JP2025504278A - 抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 - Google Patents

抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 Download PDF

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JP2025504278A
JP2025504278A JP2024530469A JP2024530469A JP2025504278A JP 2025504278 A JP2025504278 A JP 2025504278A JP 2024530469 A JP2024530469 A JP 2024530469A JP 2024530469 A JP2024530469 A JP 2024530469A JP 2025504278 A JP2025504278 A JP 2025504278A
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antibody
antigen
cancer
binding fragment
dose
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JP2025504278A5 (enExample
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アカラ，オモボラジ
チャータシュ，エリオット・キース
デ・ミランダ・シルヴァ，カロリーナ
ララ，マリカ
マヤワラ，カピル
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メルク・シャープ・アンド・ドーム・エルエルシー
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    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
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    • C12N9/2474—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
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JP2024530469A 2022-10-12 2023-10-11 抗ｐｄ１抗体の皮下投与により癌を治療するための組成物及び方法 Pending JP2025504278A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202263415526P 2022-10-12 2022-10-12
US63/415,526 2022-10-12
US202263415928P 2022-10-13 2022-10-13
US63/415,928 2022-10-13
US202363449478P 2023-03-02 2023-03-02
US63/449,478 2023-03-02
PCT/US2023/034872 WO2024081274A1 (en) 2022-10-12 2023-10-11 Compositions and methods for treating cancer with subcutaneous administration of anti-pd1 antibodies

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JP2025504278A true JP2025504278A (ja) 2025-02-12
JP2025504278A5 JP2025504278A5 (enExample) 2025-03-18

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US (3) US20260144865A1 (enExample)
EP (1) EP4601693A1 (enExample)
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KR (1) KR20250084959A (enExample)
CN (1) CN120265320A (enExample)
AU (1) AU2023361390A1 (enExample)
CL (2) CL2025001101A1 (enExample)
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CN112203642B (zh) 2019-03-25 2025-03-07 阿特根公司 用于皮下注射的包含人透明质酸酶ph20变体和药物的药物组合物
TW202615652A (zh) 2020-01-23 2026-04-16 南韓商阿特根公司 新穎的具有改善的穩定性的玻尿酸酶變異體及含有其的醫藥組合物
EP4684798A3 (en) * 2025-09-12 2026-05-06 Qilu Pharmaceutical Co., Ltd. A high-concentration composition of pd-1 antibody

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US20170218069A1 (en) * 2014-08-28 2017-08-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
WO2022066832A1 (en) * 2020-09-24 2022-03-31 Merck Sharp & Dohme Corp. Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
WO2022146948A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
WO2022146947A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof

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WO2021242728A1 (en) * 2020-05-26 2021-12-02 Regeneron Pharmaceuticals, Inc. Methods of treating cervical cancer by administering the pd-1 inhibitor antibody cemiplimab

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US20170218069A1 (en) * 2014-08-28 2017-08-03 Halozyme, Inc. Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
WO2022066832A1 (en) * 2020-09-24 2022-03-31 Merck Sharp & Dohme Corp. Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof
WO2022094567A1 (en) * 2020-10-28 2022-05-05 Ikena Oncology, Inc. Combination of an ahr inhibitor with a pdx inhibitor or doxorubicine
WO2022146948A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
WO2022146947A1 (en) * 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof

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FELIP, E., ET AL.: "Subcutaneous versus intravenous pembrolizumab, in combination with chemotherapy, for treatment of me", ANNALS OF ONCOLOGY, JPN6025023889, 2025, ISSN: 0005818648 *

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US20260151481A1 (en) 2026-06-04
CO2025004617A2 (es) 2025-04-28
US20240150467A1 (en) 2024-05-09
IL320229A (en) 2025-06-01
TWI887800B (zh) 2025-06-21
MX2025004328A (es) 2025-05-02
CL2025003511A1 (es) 2026-01-30
CN120265320A (zh) 2025-07-04
KR20250084959A (ko) 2025-06-11
WO2024081274A1 (en) 2024-04-18
AU2023361390A1 (en) 2025-05-22
TW202535929A (zh) 2025-09-16
CL2025001101A1 (es) 2025-08-18
EP4601693A1 (en) 2025-08-20
TW202423971A (zh) 2024-06-16
TW202535471A (zh) 2025-09-16
US20260144865A1 (en) 2026-05-28

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