TWI805112B - Colorimetric device and checkup system - Google Patents

Abstract

A colorimetric device includes a colorimetric board. The colorimetric board includes a slot, a plurality of calibration blocks, and a plurality of corner positioning patterns. The slot is configured to accommodate a test strip, wherein the test strip includes at least one color presenting portion, and the color presenting portion presents an inspection color after contacting with a specimen. The inspection color is determined by a concentration of an inspection item of the specimen. The calibration blocks are adjacent to the slot, and colors of the calibration blocks are selected from colors of a color checker. The corner positioning patterns are respectively arranged on a plurality of corners of the colorimetric board.

Description

Colorimetric device and inspection system

The present invention relates to a colorimetric device and an inspection system, and in particular relates to a colorimetric device and an inspection system which are favorable for image analysis.

With the development of medical testing technology, many rapid screening test strips have emerged, such as urine test strips, fecal occult blood test strips, etc., to help users quickly obtain a preliminary understanding of their own health status. A common testing method is to contact the specimen to be tested with the corresponding test piece, and then visually compare the coloring result of the test piece with the standard color sample to obtain the test result. However, the use of visual comparison method is prone to errors, resulting in inaccurate test results.

In order to solve the above-mentioned deficiencies, another company has developed an image recognition system, which is to take images of color guides and test pieces by users themselves. There are a plurality of standard color samples printed on the color guide, and each standard color sample represents For a test result of a test item of the specimen to be tested, the image recognition system analyzes the color rendering results of the standard color sample on the color guide board and the test piece in the image to obtain the test result. However, different color guides need to be printed for different inspection items, that is, the existing color guides are designed for specific inspection items and cannot be applied to other inspection items. In addition, when it is found that the new standard color sample is more representative than the existing standard color sample, if the color guide with the existing standard color sample is continued to be used to consume the inventory, it will not be conducive to updating and controlling the inspection effect. Yes, if the color guides printed with existing standard color samples are eliminated, it will cause waste and increase costs.

The object of the present invention is to provide a colorimetric device and inspection system to solve the above problems.

One embodiment of the present invention provides a colorimetric device, including a colorimetric plate. The color guide includes a slot, a plurality of calibration color blocks and a plurality of corner positioning patterns. The slot is used for accommodating a test piece, wherein the test piece includes at least one color-forming portion, and the color-forming portion presents a test color after being in contact with a sample, and the test color depends on the concentration of a test item of the sample. The calibration color block is arranged adjacent to the slot, and the color of the calibration color block is selected from the color of a color calibration card. The corner positioning patterns are respectively arranged on a plurality of corners of the color guide.

Another embodiment of the present invention provides an inspection system, including the above-mentioned colorimetric device, an image capture unit, a processing unit, and a storage unit. The image capturing unit is used for capturing an original image of the colorimetric device and the test strip. The processing unit is connected with the image capturing unit. The storage unit is connected to the processing unit, and the storage unit stores Hue, Saturation, Value (HSV) values of a plurality of standard color samples, and each standard color sample represents a test result of a test item of the specimen. The processing unit is configured to perform: receiving the original image; performing position correction on the original image to obtain a position-corrected image; performing color correction on the position-corrected image to obtain a color-corrected image; reading the HSV value of the color-checked image in the color-corrected image; according to The HSV value of the inspection color and the HSV values of the plurality of standard color samples select a standard color sample; and output the inspection result represented by the selected standard color sample.

Compared with the prior art, the color guide in the color comparison device of the present invention can correct the color of the color block The color system is selected from the colors of a color calibration card, instead of using a standard color sample representing the test result, and can be applied to different test items, which has the advantage of high versatility. The inspection system of the present invention uses the aforementioned colorimetric device and also has the advantage of high versatility. The inspection system of the present invention uses an image analysis method instead of a visual comparison method, which is beneficial to improve the accuracy of inspection results. The inspection system of the present invention stores the standard color samples in the storage unit in the form of HSV values. When a new standard color sample is more representative than the existing standard color samples, the existing standard color samples in the storage unit can be directly The HSV value is modified to the HSV value of the new standard color sample, without reprinting the color guide, which is conducive to updating and controlling the inspection efficiency.

100: Colorimetric device

110: carrier

111: storage tank

112: First plane

112a: long slot

113: second plane

114: polyline

120: Shade Guide

121: slotting

122: Correct color block

123: Corner positioning pattern

124:Position color block

200: inspection test piece

201, 202, 203, 204, 205, 206, 207, 208, 209, 210: Color rendering department

300: image capture unit

400: processing unit

500: storage unit

610, 620, 630, 640, 650, 660, 670: steps

710: Original image

720:Position correction image

730:Color Corrected Image

800: standard color card

801, 802, 803, 804, 805, 811, 812, 813: standard color samples

900:HSV color space

1000: inspection system

a1,a2,a3,b1,b2: area

P, D1, D2, D3: points

L1, L2, L3, L4, L5, L6, L7, L8, L9, L10: color block column

FIG. 1 is a schematic plan view of a colorimetric device according to an embodiment of the present invention.

Figure 2 is an exploded view of the colorimetric device in Figure 1.

Fig. 3 is a schematic diagram of the colorimetric device in Fig. 1 accommodating test strips.

Figure 4 is an expanded view of the stage in Figure 2.

FIG. 5 is a functional block diagram of an inspection system according to an embodiment of the present invention.

FIG. 6 is a flow chart of the steps of image analysis performed by the processing unit according to an embodiment of the present invention.

FIG. 7 is a schematic diagram of position correction according to an embodiment of the present invention.

FIG. 8 is a schematic diagram of color correction according to an embodiment of the present invention.

FIG. 9 is a schematic diagram of selecting a standard color sample from a plurality of standard color samples according to an embodiment of the present invention.

Please refer to Figures 1 to 4, Figure 1 is a colorimetric device according to an embodiment of the present invention Plane schematic diagram, Figure 2 is an exploded view of the colorimetric device in Figure 1, Figure 3 is a schematic diagram of the colorimetric device in Figure 1 containing a test piece, Figure 4 is the expansion of the carrier in Figure 2 picture. In FIGS. 1 and 2 , the colorimetric device 100 includes a stage 110 and a colorimetric plate 120 . The stage 110 is used for carrying the color guide 120 . The color guide 120 can be fixed on the stage 110 by sticking.

The carrier 110 includes a receiving slot 111 . As shown in FIG. 3 , the accommodating groove 111 is used for accommodating the test piece 200 . As shown in Figure 4, the carrier 110 includes a first plane 112 and a second plane 113, the first plane 112 is provided with a long groove 112a, and the first plane 112 and the second plane 113 are bonded together along the folding line 114 , the stage 110 can be formed, and the long groove 112 a and the corresponding part of the second plane 113 together form the accommodating groove 111 . According to an embodiment of the present invention, the stage 110 can be integrally formed, and can be made of model cardboard with a thickness of 1 mm. Thereby, sufficient strength can be provided, which is beneficial to mass production and reduces material cost.

In Fig. 2, the color guide 120 includes a slot 121, a plurality of correction color blocks 122 and a plurality of corner positioning patterns 123, and optionally includes a plurality of positioning color blocks 124, wherein the correction color blocks 122 are arranged in the area b1, b2, the positioning color blocks 124 are set in areas a1, a2, a3, and the areas a1, a2, a3, b1, b2 are used to illustrate the positions of the correction color blocks 122 and positioning color blocks 124. In practice, areas a1, The boundaries of a2, a3, b1, and b2 are not printed on the color guide 120, so the boundaries of the areas a1, a2, a3, b1, and b2 are drawn with dotted lines.

The slot 121 is used for accommodating the test piece 200 . In this embodiment, the accommodating groove 111 of the stage 110 corresponds to the slot 121 of the color guide plate 120 to accommodate the test piece 200 together. In this way, the stage 110 can support the test strip 200 . In other embodiments, the colorimetric device 100 may only include the colorimetric plate 120 without the stage 110. During use, the user may place the colorimetric plate 120 on a flat surface (such as a desktop), and the inspection surface may be supported by the flat surface. Test piece 200.

The calibration color block 122 is adjacent to the slot 121, and the color of the calibration color block 122 is selected from a color calibration card. Preferably, the color correction card is a Macbeth color checker (Macbeth color checker), which was first issued by Macbeth in 1976 AD. The Macbeth color correction card contains 24 color blocks, and the correction color block is 122 The number and color of the color are the same as the number and color of the color blocks on the Mark Bess color correction card.

The corner positioning patterns 123 are respectively disposed on a plurality of corners of the color guide 120 . Here, the color guide 120 is a rectangle, and the number of corner positioning patterns 123 is four, which are respectively arranged on the four corners of the color guide 120 . Preferably, each corner positioning pattern 123 is a concentric circle, and here, the gap between the two concentric circles is filled with a color (blue for example in this example), which is beneficial to base on the principle of Hough Transform (Hough Transform) The position of the corner positioning pattern 123 is detected. In other embodiments, the corner positioning pattern 123 can also be a single circle, ellipse or other geometric figures that can be detected by Hough transform.

The positioning color block 124 is adjacent to the calibration color block 122 , and the positioning color block 124 is used for assisting in positioning the calibration color block 122 . Preferably, the colors of the plurality of positioning color blocks 124 are the same, and the color of the positioning color blocks 124 is darker than the background color of the color board 120 . Here, the background color of the color guide 120 is white, and the color of the positioning color block 124 is black as an example. Thereby, the contrast between the background color of the color guide 120 and the color of the positioning color block 124 is large, which is beneficial for identifying and positioning the positioning color block 124 during image analysis (for example, establishing the center coordinates of the positioning color block 124 ). As shown in Figure 2, some calibration color blocks 122 are light in color and are not conducive to detection. For example, the calibration color block 122 located in the area b1 and ranked fourth from top to bottom can be determined by setting the positioning color block 124. Positioning the calibration color block 122 by locating the center coordinates of the color block 124 and its relative positional relationship with the calibration color block 122 can improve detection accuracy.

In FIG. 3 , the test strip 200 includes at least one color-forming portion 201-210, and the color-forming portion 201-210 presents a test color after being in contact with a sample, and the test color depends on the concentration of the test item of the sample. In this embodiment, the test strip 200 is exemplified as a urine test strip, which includes ten color-forming parts 201-210, which are respectively used to test leukocyte esterase, nitrite, urobilin, and protein in urine. , pH, occult blood reaction, specific gravity, ketones, bilirubin and glucose. However, the present invention is not limited thereto, and the number of the coloring parts 201 - 210 can be adjusted accordingly according to the test items of the test strip 200 . In addition, the test strip 200 is not limited to the urine test strip, as long as the color of the colored parts 201-210 of the test strip 200 can change with the concentration of the test item of the specimen, it is suitable for the present invention. For example, in other embodiments, the test strip 200 can be a gastric Helicobacter pylori test strip, a fecal occult blood test strip, or a luteinizing hormone test strip.

Please refer to FIG. 5 , which is a functional block diagram of an inspection system according to an embodiment of the present invention. The inspection system 1000 includes the above-mentioned colorimetric device 100 , an image capture unit 300 , a processing unit 400 and a storage unit 500 . The image capturing unit 300 is used to capture an original image of the colorimetric device 100 and the test strip 200 . The processing unit 400 is connected to the image capture unit 300 . The storage unit 500 is connected to the processing unit 400, and the storage unit 500 stores the hue, saturation, and lightness (Hue, Saturation, Value; HSV) value, each standard color sample represents a test result of the test item of the specimen.

In detail, the connection between the processing unit 400 and the image capture unit 300 and the storage unit 500 may be wired connection or wireless connection. In this way, information can be transmitted among the processing unit 400 , the image capture unit 300 and the storage unit 500 . The image capture unit 300 is capable of capturing images. For example, the image capture unit 300 can be a camera set on a smart phone or a tablet computer. The processing unit 400 has analytical and computing capabilities. For example, the processing unit 400 may be a central processing unit (Central Processing Unit, CPU) or a microprocessor (Microprocessor) of a smart phone. The storage unit 500 has the ability to store data and is used for storing video Relevant data required for image analysis, in addition to the aforementioned HSV values of the plurality of standard color samples, can still store the size information of the color comparison device 100, the original color value of the calibration color block 122, etc. The size information of the aforementioned color comparison device 100 includes The length, width, and thickness of the colorimetric device 100 , the size of the slot 121 on the colorimetric plate 120 , the calibration color block 122 , the corner positioning pattern 123 , the positioning color block 124 , and the relative positional relationship between them, etc. For example, the storage unit 500 may be, but not limited to, a random access memory (Random Access Memory; RAM), and a read-only memory (Read-Only Memory; ROM). According to an embodiment of the present invention, the image capture unit 300 can be set on a handheld device, the processing unit 400 and the storage unit 500 can be set on a server, and the handheld device and the server transmit signals through the Internet, and the user can use the handheld device The image capture unit 300 captures the original images of the colorimetric device 100 and the test strip 200, and uploads the original images to the server for image analysis through cloud computing. In other embodiments, the image capture unit 300, the processing unit 400, and the storage unit 500 can all be set in the handheld device, and the user can download the data required for image analysis to the handheld device in advance, and use it with the handheld device. The image capture unit 300 captures the original images of the colorimetric device 100 and the test strip 200 and then directly performs image analysis by the handheld device.

Referring to FIG. 6 , it is a flow chart of the steps of image analysis performed by the processing unit according to an embodiment of the present invention. The processing unit 400 is configured to perform steps 610 to 660 , and optionally includes step 670 . Step 610 is to receive the original image; Step 620 is to perform position correction on the original image to obtain a position-corrected image; Step 630 is to perform color correction to the position-corrected image to obtain a color-corrected image; Step 640 is to read the color-corrected image for inspection The HSV numerical value of color; Step 650 is to select a standard color sample according to the HSV numerical value of the inspection color and the HSV numerical value of a plurality of standard color samples; Step 660 is to output the inspection result represented by the selected standard color sample; The inspection result represented by the selected standard color sample is stored in the storage unit 500 .

Steps 610 to 670 are described below with the colorimetric device 100 and the test strip 200 as examples. match Referring to FIG. 7 , it is a schematic diagram of position calibration according to an embodiment of the present invention. When the user uses the image capture unit 300 to capture an image, the original image 710 may have a three-dimensional rotation offset due to a skewed shooting angle, such as a position offset, an angle tilt, and an error in image recognition. In order to avoid the above In this case, position correction is required first. Correcting the position of the original image 710 to obtain the position-corrected image 720 (step 620) may include detecting the position of the corner positioning pattern 123 in the original image 710, which can be realized based on the principle of Hough transformation, and four sides are respectively defined The center coordinates of the corner positioning pattern 123 (here, the circle center coordinates). Then, the position correction image 720 can be generated according to the detected position of the corner positioning pattern 123 and the size information of the colorimetric device 100 stored in the storage unit 500 , which can be realized based on the principle of perspective transformation. In this way, the rotation and offset of the original image 710 in the three-dimensional space can be corrected. If it is detected that the corner positioning pattern 123 is too deformed, the user may be required to take another shot. The processing unit 400 can further define the center coordinates of the positioning color block 124 and the calibration color block 122 in the position correction image 720 to facilitate subsequent image analysis. The principle of Hough transformation, the principle of mapping transformation and how to define the center coordinates of the positioning color block 124 and the calibration color block 122 are common knowledge in the art, and will not be repeated here.

Referring to FIG. 8 , it is a schematic diagram of color correction according to an embodiment of the present invention. The color of the original image 710 may be different due to different hand-held devices used by the user, different lighting conditions of the shooting environment, hand shaking during shooting, etc., and color correction is required. Performing color correction on the position-corrected image 720 to obtain the color-corrected image 730 (step 630) includes reading the detected color value of the corrected color block 122 in the position-corrected image 720, and the detected color value and storage unit according to the corrected color block 122 The original color values of the corrected color blocks 122 that are stored in 500 generate a color corrected image 730 , and the aforementioned detected color values and original color values can be RGB values based on the RGB color model. By calculating the deviation between the detected color value and the original color value, the color of the image can be restored, and the problem of the color difference of the original image 710 can be corrected.

After the position and color are calibrated, read the HSV value of the test color of each color rendering part 201-210 in the color correction image 730 (step 640), based on the HSV value of the test color and the standard color sample stored in the storage unit 500 A standard color sample is selected by the HSV value (step 650). Referring to FIG. 9 , it is a schematic diagram of selecting a standard color sample from a plurality of standard color samples according to an embodiment of the present invention. In Figure 9, the standard color card 800 is provided by the manufacturer when purchasing the test piece 200. The standard color card 800 includes ten color block columns L1~L10, corresponding to the ten color rendering parts 201~210 respectively. The color block column L1 includes A plurality of standard color samples 801-805 represent different test results of the test items corresponding to the color rendering unit 201 (in this example, leukocyte esterase). The color block column L2 includes a plurality of standard color samples 811-813, which respectively represent Different test results of the test items corresponding to the color rendering unit 202 (here, nitrite is exemplified) and so on. Taking the color rendering unit 202 as an example, the processing unit 400 reads the HSV value of the test color of the color rendering unit 202, and then imports the HSV value of the test color of the color rendering unit 202 and the HSV values of the standard color samples 811, 812, and 813 into HSV In the color space 900, the positions of the HSV values of the inspection color of the color rendering unit 202 and the standard color samples 811, 812, and 813 in the HSV color space 900 are point P, point D1, point D2, and point D3 respectively, and point P is calculated respectively. The distance between point D1, point D2, and point D3 is the smallest distance between point P and point D1, indicating that the test color of the color rendering unit 202 is closest to the color of the standard color sample 811, so the standard color sample 811 represents The inspection result is used as the inspection result of the color rendering unit 202 . Afterwards, the processing unit 400 outputs the inspection result represented by the selected standard color sample 811 (step 660), for example, it can be output to the user's hand-held device, which is helpful for the user to know the inspection result immediately, and the selected The test results represented by the standard color sample 811 are stored in the storage unit 500 (step 670 ), for the user to browse and use in the future and to facilitate long-term tracking of the user's health status.

Compared with the prior art, in the color guide plate in the color comparison device of the present invention, the color of the calibration color block is selected from the color of a color calibration card, instead of using a standard color sample representing the test result, and can be applied to different The inspection items have the advantages of high versatility. The inspection system of the present invention uses the aforementioned The colorimetric device also has the advantage of high versatility. The inspection system of the present invention uses an image analysis method instead of a visual comparison method, which is beneficial to improve the accuracy of inspection results. The inspection system of the present invention stores the standard color samples in the storage unit in the form of HSV values. When there is a new standard color sample that is more representative than the existing standard color samples, the existing standard color samples in the storage unit can be directly The HSV value of the new standard color sample is changed to the HSV value of the new standard color sample, and there is no need to reprint the color guide, which is conducive to updating and controlling the inspection efficiency. The inspection system of the present invention can perform image analysis on the inspection colors of multiple color-forming parts on the inspection test piece at the same time. Compared with visual comparisons that need to be compared one by one, the inspection system of the present invention can greatly shorten the inspection time. The inspection system of the present invention can be used for self-inspection by users without going to a hospital or health examination center, which greatly improves the convenience of inspection.

The above descriptions are only preferred embodiments of the present invention, and all equivalent changes and modifications made according to the scope of the patent application of the present invention shall fall within the scope of the present invention.

100: Colorimetric device

110: carrier

111: storage tank

120: Shade Guide

121: slotting

122: Correct color block

123: Corner positioning pattern

124:Position color block

Claims (13)

A colorimetric device, comprising: a colorimetric plate, comprising: a slot for accommodating a test piece, wherein the test piece comprises at least one color-forming portion, and the color-forming portion appears after contacting a sample a test color, the test color depends on the concentration of one test item of the sample; a plurality of calibration color blocks are adjacent to the slot, and the colors of the calibration color blocks are selected from the colors of a color calibration card, and The calibration color blocks exclude a plurality of standard color samples representing test results; and a plurality of corner positioning patterns are respectively arranged on a plurality of corners of the color guide. The colorimetric device according to claim 1, wherein each of the corner positioning patterns is a concentric circle. The color comparison device as claimed in claim 1, wherein the color comparison board further includes: a plurality of positioning color blocks adjacent to the calibration color blocks, and the positioning color blocks are used to assist in positioning the calibration color blocks. The color comparison device according to claim 3, wherein the positioning color blocks have the same color, and the color of the positioning color blocks is darker than the background color of the color guide. The colorimetric device as described in claim 1, further comprising: a stage for carrying the colorimetric plate, the stage includes an accommodating groove, the accommodating groove is used for accommodating the inspection test piece and is connected with the Slotted correspondence. An inspection system, comprising: a colorimetric device as described in claim 1; an image capture unit, used to capture an original image of the colorimetric device and the inspection test piece; a processing unit, and the image capture unit and a storage unit connected to the processing unit, the storage unit stores the hue, saturation, lightness (Hue, Saturation, Value; HSV) values of the standard color samples, and each of the standard color samples represents the detection An inspection result of the inspection item of the body; wherein the processing unit is configured to perform: receiving the original image; performing position correction on the original image to obtain a position correction image; performing color correction on the position correction image to obtain a color correction image; read the HSV value of the inspection color in the color correction image; select a standard color sample according to the HSV value of the inspection color and the HSV values of the standard color samples; and output the selected standard color sample result of this test. The inspection system as claimed in claim 6, wherein the processing unit is further configured to execute: storing the inspection result represented by the selected standard color sample in the storage unit. The inspection system as described in claim 6, wherein the storage unit further stores the size information of the colorimetric device, and performing position correction on the original image to obtain the position correction image includes: detecting the corners in the original image The position of the positioning pattern; and generating the position correction image according to the positions of the corner positioning patterns and the size information of the colorimetric device. The inspection system as claimed in claim 8, wherein detecting the positions of the corner positioning patterns in the original image is based on the principle of Hough transform. The inspection system as claimed in claim 8, wherein generating the position correction image according to the positions of the corner positioning patterns and the size information of the colorimetric device is based on a mapping conversion principle. The inspection system as described in claim 6, wherein the storage unit further stores the original color values of the corrected color blocks, and performing color correction on the position-corrected image to obtain the color-corrected image includes: reading the position-corrected image from the The detected color values of the corrected color blocks; and the color corrected image is generated according to the detected color values of the corrected color blocks and the original color values of the corrected color blocks. The inspection system as described in claim 6, wherein selecting a standard color sample according to the HSV value of the inspection color and the HSV values of the standard color samples is to calculate the HSV value of the inspection color and the HSV of the standard color samples respectively The distance between values in an HSV color space, and the one with the smallest distance is used as the selected standard color sample. The inspection system according to claim 6, wherein the image capture unit is set on a handheld device, and the processing unit and the storage unit are set on a server.

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