TWI826829B - Deer antler extract is used to repair hair and promote hair regeneration. - Google Patents
Deer antler extract is used to repair hair and promote hair regeneration. Download PDFInfo
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- 210000003056 antler Anatomy 0.000 title claims abstract description 40
- 210000004209 hair Anatomy 0.000 title claims abstract description 28
- 230000003660 hair regeneration Effects 0.000 title abstract description 7
- 241000282994 Cervidae Species 0.000 title description 10
- 210000003780 hair follicle Anatomy 0.000 claims abstract description 24
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 13
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 13
- 239000000203 mixture Substances 0.000 claims abstract description 11
- 230000017423 tissue regeneration Effects 0.000 claims abstract description 6
- 210000003491 skin Anatomy 0.000 claims description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 9
- 210000000981 epithelium Anatomy 0.000 claims description 6
- 210000001519 tissue Anatomy 0.000 claims description 6
- 210000000130 stem cell Anatomy 0.000 claims description 5
- 230000004663 cell proliferation Effects 0.000 claims description 4
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101150100611 KRT15 gene Proteins 0.000 claims description 2
- 230000003779 hair growth Effects 0.000 abstract description 14
- 201000004384 Alopecia Diseases 0.000 abstract description 12
- 208000024963 hair loss Diseases 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 9
- 230000003676 hair loss Effects 0.000 abstract description 8
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 230000003752 improving hair Effects 0.000 abstract description 4
- 108010062276 T-Cell Acute Lymphocytic Leukemia Protein 1 Proteins 0.000 abstract description 2
- 102100040365 T-cell acute lymphocytic leukemia protein 1 Human genes 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 description 19
- 239000006071 cream Substances 0.000 description 8
- 230000036541 health Effects 0.000 description 6
- 210000000442 hair follicle cell Anatomy 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003929 acidic solution Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000010186 staining Methods 0.000 description 3
- 239000000052 vinegar Substances 0.000 description 3
- 235000021419 vinegar Nutrition 0.000 description 3
- 238000011740 C57BL/6 mouse Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 230000016507 interphase Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000007490 hematoxylin and eosin (H&E) staining Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229940107889 rogaine Drugs 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 231100000872 sexual dysfunction Toxicity 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
本發明係提供一種鹿茸萃取物用於毛髮修護與促進毛髮新生之用途，意即透過投予有效量之鹿茸萃取物或是含有有效量之鹿茸萃取物的組合物至一個體時，係能夠提升毛囊幹細胞蛋白、毛髮上提組織修復蛋白表現，藉以達到促進毛髮生長、修復毛囊之功效，進而能夠有效地治療或改善脫髮或掉髮之效果。The present invention provides a use of velvet antler extract for hair repair and promotion of hair regeneration, which means that by administering an effective amount of velvet antler extract or a composition containing an effective amount of velvet antler extract to an individual, it can Improve the performance of hair follicle stem cell proteins and hair lift tissue repair proteins to achieve the effects of promoting hair growth and repairing hair follicles, thereby effectively treating or improving hair loss or hair loss.
Description
本發明係有關於一種萃取物之第二用途，特別係指一種鹿茸萃取物用於毛髮修護與促進毛髮新生之用途。The present invention relates to the second use of an extract, particularly the use of a deer antler extract for hair repair and promotion of hair regeneration.
按，毛髮在哺乳類動物中是少數可以不斷生長者，毛囊是毛髮之根基，於生長期之毛囊細胞每天可以分裂一次，是人體分裂最快的細胞之一。對於現代人來說，毛髮已經跳脫禦寒或維持體溫之用途，而成為外觀與自信之來源。根據研究，癌症治療過程中所產生之掉髮副作用，對於癌症患者所產生之心理壓力遠大於癌症治療之害怕與不適，顯示毛髮是否脫落與個人心理健康息息相關。According to reports, hair is one of the few mammals that can grow continuously. Hair follicles are the foundation of hair. During the growth period, hair follicle cells can divide once a day and are one of the fastest dividing cells in the human body. For modern people, hair has no longer been used to protect against cold or maintain body temperature, but has become a source of appearance and self-confidence. According to research, the psychological stress caused by the side effects of hair loss during cancer treatment is far greater than the fear and discomfort of cancer treatment, indicating that hair loss is closely related to personal mental health.
臨床上活化毛囊幹細胞之方法，最常用的是使用如落健（minoxidil）或非那斯特萊（Finasteride）等藥物，其中，落健係使毛囊由休止期提早進入生長期，刺激頭髮生長，並增加頭髮厚度，不過此方法僅對於暫時性脫髮者有幫助，且必須要長期使用；而非那斯特萊係為賀爾蒙調控藥物，能夠抑制體內男性荷爾蒙形成，但是同時地會產生造成性功能障礙之副作用，且此方法不適用於女性。Clinically, the most commonly used method of activating hair follicle stem cells is to use drugs such as minoxidil or Finasteride. Among them, Rogaine causes hair follicles to enter the growth phase from the resting phase in advance, stimulates hair growth, and increases the number of hair follicles. Hair thickness, but this method is only helpful for people with temporary hair loss and must be used for a long time; Finastela is a hormone regulating drug that can inhibit the formation of male hormones in the body, but at the same time it will cause sexual dysfunction. side effects of the disorder, and this method is not suitable for women.
本發明之主要目的係在於提供一種鹿茸萃取物用於毛髮修護與促進毛髮新生之用途，其係能夠有效地修復毛囊與毛髮上皮組織，達到促進毛髮生長及修護頭皮之功效。The main purpose of the present invention is to provide a deer antler extract for hair repair and promotion of hair regeneration, which can effectively repair hair follicles and hair epithelial tissue to achieve the effects of promoting hair growth and repairing the scalp.
本發明之另一目的係在於提供一種鹿茸萃取物用於毛髮修護與促進毛髮新生之用途，其係透過可食用食材作為原料，故長時間使用亦不會對於人體造成副作用，Another object of the present invention is to provide a deer antler extract for hair repair and promotion of hair regeneration. It uses edible food as raw material, so long-term use will not cause side effects on the human body.
緣是，為能達成上述目的，本發明係揭露一種鹿茸萃取物用於製備與毛髮生長或/及毛囊健康相關組合物之用途，其中，該鹿茸萃取物係由一鹿茸以一酸性溶液進行萃取所得者。藉由投予有效量之鹿茸萃取物或是含有有效量鹿茸萃取物之組合物至一個體，係能夠有效地改善或治療脫毛或落髮。Therefore, in order to achieve the above object, the present invention discloses the use of a velvet antler extract for preparing a composition related to hair growth or/and hair follicle health, wherein the velvet antler extract is extracted from a velvet antler with an acidic solution. Gainer. By administering an effective amount of velvet antler extract or a composition containing an effective amount of velvet antler extract to an individual, hair loss or hair loss can be effectively improved or treated.
更進一步來說，本發明所揭鹿茸萃取物係具有提升與毛囊幹細胞增生相關蛋白及毛髮上皮組織修復蛋白之表現之能力，因此，本發明所揭與毛髮生長或/及毛囊健康相關組合物係能夠有效地修復受損毛囊及毛囊上皮組織、維護毛囊健康，以避免毛囊細胞進入休止期或是加速毛囊細胞進入生長期，達到促進毛髮新生及改善掉髮之功效。Furthermore, the velvet antler extract disclosed in the present invention has the ability to enhance the performance of proteins related to hair follicle stem cell proliferation and hair epithelial tissue repair proteins. Therefore, the composition disclosed in the present invention is related to hair growth or/and hair follicle health. It can effectively repair damaged hair follicles and hair follicle epithelial tissue, maintain hair follicle health, prevent hair follicle cells from entering the resting phase or accelerate hair follicle cells from entering the growth phase, thereby promoting hair regeneration and improving hair loss.
於本發明之實施例中，該酸性溶液係為一醋酸，如食用醋。In an embodiment of the present invention, the acidic solution is acetic acid, such as edible vinegar.
於本發明之實施例中，該與毛髮生長或/及毛囊健康相關組合物係得被製備為一外用美容品或一藥品，舉例來說，倘若該與毛髮生長或/及毛囊健康相關組合物係被製備為一外用劑型，則係以塗抹或噴灑之方式使該鹿茸萃取物接觸皮膚；而若該與毛髮生長或/及毛囊健康相關組合物係為一種口服劑型，則係以吞食之方式使該鹿茸萃取物進入體內。In embodiments of the present invention, the composition related to hair growth or/and hair follicle health can be prepared as an external cosmetic product or a medicine. For example, if the composition related to hair growth or/and hair follicle health If the composition is prepared as an external dosage form, the deer antler extract is applied or sprayed to contact the skin; and if the composition related to hair growth or/and hair follicle health is an oral dosage form, the deer antler extract is ingested. Let the velvet antler extract enter the body.
本發明係提供一種鹿茸萃取物用於毛髮修護與促進毛髮新生之用途，意即透過投予有效量之鹿茸萃取物或是含有有效量之鹿茸萃取物的組合物至一個體時，係能夠提升毛囊幹細胞蛋白、毛髮上提組織修復蛋白表現，藉以達到促進毛髮生長、修復毛囊之功效，進而能夠有效地治療或改善脫髮或掉髮之效果。The present invention provides a use of velvet antler extract for hair repair and promotion of hair regeneration, which means that by administering an effective amount of velvet antler extract or a composition containing an effective amount of velvet antler extract to an individual, it can Improve the performance of hair follicle stem cell proteins and hair lift tissue repair proteins to achieve the effects of promoting hair growth and repairing hair follicles, thereby effectively treating or improving hair loss or hair loss.
更進一步來說，本發明所揭鹿茸萃取物係由一鹿茸以一酸性溶液進行萃取所得者，該酸性溶液係為一醋酸溶液或一食用醋。Furthermore, the velvet antler extract disclosed in the present invention is obtained by extracting a velvet antler with an acidic solution, and the acidic solution is an acetic acid solution or edible vinegar.
以下，為能說明及驗證本發明之技術特徵及其功效，將茲舉若干實例並搭配圖式作詳細說明如後。In the following, in order to illustrate and verify the technical features and effects of the present invention, several examples will be given and illustrated in detail below.
以下實例中所使用之C57BL/6雄性小鼠，係為商業購入，並且實驗流程皆符合動物試驗及研究相關規範。The C57BL/6 male mice used in the following examples were purchased commercially, and the experimental procedures complied with relevant standards for animal testing and research.
實例一：製備鹿茸萃取物Example 1: Preparation of deer antler extract
新鮮鹿茸切片秤重500 克，加入2500 毫升無菌水與2500 毫升食用醋，經超音波於50度C 震盪萃取1 小時後，移除殘渣後獲得萃取液，經冷凍乾燥後製備成蛋白粉末，此即為鹿茸萃取物。Weigh 500 grams of fresh velvet antler slices, add 2500 ml of sterile water and 2500 ml of edible vinegar, shake and extract with ultrasonic at 50 degrees C for 1 hour, remove the residue and obtain the extract, which is freeze-dried and prepared into protein powder. That is deer antler extract.
將所獲得之蛋白粉末測量重量後，取不同體積的水解液濃縮至50 mL（含乾物重2 g），進行離心（10,000 μg、15分鐘），取上清液1 mL（乾物重0.04 g），過濾後，以管柱Sephadex LH-20 （Amersham Pharmasia Biotech, Tokyo, Japan）進行分析，其中，流速1 mL/min。以30%甲醇洗脫，流速0.5 ml/min，使用在線分光光度計測量，波長280 nm。分析結果如圖1所示，可知本發明所揭鹿茸萃取物經LC管柱定量分析，其最主要之波峰值位於214、341、509、614、752、1003分鐘。After measuring the weight of the obtained protein powder, take different volumes of hydrolyzate and concentrate it to 50 mL (containing 2 g of dry matter), centrifuge (10,000 μg, 15 minutes), and take 1 mL of supernatant (0.04 g of dry matter). , after filtration, the column Sephadex LH-20 (Amersham Pharmasia Biotech, Tokyo, Japan) was used for analysis, where the flow rate was 1 mL/min. Elute with 30% methanol, flow rate 0.5 ml/min, use online spectrophotometer to measure, wavelength 280 nm. The analysis results are shown in Figure 1. It can be seen that the velvet antler extract disclosed in the present invention is quantitatively analyzed by an LC column, and its most important peaks are located at 214, 341, 509, 614, 752, and 1003 minutes.
實例二：動物試驗Example 2: Animal testing
將C57BL/6雄性小鼠隨機分為4組，每組6隻小鼠，其中：C57BL/6 male mice were randomly divided into 4 groups, with 6 mice in each group, including:
第1組：使用脫毛膏脫除小鼠背部1.5*3.0 cm2範圍之毛髮，並每天一次塗抹100μl塗抹不含鹿茸萃取物之乳膏。Group 1: Use hair removal cream to remove hair in the area of 1.5*3.0 cm2 on the back of mice, and apply 100 μl of cream without velvet antler extract once a day.
第2組：使用脫毛膏脫除小鼠背部1.5*3.0 cm2範圍之毛髮，並每天一次塗抹100μl含鹿茸萃取物之乳膏，鹿茸萃取物之劑量為50 mg/mL。Group 2: Use hair removal cream to remove hair in the area of 1.5*3.0 cm2 on the back of mice, and apply 100 μl of cream containing velvet antler extract once a day. The dose of velvet antler extract is 50 mg/mL.
第3組：使用脫毛膏脫除小鼠背部1.5*3.0 cm2範圍之毛髮，並每天一次塗抹100μl塗抹含鹿茸萃取物之乳膏，鹿茸萃取物之劑量為150 mg/mL。Group 3: Use hair removal cream to remove hair in the area of 1.5*3.0 cm2 on the back of mice, and apply 100 μl of cream containing velvet antler extract once a day. The dose of velvet antler extract is 150 mg/mL.
第4組：使用脫毛膏脫除小鼠背部1.5*3.0 cm2範圍之毛髮，並每天一次塗抹100μl塗抹含鹿茸萃取物之乳膏，鹿茸萃取物之劑量為450 mg/mL。Group 4: Use hair removal cream to remove hair in the area of 1.5*3.0 cm2 on the back of mice, and apply 100 μl of cream containing velvet antler extract once a day. The dose of velvet antler extract is 450 mg/mL.
試驗期間（共2週），每週拍照紀錄各組小鼠，結果如圖2所示，並於試驗結束後予以犧牲。During the test period (a total of 2 weeks), mice in each group were photographed and recorded every week. The results are shown in Figure 2, and they were sacrificed after the end of the test.
由圖2之結果可知，相較於第1組小鼠來說，投予含有本發明所揭鹿茸萃取物之第2組至第4組小鼠的毛髮生長情形明顯較快，顯示本發明所揭鹿茸萃取物確實有促進毛髮生長之功效。It can be seen from the results in Figure 2 that compared with the mice in the first group, the hair growth of the mice in the second to fourth groups containing the velvet antler extract disclosed in the present invention was significantly faster, showing that the hair growth of the mice in the first group was significantly faster. Deer antler extract indeed has the effect of promoting hair growth.
實例三：皮膚切片染色分析Example 3: Skin section staining analysis
實例二之各組小鼠犧牲後，分別取背部皮膚組織，進行石蠟固定包埋處理後切片，再進行H&E染色及免疫組織染色分析，其中，所使用之抗體包有與抗CD34抗體、抗Krt15抗體、抗Lrg5抗體、抗Lrg6抗體。切片染色後於顯微鏡下觀察結果如圖3及圖4所示。In Example 2, after the mice in each group were sacrificed, the back skin tissues were removed, fixed and embedded in paraffin, sectioned, and then subjected to H&E staining and immunohistological staining analysis. The antibodies used included anti-CD34 antibody and anti-Krt15. Antibodies, anti-Lrg5 antibodies, anti-Lrg6 antibodies. The results of staining the sections and observing them under a microscope are shown in Figures 3 and 4.
由圖3及圖4之結果可知，相較於第1組小鼠來說，投予含有本發明所揭鹿茸萃取物之第2組至第4組小鼠之毛囊細胞中之毛囊幹細胞增生蛋白：CD34及Krt15之表現量皆有增加，並且毛髮上皮組織修復蛋白Lrg6之表現量亦有明顯增加，其中，第2組至第4組小鼠之毛囊細胞中之Lrg5的表現量之所以沒有明顯提昇，乃是因為Lrg5係為位於深層組織，因而於實例二中之脫毛處理對於皮膚深層組織未產生傷害，故不影響Lrg5之表現量，不過基於Lrg6為接近皮膚上層組織之蛋白，故因為各組小鼠處理手段不同而有不同表現量。It can be seen from the results of Figure 3 and Figure 4 that compared with the mice of the first group, the hair follicle stem cell proliferation protein in the hair follicle cells of the mice of the second to fourth groups containing the velvet antler extract disclosed by the present invention was administered. : The expression amounts of CD34 and Krt15 increased, and the expression amount of hair epithelial tissue repair protein Lrg6 also increased significantly. Among them, the expression amount of Lrg5 in the hair follicle cells of mice in groups 2 to 4 was not obvious. The improvement is because Lrg5 is located in the deep tissue. Therefore, the hair removal treatment in Example 2 did not cause damage to the deep tissue of the skin, so it does not affect the expression of Lrg5. However, since Lrg6 is a protein close to the upper layer of the skin, each Groups of mice treated with different methods have different performance levels.
由圖3及圖4之結果顯示本發明所揭鹿茸萃取物確實能夠促進毛囊生長，並且修復毛囊周遭皮膚上皮組織，進而提昇毛髮生長效率，促使毛囊新生，達到治療或改善脫毛或掉髮之功效。The results of Figures 3 and 4 show that the deer antler extract disclosed in the present invention can indeed promote the growth of hair follicles and repair the epithelial tissue of the skin around the hair follicles, thereby improving the hair growth efficiency, promoting the regeneration of hair follicles, and achieving the effect of treating or improving hair loss or hair loss. .
無without
圖1係為本發明所揭鹿茸萃取物經LC管柱分析之結果。 圖2係為紀錄各組小鼠於試驗期間之各週毛髮生長情形之結果。 圖3係為各組小鼠皮膚組織切片經染色後之觀察結果（一）。 圖4係為各組小鼠皮膚組織切片經染色後之觀察結果（二）。 Figure 1 shows the results of LC column analysis of the velvet antler extract disclosed in the present invention. Figure 2 shows the results of recording the hair growth of mice in each group during each week of the test. Figure 3 shows the observation results of stained skin tissue sections of mice in each group (1). Figure 4 shows the observation results of stained skin tissue sections of mice in each group (2).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW201733588A (en) * | 2015-12-28 | 2017-10-01 | 壯生和壯生消費者公司 | Hair growth composition and method |
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| TW201733588A (en) * | 2015-12-28 | 2017-10-01 | 壯生和壯生消費者公司 | Hair growth composition and method |
Non-Patent Citations (1)
| Title |
|---|
| 期刊 Yang et al Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model Asian-Aust. J. Anim. Sci 25 Asian-Aust. J. Anim. Sci 2012 708-716 * |
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