TWI873167B - 以結合191p4d12蛋白質之抗體藥物結合物(adc)治療癌症 - Google Patents

以結合191p4d12蛋白質之抗體藥物結合物(adc)治療癌症 Download PDF

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Publication number
TWI873167B
TWI873167B TW109127017A TW109127017A TWI873167B TW I873167 B TWI873167 B TW I873167B TW 109127017 A TW109127017 A TW 109127017A TW 109127017 A TW109127017 A TW 109127017A TW I873167 B TWI873167 B TW I873167B
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Taiwan
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antibody
amino acid
acid sequence
cdr
antigen
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TW109127017A
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English (en)
Chinese (zh)
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TW202120557A (zh
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歐伊威爾 Ｏ 亞比多伊
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美商艾澤西公司
美商思進公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K9/0012—Galenical forms characterised by the site of application
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW109127017A 2019-08-13 2020-08-10 以結合191p4d12蛋白質之抗體藥物結合物(adc)治療癌症 TWI873167B (zh)

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US201962886270P 2019-08-13 2019-08-13
US62/886,270 2019-08-13

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TW202120557A TW202120557A (zh) 2021-06-01
TWI873167B true TWI873167B (zh) 2025-02-21

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TW109127017A TWI873167B (zh) 2019-08-13 2020-08-10 以結合191p4d12蛋白質之抗體藥物結合物(adc)治療癌症
TW114105048A TW202540197A (zh) 2019-08-13 2020-08-10 以結合191p4d12蛋白質之抗體藥物結合物(adc)治療癌症

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US (1) US20230001005A1 (enExample)
EP (1) EP4013795A4 (enExample)
JP (2) JP7657774B2 (enExample)
KR (1) KR20220054321A (enExample)
CN (1) CN114901690A (enExample)
AU (1) AU2020329761A1 (enExample)
BR (1) BR112022002391A2 (enExample)
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IL (1) IL290391A (enExample)
MX (1) MX2022001731A (enExample)
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Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
EA202191201A1 (ru) 2018-12-03 2022-01-26 Эдженсис, Инк. Фармацевтические композиции, включающие конъюгаты анти-191p4d12 антитело-лекарственное средство, и способы их применения
WO2021221500A1 (en) * 2020-04-27 2021-11-04 Agendia N.V. Treatment of her2 negative, mammaprint high risk 2 breast cancer.
KR20230106607A (ko) * 2020-10-11 2023-07-13 어젠시스 인코포레이티드 191p4d12 단백질에 결합하는 항체 약물 접합체(adc)로 암을 치료하는 방법
EP4301774A4 (en) * 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
WO2024012536A1 (zh) * 2022-07-14 2024-01-18 百奥泰生物制药股份有限公司 抗Nectin-4抗体、其抗体药物偶联物及应用
JP2026508244A (ja) 2023-02-22 2026-03-10 ナンジング リーズ バイオラブズ シーオー．， エルティーディー． 抗Ｎｅｃｔｉｎ－４抗体及びそれを含む多重特異性抗体
KR20250057677A (ko) * 2023-10-19 2025-04-29 (주)셀트리온 캄프토테신 유도체를 포함하는 항-Nectin-4 항체-약물 접합체

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