TWI887800B - 經由皮下投予抗pd1抗體以治療癌症之組合物及方法 - Google Patents

經由皮下投予抗pd1抗體以治療癌症之組合物及方法 Download PDF

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TWI887800B
TWI887800B TW112138765A TW112138765A TWI887800B TW I887800 B TWI887800 B TW I887800B TW 112138765 A TW112138765 A TW 112138765A TW 112138765 A TW112138765 A TW 112138765A TW I887800 B TWI887800 B TW I887800B
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Taiwan
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antibody
cancer
weeks
patient
pembrolizumab
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TW112138765A
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Chinese (zh)
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TW202423971A (zh
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奧莫博拉吉 阿卡拉
艾利歐特 凱斯 查許
卡洛琳娜 德 米蘭達 喜爾瓦
瑪莉卡 拉拉
卡皮爾 瑪雅瓦拉
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美商默沙東有限責任公司
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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TW112138765A 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法 TWI887800B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202263415526P 2022-10-12 2022-10-12
US63/415,526 2022-10-12
US202263415928P 2022-10-13 2022-10-13
US63/415,928 2022-10-13
US202363449478P 2023-03-02 2023-03-02
US63/449,478 2023-03-02

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TW202423971A TW202423971A (zh) 2024-06-16
TWI887800B true TWI887800B (zh) 2025-06-21

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TW112138765A TWI887800B (zh) 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法
TW114119685A TW202535929A (zh) 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法
TW114119686A TW202535471A (zh) 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法

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TW114119685A TW202535929A (zh) 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法
TW114119686A TW202535471A (zh) 2022-10-12 2023-10-11 經由皮下投予抗pd1抗體以治療癌症之組合物及方法

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US (1) US20240150467A1 (enExample)
EP (1) EP4601693A1 (enExample)
JP (1) JP2025504278A (enExample)
KR (1) KR20250084959A (enExample)
CN (1) CN120265320A (enExample)
AU (1) AU2023361390A1 (enExample)
CL (2) CL2025001101A1 (enExample)
CO (1) CO2025004617A2 (enExample)
IL (1) IL320229A (enExample)
MX (1) MX2025004328A (enExample)
TW (3) TWI887800B (enExample)
WO (1) WO2024081274A1 (enExample)

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KR102650991B1 (ko) 2019-03-25 2024-03-27 (주)알테오젠 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물

Citations (4)

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TW202210098A (zh) * 2020-05-26 2022-03-16 美商再生元醫藥公司 通過投予pd-1抑制劑治療子宮頸癌的方法
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
TW202227133A (zh) * 2020-09-24 2022-07-16 美商默沙東藥廠 計畫性死亡受體1(pd-1)抗體及玻尿酸酶變異體及其片段之穩定調配物及其使用方法
TW202235433A (zh) * 2020-12-28 2022-09-16 美商必治妥美雅史谷比公司 治療腫瘤之方法

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PT3186281T (pt) * 2014-08-28 2019-07-10 Halozyme Inc Terapia de combinação com uma enzima de degradação de hialuronano e um inibidor de pontos de verificação imunológica
US20220233693A1 (en) * 2020-12-28 2022-07-28 Bristol-Myers Squibb Company Antibody Compositions and Methods of Use Thereof

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TW202210098A (zh) * 2020-05-26 2022-03-16 美商再生元醫藥公司 通過投予pd-1抑制劑治療子宮頸癌的方法
TW202227133A (zh) * 2020-09-24 2022-07-16 美商默沙東藥廠 計畫性死亡受體1(pd-1)抗體及玻尿酸酶變異體及其片段之穩定調配物及其使用方法
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
TW202235433A (zh) * 2020-12-28 2022-09-16 美商必治妥美雅史谷比公司 治療腫瘤之方法

Non-Patent Citations (1)

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Title
期刊 Shawn Shouye Wang, et al., "US FDA-approved therapeutic antibodies with high-concentration formulation: summaries and perspectives", Antibody Therapeutics, Vol. 4, Issue 4, 無, 18 November 2021, Pages 262–272 *

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TW202535929A (zh) 2025-09-16
US20240150467A1 (en) 2024-05-09
JP2025504278A (ja) 2025-02-12
MX2025004328A (es) 2025-05-02
TW202535471A (zh) 2025-09-16
IL320229A (en) 2025-06-01
EP4601693A1 (en) 2025-08-20
WO2024081274A1 (en) 2024-04-18
CN120265320A (zh) 2025-07-04
TW202423971A (zh) 2024-06-16
KR20250084959A (ko) 2025-06-11
CL2025001101A1 (es) 2025-08-18
AU2023361390A1 (en) 2025-05-22
CO2025004617A2 (es) 2025-04-28
CL2025003511A1 (es) 2026-01-30

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