stage 280 (as shown in FIG. 1 ) of the air pressure supply device 400 , and the air pressure supply device 400 provides 12 sets of air pressure paths, These include 2 sets of paths providing slightly positive pressure, slightly negative pressure or normal pressure, 8 sets of paths providing positive pressure, negative pressure or normal pressure, 1 set of paths providing negative pressure or normal pressure, and 1 set of empty air pressure paths , so as to conform to the microfluidic wafer 100 shown in FIG. 2 .

The two groups of the air pressure supply device 400 for providing micro-positive pressure, micro-negative pressure or normal pressure are the first micro-air pressure path and the second micro-air pressure path, which make the first pump 110 and the second micro-air pressure path of the microfluidic chip 100 respectively. Pump 120 in action. The first micro air pressure path is for the positive pressure motor 222 to provide positive pressure to the first positive pressure micro-regulating valve 242 through the positive pressure air distribution groove 224 to generate the first micro positive pressure, and the negative pressure motor 232 to provide negative pressure through the negative pressure air distribution groove 234 pressure to the first negative pressure micro-regulating valve 252 to generate the first micro-negative pressure, the generated first micro-positive pressure and the first micro-negative pressure are supplied to the first solenoid valve 411, and the first solenoid valve 411 controls the first micro-positive pressure Or the first micro-negative pressure is delivered to the second solenoid valve 412 , and the second solenoid valve 412 controls the first micro-positive pressure or the first micro-negative pressure or the normal pressure to be delivered to the micro-channel chip 100 to activate the first pump 110 . The second micro-pressure path is for the positive-pressure motor 222 to provide positive pressure to the second positive-pressure micro-regulating valve 244 through the positive-pressure air distribution groove 224 to generate the second micro-positive pressure, and the negative-pressure motor 232 passes through The negative pressure gas distribution groove 234 provides negative pressure to the second negative pressure micro-regulating valve 254 to generate the second micro-negative pressure, and the generated second micro-positive pressure and the second micro-negative pressure are provided to the first solenoid valve 421, and the first solenoid The valve 421 controls the second micro-positive pressure or the second micro-negative pressure to be transported to the second solenoid valve 422, and the second solenoid valve 422 controls the second micro-positive pressure or the second micro-negative pressure or the normal pressure to be transported to the micro-channel wafer 100, to actuate the second pump 120 . Likewise, a first pressure sensor 312 and a second pressure sensor 314 may be respectively disposed on the first micro-pressure path and the second micro-pressure path to sense the first micro-positive pressure or the first micro-negative pressure, respectively , and the magnitude of the second micro-positive pressure or the second micro-negative pressure.

In this embodiment, the upward and downward pressures of the first pump 110 and the second pump 120 of the microfluidic chip 100 through the respective membranes cause liquid flow in the liquid channel. When the air pressure supply device 400 provides a slight positive pressure to the first pump 110 and the second pump 120 of the microfluidic chip 100 , the thin films of the first pump 110 and the second pump 120 are pressed down. When the air pressure supply device 400 provides a slight negative pressure to the first pump 110 and the second pump 120 of the microfluidic chip 100 , the thin films of the first pump 110 and the second pump 120 rise. When the air pressure supply device 400 supplies the normal pressure to the first pump 110 and the second pump 120 of the microfluidic chip 100 , the thin films of the first pump 110 and the second pump 120 are in a flat state. Since the first pump 110 and the second pump 120 of the microfluidic chip 100 move the liquid in the liquid channel of the microfluidic chip 100 through the action of a thin film, if the positive and negative pressures provided are too large, the thin film will be damaged. Therefore, the first micro-air pressure path and the second micro-air pressure path can provide slight air pressure, so that the films of the first pump 110 and the second pump 120 will not be damaged under the condition of maximum liquid flow. In addition, the first micro-air pressure path and the second micro-air pressure path can also provide normal pressure, so that the film is subjected to micro-negative pressure. After the pressure rises, it can be restored to a flat state first, and then pressed down by a slight positive pressure, which can prevent the biological material in the biological liquid sample from being damaged by being quickly squeezed by the film.

The eight sets of paths of the air pressure supply device 400 for providing positive pressure, negative pressure or normal pressure are the first air pressure path to the eighth air pressure path, which respectively actuate the eight valves 130A- 130H of the microfluidic chip 100 . Each air pressure path is the same. The positive pressure air distribution groove 224 and the negative pressure air distribution groove 234 respectively provide positive pressure and negative pressure to each of the first solenoid valves 431A to 431H, and each of the first solenoid valves 431A to 431H applies the positive pressure Or negative pressure is delivered to the respective corresponding second solenoid valves 432A- 432H, and each second solenoid valve 432A- 432H then delivers positive pressure, negative pressure or normal pressure to the respective corresponding valves 130A- 130H. Taking the first air pressure path as an example, the first air pressure path is that the positive pressure motor 222 provides positive pressure to the first solenoid valve 431A through the positive pressure air distribution groove 224, and the negative pressure motor 232 provides negative pressure to the first solenoid valve 431A through the negative pressure air distribution groove 234. A solenoid valve 431A, the first solenoid valve 431A controls positive or negative pressure to be delivered to the second solenoid valve 432A, and the second solenoid valve 432A controls positive or negative pressure or normal pressure to deliver to the microfluidic chip 100, so that the valve 130A action. Since the valves 130A- 130H of the micro-channel chip 100 require strong air pressure to actuate, the first air pressure path to the eighth air pressure path can provide air pressures of ±0.1-12 psi for the valves 130A- 130H to actuate.

In this embodiment, when the air pressure supply device 400 provides negative pressure to the valves 130A- 130H of the microfluidic chip 100, the valves 130A- 130H rise and open. When the air pressure supply device 400 provides positive pressure to the valves 130A to 130H of the microfluidic chip 100 , the valves 130A to 130H are pressed down and closed. When the air pressure supply device 400 supplies normal pressure to the valves 130A- 130H of the micro-channel chip 100, the valves 130A- 130H are in a closed state.

One set of paths for supplying negative pressure or normal pressure of the air pressure supply device 400 is a negative pressure path, which is connected to the collection area 140 of the microfluidic wafer 100 , so that the waste liquid in the collection area 140 is collected into the collection tank 320 . The negative pressure path is that the positive pressure motor 222 provides positive pressure to the first solenoid valve 441 through the positive pressure gas distribution groove 224 , the negative pressure motor 232 provides negative pressure to the first solenoid valve 441 through the negative pressure gas distribution groove 234 , and the first solenoid valve 441 . 441 provides negative pressure to the second solenoid valve 442, and the second solenoid valve 442 controls the negative pressure or normal pressure to be transported to the collection tank 320, and then transported to the collection area 140 of the microfluidic wafer 100, so that the waste liquid in the collection area 140 is transported to the collection tank 320. Collected in the collection tank 320 by negative pressure.

In this embodiment, when the air pressure supply device 400 provides negative pressure to the collection area 140 of the microfluidic wafer 100 , the waste liquid in the collection area 140 is collected into the collection tank 320 . When there is no waste liquid in the collection area 140 of the microfluidic wafer 100 or the waste liquid has not reached the amount to be removed, the air pressure supply device 400 may provide normal pressure to the collection region 140 of the microfluidic wafer 100 .

In this embodiment, each first solenoid valve and each second solenoid valve are controlled by the controller 350 (as shown in FIG. 1 ) to control the positive pressure inlet, negative pressure inlet or normal pressure inlet of each solenoid valve to open to The micro-positive pressure, micro-negative pressure, positive pressure, negative pressure or normal pressure are transported to the micro-channel wafer 100 .

In this embodiment, in order to conform to the microfluidic chip 100 of FIG. 2 , the air pressure supply device 400 leaves a set of inactive air pressure paths. When other detection devices are required, this set of air pressure paths can provide positive pressure, negative pressure or normal pressure. This set of air pressure paths is provided by the positive pressure motor 222 to the first solenoid valve 451 through the positive pressure air distribution groove 224, and the negative pressure Press the horse Da 232 provides negative pressure to the first solenoid valve 451 through the negative pressure air distribution groove 234, the first solenoid valve 451 sends the positive pressure or negative pressure to the second solenoid valve 452, and the second solenoid valve 452 then sends the positive pressure or negative pressure Or the normal pressure is transported to the required place of the detection device.

In this embodiment, the air pressure supply device 400 also includes a magnetic device 330 (as shown in FIG. 1 ) that can generate a magnetic field to attract the magnetic substances in the microfluidic chip 100 , and a heating device for heating and cooling the microfluidic chip 100 respectively. Device 282 and fan 340 (shown in Figure 1).

To sum up, the present invention can indeed use a novel concept. The air pressure supply device provides micro-positive pressure, micro-negative pressure, positive pressure, negative pressure and normal pressure to the detection device through three paths, so as to control and detect more precisely. The operation of each element in the device, and reduce the damage of the substance under test. Therefore, those who are familiar with this technique can make all kinds of modifications by craftsmen, but they will not deviate from the protection of the scope of the patent application attached.

10: Detection device

20: Air pressure supply device

210: Ontology

212: Upper Floor

214: Lower Floor

220: Positive pressure supply source

222: Positive pressure motor

224: Positive pressure gas distribution groove

230: Negative pressure supply source

232: Negative pressure motor

234: Negative pressure gas distribution groove

240: Positive pressure micro-regulating valve

250: Negative pressure micro-regulating valve

260: The first solenoid valve group

262, 264, 266: the first solenoid valve

270: The second solenoid valve group

272, 274, 276: Second solenoid valve

273, 275, 277: Atmospheric port

280: carrying platform

282: Heating device

310: Pressure Sensor

320: Collection trough

330: Magnetic Device

340: Fan

350: Controller

Claims (16)

An air pressure supply device for providing a positive pressure, a negative pressure or a normal pressure to a micro-channel chip, wherein the micro-channel chip includes a first pump, and the air pressure supply device includes: a body; a carrying table, disposed on the body, for carrying the microfluidic chip; a positive pressure motor, disposed on the body, for generating the positive pressure; a negative pressure motor, disposed on the body, for generating the negative pressure; a first positive pressure micro-regulating valve, connected to the positive pressure motor, for precisely adjusting the magnitude of the positive pressure to generate a first micro positive pressure; a first negative pressure micro-regulating valve, connected with the negative pressure motor, for precisely adjusting the magnitude of the negative pressure to generate a first micro negative pressure; A first solenoid valve, having two first inlets and a first outlet, wherein the two first inlets are respectively connected with the first positive pressure micro-regulating valve and the first negative pressure micro-regulating valve for controlling the first A slight positive pressure or the first slight negative pressure is passed; and A second solenoid valve has a second inlet, a first atmospheric port and a second outlet, wherein the second inlet is connected to the first outlet of the first solenoid valve for supplying the first micro-positive pressure Or the first micro-negative pressure passes through, the first atmospheric port is used to provide the normal pressure through, the second outlet is connected to the first pump of the micro-channel chip, and the second solenoid valve is used to pass the first pump. A micro-positive pressure, the first micro-negative pressure or the normal pressure is provided to the micro-channel chip, so that the The first pump action. The air pressure supply device according to claim 1, wherein the microfluidic chip further comprises a second pump, and the air pressure supply device further comprises: a second positive pressure micro-regulating valve, connected with the positive pressure motor, for precisely adjusting the magnitude of the positive pressure to generate a second micro positive pressure; a second negative pressure micro-regulating valve, connected with the negative pressure motor, for precisely adjusting the magnitude of the negative pressure to generate a second micro negative pressure; A third solenoid valve has two third inlets and a third outlet, wherein the two third inlets are respectively connected with the second positive pressure micro-regulating valve and the second negative pressure micro-regulating valve for controlling the second A slight positive pressure or the second slight negative pressure is passed; and A fourth solenoid valve has a fourth inlet, a second atmospheric port and a fourth outlet, wherein the fourth inlet is connected to the third outlet of the third solenoid valve for supplying the second micro-positive pressure Or the second micro-negative pressure passes through, the second atmospheric port is used to provide the normal pressure through, the fourth outlet is connected to the second pump of the micro-channel chip, and the fourth solenoid valve is used to pass the first Two micro-positive pressure, the second micro-negative pressure or the normal pressure are supplied to the micro-channel chip, and then the second pump is actuated. The air pressure supply device as claimed in claim 2, further comprising a pressure sensor disposed between the second solenoid valve and the fourth solenoid valve and the micro-channel chip for sensing the first micro-positive pressure, the second micro-positive pressure, the first micro-negative pressure or the second micro-negative pressure. The air pressure supply device as claimed in claim 2, wherein the microfluidic chip further comprises a plurality of valves, and the air pressure supply device further comprises: A plurality of fifth solenoid valves, each with two fifth inlets and a fifth outlet, wherein the two fifth inlets are respectively connected with the positive pressure motor and the negative pressure motor to control the passage of the positive pressure or the negative pressure; as well as A plurality of sixth solenoid valves, each of which is respectively connected with each of the fifth solenoid valves, each of the sixth solenoid valves has a sixth inlet, a third air port and a sixth outlet, wherein the sixth solenoid valve The inlet is connected to the fifth outlet of the corresponding fifth solenoid valve for passing the positive pressure or the negative pressure, the third large port is used to provide the normal pressure, and the sixth outlet is connected to the micro-channel chip One of the plurality of valves is connected, and the positive pressure, the negative pressure or the normal pressure is supplied to the microfluidic chip through the plurality of sixth solenoid valves, so that the plurality of valves are actuated. The air pressure supply device of claim 4, further comprising a positive pressure air distribution groove and a negative pressure air distribution groove, wherein the positive pressure air distribution groove is connected to the positive pressure motor for storing the air generated by the positive pressure motor a positive pressure gas, and supply the positive pressure gas to the first positive pressure micro-regulating valve, the second positive pressure micro-regulating valve and the plurality of fifth solenoid valves, and the negative pressure gas distribution groove is connected to the negative pressure motor is used to store a vacuum suction force generated by the negative pressure motor, and provide the vacuum suction force to the first negative pressure micro-regulating valve, the second negative pressure micro-regulating valve and the plurality of fifth solenoid valves. The air pressure supply device as claimed in claim 5, further comprising a collection tank, wherein the micro-channel chip further includes a collection area, the collection tank is arranged between the negative pressure gas distribution tank and the collection area of the micro-channel chip, and is used for a waste liquid in the collection area Collected into the collection tank by the negative pressure. The air pressure supply device as claimed in claim 1, further comprising a magnetic device disposed below the support table for generating a magnetic field to attract a magnetic substance in the microfluidic chip. The air pressure supply device as claimed in claim 1, further comprising at least one fan disposed on the body, and the support table includes a heating device, wherein the heating device and the at least one fan are respectively used for the microfluidic chip Heating and cooling. An air pressure supply device for providing air pressure to a detection device, comprising: a body; a bearing platform, disposed on the main body, for bearing the detection device; a positive pressure motor, disposed on the body, for generating a positive pressure; a negative pressure motor, disposed on the body, for generating a negative pressure; a first solenoid valve, having two first inlets and a first outlet, wherein the two first inlets are respectively connected with the positive pressure motor and the negative pressure motor for controlling the passage of the positive pressure or the negative pressure; and A second solenoid valve has a second inlet, an atmospheric port and a second outlet, wherein the second inlet is connected to the first outlet of the first solenoid valve for allowing the positive pressure or the negative pressure to pass through , the atmospheric port is used to provide a normal pressure through, the second outlet is connected to the detection device, and the positive pressure, the negative pressure or the normal pressure is supplied to the detection device through the second solenoid valve. The air pressure supply device as claimed in claim 9, further comprising: a positive pressure micro-regulating valve connected to the positive pressure motor for precisely adjusting the magnitude of the positive pressure to generate a micro-positive pressure; a negative pressure micro-regulating valve , connected with the negative pressure motor to precisely adjust the magnitude of the negative pressure to generate a micro negative pressure; a third solenoid valve with two third inlets and a third outlet, wherein the two third inlets are respectively connected to the The positive pressure micro-regulating valve and the negative pressure micro-regulating valve are connected to control the passage of the micro-positive pressure or the micro-negative pressure; and a fourth solenoid valve, which has a fourth inlet, a second air port and a fourth an outlet, wherein the fourth inlet is connected to the third outlet of the third solenoid valve for the passage of the slight positive pressure or the slight negative pressure, the second atmospheric port is used for the passage of the normal pressure, the fourth The outlet is connected to the detection device, and the slight positive pressure, the slight negative pressure or the normal pressure is provided to the detection device through the fourth solenoid valve. The air pressure supply device as claimed in claim 10, further comprising a pressure sensor disposed between the fourth solenoid valve and the detection device for sensing the magnitude of the micro positive pressure or the micro negative pressure. The air pressure supply device of claim 10, further comprising a positive pressure air distribution groove and a negative pressure air distribution groove, wherein the positive pressure air distribution groove is connected to the positive pressure motor for storing the air generated by the positive pressure motor a positive pressure gas, and provides The positive pressure gas is connected to the first solenoid valve and the positive pressure micro-regulating valve, and the negative pressure gas distribution groove is connected to the negative pressure motor for storing a vacuum suction force generated by the negative pressure motor and providing the vacuum suction force to the first solenoid valve and the negative pressure micro-regulating valve. The air pressure supply device according to claim 12, further comprising a collection tank, wherein the collection tank is arranged between the negative pressure air distribution tank and the detection device, and is used for a waste liquid in the detection device to pass through the detection device. The negative pressure is collected into the collection tank. The air pressure supply device as claimed in claim 9, further comprising a magnetic device disposed under the bearing platform for generating a magnetic field to attract a magnetic substance in the detection device. The air pressure supply device according to claim 9, further comprising at least one fan disposed on the main body, and the supporting platform includes a heating device, wherein the heating device and the at least one fan are respectively used for heating and Cool down. An air pressure supply device for supplying air pressure to a detection device, comprising: a main body; a bearing platform arranged on the main body to carry the detection device; a positive pressure motor arranged on the main body to generate the positive pressure; a negative pressure motor installed on the body to generate the negative pressure; a positive pressure micro-regulating valve connected to the positive pressure motor to precisely adjust the magnitude of the positive pressure to generate a micro positive pressure pressure; a negative pressure micro-regulating valve, connected with the negative pressure motor, for precisely adjusting the magnitude of the negative pressure to generate a micro negative pressure; and A solenoid valve has two inlets and an outlet, wherein the two inlets are respectively connected with the positive pressure micro-regulating valve and the negative pressure micro-regulating valve, for controlling the passage of the micro-positive pressure or the micro-negative pressure, and the outlet is connected to the micro-positive pressure or the micro-negative pressure. The detection device is connected to provide the micro positive pressure or the micro negative pressure to the detection device.

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