TWM537906U - Compound particle structure - Google Patents

Description

Composite particle structure

The present invention is a healthy composite particle structure of sweet potato protein and green banana starch, which can be used for weight loss, regulating blood sugar, and increasing intestinal probiotics.

Health is something that everyone should pay attention to, but often taking care of it because of busy life makes many health problems cause life problems. Obesity and the imbalance of intestinal health can greatly increase the risk of disease.

There are many ways to control obesity, the principle is nothing more than reducing calorie intake or increasing calorie expenditure. Reducing calorie intake can be achieved by eating low-calorie foods or high-satisfaction foods. The most common product on the market is dietary fiber, which absorbs water in the digestive system, increasing the volume of food and causing satiety. In addition to exercise, there are also some products, such as capsaicin and conjugated linoleic acid, which can increase the body's metabolic rate and consume calories after taking it.

The large and small intestines are the organs that the body mainly absorbs nutrients. Many microorganisms in the intestines will help digestion and nutrient absorption. However, the imbalance of nutrition may cause the imbalance of the bacteria in the intestinal tract, resulting in the reduction of probiotics, which may cause intestinal diseases, inflammation or even cancer. There are many products on the market that improve the health of the intestines. Among them, lactic acid bacteria are the bulk, and most of them are taken by drinks.

However, there are still some shortcomings in the market. Dietary fiber has a drink or added to it. The way in which the food is used, the beverage has the product to be carried, the storage problem to be used as soon as possible after opening, and the food is added to the food, the taste is not good; and the lactic acid bacteria product is mainly based on drinks, and more must be refrigerated, otherwise Easy to lose activity. Therefore, at present, the products on the market have problems of poor carrying convenience, poor taste and inconvenient storage, and there is no product on the market that has both weight-reducing effects and gastrointestinal health and no taste and storage difficulties. Characteristics, can bring more convenience to the public to achieve health promotion.

In order to reduce the inconvenience of the public to take such nutritional supplements, and also to take into account the intestinal health in weight loss, this creation provides a composite particle structure, which uses sweet potato protein or green banana starch as the core, and then package the effectiveness. The component layer is on the periphery of the core and is covered with a protective layer in addition to the effective component layer. The sweet potato protein system contains Trypsin Inhibitor (TI) and glycoprotein, which is easily absorbed by the intestine and can increase satiety, regulate blood lipids and promote metabolism. The green banana starch contains a high amount of Resistant Starch (RS), which can produce short-chain fatty acids in the large intestine and increase the number of beneficial bacteria to protect the health of the large intestine cells. The particle structure of the composite is between 120 μm and 500 μm, the core thickness is between 30 μm and 150 μm , and the thickness of the effective component layer is between 20 μm and 70 μm . between.

Preferably, the effectiveness component layer comprises at least one of the following components: plantain starch, sweet potato protein, Citrus extract, probiotics, and any combination thereof. Preferably, the green banana starch does not simultaneously appear in the core and the active ingredient layer. Preferably, the sweet potato protein does not simultaneously appear in the core and the active ingredient layer. Preferably, the core comprises one of green banana starch and sweet potato protein, and the active ingredient layer comprises the other. The components of the effectiveness component layer have the following functions: Helps increase satiety, suppress appetite, increase antioxidant capacity, promote metabolism, increase intestinal probiotics, and control blood sugar.

In a preferred embodiment of the present invention, the composite particulate structure is used as a health food or a pharmaceutical product; it can be filled into a capsule or in the form of a tablet.

In a preferred embodiment of the present invention, the composite particulate structure can be filled into a powder packet.

In addition to providing a feeling of satiety, the effect of this creation has the effects of suppressing appetite, regulating blood sugar and blood fat, accelerating fat decomposition and promoting metabolism, increasing intestinal probiotics and protecting intestinal health. At the same time, the composite particle structure of the present invention has the characteristics of reducing weight and improving intestinal health, and has the disadvantages of poor taste of the dietary fiber product and difficulty in storage and inconvenience of the lactic acid bacteria product. The creator has developed a product that combines both weight loss and improved intestinal health, enabling the general public to get health care in a more direct and convenient way.

The creation of a healthy complex microparticle structure with weight loss and improved intestinal health functions can reduce body weight, reduce body fat, increase satiety, lower blood fat, lower blood sugar, improve insulin sensitivity (Insulin sensibility), and improve intestinal tract. Multiple effects such as health, increased intestinal probiotics, and cancer prevention.

1‧‧‧Health Composite Particle Structure

10‧‧‧Protective layer

20‧‧‧ Effective ingredient layer

30‧‧‧ core

40‧‧‧Capsule body

50‧‧‧ Groove

60‧‧‧Powder

70‧‧‧ incision

80‧‧‧Plate base

90‧‧‧Lozenges

The first figure is a schematic cross-sectional view of a healthy composite particle structure according to a preferred example of the present invention; the second figure is a perspective sectional view of a healthy composite particle structure of a preferred embodiment of the present invention filled in a capsule; The third figure is a schematic view of a powder package of a healthy composite particle structure according to a preferred embodiment of the present invention; The fourth figure is a schematic diagram of a tablet made from a healthy composite particle structure of a preferred embodiment of the present invention.

This creation provides a healthy complex particle structure that reduces weight and promotes intestinal health. For a complete and clear disclosure of the efficacies of the technical content of the present invention, the following detailed description, and reference to the first figure, is a schematic cross-sectional view showing one embodiment of the present invention. In this example, the sphere is selected as a schematic diagram, but not limited thereto. The present invention relates to a healthy composite particulate structure 1 comprising a protective layer 10, a effectiveness component layer 20 and a core 30 comprising sweet potato protein or green banana starch. The aforementioned sweet potato protein is extracted and purified by a special technique, which contains natural trypsin inhibitor and glycoprotein, which can increase the feeling of satiety, regulate blood lipids and promote metabolism. The starch is a starch extracted by a special technique, which contains a high amount of anti-gelatinized starch, and can be produced by microbial fermentation in the large intestine to produce short-chain fatty acids and increase the number of beneficial bacteria to protect the health of the large intestine cells.

This creation provides a healthy composite microparticle structure with weight loss and intestinal health promotion. The particle size of the microparticle structure is between 120 μm and 500 μm . The core consists of sweet potato protein or green banana starch. The thickness of 30 is between 30 μm and 150 μm , and the thickness of the effectiveness component layer 20 is between 20 μm and 70 μm .

Sweet potato, also known as sweet potato, sweet potato, sweet potato, sweet potato, etc., is an annual plant of the genus Asteraceae, a healthy food for both medicine and food. Sweet potato contains dietary fiber, carotene, vitamin A, B, C, E and more than 10 kinds of trace elements such as potassium, iron, copper, selenium and calcium. It has high nutritional value and is called the most balanced health food.

The sweet potato protein of this creation can stimulate the small intestine to secrete cholecystokinin (CCK), and transmit the satiety signal to the hypothalamus of the brain, so it can increase the satiety after taking it and effectively reduce the food intake. Sweet potato protein can also affect the proliferation and differentiation of fat cells, resulting in the reduction of fat cells and the effect of reducing fat.

The green banana starch is an ultra-purity starch extracted by the creator's special extraction technology, which contains more than 50% of natural anti-gelatinized starch. The banana banana starch can resist the decomposition of the starch in the small intestine without being decomposed, and is microbially fermented in the large intestine to produce short-chain fatty acids, including Acetate, Propionate, and Butyrate. The green banana starch can greatly increase the number of intestinal microbes, and the amount of probiotics in the intestine increases tens to 100 times depending on the species. The amount of short-chain fatty acids can be increased by 12%, and butyric acid is increased by 28%. Short-chain fatty acids are the nutrients of many intestinal probiotics, especially butyric acid, which is the main source of nutrients for large intestinal epithelial cells. Anti-mycorrhizal starch can make large epithelial cells have sufficient nutrients, reduce cell mutation, and prevent colon in the large intestine. The effect of cancer. Therefore, the green banana starch has the effect of improving intestinal health and preventing cancer.

The healthy composite microparticle structure of the present invention 1 wherein the sweet potato protein and the green banana starch containing the sweet potato protein or the green banana starch core 30 are all made by a special process. The process of sweet potato protein is as follows: firstly wash and peel the sweet potato into the grinder and grind it into mud, then use the homogenizer to achieve the particle effect of the sweet potato molecular particles; place the sweet potato particles in the refrigerator and add 1~5% acetic acid (to make the pH value) 4) and 1% to 10% sodium chloride were extracted from the trypsin inhibitor; the sweet potato pellet in the sweet potato microparticles was separated from the sweet potato liquid by a centrifuge (rpm 1,500 rpm to 2,500 rpm), and the sweet potato liquid was taken out (including The desired trypsin inhibitor and glycoprotein); after that, the sweet potato liquid is heated to 72-80 degrees by heating equipment, the components other than the trypsin inhibitor are removed, and then the ice bucket is used to cool to 20 to 25 degrees; filter The membrane removes the tiny molecules in the sweet potato liquid; the organic molecules of the larger molecular weight in the sweet potato liquid are removed by the microfiltration membrane to select the sweet potato extract of the target protein having a molecular weight of 20 to 200 KD, and finally the obtained extract is vacuum freeze-dried. Dry to preserve its biological activity.

The healthy composite microparticle structure of the present invention 1 wherein the sweet potato protein and the green banana starch containing the sweet potato protein or the green banana starch core 30 are all made by a special process. The process of the green banana starch is as follows: the immature banana is peeled and diced, and then placed in a homogenizer together with 0.05 to 0.25 N NaOH, stirred and allowed to stand for 4 to 12 hours. After passing the solution through the sieve, the starch was precipitated at the bottom by centrifugation, and then taken out and dried.

The present invention relates to a healthy composite particulate structure 1 wherein the effectiveness component layer 20 comprises at least one of the following components: green banana starch, sweet potato protein, citrus extract, probiotics, and any combination thereof. According to a preferred embodiment of the present invention, when the core 30 comprises sweet potato protein, the effective component layer 20 is selected from at least one of the group consisting of: banana leaf starch, citrus extract, probiotics and random combination. According to a preferred embodiment of the present invention, when the core 30 comprises the green banana starch, the effective component layer 20 is selected from at least one of the group consisting of sweet potato protein, citrus extract, probiotics and random combination. The component of the active ingredient layer 20 has the following functions: it helps to increase satiety, suppress appetite, enhance antioxidant capacity, promote metabolism, increase intestinal probiotics, control blood sugar, and prevent cancer.

The citrus extract is extracted from the whole fruit of kumquat, flat lemon and lemon. It contains flavonoids, vitamin C, Nobilatin, etc., which enhances antioxidant power and controls blood sugar. And so on.

Probiotics contain Bifidobacterium bifidum, Reiter At least one of B bacteria (Bifidobacterium lactis), Lactobacillus acidophilus, Lactobacillus reuteri, Eubacterium rectale, Eubacterium ramulus, Roseburia cecicola, and the like. Probiotics can promote digestion, reduce intestinal allergic reactions, improve immunity and increase the production of butyric acid.

In one example of the present invention, the total amount of the healthy composite microparticle structure is 1500 mg, wherein the core is sweet potato protein and the effective component layer is green banana starch, and the sweet potato protein accounts for about 10% or more of the total banana starch starch relative to the total weight. About 80% of the total.

In another example of the present invention, the total amount of the healthy composite microparticle structure is 1500 mg, wherein the core is a green banana starch and the effective component layer is sweet potato protein, and the green banana starch accounts for about 80% of the total weight, and the sweet potato protein is compared with the total weight. About 10% of the total.

In another example of the creation, the total amount of the healthy composite microparticle structure is 1500 mg, wherein the core is a green banana starch and the effective component layer contains sweet potato protein and probiotic bacteria, and the green banana starch accounts for about 80% of the total weight. And sweet potato protein and probiotics account for about 10% and 6% of the total, respectively.

In another example of the present invention, the total amount of the healthy composite microparticle structure is 1500 mg, wherein the core is a green banana starch and the effective component layer contains probiotic bacteria and citrus extract, and the green banana starch accounts for about 80% of the total weight relative to the total weight. And probiotics and citrus extracts account for about 6% and more than 10% of the total.

In yet another example of the present invention, the total amount of the fine structure of the healthy composite is 1500 mg, wherein the core is sweet potato protein and the effective ingredient layer contains green banana starch, probiotics and citrus extract. Compared with the total amount of 1500mg, 100%, the sweet potato protein is about 10% or more, and the green banana starch It is 50%, 6% for probiotics, and 10% or more for citrus extract.

Four 12-week-old Sprague-Dawley rats were subjected to an eight-week animal test using the healthy composite particle structure of the present invention. The experimental animals were divided into normal control group (ND), high calorie group (HE), and low dose. Treatment group (L-HE, sweet potato and green banana health complex A), medium dose treatment group (M-HE, sweet potato and green banana health complex B), high dose treatment group (H-HE, sweet potato and green banana health complex C ), low-dose plus bacteria group (L-HE+, sweet potato and green banana health complex A+), medium-dose plus bacteria group (M-HE+, sweet potato and green banana health complex B+), high-dose plus bacteria group (H-HE+, Eight groups of sweet potato green banana health complex C+) (Table 1). The test substance (ie, the sweet potato green banana health complex in Table 1) is a sweet potato core, and the green banana starch is a useful component layer, and the ratio of sweet potato protein to the green banana starch is shown in Table 1. The core of the test substance of the added bacteria group is sweet potato protein; the effective component layer is the green banana starch plus 6% of the total weight of Bifidobacterium spp. and Eubacterium spp. The same amount of dry powder, the ratio of sweet potato protein to the banana starch As shown in Table 1. The test animals were continuously administered the test substance (475 mg/kg/day) for eight weeks, and the efficacy index analysis and the safety index analysis were performed.

Efficacy indicator measurement method

Induced animal obesity: In addition to the normal control group, the test animals were fed with high-calorie food (HED), and the body weight after feeding HED was higher than 20% of the normal control group as the basis for the induction success. The test animals successfully induced obesity six weeks after feeding HED.

Body weight: The body weight of the test animals was measured periodically every week during the test, and the weight at the beginning and end of the test was compared.

Food intake: The feed intake of each test animal was recorded daily.

Body fat and body rate: When the animal is sacrificed, the fat in the abdominal cavity (the fat in the vicinity of the epidural (epididymis), around the kidney and on the intestinal membrane) is weighed. As body fat is heavy. The body fat percentage is [body fat weight (g) / body weight (g)] * 100%.

Blood collection: The test animals were fasted for 12 hours before sacrifice, anesthetized with carbon dioxide, and the abdominal venous blood was collected. After centrifugation, the supernatant (serum) was taken for analysis. The following items were analyzed using a fully automated serum analyzer (Vitros 5.1 FS, Johnson & Johnson, Inc., USA):

A blood sugar

B blood lipids: total cholesterol (TC), low density cholesterol (LDL-C), high density cholesterol (HDL-C), triglyceride (TG), non-esterified free fatty acid (FFA)

C liver function test: AST, ALT

D renal function test: uric acid (UA), creatine (CRE)

E electrolyte balance state: detection of sodium (Na) and potassium (K) concentrations in blood

F blood ketone body concentration

Intestinal Bacterial Amount: The animal was sacrificed and the cecum was taken out to extract DNA. The amount of Lactobacillus sps., Bifidobacterium sps. and Clostridium cluster XIVa+b in the intestine was tested by qPCR, and SYBR® Green qPCR reagent (assay) was used in ABI Prism 7900HT. Analysis was performed in a sequence detection system (Applied Biosystems, Foster City, CA).

Functional indicator estimation result

Animal observation and body weight: There were no significant abnormalities in the activity and response of the test animals during the test. The body weight was measured once a week during the test, and the results showed that the body weight of each of the combined test animals showed a tendency to decrease regardless of the treatment. At the end of the experiment, the body weight of the M-HE, H-HE, M-HE+ and H-HE+ groups was significantly lower than that of the high calorie group (HE). Both the body fat mass and the body fat percentage have the same condition (Table 2).

Food intake: There was no significant difference between the treatment group and the control group.

Body fat mass and body fat percentage: After the animal sacrificed, the fat in the abdominal cavity was taken out for weighing, and the results showed that the fat weight of the normal control group (ND) was significantly lower than that of the other groups. The fat mass and body fat percentage of the high-calorie control group (HE) were significantly higher than those of all other treatment groups, and the high-fat rate of the caloric control group (HE) was also significantly higher than that of the other treatment groups (Table 2).

The amount of beneficial bacteria: Lactobacillus spp., Bifidobacterium spp. and Clostridium cluster XIVa+b were used as indicators. The treatment groups except L-HE were significantly higher than the normal control group (ND) and the high-calorie control group ( HE), there was a significant increase in the amount of beneficial bacteria in the treatment group with the addition of probiotics compared to the treatment group without the addition of the beneficial bacteria (Table 3).

Safety index evaluation results: The safety index evaluation results showed that the experimental rats were not found in renal function, liver function, blood ketone body, electrolyte balance, blood glucose and non-esterified free fatty acids after eight weeks of administration of test substances. abnormal.

Blood lipids: Total cholesterol (TC) and total triglyceride (TG) in the blood lipids were significantly different from the other treatment groups, and there was no difference between the treatment groups. There was no difference between the groups of high-density cholesterol (HDL-C). Low-density cholesterol (LDL-C) was only significantly different between the low-dose group (L-ME) and the low-dose group (L-ME+) compared with the control group, and the other treatment groups did not exist (Table 4). The results indicate that the test substance is effective in reducing total cholesterol, triglyceride and low density cholesterol in the blood of the test animals.

Note: ^{a, b} distinct letters indicate statistical differences between groups.

The test substance has a function of lowering body weight, body fat, body fat percentage and blood lipid, and has an effect of promoting the number of beneficial bacteria in the intestine. In combination with various treatment combinations, the medium dose plus bacteria group (M-HE) has a better combined effect.

The manufacturing process of the healthy composite particulate structure according to an example of the present invention is described below, which is a core body 30 of green banana starch, a layer of the active ingredient 20, and a protective layer 10 from the inside out. 500 g of plantain starch was taken, 10% gum arabic was added as an excipient, and then placed in an automatic tableting machine to be compressed into an ingot. After the pulverizer was adjusted to a fineness of 70 mesh, the granules were granulated and passed through an 80-mesh sieve to make the particle size of the green banana starch core uniform. The sieved green banana starch core and 100 g of the effective component layer raw materials are added to a research and development spray, drying, granulating and film coating machine, and sprayed on the surface of the core by side spray spray granulation, and The active ingredient layer 20 and the protective layer 10 are sequentially wrapped to complete the healthy composite particle structure. Other healthy compound particle structures of the various embodiments mentioned herein, such as the various health complex particle structures mentioned in Table 1, can be made by those skilled in the art in light of the above-described procedures.

According to a preferred embodiment of the present invention, the protective layer 10 is selected from gelatinous substances such as gelatin, gum arabic, corn syrup, and tragacanth which are available for human consumption. According to another embodiment of the present invention, the protective layer 10 further comprises an excipient, wherein the excipient is selected from the group consisting of a flavoring agent, a sweetener, a preservative, an antioxidant, a chelating agent, a penetrating agent, a lubricant, A group of colorants and binders.

According to another example of the present invention, the protective layer 10 is processed into a film protective layer by using a film coat; the film protective layer includes: a sugar coating, a sustained release film coat, One or more of an enteric film coat, a transparent water-soluble film coat, a yellow film coat, etc.; so that when the healthy composite particle structure of the present invention is an oral tablet type, the smoothness of the surface can be maintained after the water is prevented, preventing When swallowed, the user sticks to the mouth or esophagus and reduces irritation to the stomach.

According to the foregoing embodiment, when the protective layer 10 is a transparent water-soluble film coat, the components thereof include, for example, a cellulose polymer such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose. , methyl hydroxyethyl cellulose; synthetic polymers, such as polyvinyl acetal diethylamine ethyl ester, amino alkyl methacrylate copolymer E, polyvinylpyrrolidone, etc.; polysaccharides, for example Polytriglucose and so on.

According to a preferred embodiment of the present invention, the protective layer 10 is an enteric film coating which dissolves in the environment of the intestine and releases the ingredients to protect the active ingredient from decomposition and decomposition of gastric acid. . The composition of the enteric-coated film coat comprises, for example, castor oil, shellac, mineral oil, propylene glycol, polymethyl propyl ester, triethyl citrate, tributyl citrate, dimethyl phthalate, Ethyl phthalate, polyethylene glycol, cellulose phthalate, methyl propyl propyl phthalate, propyl propyl cellulose succinate acetate, or the like Multiple.

The present invention provides a healthy composite microparticle structure having weight loss and promoting intestinal health, and the protective layer 10 completely encapsulates the active ingredient of the core 30 containing the sweet potato protein or the green banana starch and the active ingredient layer 20, It can be deteriorated to prevent external pollution, and at the same time, it can have the effect of prolonging and preserving the active ingredient of sweet potato protein. Furthermore, the protective layer 10 can protect the active ingredient of the sweet potato protein from the digestive juice in the gastrointestinal tract of the body, and has the effect of effectively helping rapid absorption.

In a preferred embodiment of the present invention, the healthy composite particle structure can be filled The form of the capsule. As shown in the second figure, a pair of capsule bodies 40 are made of an edible grade of gelatinous material, the pair of capsule bodies 40 are respectively concavely formed with grooves 50, and the pair of capsule bodies 40 can be grooved. The openings of 50 are covered with each other. The healthy composite particulate structure 1 of the present invention can be installed in the capsule body 40.

In a preferred embodiment of the present invention, the healthy composite particulate structure 1 can be directly ingested by the oral cavity. As shown in the third figure, the healthy composite particle structure 1 can be made into a powder package 50, and the consumer can be directly taken by the incision 70. The present invention comprises a protective layer 10, a layer of the active ingredient 20 and a sweet potato. The healthy composite microparticle structure 1 of the protein or amarylose core 30 can be conveniently used. The powder pack can contain a healthy complex particle structure required by the human body for one day according to the basis of 475 mg/kg/day.

In a preferred embodiment of the present invention, a tablet base such as lactose, starch or cellulose, a foaming component or a sustained-release component containing citric acid or malic acid and sodium hydrogencarbonate may be added, and the tablet may be formed into a tablet by pressurization. Such as double-layer ingots, foamed ingots, slow-release ingots, and the like. As shown in the fourth figure, a plurality of healthy composite fine particle structures 1 are uniformly dispersed on the tablet base 80 to form a tablet 90 which can be used as a health food or a pharmaceutical.

In one preferred embodiment of the present invention, the subject takes an empty packet as shown in the second figure 30 minutes before eating each morning, for 45 to 60 days after the subject is in weight, food intake, and abdomen. There are significant improvements in all aspects of fat and cholesterol.

The above description is only for the purpose of explaining the preferred embodiment of the present invention, and is not intended to impose any form of limitation on the creation, so that any modification or alteration of the creation made in the same creative spirit is provided. , should still be included in the scope of protection of this creative intent.

1‧‧‧Health Composite Particle Structure

10‧‧‧Protective layer

20‧‧‧ Effective ingredient layer

30‧‧‧ core

Claims (10)

A composite particulate structure comprising: a core comprising one of a sweet potato protein and a green banana starch; a layer of a protective component covering the core; and coating the core a protective layer of the active ingredient layer, wherein the sweet potato protein comprises a trypsin inhibitor and a glycoprotein, and the plantain starch comprises an anti-mycorrhizal starch, wherein the active ingredient is when the core comprises the sweet potato protein The layer contains the green banana starch. The composite particle structure according to claim 1, wherein: when the core comprises the sweet potato protein, the effective component layer further comprises at least one of the following group: Citrus (Citrus) An extract, the sweet potato protein, the green banana starch, a probiotic, and any combination thereof; and when the core comprises the green banana starch, the effective ingredient layer comprises at least one of the group consisting of : the sweet potato protein, the green banana starch, the citrus extract, the probiotic, and any combination thereof. The composite particulate structure of claim 1, wherein the core comprises the sweet potato protein, and the active ingredient layer comprises the green banana starch. The composite particulate structure of claim 1, wherein the core comprises the green banana starch, and the active ingredient layer comprises the sweet potato protein. The composite particulate structure of claim 3, wherein the weight ratio of the sweet potato protein to the green banana starch is between 1:5 and 1:10. The composite particulate structure of claim 5, wherein the weight ratio of the sweet potato protein to the green banana starch is 1:8. The composite particulate structure according to claim 1, wherein the core has a core thickness of between 30 μm and 150 μm , and the effective component layer has a thickness of between 20 μm and 70 μm A thickness of the composite, and the composite particulate structure has a particle size between 120 μm and 500 μm. The composite particulate structure according to claim 1, which is a health food or a pharmaceutical product. The composite particulate structure as described in claim 1 of the patent application can be filled with a powder package. The composite particulate structure as described in claim 1 can be filled in a capsule or as a tablet.