TWI828800B - Arg1及/或arg2之抑制劑 - Google Patents

Arg1及/或arg2之抑制劑 Download PDF

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Publication number
TWI828800B
TWI828800B TW108141665A TW108141665A TWI828800B TW I828800 B TWI828800 B TW I828800B TW 108141665 A TW108141665 A TW 108141665A TW 108141665 A TW108141665 A TW 108141665A TW I828800 B TWI828800 B TW I828800B
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TW
Taiwan
Prior art keywords
cancer
group
alkyl
pharmaceutically acceptable
hydrate
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TW108141665A
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English (en)
Chinese (zh)
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TW202033203A (zh
Inventor
喬伊爾 比提
肯妮 妮可 佛洛伊
瑞貝卡 路易絲 葛蘭居
泰茲肯 岡尼
史蒂芬 唐納德 雅各
傑洛斯勒 卡里斯卡
曼摩漢 瑞迪 賴勒提
艾瑞克 艾倫 林德西
廸巴西斯 曼多
艾瑞克 湯馬士 紐康
傑 派翠克 包爾斯
布蘭登 里德 羅森
蘇永利
安 圖 特蘭
Original Assignee
美商阿克思生物科學有限公司
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Publication of TW202033203A publication Critical patent/TW202033203A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
TW108141665A 2018-11-16 2019-11-15 Arg1及/或arg2之抑制劑 TWI828800B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862768284P 2018-11-16 2018-11-16
US62/768,284 2018-11-16

Publications (2)

Publication Number Publication Date
TW202033203A TW202033203A (zh) 2020-09-16
TWI828800B true TWI828800B (zh) 2024-01-11

Family

ID=70731928

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108141665A TWI828800B (zh) 2018-11-16 2019-11-15 Arg1及/或arg2之抑制劑

Country Status (12)

Country Link
US (1) US12226425B2 (enExample)
EP (1) EP3880685B1 (enExample)
JP (1) JP7461350B2 (enExample)
KR (1) KR102718333B1 (enExample)
CN (1) CN113382998A (enExample)
AR (1) AR117102A1 (enExample)
AU (1) AU2019379808C1 (enExample)
CA (1) CA3120196A1 (enExample)
ES (1) ES3034676T3 (enExample)
TW (1) TWI828800B (enExample)
UY (1) UY38476A (enExample)
WO (1) WO2020102646A2 (enExample)

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TW202325279A (zh) 2021-10-29 2023-07-01 美商阿克思生物科學有限公司 HIF-2α抑制劑及其使用方法
CN119156228A (zh) 2022-05-02 2024-12-17 艾库斯生物科学有限公司 抗tigit抗体及其用途
EP4554680A1 (en) 2022-07-15 2025-05-21 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
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Also Published As

Publication number Publication date
EP3880685A4 (en) 2022-07-27
AU2019379808B2 (en) 2023-08-03
JP2022507474A (ja) 2022-01-18
EP3880685B1 (en) 2025-06-18
KR20210108954A (ko) 2021-09-03
UY38476A (es) 2020-06-30
ES3034676T3 (en) 2025-08-21
EP3880685A2 (en) 2021-09-22
TW202033203A (zh) 2020-09-16
US20220016143A1 (en) 2022-01-20
US12226425B2 (en) 2025-02-18
AU2019379808A1 (en) 2021-06-24
WO2020102646A2 (en) 2020-05-22
JP7461350B2 (ja) 2024-04-03
AU2019379808C1 (en) 2024-01-25
KR102718333B1 (ko) 2024-10-17
CA3120196A1 (en) 2020-05-22
AR117102A1 (es) 2021-07-14
WO2020102646A3 (en) 2020-08-13
CN113382998A (zh) 2021-09-10
EP3880685C0 (en) 2025-06-18

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