M394820 五、新型說明： 【新型所屬之技術領域】 本創作為一種乳酸菌結合天然草本萃取液可預防與治療女性 泌尿道感染與去除陰部異味之雙層膠體微粒子結構。 【先前技術】 由先前技術之參考文獻1〜6中指出，/ (嗜酸乳桿菌）、case/ (乾酷乳桿菌）兩種乳酸菌，各別 均對人體中所產生的念珠_有抑制效果，及對女性陰道炎有抑制 效果。由先前技術之參考文獻7中指出，先前在臨床治療上，多 採用抗生素及類固醇相關藥物，長期及過度的使用下，均對人類 身體造成不良作用，之後隨即積極地發展出乳酸菌在各方面的應 用，與臨床治療做結合。念珠菌即是存在婦女泌尿道系統中的一 種微生物菌，在正常的生理情況下，女性的陰道會分泌少許的分 泌物，該分泌物具有潤滑陰道的作用，其對於陰道係不可或缺的。 但在衛生習慣不佳、病原菌感染或抵抗力下降的情形，有時會發 生陰道分泌物增多，顏色改變且具有異味的現象，即係罹患了陰 道炎。而陰道炎所產生的分泌物尚可能造成外陰紅腫及癢痛的現 象，即係所謂的外陰炎，陰道炎及外陰炎可通稱為陰部感染。 一般會造成女性陰部感染的原因包括：（1)黴菌感染（2)細菌感染， (3)滴蟲感染。正常的陰道環境並不是無菌的，它包含了大約六種 細菌，當中有金黃色葡萄球菌、大腸桿菌、類白喉菌、念珠菌及 M394820M394820 V. New description: 【New technical field】 This is a double-layer colloidal microparticle structure that can prevent and treat female urinary tract infection and remove genital odor. [Prior Art] It is pointed out from references 1 to 6 of the prior art that two kinds of lactic acid bacteria, /( Lactobacillus acidophilus) and case/(Lactobacillus militaris), have inhibitory effects on the rosary produced in the human body. And have a inhibitory effect on female vaginitis. As pointed out in the prior art reference 7, previously used antibiotics and steroid-related drugs in clinical treatment, long-term and excessive use have adverse effects on the human body, and then actively develop lactic acid bacteria in various aspects. Application, combined with clinical treatment. Candida is a microbial bacterium in the urinary tract system of women. Under normal physiological conditions, a woman's vagina secretes a small amount of secretions, which has the effect of lubricating the vagina, which is indispensable for the vaginal system. However, in the case of poor hygiene, pathogenic infection or decreased resistance, vaginal discharge, color change and odor may occur, which may cause vaginitis. The secretions produced by vaginitis may cause redness and itching of the vulva, which is called vulvitis. Vaginitis and vulvitis can be called genital infections. Common causes of female genital infections include: (1) mold infections (2) bacterial infections, and (3) trichomoniasis infections. The normal vaginal environment is not sterile. It contains about six bacteria, including Staphylococcus aureus, Escherichia coli, diphtheria-like bacteria, Candida and M394820.
乳酸桿菌等菌。其中含量最多的乳酸桿菌係為益生菌，而金黃色 葡萄球菌、大腸桿菌、類白喉菌及念珠菌等係為有害菌，但「有 害菌」在量少的時候，對陰道的健康並不會產生不良的影響，且 只要陰道維持在正常菌相，也就是所謂的「益生菌」佔優勢時， 壞菌就不致於大量滋生，因此就不會有前述泌尿道感染與陰部出 現異味的情形發生。 維持陰道正常的酸驗值也相#重要，正常陰道的酸驗值約為 PH 3.8〜4.2，偏弱酸性。—但陰道的酸驗似變成較偏中性或驗 性，則會有感染的情形發生。而乳酸桿g可以保持陰道酸驗值的 值定性’可以讓陰道環境維持在正㈣驗值狀態下的阳38〜42 種弱的陰如境巾，大部分造成陰道錢的病原菌無法 生長，因此陰道得以維持健康。 —目H療女性陰部感染的方法，—般為使用抗生素、類固醇 等樂㈤進行治療’但是往往會將益生菌與壞菌—併殺死，因而會 造成治療初期陰道環 競爭，此競爭的結果 發生重複感染的狀況 境呈現無菌狀態，此時益生菌與壞菌會互相 ’病原菌的生長往往勝於益生菌，因此容易 ，而需反覆進行治療。但反覆使用抗生素及 類固醇治療，容易使病原菌產生抗藥性 統受損。 甚至會造成人體免疫系 呆養°°夕為含碘的化學藥劑，其在短期f 然可減輕感染症狀，但 於八PH值為中性，使用後會造成陰 pH值上升，轉變為 純適合病原菌生長的環境，因此感染症狀: M394820 復發，致使該症狀難以根治。 因此，積極尋找一種可用以抑制病原菌生長，並同時能促進 益生菌生長，且不會刺激皮膚的一種新的防止陰道感染與去除陰 道異味之雙層膠體微粒子結構’便成為一件極為重要的事。 先前技術之參考文獻： 1. Inhibition of Candida albicans by Lactobacillus acidophilus. Collins EB, Hardt P. J Dairy Sci. 1980 May;63(5):830-2. 2. \n vitro effect of carbohydrates and enteric bacteria on adherence of Candida albicans. Biasoli MS, Magaro HM. Rev Iberoam Micol. 2003 Dec;20(4):160-3. 3. Lactobacillus acidophilus and yogurt in the prevention and therapy of bacterial vaginosis. Sieber, R.; Dietz, U.T. International Dairy Journal.8, 1998, 599-607 4. The effect of oral bacteria on Candida albicans germ-tube formation. Nair RG, Anil S, Samaranayake LP. APMIS. 2001 Feb;109(2):147-54. 5. Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences. Marcone V, Calzolari E, Bertini M. New Microbiol. 2008 Jul;31(3):429-33. 6. Probiotics for the treatment of women with bacterial vaginosis. Falagas ME, Betsi GI, Athanasiou S. Clin Microbiol Infect. 2007 Jul;13(7):657-64. 7. Pharmaceutical probiotics for the treatment of anaerobic and other infections. McFarland LV, Elmer GW. Anaerobe. 1997 Apr-Jun;3(2-3):73-8. 【新型内容】 本創作主要係為解決前述習知技術的問題，為解決女性選用 各種不同的婦潔治療藥品的選用限制，本創作目的提供即為提供 一種可維持陰道中正常菌相，使陰道酸鹼值維持在pH 3.8〜4.2,以 使病原菌不易生長，同時促進益生菌生長，且不會刺激皮膚的一 5 M394820 種不會產生抗藥性之應用於女性陰部的之雙層膠體微粒子結構β 本創作主要係包括兩種乳酸8的複合共生培養發酵液、三種 草本的萃取液.；5；^花萃取液、紫蘇萃取液及蘆等萃取液與三仙 膠體，共同組成本創作之雙層膠體微粒子結構。本創作主要係創 新多株《g複合共生發酵製程，取代原本的單株乳酸g發酵製 程；搭配上天然活性草本萃取物，再利用膠體將乳酸菌發酵萃取 物與天然活性草本萃取物包覆形成雙層膠體微粒子。 較佳的，該乳酸菌的發酵液中的乳酸菌係選自包括乳酸菌， 尤其是乳酸桿菌屬。 較佳的，该乳酸桿菌屬係選自包括⑽ (嗜酸乳桿g)、cosez·(乾酪乳桿菌）或其等之組合。 上述兩種乳酸桿菌係接種於一奶類中，在30〇c〜45〇c下複合共 生發酵培養出其發酵液。上述的奶類並無特別限制，可為各種動 物所產的乳水，也可為還原乳》本創作所採用的奶類為牛奶，兩 種乳酸菌株由Zacic^acz/ZM·? πΰ/ορ/π·/⑽（嗜性乳桿菌）、 (乾酪乳桿菌）複合共生培養發酵完成後，所產 生的發酵液經離心及過濾等去除菌體的步驟處理程序後，所分離 出的乳酸菌發酵液，再與天然草本的石榴花萃取液、紫蘇萃取液 及蘆薈萃取液，再與三仙膠混合而成，構成本創作的一種乳酸菌 結合天然草本萃取液之雙層膠體微粒子結構。 本創作之雙層勝體微粒子結構，可用以促進陰道内益生菌的 生長’因此可使陰道中的PH值維持在正常的範圍内（pH 3.8〜4.2)， 6 M394820Lactobacillus and other bacteria. The most abundant Lactobacilli are probiotics, while Staphylococcus aureus, Escherichia coli, Diphtheria-like and Candida are harmful bacteria, but when the amount of harmful bacteria is small, the health of the vagina will not be Bad effects are caused, and as long as the vagina is maintained in the normal bacterial phase, that is, the so-called "probiotics" predominate, the bad bacteria will not grow in a large amount, so there will be no urinary tract infection and odor in the genitals. . Maintaining the normal vaginal acid test value is also important. The normal vaginal acid test value is about PH 3.8~4.2, which is weakly acidic. - However, the acidity of the vagina may become more neutral or testable, and infection may occur. The lactic acid rod g can maintain the value of the vaginal acid test value, which can make the vaginal environment maintain a positive (4) value of the yang 38~42 kinds of weak yin, such as the pathogen, which causes the vaginal money to grow, so the pathogen can not grow, so The vagina is healthy. - H-treatment of female genital infections, generally for the treatment of antibiotics, steroids and other music (five) but often will kill probiotics and bad bacteria, and thus will cause vaginal ring competition in the early stage of treatment, the result of this competition occurs The condition of repeated infections is sterilized. At this time, the probiotics and the bad bacteria will mutually grow. The growth of the pathogens is often better than that of the probiotics, so it is easy and needs to be treated repeatedly. However, repeated use of antibiotics and steroids is likely to cause damage to the pathogens. It may even cause the body's immune system to stay in the evening. It is a chemical containing iodine, which can alleviate the symptoms of infection in the short term, but it is neutral at the pH of eight. After use, it will cause the pH of the yin to rise and become purely suitable. The environment in which the pathogen grows, so the symptoms of infection: M394820 recurrence, making this symptom difficult to cure. Therefore, it is extremely important to actively find a new type of colloidal microparticle structure that can prevent the growth of pathogenic bacteria and promote the growth of probiotics without irritating the skin, which prevents vaginal infection and vaginal odor removal. . References to prior art: 1. Inhibition of Candida albicans by Lactobacillus acidophilus. Collins EB, Hardt P. J Dairy Sci. 1980 May;63(5):830-2. 2. \n vitro effect of carbohydrates and enteric bacteria on Appetence of Candida albicans. Biasoli MS, Magaro HM. Rev Iberoam Micol. 2003 Dec;20(4):160-3. 3. Lactobacillus acidophilus and yogurt in the prevention and therapy of bacterial vaginosis. Sieber, R.; Dietz, UT International Dairy Journal.8, 1998, 599-607 4. The effect of oral bacteria on Candida albicans germ-tube formation. Nair RG, Anil S, Samaranayake LP. APMIS. 2001 Feb;109(2):147-54. Effectiveness of vaginal administration of Lactobacillus rhamnosus following conventional metronidazole therapy: how to lower the rate of bacterial vaginosis recurrences. Marcone V, Calzolari E, Bertini M. New Microbiol. 2008 Jul;31(3):429-33. 6. Probiotics For the treatment of women with bacterial vaginosis. Falagas ME, Betsi GI, Athanasiou S. Clin Microbiol Infect. 2007 Jul;13(7):657-64 7. Pharmaceutical probiotics for the treatment of anaerobic and other infections. McFarland LV, Elmer GW. Anaerobe. 1997 Apr-Jun; 3(2-3): 73-8. [New content] This creation is mainly to solve the aforementioned habits. Knowing the technical problems, in order to solve the limitations of women's choice of different types of women's cleansing treatment drugs, the purpose of this creation is to provide a way to maintain the normal bacterial phase in the vagina, so that the vaginal pH is maintained at pH 3.8~4.2, so that The pathogen is not easy to grow, and promotes the growth of probiotics, and does not irritate the skin. A 5 M394820 species that does not produce drug resistance is applied to the female genital layer of the two-layer colloidal microparticle structure. This creation mainly consists of two lactic acid 8 complex symbiosis. The fermentation broth, the extracts of the three herbs, and the extracts of the flower extract, the perilla extract and the ruth, together with the three celestial colloids, form the two-layer colloidal microparticle structure of the present invention. This creation is mainly to create a multi-plant "g composite symbiotic fermentation process, replacing the original single-plant lactic acid g fermentation process; with natural active herbal extracts, and then using colloids to coat the lactic acid bacteria fermentation extract with natural active herbal extracts to form a double Layer colloidal particles. Preferably, the lactic acid bacteria in the fermentation broth of the lactic acid bacteria are selected from the group consisting of lactic acid bacteria, particularly Lactobacillus. Preferably, the Lactobacillus is selected from the group consisting of (10) (acidophilus lobe g), cosez (Lactobacillus casei), or the like. The above two Lactobacillus strains are inoculated into a milk, and the fermentation broth is cultured by a composite symbiotic fermentation at 30 〇 c to 45 〇 c. The above-mentioned milk is not particularly limited, and may be milk for various animals or reduced milk. The milk used in the creation is milk, and the two lactic acid strains are Zacic^acz/ZM·? πΰ/ορ /π·/(10) (Lactobacillus faecalis), (L. lactis) complex symbiotic culture after fermentation, the fermentation broth produced by centrifugation and filtration, etc., after removing the bacteria, the lactic acid bacteria fermentation broth It is combined with natural herbal pomegranate extract, perilla extract and aloe extract, and then mixed with Sanxian gum to form a double-layer colloidal microparticle structure of the lactic acid bacteria combined with natural herbal extract. The double-layered microparticle structure of this creation can be used to promote the growth of probiotic bacteria in the vagina. Therefore, the pH in the vagina can be maintained within the normal range (pH 3.8~4.2), 6 M394820
使病原菌在此pH值下不易生長。因此本創作之雙層膠體微粒子結 構可用以抑制病原菌（即會造成陰道感染的微生物）的生長’參見第 二圖，藉以使陰道中的菌相維持在正常的狀態，故可用於預防及 治療女性陰部感染與去除陰部異味。 本創作之雙層膠體微粒子結構由内側至外側依序為，配合第一 圖所示：内部功效層（4〇)(乳酸菌發酵液）、内部保護層（3〇)(三仙 膠）、外部功效層⑽(石職萃取液、紫蘇萃取液及蘆薈萃取液）、 外部保護層⑽(三仙膠）。内部功效層⑽)可以抑制壞菌生長，可 並維持陰道酸性環境；外部 提供陰道益生菌叢生長的營養來源 薈萃取液）具有保濕潤 色素及促進皮膚代謝 功效層（2〇)(石榴花萃取液、紫蘇萃取液及蘆 澤、鎮靜、消炎之作用，也可以淡化皮膚零 等修復功能。當中更有肌膚保濕因子並具抗發炎、促進傷口療合 等作用。 本創作之雙層雜齡子結構的優點：㈣各械驗結果呈 現，溫和不刺激皮膚，長時間使„不會造成皮膚過敏或刺激。 因此可狀純陰料日及經期前後的清潔與保養。另外，本創 作之雙層膝體微粒子結構可迅速降低陰道的阳值，避免女性在性 行為後陰道PH值上升，因此可詩女性性行為後陰道的清潔。本 創作為-⑽菌以天然方法複合共生發酵所分離出的γ〇_ m她精祕料，與天然草本萃取液精華(蝴㈣液、紫蘇 萃取液及Μ萃取液)和三仙膠所構成之雙層膠體微粒子結構，本 創作之雙層膠體微粒子結構以喷霧罐裝方式製作料方便女性 7 M394820 攜帶，可以隨時在如廁後或生理期前後使用，可以預防與治療女 性泌尿道感染及去除異味。 【實施方式】 本創作係提供一種乳酸菌結合天然草本可預防與治療女性泌 尿道感染與去除陰部異味的之雙層膠體微粒子結構，其係主要由 乳酸菌複合共生發酵培養出的發酵液（Yogurt filtrate)精華與天然 草本精華：石榴花萃取液、紫蘇萃取液、蘆薈萃取液和三仙膠等 成分所構成其雙層膠體微粒子結構。本創作經過實驗測試，雙層 膠體微粒子結構係置入罐裝立體喷霧裝置，女性可以在如廁後、 生理期間或平時保養時使用，隨時保持女性私密處清爽舒適，維 持陰道内正常的酸鹼值，見第三圖；長期使用可以抑制各項病原 菌生長，見第二圖。即時達到女性私密肌膚淨化、防護、中和異 味、預防與治療女性泌尿道感染，發揮對女性私密肌膚處保健保 養的功效。 依據本創作，基於上述雙層膠體微粒結構，内外部保護層（第 一圖（10)(30))，可以有效保護内外功效層（第一圖（20)(40))的精華 活性成分，有效保護其功效層的穩定性，本創作可以製作成乳液、 喷霧或凝膠等使用模式，本創作經適當製作使用，雙層結構可層 層破裂，釋放出精華成分，有效發揮對女性陰部保健保養完整的 功效。 8 M394820 【圖式簡單說明】 第一圖係本創作之一較佳的實施例之平面圖。 第二圖係本創作之乳酸菌發酵液對致病菌的生長抑制示音圖 第三圖係本創作之乳酸菌發酵液使用後之酸鹼值變化示意圖 【主要元件符號說明】 (10)外部保護層 (20)外部功效層 (30)内部保護層 (40)内部功效層The pathogen is not easily grown at this pH. Therefore, the two-layer colloidal microparticle structure of the present invention can be used to inhibit the growth of pathogenic bacteria (i.e., microorganisms that cause vaginal infection). Referring to the second figure, the bacteriological phase in the vagina can be maintained in a normal state, so it can be used for the prevention and treatment of females. Pussy infection and removal of genital odor. The two-layer colloidal microparticle structure of this creation is sequentially from the inside to the outside, as shown in the first figure: internal efficacy layer (4〇) (lactic acid bacteria fermentation liquid), internal protective layer (3〇) (Sanxian gum), external Efficacy layer (10) (Shishi extract, perilla extract and aloe extract), external protective layer (10) (Sanxian gum). The internal efficacy layer (10) can inhibit the growth of bad bacteria, and can maintain the vaginal acidic environment; the external nutrient source extract that provides vaginal probiotic flora growth has a layer of moisturizing pigment and promoting skin metabolism (2〇) (Pomegranate flower extract The effect of liquid, perilla extract and luzer, sedative and anti-inflammatory can also reduce the skin's zero repair function. It also has skin moisturizing factor and anti-inflammatory, promote wound healing and so on. Advantages of the structure: (4) The results of each test are presented, mild and non-irritating to the skin, and do not cause skin allergies or irritation for a long time. Therefore, it can be cleaned and maintained on the day of the pure fecal material and before and after menstruation. In addition, the double layer of this creation The structure of the corpus callosum can rapidly reduce the vaginal value of the vagina, avoiding the increase of the vaginal PH value of women after sexual behavior, so it can clean the vagina after sexual behavior. This creation is - (10) γ 〇 isolated by natural method combined symbiotic fermentation _ m her secret ingredients, and the natural herbal extract essence (Hua (four) liquid, perilla extract and sputum extract) and Sanxianjiao two-layer colloidal micro Particle structure, the two-layer colloidal particle structure of this creation is made by spray canning method. It is convenient for women 7 M394820 to carry. It can be used at any time after going to the toilet or before and after the physiological period, which can prevent and treat female urinary tract infection and remove odor. The present invention provides a two-layer colloidal microparticle structure in which a lactic acid bacteria combined with natural herbs can prevent and treat female urinary tract infections and remove genital odors, and is a fermentation broth (Yogurt filtrate) which is mainly cultivated by lactic acid bacteria composite symbiotic fermentation. It is composed of natural herbal extracts: pomegranate extract, perilla extract, aloe extract and Sanxian gum. It is composed of two layers of colloidal microparticle structure. This experiment has been experimentally tested, and the two-layer colloidal microparticle structure is placed in a canned stereo spray. In the fog device, women can use it after going to the toilet, during physiological period or during normal maintenance. Keep the female private place fresh and comfortable at all times, maintain the normal pH value in the vagina, see the third picture; long-term use can inhibit the growth of various pathogens, see The second picture. Instantly achieve female skin cleansing, protection, and middle Odor, prevention and treatment of female urinary tract infections, play a role in the health care of women's private skin. According to the creation, based on the above two-layer colloidal particle structure, the inner and outer protective layer (first picture (10) (30)), Effectively protect the inner and outer efficacy layer (the first picture (20) (40)) of the essence of active ingredients, effectively protect the stability of its efficacy layer, this creation can be made into a lotion, spray or gel use mode, this creation is appropriate Made and used, the double-layer structure can be layered and ruptured, releasing the essence and effectively exerting the full effect on the female genital health care. 8 M394820 [Simplified illustration] The first picture is a plan view of a preferred embodiment of the present creation The second picture shows the growth inhibition of the lactic acid bacteria fermentation broth of the present invention. The third picture shows the change of pH value after the use of the lactic acid bacteria fermentation broth of the present invention. [Main component symbol description] (10) External protection Layer (20) external power layer (30) internal protective layer (40) internal power layer