TWI869633B - 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 - Google Patents

用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 Download PDF

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TWI869633B
TWI869633B TW110139834A TW110139834A TWI869633B TW I869633 B TWI869633 B TW I869633B TW 110139834 A TW110139834 A TW 110139834A TW 110139834 A TW110139834 A TW 110139834A TW I869633 B TWI869633 B TW I869633B
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quinidine
dextromethorphan
salts
study
avp
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TW110139834A
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Chinese (zh)
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TW202231278A (zh
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若奧 西佛特
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美商阿瓦尼爾製藥股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/485Morphinan derivatives, e.g. morphine, codeine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/49Cinchonan derivatives, e.g. quinine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/28Morphinans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/485Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
TW110139834A 2014-09-14 2015-09-14 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物 TWI869633B (zh)

Applications Claiming Priority (34)

Application Number Priority Date Filing Date Title
US201462050170P 2014-09-14 2014-09-14
US62/050,170 2014-09-14
US201462061451P 2014-10-08 2014-10-08
US62/061,451 2014-10-08
US201462063122P 2014-10-13 2014-10-13
US62/063,122 2014-10-13
US201462063861P 2014-10-14 2014-10-14
US62/063,861 2014-10-14
US201462068742P 2014-10-26 2014-10-26
US62/068,742 2014-10-26
US201562111053P 2015-02-02 2015-02-02
US62/111,053 2015-02-02
US201562111590P 2015-02-03 2015-02-03
US62/111,590 2015-02-03
US201562128446P 2015-03-04 2015-03-04
US62/128,446 2015-03-04
US201562162140P 2015-05-15 2015-05-15
US62/162,140 2015-05-15
US201562165535P 2015-05-22 2015-05-22
US62/165,535 2015-05-22
US201562169997P 2015-06-02 2015-06-02
US62/169,997 2015-06-02
US201562180026P 2015-06-15 2015-06-15
US62/180,026 2015-06-15
US201562193347P 2015-07-16 2015-07-16
US62/193,347 2015-07-16
US201562205061P 2015-08-14 2015-08-14
US62/205,061 2015-08-14
US201562216636P 2015-09-10 2015-09-10
US62/216,636 2015-09-10
US201562217470P 2015-09-11 2015-09-11
US201562217142P 2015-09-11 2015-09-11
US62/217,142 2015-09-11
US62/217,470 2015-09-11

Publications (2)

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TW202231278A TW202231278A (zh) 2022-08-16
TWI869633B true TWI869633B (zh) 2025-01-11

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TW110139834A TWI869633B (zh) 2014-09-14 2015-09-14 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物
TW109114123A TW202106301A (zh) 2014-09-14 2015-09-14 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物
TW104130311A TW201613591A (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a DEXTROMETHORPHAN compound and QUINIDINE for the treatment of agitation in dementia

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TW109114123A TW202106301A (zh) 2014-09-14 2015-09-14 用於治療失智症中躁動行為之包含右旋美索芬(dextromethorphan)化合物及奎尼丁(quinidine)的藥學組成物
TW104130311A TW201613591A (en) 2014-09-14 2015-09-14 Pharmaceutical compositions comprising a DEXTROMETHORPHAN compound and QUINIDINE for the treatment of agitation in dementia

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US (3) US20190111047A1 (cg-RX-API-DMAC7.html)
EP (4) EP3708168A3 (cg-RX-API-DMAC7.html)
JP (4) JP2017531033A (cg-RX-API-DMAC7.html)
KR (1) KR20170052684A (cg-RX-API-DMAC7.html)
CN (3) CN107072990A (cg-RX-API-DMAC7.html)
AU (3) AU2015314710A1 (cg-RX-API-DMAC7.html)
CA (1) CA2960031A1 (cg-RX-API-DMAC7.html)
IL (2) IL250786A0 (cg-RX-API-DMAC7.html)
MX (3) MX2017003066A (cg-RX-API-DMAC7.html)
MY (1) MY198587A (cg-RX-API-DMAC7.html)
PH (1) PH12017500444A1 (cg-RX-API-DMAC7.html)
RU (1) RU2017112747A (cg-RX-API-DMAC7.html)
SG (2) SG10201901242PA (cg-RX-API-DMAC7.html)
TW (3) TWI869633B (cg-RX-API-DMAC7.html)
WO (1) WO2016040930A1 (cg-RX-API-DMAC7.html)

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WO2016040930A1 (en) 2016-03-17
AU2020289733A1 (en) 2021-01-21
EP3708168A2 (en) 2020-09-16
RU2020116666A (ru) 2020-07-31
MX2017003066A (es) 2017-09-12
JP2023105265A (ja) 2023-07-28
AU2015314710A1 (en) 2017-04-20
TW202106301A (zh) 2021-02-16
CA2960031A1 (en) 2016-03-17
MX2021010696A (es) 2021-10-01
EP3193872A4 (en) 2018-02-28
IL250786A0 (en) 2017-04-30
EP3193872A1 (en) 2017-07-26
PH12017500444A1 (en) 2017-07-31
US20190111047A1 (en) 2019-04-18
CN117427077A (zh) 2024-01-23
JP2020019818A (ja) 2020-02-06
KR20170052684A (ko) 2017-05-12
MX2022008181A (es) 2022-08-10
JP2017531033A (ja) 2017-10-19
AU2022283671B2 (en) 2025-03-20
EP3932907A2 (en) 2022-01-05
EP3708168A3 (en) 2020-12-09
US20240082237A1 (en) 2024-03-14
SG11201701645WA (en) 2017-04-27
JP2021080300A (ja) 2021-05-27
CN110664801A (zh) 2020-01-10
TW202231278A (zh) 2022-08-16
JP7360409B2 (ja) 2023-10-12
RU2017112747A3 (cg-RX-API-DMAC7.html) 2019-04-29
IL274742A (en) 2020-07-30
TW201613591A (en) 2016-04-16
EP4166141A1 (en) 2023-04-19
AU2022283671A1 (en) 2023-02-02
RU2017112747A (ru) 2018-10-15
US20200289499A1 (en) 2020-09-17
SG10201901242PA (en) 2019-03-28
CN107072990A (zh) 2017-08-18
EP3932907A3 (en) 2022-03-30
MY198587A (en) 2023-09-06

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