TWI884224B - 縮合三環性化合物及其醫藥用途 - Google Patents

縮合三環性化合物及其醫藥用途 Download PDF

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TWI884224B
TWI884224B TW110107548A TW110107548A TWI884224B TW I884224 B TWI884224 B TW I884224B TW 110107548 A TW110107548 A TW 110107548A TW 110107548 A TW110107548 A TW 110107548A TW I884224 B TWI884224 B TW I884224B
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Taiwan
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compound
group
substituted
pharmaceutically acceptable
acceptable salt
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TW110107548A
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Chinese (zh)
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TW202146410A (zh
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須澤孝一
藤島悠記
希
上野弘資
眞部知幸
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日商日本煙草產業股份有限公司
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11002—[Pyruvate dehydrogenase (acetyl-transferring)] kinase (2.7.11.2)

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TW110107548A 2020-03-04 2021-03-03 縮合三環性化合物及其醫藥用途 TWI884224B (zh)

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JP2020-036931 2020-03-04
JP2020036931 2020-03-04
JP2021-001452 2021-01-07
JP2021001452 2021-01-07

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TW202146410A TW202146410A (zh) 2021-12-16
TWI884224B true TWI884224B (zh) 2025-05-21

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US (1) US20230025880A1 (enExample)
EP (2) EP4663189A3 (enExample)
JP (2) JP7739012B2 (enExample)
KR (1) KR20220149688A (enExample)
CN (1) CN115151543B (enExample)
AU (1) AU2021230880B2 (enExample)
BR (1) BR112022014749A2 (enExample)
CA (1) CA3166747A1 (enExample)
CL (1) CL2022002355A1 (enExample)
CO (1) CO2022012548A2 (enExample)
DK (1) DK4116301T3 (enExample)
ES (1) ES3052010T3 (enExample)
FI (1) FI4116301T3 (enExample)
HR (1) HRP20251364T1 (enExample)
IL (1) IL295836B2 (enExample)
LT (1) LT4116301T (enExample)
MX (1) MX428218B (enExample)
PE (1) PE20221908A1 (enExample)
PH (1) PH12022552259A1 (enExample)
PL (1) PL4116301T3 (enExample)
PT (1) PT4116301T (enExample)
RS (1) RS67408B1 (enExample)
SI (1) SI4116301T1 (enExample)
SM (1) SMT202500464T1 (enExample)
TW (1) TWI884224B (enExample)
WO (1) WO2021177330A1 (enExample)
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Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
PE20211273A1 (es) * 2018-02-01 2021-07-19 Japan Tobacco Inc Compuesto de amida heterociclica nitrogenada y su uso para fines medicos
WO2023032940A1 (ja) * 2021-09-01 2023-03-09 日本たばこ産業株式会社 含窒素三環性化合物及びその医薬用途
BR112022014749A2 (pt) * 2020-03-04 2022-10-11 Japan Tobacco Inc Composto tricíclico fundido e uso medicinal do mesmo

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020981A1 (en) * 2015-07-31 2017-02-09 Merck Patent Gmbh Bicyclic heterocyclic derivatives
WO2019151274A1 (ja) * 2018-02-01 2019-08-08 日本たばこ産業株式会社 含窒素複素環アミド化合物及びその医薬用途

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Publication number Priority date Publication date Assignee Title
ATE455547T1 (de) * 2003-04-11 2010-02-15 High Point Pharmaceuticals Llc Pharmazeutische verwendungen von kondensierten 1, 2,4-triazolen
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
KR100808551B1 (ko) * 2006-12-01 2008-03-03 한국생명공학연구원 트리아졸 유도체를 유효성분으로 함유하는 대사성 질환 예방 및 치료용 약학적 조성물
TWI633885B (zh) * 2013-03-15 2018-09-01 日商日本煙草產業股份有限公司 吡唑－醯胺化合物及其醫藥用途
EP3851103A4 (en) 2018-09-11 2022-06-08 Japan Tobacco Inc. THERAPEUTIC OR PROPHYLACTIC AGENT FOR CHRONIC KIDNEY DISEASE CONTAINING A PYRAZOLE-AMIDE COMPOUND
BR112022014749A2 (pt) * 2020-03-04 2022-10-11 Japan Tobacco Inc Composto tricíclico fundido e uso medicinal do mesmo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020981A1 (en) * 2015-07-31 2017-02-09 Merck Patent Gmbh Bicyclic heterocyclic derivatives
WO2019151274A1 (ja) * 2018-02-01 2019-08-08 日本たばこ産業株式会社 含窒素複素環アミド化合物及びその医薬用途

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CA3166747A1 (en) 2021-09-10
SMT202500464T1 (it) 2026-01-12
FI4116301T3 (fi) 2025-12-19
SI4116301T1 (sl) 2025-12-31
KR20220149688A (ko) 2022-11-08
LT4116301T (lt) 2025-11-10
IL295836A (en) 2022-10-01
PT4116301T (pt) 2025-11-12
CO2022012548A2 (es) 2022-09-20
EP4663189A2 (en) 2025-12-17
PL4116301T3 (pl) 2026-02-16
JP2025175000A (ja) 2025-11-28
HRP20251364T1 (hr) 2025-12-19
ZA202209620B (en) 2023-12-20
WO2021177330A1 (ja) 2021-09-10
BR112022014749A2 (pt) 2022-10-11
PE20221908A1 (es) 2022-12-23
AU2021230880A1 (en) 2022-09-29
MX428218B (es) 2025-11-13
EP4116301A1 (en) 2023-01-11
US20230025880A1 (en) 2023-01-26
CN115151543A (zh) 2022-10-04
ES3052010T3 (en) 2025-12-30
CL2022002355A1 (es) 2023-03-03
MX2022010950A (es) 2022-10-07
TW202146410A (zh) 2021-12-16
EP4116301A4 (en) 2024-04-03
AU2021230880B2 (en) 2026-06-25
CN115151543B (zh) 2024-12-17
PH12022552259A1 (en) 2023-11-20
IL295836B1 (en) 2025-09-01
IL295836B2 (en) 2026-01-01
RS67408B1 (sr) 2025-12-31
JP2022007994A (ja) 2022-01-13
DK4116301T3 (da) 2025-10-20
JP7739012B2 (ja) 2025-09-16
EP4116301B1 (en) 2025-10-08

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