TWI835821B - 唑并嘧啶化合物之固體型式 - Google Patents

唑并嘧啶化合物之固體型式 Download PDF

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Publication number
TWI835821B
TWI835821B TW108125369A TW108125369A TWI835821B TW I835821 B TWI835821 B TW I835821B TW 108125369 A TW108125369 A TW 108125369A TW 108125369 A TW108125369 A TW 108125369A TW I835821 B TWI835821 B TW I835821B
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Taiwan
Prior art keywords
cancer
compound
solid form
xrpd
degrees
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TW108125369A
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English (en)
Chinese (zh)
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TW202011964A (zh
Inventor
珍那 梨 傑佛瑞
曼摩漢 瑞迪 賴勒提
迪倫 哈汀 邁爾斯
傑 派翠克 包爾斯
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美商阿克思生物科學有限公司
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Publication of TW202011964A publication Critical patent/TW202011964A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
TW108125369A 2018-07-18 2019-07-18 唑并嘧啶化合物之固體型式 TWI835821B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862700064P 2018-07-18 2018-07-18
US62/700,064 2018-07-18

Publications (2)

Publication Number Publication Date
TW202011964A TW202011964A (zh) 2020-04-01
TWI835821B true TWI835821B (zh) 2024-03-21

Family

ID=69164033

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108125369A TWI835821B (zh) 2018-07-18 2019-07-18 唑并嘧啶化合物之固體型式

Country Status (12)

Country Link
US (1) US11993584B2 (https=)
EP (1) EP3823614A4 (https=)
JP (2) JP7522720B2 (https=)
KR (1) KR102826213B1 (https=)
CN (1) CN113015523B (https=)
AU (1) AU2019306582B2 (https=)
CA (1) CA3106366A1 (https=)
MY (1) MY205549A (https=)
PH (1) PH12021550084A1 (https=)
SG (1) SG11202100267TA (https=)
TW (1) TWI835821B (https=)
WO (1) WO2020018680A1 (https=)

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CN113795267A (zh) 2019-03-12 2021-12-14 艾库斯生物科学有限公司 致癌基因驱动的癌症的治疗
WO2020205527A1 (en) 2019-03-29 2020-10-08 Arcus Biosciences, Inc. Treatment of cancer utilizing an identified adenosine fingerprint
CN119768155A (zh) 2022-09-14 2025-04-04 艾库斯生物科学有限公司 依曲地南的分散体
WO2024097736A1 (en) 2022-11-02 2024-05-10 Arcus Biosciences, Inc. Processes for preparing azolopyrimidine compounds
WO2025193759A1 (en) 2024-03-12 2025-09-18 Gilead Sciences, Inc. Solid forms of an azolopyrimidine compound

Citations (1)

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UY37574A (es) * 2017-01-20 2018-05-31 Arcus Biosciences Inc Azolopirimidina para el tratamiento de trastornos relacionados con el cáncer

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Also Published As

Publication number Publication date
JP2021531273A (ja) 2021-11-18
US11993584B2 (en) 2024-05-28
KR102826213B1 (ko) 2025-06-27
PH12021550084A1 (en) 2021-11-08
CN113015523A (zh) 2021-06-22
JP2024083556A (ja) 2024-06-21
EP3823614A4 (en) 2022-03-30
SG11202100267TA (en) 2021-02-25
JP7522720B2 (ja) 2024-07-25
TW202011964A (zh) 2020-04-01
WO2020018680A1 (en) 2020-01-23
CA3106366A1 (en) 2020-01-23
AU2019306582B2 (en) 2023-03-16
KR20210033503A (ko) 2021-03-26
US20210269422A1 (en) 2021-09-02
MY205549A (en) 2024-10-25
CN113015523B (zh) 2024-07-16
AU2019306582A1 (en) 2021-03-11
EP3823614A1 (en) 2021-05-26

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