JP2025504278A - 抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 - Google Patents

抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 Download PDF

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JP2025504278A
JP2025504278A JP2024530469A JP2024530469A JP2025504278A JP 2025504278 A JP2025504278 A JP 2025504278A JP 2024530469 A JP2024530469 A JP 2024530469A JP 2024530469 A JP2024530469 A JP 2024530469A JP 2025504278 A JP2025504278 A JP 2025504278A
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antibody
antigen
cancer
binding fragment
dose
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JP2025504278A5 (enExample
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アカラ，オモボラジ
チャータシュ，エリオット・キース
デ・ミランダ・シルヴァ，カロリーナ
ララ，マリカ
マヤワラ，カピル
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メルク・シャープ・アンド・ドーム・エルエルシー
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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    • C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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JP2024530469A 2022-10-12 2023-10-11 抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 Pending JP2025504278A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202263415526P 2022-10-12 2022-10-12
US63/415,526 2022-10-12
US202263415928P 2022-10-13 2022-10-13
US63/415,928 2022-10-13
US202363449478P 2023-03-02 2023-03-02
US63/449,478 2023-03-02
PCT/US2023/034872 WO2024081274A1 (en) 2022-10-12 2023-10-11 Compositions and methods for treating cancer with subcutaneous administration of anti-pd1 antibodies

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JP2025504278A true JP2025504278A (ja) 2025-02-12
JP2025504278A5 JP2025504278A5 (enExample) 2025-03-18

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US (1) US20240150467A1 (enExample)
EP (1) EP4601693A1 (enExample)
JP (1) JP2025504278A (enExample)
KR (1) KR20250084959A (enExample)
CN (1) CN120265320A (enExample)
AU (1) AU2023361390A1 (enExample)
CL (2) CL2025001101A1 (enExample)
CO (1) CO2025004617A2 (enExample)
IL (1) IL320229A (enExample)
MX (1) MX2025004328A (enExample)
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KR102650991B1 (ko) 2019-03-25 2024-03-27 (주)알테오젠 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물

Citations (5)

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US20170218069A1 (en) * 2014-08-28 2017-08-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
WO2022066832A1 (en) * 2020-09-24 2022-03-31 Merck Sharp & Dohme Corp. Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
WO2022146948A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
WO2022146947A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof

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MX2022014734A (es) * 2020-05-26 2023-03-15 Regeneron Pharma Metodos de tratamiento del cancer de cuello uterino mediante la administracion del anticuerpo inhibidor de pd-1 cemiplimab.

Patent Citations (5)

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Publication number Priority date Publication date Assignee Title
US20170218069A1 (en) * 2014-08-28 2017-08-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
WO2022066832A1 (en) * 2020-09-24 2022-03-31 Merck Sharp & Dohme Corp. Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
WO2022146948A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
WO2022146947A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof

Non-Patent Citations (1)

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Title
FELIP, E., ET AL.: "Subcutaneous versus intravenous pembrolizumab, in combination with chemotherapy, for treatment of me", ANNALS OF ONCOLOGY, JPN6025023889, 2025, ISSN: 0005818648 *

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TWI887800B (zh) 2025-06-21
TW202535929A (zh) 2025-09-16
US20240150467A1 (en) 2024-05-09
MX2025004328A (es) 2025-05-02
TW202535471A (zh) 2025-09-16
IL320229A (en) 2025-06-01
EP4601693A1 (en) 2025-08-20
WO2024081274A1 (en) 2024-04-18
CN120265320A (zh) 2025-07-04
TW202423971A (zh) 2024-06-16
KR20250084959A (ko) 2025-06-11
CL2025001101A1 (es) 2025-08-18
AU2023361390A1 (en) 2025-05-22
CO2025004617A2 (es) 2025-04-28
CL2025003511A1 (es) 2026-01-30

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