TWI805841B - 隱形眼鏡用處理溶液 - Google Patents
隱形眼鏡用處理溶液 Download PDFInfo
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- TWI805841B TWI805841B TW108133428A TW108133428A TWI805841B TW I805841 B TWI805841 B TW I805841B TW 108133428 A TW108133428 A TW 108133428A TW 108133428 A TW108133428 A TW 108133428A TW I805841 B TWI805841 B TW I805841B
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- 239000000178 monomer Substances 0.000 claims abstract description 69
- 238000007334 copolymerization reaction Methods 0.000 claims abstract description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
- 125000000217 alkyl group Chemical group 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 238000007598 dipping method Methods 0.000 abstract description 4
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- -1 and among them Chemical group 0.000 description 37
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- 230000000694 effects Effects 0.000 description 17
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- 238000000034 method Methods 0.000 description 15
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- 125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
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- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- VMOXILJFUFEZJL-UHFFFAOYSA-M sodium;ethylmercury;2-sulfanylbenzoate Chemical compound [Na+].CC[Hg].[O-]C(=O)C1=CC=CC=C1S VMOXILJFUFEZJL-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- 229960001947 tripalmitin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
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- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3784—(Co)polymerised monomers containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F120/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
- C08F120/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F120/10—Esters
- C08F120/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
- C08F120/36—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate containing oxygen in addition to the carboxy oxygen, e.g. 2-N-morpholinoethyl (meth)acrylate or 2-isocyanatoethyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/16—Organic compounds
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- C11D3/30—Amines; Substituted amines ; Quaternized amines
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/36—Organic compounds containing phosphorus
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11D3/3757—(Co)polymerised carboxylic acids, -anhydrides, -esters in solid and liquid compositions
- C11D3/3761—(Co)polymerised carboxylic acids, -anhydrides, -esters in solid and liquid compositions in solid compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
- C08F2800/10—Copolymer characterised by the proportions of the comonomers expressed as molar percentages
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
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Abstract
本發明係一種隱形眼鏡用處理溶液,其特徵在於以A:B=1000:1~2:1(重量比)包含以下之共聚物A及共聚物B。根據本發明,可提供一種隱形眼鏡用處理溶液,其藉由簡便之浸漬處理,可將附著於隱形眼鏡表面之污垢去除,而且可對隱形眼鏡表面賦予持續之親水性。
共聚物A:使式1所表示之單體a、及式2所表示之單體b共聚合所獲得之共聚物,且上述單體a、單體b之共聚合比率為a:b=7:3~9:1(莫耳比)且重量平均分子量為400,000~700,000之共聚物。
共聚物B:使式3所表示之單體c、及式4所表示之單體d共聚合所獲得之共聚物,且上述單體c、單體d之共聚合比率為c:d=1:4~9:1(莫耳比)且重量平均分子量為20,000~90,000之共聚物。
Description
本發明係關於一種隱形眼鏡(以下存在記作CL(contact lens)之情況)用處理溶液。更詳細而言,關於一種CL用處理溶液、及經該CL用處理溶液處理之CL,該CL用處理溶液可將附著於CL之污垢洗淨,而且對CL表面賦予持續之親水性。
通常,隱形眼鏡於佩戴時會沈積源自淚液或眼脂、皮脂、化妝品等之蛋白質、脂質等污垢,該等污垢會導致佩戴感之惡化、矯正視力之惡化、傳染病等。因此,開發有各種針對上述CL污垢之對策。
作為先前之將附著於CL之污垢去除之方法,廣泛利用使用包含界面活性劑、氧化劑、研磨劑等之洗淨劑將CL洗淨之方法。進而,如專利文獻1所代表,亦廣泛利用藉由於CL洗淨液中添加酵素來高效地去除隱形眼鏡之污垢之方法。於該等方法中,主要著眼於去除附著於CL之污垢,就防止污垢附著於CL,並未獲得充分之效果。
相對於該等,作為防止污垢附著於CL之方法,已知有使CL表面親水化之方法。例如,於專利文獻2中,提出有使用包括含有磷酸膽鹼基之聚合物之溶液來使CL之表面親水化之方法。但,於上述方法中,主要著眼於防止污垢附著於CL,就去除附著於CL之污垢,並未獲得充分之效果。
作為兼顧去除附著於CL之污垢及防止污垢附著於CL的方法,於專利文獻3中,提出有以特定比率包括含有磷酸膽鹼基之聚合物、烷基醯胺聚氧乙烯醚硫酸鹽、及水解酵素的CL用處理溶液。若使用該處理溶液,則可將蛋白質、脂質污垢去除,且可對CL表面賦予親水性而防止蛋白質、脂質污垢之吸附。
[先前技術文獻]
[專利文獻]
[專利文獻1]日本專利特開平1-180515號公報
[專利文獻2]日本專利特開平7-166154號公報
[專利文獻3]日本專利特開2000-147442號公報
[發明所欲解決之問題]
上述專利文獻3中記載之CL用處理溶液對防止污垢附著於CL及去除附著於CL之污垢具有一定之效果,但就對CL表面賦予之親水性之持久性(以下亦稱作持續之親水性)而言尚存在改善之餘地。
本發明之目的在於提供一種CL用處理溶液、及經該CL用處理溶液處理之CL,該CL用處理溶液藉由簡便之浸漬處理,可將附著於CL表面之污垢去除,且可對CL表面賦予持續之親水性。
[解決問題之技術手段]
本發明人等鑒於上述問題點而進行了努力研究,結果意外發現藉由以特定比率使用特定之兩種共聚物,可解決問題,從而完成本發明。
即,本發明係以下之[1]~[2]之CL用處理溶液、以及CL。
[1]一種CL用處理溶液,其特徵在於以A:B=1000:1~2:1(重量比)包含以下之共聚物A及共聚物B。
共聚物A:使下述式1所表示之單體a、及下述式2所表示之單體b共聚合所獲得之共聚物,且上述單體a、單體b之共聚合比率為a:b=7:3~9:1(莫耳比)且重量平均分子量為400,000~700,000之共聚物。
共聚物B:使下述式3所表示之單體c、及下述式4所表示之單體d共聚合所獲得之共聚物,且上述單體c、單體d之共聚合比率為c:d=1:4~9:1(莫耳比)且重量平均分子量為20,000~90,000之共聚物。
[化1]
(式1中,R1
表示氫原子、或甲基)
[化2]
(式2中,R2
表示氫原子、或甲基,R3
表示碳數2~6之烷基)
[化3]
(於式3中,R4
表示氫原子或甲基,n為1~4之整數)
[化4]
(於式4中,R5
表示氫原子或甲基,R6
表示碳數8~22之烴基)
[2]一種隱形眼鏡,其經如[1]中記載之隱形眼鏡用處理溶液進行處理。
[發明之效果]
根據本發明,可提供一種CL用處理溶液、及經該CL用處理溶液處理之CL,該CL用處理溶液藉由簡便之浸漬處理,可將附著於CL表面之污垢去除,且可對CL表面賦予持續之親水性。
以下,詳細地對本發明進行說明。
再者,於本說明書中,「(甲基)丙烯酸」係指「丙烯酸或甲基丙烯酸」,其他類似用語亦相同。
又,於本說明書中,於階段性地記載較佳之數值範圍(例如,含量或重量平均分子量之範圍)之情形時,各下限值及上限值可分別獨立地組合。例如,於「較佳為10~100,更佳為20~90」之記載中,可將「較佳之下限值:10」與「更佳之上限值:90」組合而設為「10~90」。
本發明之CL用處理用液以A:B=1000:1~2:1(重量比)包含以下之共聚物A及共聚物B。
共聚物A:使下述式1所表示之單體a、及下述式2所表示之單體b共聚合所獲得之共聚物,且上述單體a、單體b之共聚合比率為a:b=7:3~9:1(莫耳比)且重量平均分子量為400,000~700,000之共聚物。
共聚物B:使下述式3所表示之單體c、及下述式4所表示之單體d共聚合所獲得之共聚物,且上述單體c、單體d之共聚合比率為c:d=1:4~9:1(莫耳比)且重量平均分子量為20,000~90,000之共聚物。
[化5]
(式1中,R1
表示氫原子、或甲基)
[化6]
(式2中,R2
表示氫原子、或甲基,R3
表示碳數2~6之烷基)
[化7]
(於式3中,R4
表示氫原子或甲基,n為1~4之整數)
[化8]
(於式4中,R5
表示氫原子或甲基,R6
表示碳數8~22之烴基)
[共聚物A]
本發明之共聚物A係上述式1所表示之單體a與上述式2所表示之單體b之共聚物。
式1所表示之單體a之R1
為氫原子或甲基,就原料獲取性之觀點而言,較佳為甲基。
式2所表示之單體b之R2
為氫原子或甲基,就共聚物A之保存穩定性之觀點而言,較佳為甲基。
又,R3
為碳數2~6之烷基。因此,作為單體b之具體例,可較佳地列舉(甲基)丙烯酸乙酯、(甲基)丙烯酸丙酯、(甲基)丙烯酸丁酯、(甲基)丙烯酸戊酯、(甲基)丙烯酸己酯等。尤其是,由於對CL賦予持續之親水性之效果較高,故單體b較佳為於式2中R3
為碳數3~5之烷基之單體,其中,更佳為(甲基)丙烯酸丁酯,尤佳為甲基丙烯酸丁酯。
本發明中之共聚物A中之單體a、b之共聚合比率為a:b=7:3~9:1(莫耳比)。藉由設為此種範圍,容易對CL表面賦予持續之親水性。共聚物A中之單體a、b之共聚合比率較佳為a:b=3:1~4:1。
再者,本發明之共聚物A及下述共聚物B中之各單體之共聚合比率係指共聚物中之源自各單體之結構單元之莫耳比。又,上述共聚合比率通常相當於使共聚物聚合時之各單體之饋入比。
本發明之共聚物A包含源自上述單體a之結構單元(下述式5)、及源自單體b之結構單元(下述式6)。又,本發明之共聚物A亦可為僅由源自上述單體a之結構單元、及源自單體b之結構單元構成者,亦可為包含該等以外之結構單元者,較佳為僅由源自單體a之結構單元、及源自單體b之結構單元構成者。
[化9]
式5中,R1
表示氫原子、或甲基。
[化10]
式6中,R2
表示氫原子、或甲基,R3
表示碳數2~6之烷基。
本發明中之共聚物A之重量平均分子量為400,000~700,000,較佳為500,000~700,000,尤佳為550,000~650,000。藉由將共聚物A之重量平均分子量製備成上述範圍,對CL賦予持續之親水性之效果變得良好。
再者,共聚物A及下述共聚物B之重量平均分子量係藉由GPC(gel permeation chromatograph,凝膠滲透層析法)測定以聚乙二醇換算求出。更具體而言,例如,可藉由使用EcoSEC系統(Tosoh股份有限公司製造)之GPC測定進行測定。
[共聚物B]
本發明之共聚物B係式3所表示之單體c與式4所表示之單體d之共聚物。
式3所表示之單體c之R4
表示氫原子或甲基,就提昇共聚物B之保存穩定性之觀點而言,較佳為甲基。
又,於式3中,n表示1~4之整數,就原料獲取性之觀點而言,n較佳為1~3,更佳為1~2。
式4所表示之單體d之R5
表示氫原子或甲基,就提昇共聚物B之保存穩定性之觀點而言,較佳為甲基。
又,於式4中,R6
為碳數8~22之烴基,其中,較佳為碳數8~22之烷基。作為此種烷基,具體而言,可列舉正辛基、正壬基、正癸基、正十一烷基、月桂基、正十三烷基、十四烷基、正十五烷基、棕櫚基、十七烷基、硬脂基、正十九烷基、二十烷基、二十一烷基、山萮基、及其異構物。尤其是,由於對CL賦予持續之親水性之效果較高,故單體d較佳為於式4中R6
為碳數12~18之烷基,其中,更佳為(甲基)丙烯酸硬脂酯,尤佳為甲基丙烯酸硬脂酯。
共聚物B中之單體c、d之共聚合比率為c:d=1:4~9:1(莫耳比)。藉由設為此種範圍,容易對CL表面賦予持續之親水性。共聚物B中之單體c、d之共聚合比率為較佳為c:d=1:1~7:3。
本發明之共聚物B包含源自上述單體c之結構單元(下述式7)、及源自單體d之結構單元(下述式8)。又,本發明之共聚物B亦可為僅由源自單體c之結構單元、及源自單體d之結構單元構成者,亦可為包含該等以外之結構單元者,較佳為僅由源自單體c之結構單元、及源自單體d之結構單元構成者。
[化11]
於式7中,R4
表示氫原子或甲基,n為1~4之整數。
[化12]
於式8中,R5
表示氫原子或甲基,R6
表示碳數8~22之烴基。
共聚物B之重量平均分子量為20,000~90,000,較佳為25,000~80,000,進而較佳為40,000~60,000。藉由將共聚物B之重量平均分子量調整為上述範圍,對CL賦予持續之親水性之效果變得良好。
[共聚物A及共聚物B之含量]
本發明之CL用處理溶液以A:B=1000:1~2:1(重量比)包含共聚物A及共聚物B。
於共聚物A及共聚物B之重量比處於上述範圍外之情形時,例如,於共聚物B過少之情形時,對CL表面賦予持續之親水性之效果下降,於共聚物B過多之情形時,無法獲得與添加量相稱之效果,不經濟。
就提高對CL表面賦予持續之親水性之效果之觀點而言,本發明之CL用處理溶液較佳為將共聚物A及共聚物B設為A:B=1000:1~10:1(重量比),進而較佳為設為A:B=100:1~10:1(重量比)。
於本發明中,藉由以上述比率使用上述兩種共聚物,可對CL賦予持續之親水性。該原理之全貌尚未弄清,但推測共聚物B優先固定於CL表面而形成基質,起到如將共聚物A留在CL表面之作用。
本發明之CL用處理溶液所使用之共聚物A與共聚物B之合計含量於處理溶液總量中較佳為0.01~5.0重量%,更佳為0.1~1.0重量%。若上述含量為0.01重量%以上,則容易獲得充分之賦予持續之親水性之效果。又,藉由設為5.0重量%以下,而獲得與添加量相應之效果,較為經濟。
[共聚物之製造方法]
作為用以獲得本發明中之共聚物A、或共聚物B之聚合方法,可使用溶液聚合、塊狀聚合、乳化聚合、懸浮聚合等公知之方法,例如,可採用使各單體於溶劑中於聚合起始劑之存在下聚合之自由基聚合等方法。
作為用於聚合反應之起始劑,只要為通常使用之起始劑則可使用任一種,例如,於自由基聚合之情形時,可使用脂肪族偶氮化合物或有機過氧化物。作為上述聚合起始劑之例,例如可列舉2,2'-偶氮二異丁腈、偶氮雙二甲基異戊腈、過氧化苯甲醯、過氧化月桂醯、過氧化二碳酸二異丙酯、過氧化(2-乙基己酸)第三丁酯、過氧化特戊酸第三丁酯、過氧化二異丁酸第三丁酯或過硫酸鉀、過硫酸銨等過硫酸鹽。該等聚合起始劑亦可將兩種以上混合使用。又,聚合起始劑之使用亦可使用氧化還原系之自由基促進劑。
作為聚合溫度,較佳為30~80℃,更佳為40~70℃。又,聚合時間較佳為2~72小時。其原因在於:聚合反應會良好地進行。進而,亦可使用溶劑以使聚合反應順暢地進行,作為該溶劑,可列舉水、甲醇、乙醇、丙醇、第三丁醇、苯、甲苯、二甲基甲醯胺、四氫呋喃、二㗁烷、氯仿、或該等之混合溶劑。
[CL用處理溶液之製備]
本發明之CL用處理溶液可藉由將上述共聚物A、共聚物B與溶劑混合而獲得。作為本發明所使用之溶劑,可自可使上述共聚物A、共聚物B溶解或穩定地分散且對CL之影響較小者任意選擇。作為此種溶劑,例如,可較佳地列舉純水等水,此外,可使用乙醇、異丙醇、乙二醇、丙二醇、甘油等具有以任意比率與水混和之性質之溶劑、及該等之混合溶劑。
較佳為使本發明之CL用處理溶液中除了上述共聚物A、B以外亦含有界面活性劑以增強清潔力。界面活性劑可自無損本發明之效果者任意選擇。
作為此種界面活性劑,例如可列舉:聚氧乙烯烷基醚硫酸鹽、聚氧乙烯脂肪酸醯胺醚硫酸鹽、N-醯基-N-甲基牛磺酸鹽、烷基肌胺酸鹽、烷基醯胺磺基琥珀酸鹽、烷基硫酸鹽、二烷基磺基琥珀酸鹽、N-烷基-N,N-二甲醚等陰離子性界面活性劑;山梨醇酐脂肪酸酯、聚氧乙烯氫化蓖麻油等非離子性界面活性劑;烷基二甲胺基乙酸甜菜鹼、2-烷基-N-羧甲基-N-羥乙基咪唑啉甜菜鹼、烷基丙基甜菜鹼、烷基胺基二乙酸鹽等兩性界面活性劑等。其中,就清潔力強、對眼睛之影響較小、溶液之穩定性等而言,較佳為陰離子性界面活性劑,其中尤佳為使用聚氧乙烯烷基醚硫酸鹽或聚氧乙烯脂肪酸醯胺醚硫酸鹽。具體而言,可列舉聚氧乙烯椰子油脂肪酸單乙醇胺硫酸鹽、月桂酸醯胺醚-硫酸酯鹽、肉豆蔻酸醯胺醚-硫酸酯鹽、及該等之混合物等。
本發明之CL用處理溶液所使用之界面活性劑之含量於CL用處理溶液總量中較佳為設為0.01~5重量%,更佳為設為0.1~2.0重量%。只要上述含量為0.01~5.0重量%以下,則會獲得充分之洗淨能力。
較佳為使本發明之CL用處理溶液中除了上述共聚物A、B以外亦含有水解酵素以使CL上之污垢分解。水解酵素可於不脫離本發明之目的之範圍內適當選擇通常所知之水解酵素而使用。具體而言,可自不會對CL之物性造成影響且可使利用界面活性劑無法完全去除之頑固污垢分解之水解酵素之中任意選擇。
尤其是,作為源自淚液之污垢成分,可列舉黏蛋白等糖蛋白質或溶菌酶等蛋白質、脂質,因此,較佳為使用具有藉由使該等分解而容易將CL上之污垢去除之效果之水解酵素。作為此種水解酵素,例如可列舉「Bioprase」(Nagase ChemteX股份有限公司製造)、「Protease CL-15」(Nagase ChemteX股份有限公司)、「Clear Lens Pro」(novozymes公司製造)、「Esperase CLC」(novozymes公司製造)等蛋白質分解酵素、脂肪酶、磷脂酶A、磷脂酶B、磷脂酶C、磷脂酶D、膽固醇酯酶等脂質分解酵素、α-澱粉酶、糖苷內切酶D、β-半乳糖苷酶、β-半乳糖苷酶、纖維素酶、聚葡萄糖酶等糖鏈分解酵素。
本發明之處理溶液所使用之水解酵素之含有比率於CL用處理溶液總量中較佳為10-10
重量%~1重量%,進而較佳為10-6
重量%~0.1重量%。只要上述含有比率為10-10
重量%~1重量%,則容易獲得充分之清潔力。
較佳為使本發明之CL用處理溶液中除了上述共聚物A、B以外亦含有緩衝劑,以保持溶液之pH值。緩衝劑可自無損本發明之效果者任意選擇,例如可較佳地列舉使用鹽酸、乙酸、檸檬酸、硼酸、磷酸、氫氧化鈉、氫氧化鉀、三乙醇胺、三(羥甲基)胺基甲烷、該等之鹽、及該等之混合物以通常之方法製備之緩衝劑。
亦可使本發明之CL用處理溶液中除了上述共聚物A、B以外亦含有螯合劑,以使溶液穩定、以及將CL表面之金屬鹽去除。螯合劑可自無損本發明之效果之螯合劑任意選擇,例如,可較佳地列舉檸檬酸、乙二胺四乙酸、環己二胺四乙酸等多元羧酸、及其鹼金屬鹽、或其混合物。
亦可使本發明之CL用處理溶液中除了上述共聚物A、B以外亦含有無機鹽類,以減小對眼睛之影響、以及等張化。無機鹽類可自不偏離本發明之目的之無機鹽類任意選擇,例如,可較佳地列舉氯化鈉、氯化鉀、氯化鎂、或該等之混合物等。
可於本發明之CL用處理溶液中除了上述共聚物A、B以外亦添加水溶性高分子化合物,以調節溶液之黏度。該等可自無損本發明之功能者任意選擇,例如可列舉聚乙二醇、聚丙二醇、聚乙烯醇、聚乙烯吡咯啶酮、羧甲基纖維素、羥乙基纖維素、羥丙基甲基纖維素、聚環氧乙烷-聚環氧丙烷嵌段共聚物、馬來酸酐-甲基乙烯基醚共聚物、及該等之混合物。
又,可於本發明之CL用處理溶液中添加防腐劑以防止雜菌繁殖。作為防腐劑,例如較佳為添加氯丁醇、氯化苄烷銨、乙基汞硫代水楊酸鈉、葡萄糖酸氯己定、對羥基苯甲酸酯、聚六亞甲基雙胍等。
作為本發明之CL用處理溶液之使用方法,可列舉使CL浸漬於該CL用處理溶液中或與其接觸之方法。其後,較佳為於配戴CL前利用水、生理食鹽液、及/或適當之洗淨液等進行洗濯。如此,藉由使用CL用處理溶液,可將附著於CL表面之污垢去除,進而,可對CL賦予持續之親水性而防止蛋白質、脂質等污垢之附著。
又,藉由該方法,可容易獲得經本發明之CL用處理溶液處理之CL。
本發明之CL用處理溶液對硬性CL、軟性CL、及通常所知之其他CL中之任一者均可較佳地使用,可簡便獲得經本發明之CL用處理溶液處理之CL。
[實施例]
以下,列舉實施例詳細地對本發明進行說明,但本發明並不限定於該等。
<共聚物之合成>
合成實施例、及比較例中使用之4種共聚物。合成表1所示之4種共聚物、即作為上述共聚物A之共聚物1、作為共聚物B之共聚物2、作為共聚物A、B以外之共聚物之共聚物3及4。
<單體(GMU)之合成>
作為下述共聚物2~3之原料之丙三醇-1-甲基丙烯醯氧基乙基胺基甲酸乙酯(以下記作GMU)係藉由以下之方法合成。於4口燒瓶中放入(R,S)-1,2-異亞丙基丙三醇330 g、及吡啶50 mL,安裝滴加漏斗及鈣管。於室溫、遮光下,緩慢滴加2-甲基丙烯醯氧基乙基異氰酸酯368 g。其後,於50℃下反應7小時。進而,將吡啶及過剩之(R,S)-1,2-異亞丙基丙三醇減壓蒸餾去除,藉此獲得(R,S)-1,2-異亞丙基丙三醇-3-甲基丙烯醯氧基乙基胺基甲酸乙酯。
於所獲得之(R,S)-1,2-異亞丙基丙三醇-3-甲基丙烯醯氧基乙基胺基甲酸乙酯500 g中,添加甲醇1.96 L及4 mol/L之鹽酸50 mL,於室溫下反應1.5小時。藉由減壓乾燥將溶劑蒸餾去除,而獲得GMU。
<合成例1>
於聚合用玻璃製燒瓶中秤取2-甲基丙烯醯氧基乙基磷酸膽鹼(以下記作MPC)19.4 g、甲基丙烯酸丁酯(以下記作BMA)2.2 g(單體組成莫耳比:MPC/BMA=8/2),於其中添加作為聚合起始劑之2,2'-偶氮二異丁腈(以下記作AIBN)86 mg、以及作為聚合溶劑之純水39.2 g及乙醇39.2 g。將反應容器內充分進行氮氣置換後,於60℃下加溫5小時,藉此進行聚合反應。將所獲得之反應液冰浴冷卻,滴加於二乙醚中,藉此使聚合物沈澱。對沈澱進行過濾分離,利用二乙醚洗淨後,進行真空乾燥而獲得白色固體之共聚物1。
所獲得之共聚物1之重量平均分子量藉由凝膠滲透層析法(以下記作GPC)測定以聚乙二醇換算確定為600,000。
<合成例2>
於聚合用玻璃製燒瓶中秤取GMU 10.5 g、甲基丙烯酸硬脂酯(以下記作SMA)9.5 g(單體組成莫耳比:GMU/SMA=6/4),於其中添加作為聚合起始劑之AIBN 120 mg、及作為聚合溶劑之乙醇140 g。將反應容器充分進行氮氣置換後,於60℃下反應8小時,藉此進行聚合反應。將所獲得之反應液冰浴冷卻,滴加於二乙醚中,藉此使聚合物沈澱。對沈澱進行過濾分離,利用二乙醚洗淨後,進行真空乾燥而獲得共聚物2。
所獲得之共聚物2之重量平均分子量藉由GPC測定以聚乙二醇換算確定為50,000。
<合成例3>
於聚合用玻璃製燒瓶中秤取GMU 20.0 g(單體組成莫耳比:GMU=10),於其中添加作為聚合起始劑之AIBN 120 mg、及作為聚合溶劑之乙醇140 g。將反應容器充分進行氮氣置換後,於60℃下反應8小時,藉此進行聚合反應。將所獲得之反應液冰浴冷卻,滴加於二乙醚中,藉此使聚合物沈澱。對沈澱進行過濾分離,利用二乙醚洗淨後,進行真空乾燥而獲得共聚物3。
所獲得之共聚物3之重量平均分子量藉由GPC測定以聚乙二醇換算確定為72,000。
<合成例4>
於聚合用玻璃製燒瓶中秤取MPC 11.7 g、甲基丙烯酸硬脂酯(以下記作SMA)3.3 g(單體組成莫耳比:MPC/SMA=8/2),於其中添加作為聚合起始劑之2,2'-偶氮二異丁腈(以下記作AIBN)433 mg、及作為聚合溶劑之乙醇84.6 g。將反應容器內充分進行氮氣置換後,於60℃下加溫6小時,藉此進行聚合反應。將所獲得之反應液冰浴冷卻,滴加於二乙醚中,藉此使聚合物沈澱。對沈澱進行過濾分離,利用二乙醚洗淨後,進行真空乾燥而獲得白色固體之共聚物4。
所獲得之共聚物4之重量平均分子量藉由GPC測定以聚乙二醇換算確定為43,000。
<GPC測定>
以上合成例1~4中之GPC測定係於以下之條件下實施。
GPC系統:高速液相層析法系統CCP&8020系列(Tosoh股份有限公司製造)
管柱:將Shodex OHpak SB-802.5HQ(昭和電工股份有限公司製造)、及SB-806HQ(昭和電工股份有限公司製造)串聯連接
展開溶劑:20 mM磷酸鈉緩衝液(pH值 7.4)
檢測器:示差折射率檢測器、UV檢測器(波長210 nm)
分子量標準:EasiVial PEG/PEO(Agilent Technologies公司製造)
流速:0.5 mL/分鐘
管柱溫度:45℃
樣品:將所獲得之共聚物以最終濃度成為0.1重量%之方式利用展開溶劑進行稀釋
<實施例1>
以表3所示之比率調配作為共聚物A之表1所示之共聚物1、作為共聚物B之表1所示之共聚物2、及其他成分,對CL用處理溶液進行調整。使用該CL用處理溶液進行以下之評價。將結果示於表3。
(I)清潔力評價(蛋白質污垢)
於包含牛血清白蛋白0.39重量%、人類γ-球蛋白0.16重量%、蛋白溶菌酶0.12重量%、豬胃黏蛋白0.10重量%之生理鹽水中,將隱形眼鏡(SEED Super Hi-O2
,SEED(股)製造)於60℃下處理2小時,將眼鏡污染。將該眼鏡於上述CL用處理溶液中浸漬4小時後,利用自來水進行洗濯,利用1%十二烷基硫酸鈉水溶液提取眼鏡上之蛋白質,利用微量BCA(2,2"-Biquinoline-4,4"-dicarboxylicacid-2Na,2,2-聯喹啉-4,4-二甲酸二鈉)套組(Thermo Scientific公司製造)對蛋白質之提取量進行定量(Cps
)。進而,使用生理鹽水代替CL用處理溶液,除此以外,以與上述相同之方式進行蛋白質之定量(Cp0
)。按照以下之數式1,算出蛋白質去除率,評價為×:未達50%、△:50%以上且未達70%、○:70%以上。
[數1]
(II)清潔力評價(脂質污垢)
於使油酸0.60重量%、亞麻油酸0.60重量%、棕櫚酸0.60重量%、三棕櫚酸甘油酯8.12重量%、鯨蠟醇2.00重量%、肉豆蔻酸鯨蠟酯8.12重量%、膽固醇0.80重量%、棕櫚酸膽固醇酯0.80重量%、蛋黃卵磷脂28.36重量%乳化之生理鹽水中,將隱形眼鏡(SEED Super Hi-O2
,SEED(股)製造)於35℃下處理4小時,將眼鏡污染。將該眼鏡於上述CL用處理溶液中浸漬4小時後,利用自來水進行洗濯,利用氯仿/甲醇=1:1(體積比)之混合溶劑提取眼鏡上之脂質,將溶劑蒸餾去除。藉由硫酸-香草醛法對殘留之脂質進行定量(Cls
)。
進而,使用生理鹽水代替CL處理溶液,除此以外,以與上述相同之方式進行脂質之定量(Cl0
)。按照以下之數式2,算出脂質去除率,評價為×:未達0%、△:0%以上且未達40%、○:40%以上。
[數2]
(III)持續之親水性
[1]利用自來水對隱形眼鏡(Hard EX1,SEED(股)製造)進行洗濯,於上述CL用處理溶液中浸漬一晩而進行處理。利用生理鹽水進行洗濯後,測定BUT(Breakup Time,破裂時間)(Wis
)。再者,BUT係將CL自生理鹽水中提起之瞬間至觀察CL凸面直到液體變乾為止之時間(秒)。
[2]進而,將該CL放入12孔板中,浸漬於生理鹽水2 mL中,振盪6小時(假定佩戴後)。針對該CL,與上述同樣地測定BUT(Wfs
)。
[3]進而,於上述[1]中,使用生理鹽水代替CL處理溶液,除此以外,以與上述[1]相同之方式,測定於生理鹽水中浸漬6小時前之BUT(Wi0
)。
[4]按照以下之數式3~4,算出於生理鹽水中浸漬6小時之前後之親水化度,浸漬前評價為C:未達0.7、B:0.7以上且未達1.0、A:1.0以上,浸漬後評價為C:未達0.7、B:0.7以上且未達1.0、A:1.0以上。進而,基於該等評價,按照表2對持續之親水性進行判定。
[數3]
[數4]
<實施例2~6>
以表3所示之組成製備CL用處理溶液,以與實施例1相同之方式進行評價。將結果示於表3。
<比較例1~4>
以表4所示之組成製備CL用處理溶液,以與實施例1相同之方式進行評價。將結果示於表4。
表3中使用之縮寫如下所述
PG:丙二醇
SPCS:Sodium PEG-4 Cocamide Sulfate
(聚氧乙烯棕櫚脂肪酸單乙醇胺硫酸鈉)
TLS:TEA-Laureth Sulfate
(聚氧乙烯月桂醚硫酸三乙醇胺)
CLP:Clear Lens Pro(novozymes公司製造)
ECLC:Esperase CLC(novozymes公司製造)
NaOH:氫氧化鈉
EDTA:乙二胺四乙酸
表4中使用之縮寫如下所述
PG:丙二醇
SPCS:Sodium PEG-4 Cocamide Sulfate
(聚氧乙烯棕櫚脂肪酸單乙醇胺硫酸鈉)
TLS:TEA-Laureth Sulfate
(聚氧乙烯月桂醚硫酸三乙醇胺)
CLP:Clear Lens Pro(novozymes公司製造)
ECLC:Esperase CLC(novozymes公司製造)
NaOH:氫氧化鈉
EDTA:乙二胺四乙酸
根據以上之實施例及比較例之結果,發現以下情況。
於比較例1中,不含共聚物B,因此,持續之親水性比各實施例差。進而,於比較例2中,為代替B成分而增加A成分之配方,但持續之親水性仍比實施例差。由此可知,為了使持續之親水性表現,需要共聚物B而非僅增加共聚物A。
於比較例3、4中,分別使用本發明之範圍外之共聚物3、4代替共聚物B。於比較例3~4中,持續之親水性亦比各實施例差。由此可知,必須使用本說明書中記載之範圍之共聚物作為共聚物B。
另一方面,於各實施例中,清潔力(蛋白質)、清潔力(脂質)、持續之親水性之全部評價項目均優於各比較例。即,藉由本發明,可提供一種CL用處理溶液,其藉由簡便之浸漬處理可將附著於CL表面之污垢去除,而且可對CL表面賦予持續之親水性。
Claims (2)
- 一種隱形眼鏡用處理溶液,其特徵在於以A:B=1000:1~2:1(重量比)包含以下之共聚物A及共聚物B, 共聚物A:使下述式1所表示之單體a、及下述式2所表示之單體b共聚合所獲得之共聚物,且上述單體a、單體b之共聚合比率為a:b=7:3~9:1(莫耳比)且重量平均分子量為400,000~700,000之共聚物, 共聚物B:使下述式3所表示之單體c、及下述式4所表示之單體d共聚合所獲得之共聚物,且上述單體c、單體d之共聚合比率為c:d=1:4~9:1(莫耳比)且重量平均分子量為20,000~90,000之共聚物, [化1] (式1中,R1 表示氫原子、或甲基) [化2] (式2中,R2 表示氫原子、或甲基,R3 表示碳數2~6之烷基) [化3] (於式3中,R4 表示氫原子或甲基,n為1~4之整數) [化4] (於式4中,R5 表示氫原子或甲基,R6 表示碳數8~22之烴基)。
- 一種隱形眼鏡,其經如請求項1之隱形眼鏡用處理溶液處理。
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