TWI780949B - Blood flow assessment method and system therefor - Google Patents

Abstract

A blood flow assessment method, which detects the blood of at least one subject through a blood return system, and includes the following steps: obtaining the change of deoxygenated hemoglobin concentration of the at least one subject when standing, lying down and standing up again, and then A change percentage of venous blood return is calculated, and an evaluation result related to the muscle mass of the at least one subject is generated according to the change percentage of venous blood return and a muscle mass standard range. Thereby, through the change of the subject's posture, the accuracy of calculating the change of the venous blood return is improved, which can not only be used for evaluating muscle mass, but also reduce equipment cost.

Description

Blood flow assessment method and system thereof

The present invention relates to a method for evaluating blood flow, in particular to a method for evaluating blood flow and a system thereof.

The "muscle mass" of the human body will affect muscle strength and physical performance. When muscle mass decreases, not only will it be difficult to walk fast, stand up, and lift heavy, but it may also increase the risk of falling. Therefore, doctors will judge whether it is sarcopenia based on muscle mass and muscle strength performance.

To evaluate muscle mass, dual-energy X-ray absorptiometry is most commonly used. Although it has many functions, the equipment is expensive, complicated to operate, and the subject must bear a certain radiation dose, so it cannot be popularized in general medical clinics.

Therefore, the object of the present invention is to provide a method and system for evaluating blood flow that is easy to use and low in cost.

Therefore, the blood flow assessment method of the present invention detects the blood of at least one subject through a blood return system, and includes the following steps:

(a) Acquiring a first deoxygenation data, the first deoxygenation data comes from the change of the concentration of deoxygenated hemoglobin when the at least one subject stands for a first time.

(b) Obtaining a second deoxygenation data, the second deoxygenation data comes from the change of deoxygenated hemoglobin concentration during the at least one subject lying down for a second time after standing for the first time.

(c) Obtaining a third deoxygenation data, the third deoxygenation data comes from the at least one subject standing for the first time, lying down for the second time, and then standing again for a third time, to Changes in oxyhemoglobin concentration.

100%｜，計算一靜脈血液回流量變化百分比。 (d) According to formula (1):

100% |, calculate the percentage change of a venous return flow.

(e) generating an evaluation result related to the muscle mass of the at least one subject according to the change percentage of venous return flow and a muscle mass standard range value.

A blood flow evaluation system for implementing the blood return flow evaluation method includes an inverted device, an oxygen saturation measurement device, and an evaluation device.

The inverted device includes a carrier suitable for carrying the at least one subject, the carrier rotates between a first position and a second position, in the first position, the carrier is perpendicular to a plane, and is suitable for carrying The at least one subject is in a standing state. In the second position, the carrier is parallel to the plane and is suitable for carrying the at least one subject in a lying state.

The oxygen saturation measuring device is used to obtain the first deoxygenation data, the second deoxygenation data, the third deoxygenation data.

The evaluating device communicates with the oxygen saturation measuring device, and is used for calculating the change percentage of the venous return flow and generating the evaluating result.

The effect of the present invention lies in: through the change of the subject's posture, the accuracy of calculating the change of the venous blood return is improved, which can not only be used for evaluating muscle mass, but also reduce equipment cost.

1: Inversion device

11: Bracket

12: carrier

2: Oxygen saturation measuring device

3: Evaluation device

4: Plane

D11: First deoxygenation data

D12: Second deoxygenation data

D13: The third deoxygenation data

O21: first oxygen data

O22: the second oxygen content data

O23: third oxygen data

D ₀ : initial value

D _min : minimum value

O _max : maximum value

O _min : minimum value

T1: the first time

T2: second time

T3: third time

t _{1_0} : start time

t _{2_0} : start time

t _{3_0} : start time

Other features and functions of the present invention will be clearly presented in the implementation manner with reference to the drawings, wherein: Fig. 1 is a schematic diagram illustrating an embodiment of the blood flow evaluation system of the present invention; Fig. 2 is a schematic diagram illustrating the present invention A carrier of the embodiment rotates between a first position and a second position; FIG. 3 is a flow chart of the embodiment; and FIG. 4 is a graph illustrating a deoxyhemoglobin concentration-time curve, and a Oxyhemoglobin concentration-time curve.

Referring to FIG. 1 and FIG. 2 , an embodiment of the blood flow evaluation system of the present invention includes an inversion device 1 , an oxygen saturation measurement device 2 , and an evaluation device 3 .

The inverted device 1 includes a support 11 standing on a plane 4 , and a carrier 12 pivotally mounted on the support 11 . The carrier 12 is suitable for carrying a subject, and rotates between a first position and a second position relative to the support 11. In the first position, the carrier 12 is substantially perpendicular to the plane 4, and is suitable for Carrying the subject in a standing state, when in the second position, the carrier 12 is substantially parallel to the plane 4 or forms an angle with the plane 4, the angle is between 0° and 15°, and is suitable for carrying the The subjects were placed in a supine position.

In this embodiment, the oxygen saturation measuring device 2 uses a light source of a specific wavelength to measure the intensity of light transmission through tissues (such as lower extremities) to calculate hemoglobin concentration and blood oxygen saturation (SO ₂ ). Among them, the hemoglobin concentration includes oxygenated hemoglobin concentration (OxyHb) and deoxygenated hemoglobin concentration (DeoxyHb). The sampling frequency of the measured signal is 5Hz. The analysis software uses MoorVMS version 4.1 for real-time measurement.

The evaluating device 3 communicates with the oxygen saturation measuring device 2 and is used to calculate a percentage change of venous return flow and generate an evaluation result related to the subject's muscle mass and blood circulation effect.

Referring to Fig. 1 ~ Fig. 4, the method for evaluating the blood return flow rate of the present invention, the following steps are performed through the evaluation device 3 of this embodiment:

Step S01: Obtain a first deoxygenation data D11 and a first oxygen content data O21.

The first deoxygenated data D11 comes from the change of the deoxygenated hemoglobin concentration of the subject during a first time T1 measured by the oxygen saturation measuring device 2, and the first oxygenated data O21 comes from the oxygen saturation The degree measuring device 2 measures the change of the oxygenated hemoglobin concentration of the subject during the first time T1. In this embodiment, the moment when the subject is brought to the first position by the carrier 12 and assumes a standing posture is the starting time t _{1_0} of the first time T1, and at the first time T1 In the process of T1, the standing posture was maintained.

Step S02: Obtain a second deoxygenation data D12 and a second oxygen content data O22.

The second deoxygenated data D12 comes from the change of the deoxygenated hemoglobin concentration of the subject during a second time T2 measured by the oxygen saturation measuring device 2, and the second oxygenated data O22 comes from the oxygen saturation The degree measuring device 2 measures the change of the oxygenated hemoglobin concentration of the subject during the second time T2. In this embodiment, the second time T2 is immediately after the first time T1, so that the subject is driven by the carrier 12, changes from the first position to the second position, and lies flat The moment of the posture is the start time t 2 — 0 of the second time _T2 , and the lying down posture is maintained during the second time T2.

Step S03: Obtain a third deoxygenation data D13 and a third oxygen content data O23.

The third deoxygenated data D13 comes from the oxygen saturation measuring device 2 measuring the change of the deoxygenated hemoglobin concentration of the subject during a third time T3, and the third oxygenated data O23 comes from the oxygen saturation The degree measuring device 2 measures the variation of the oxygenated hemoglobin concentration of the subject during the third time T3. In this embodiment, the third time T3 is immediately after the second time T2, so that the subject is driven by the carrier 12, changes from the second position to the first position again, and is standing The moment of posture is the start time t 3 — 0 of the third time _T3 , and during the third time T3, the standing posture is maintained.

It is worth noting that the first time T1=the second time T2=the third time T3=5 minutes.

Step S04: Calculate a percentage change of venous blood return flow rate ΔHHb(%) according to formula (1).

。 It should be noted that the initial value D ₀ of the second deoxygenation data D12 corresponds to the concentration of _deoxygenated hemoglobin obtained at the initial time t 2 — 0 . Referring to FIG. 4 , for example, the minimum value D _min of the second deoxygenation data D12 =100, and the initial value D ₀ of the second deoxygenation data D12 =167, then the percentage change of the venous blood return flow ΔHHb( %)=｜

.

Step S05: Obtain a blood pressure difference ΔP according to the subject's height.

It is worth noting that the blood pressure difference △P comes from the net water pressure difference caused by the height difference from the head to the measurement site, and is proportional to the height. In this example, the The blood pressure difference △P is obtained by looking up the table.

Step S06: Calculate an arterial blood input resistance according to formula (2).

。 Referring to FIG. 4 , for example, the maximum value O _max =250 of the third oxygen content data O23, the minimum value O _min =200 of the second oxygen content data O22, and the average of the last 30 seconds of the first oxygen content data O21 value=200, blood pressure difference △P is about 92.6mmHg, then

.

Step S06: According to the change percentage of venous blood return flow ΔHHb(%) and a standard range value H ₀ of muscle mass, and according to the arterial blood input resistance R and a standard range value R ₀ of resistance, generate a correlation with the measured The evaluation results of muscle mass and blood circulation effect of patients.

In this embodiment, the muscle mass standard range value H0 is the average value of the change percentage _ΔHHb (%) of the venous blood return flow rate of subjects of each age group, and the resistance standard range value _R0 is also the average value of each age group The average value of arterial blood input resistance of the subjects ranged from 368 to 598.

Since the blood vessel density and blood content in the muscle tissue should increase and decrease synchronously with the muscle mass, that is, the blood content in the muscle tissue is proportional to the volume of the muscle tissue. Therefore, when the venous blood return flow rate change percentage △HHb(%) When < the muscle mass standard range value H ₀ , it means that the "effective blood volume" in the muscle tissue is low, and the evaluation result will show abnormal (low) muscle mass.

When the arterial blood input resistance > the resistance standard range value R0, it means that the vascular resistance in the muscular tissue of the lower limbs of the subject is relatively large, resulting in the oxygenated blood volume of the lower limbs. Because the subject changes from a standing posture to a lying posture, The concentration of oxygenated hemoglobin is not easy to drop, and it is not easy to increase the concentration of oxygenated hemoglobin when changing from a lying posture to a standing posture. In other words, the evaluation result will show the evaluation result of abnormal blood input resistance of blood circulation arteries.

In this way, the evaluation results can be used to assess the possibility of sarcopenia, or to assess the risk of cardiovascular disease, but it should be noted that the evaluation results do not involve medical diagnosis. In practice, it is necessary to judge whether it is sarcopenia , or to judge whether it is a high-risk group of cardiovascular diseases, it still needs to be diagnosed by a physician.

Through the above description, the advantages of the aforementioned embodiments can be summarized as follows:

1. The present invention can accurately calculate the "effective blood volume" in the tissue by calculating the change percentage of venous return flow △HHb(%), so as to know the muscle mass. Apparently, the present invention can measure the blood content of the tissue through simple equipment and the change of the subject's posture, which is not only low in cost, easy to use and operate, but also not disturbed by varicose veins or edema at the test site.

2. In addition, through the change of the subject's posture, it is also possible to further measure the arterial blood input resistance and the ability to adjust, so as to evaluate the risk of cardiovascular disease.

But what is described above is only an embodiment of the present invention, and should not limit the scope of the present invention. All simple equivalent changes and modifications made according to the patent scope of the present invention and the content of the patent specification are still within the scope of the present invention. Within the scope covered by the patent of the present invention.

1: Inversion device

11: Bracket

12: carrier

2: Oxygen saturation measuring device

3: Evaluation device

Claims (9)

A method for assessing blood return flow, which comprises detecting the blood of at least one subject through a blood return system, and performing the following steps: (a) acquiring a first deoxygenation data, the first deoxygenation data comes from the at least one subject During the process of the subject standing for a first time, the change of the deoxyhemoglobin concentration; (b) obtaining a second deoxygenation data, the second deoxygenation data comes from the average of the at least one subject standing for the first time During the process of lying down for a second time, the change of deoxygenated hemoglobin concentration; (c) obtaining a third deoxygenation data, the third deoxygenation data comes from the at least one subject standing for the first time, lying down for the After the second time, during the process of standing again for a third time, the change of deoxygenated hemoglobin concentration; (d) according to formula (1):

100%|, calculating a percentage change of venous blood return; and (e) generating an evaluation result related to the muscle mass of the at least one subject according to the percentage change of venous blood return and a muscle mass standard range value. The blood return flow assessment method according to claim 1, wherein the initial value of the second deoxygenation data comes from the deoxygenated hemoglobin concentration at second 0 when the at least one subject changes from standing to lying down. The method for assessing blood return flow as described in Claim 1 is used to evaluate the muscle mass of several subjects, wherein the muscle mass standard range value is the average value of the percentage change of venous return flow of subjects of each age group . The blood flow assessment method as described in claim 3, wherein, when the vein When the percentage change of blood return flow is less than the standard range value of muscle mass, an evaluation result representing abnormality is produced. The method for assessing blood return flow rate according to claim 1, wherein, in step (a), a first oxygen content data is further acquired, and the first oxygen content data comes from the at least one subject standing on the first In the process of time, the change of oxygenated hemoglobin concentration, in step (b), a second oxygen content data is further obtained, and the second oxygen content data comes from the process of the at least one subject standing for the second time In the change of oxygenated hemoglobin concentration, in step (c), a third oxygen content data is further obtained, and the third oxygen content data comes from the process of the at least one subject standing for the third time, including Changes in oxyhemoglobin concentration. The method for assessing blood return as described in claim 5, further comprising the following steps after step (d): (f) obtaining a blood pressure difference according to the height of the subject; and (g) according to formula (2) : The blood pressure difference =

, calculating the arterial blood input resistance; and step (e) is further based on the arterial blood input resistance and a resistance standard range value, generating the evaluation result related to the blood circulation effect of the at least one subject. The blood return flow assessment method according to Claim 6, wherein when the arterial blood input resistance is greater than the resistance standard range value, an assessment result representing abnormality is generated. A method for evaluating blood return flow as described in any one of request items 1 to 4 A blood flow assessment system according to the method, comprising: an inverted device, including a carrier suitable for carrying the at least one subject, the carrier rotates between a first position and a second position, when in the first position, the The carrier is perpendicular to a plane and is suitable for carrying the at least one subject in a standing state, and in the second position, the carrier is parallel to the plane and is suitable for carrying the at least one subject in a lying state; an oxygen saturation measuring device adapted to the inverted device and used to obtain the first deoxygenation data, the second deoxygenated data, and the third deoxygenated data; and an evaluation device adapted to the inverted device, And it communicates with the oxygen saturation measuring device, and is used to calculate the change percentage of the venous blood return flow, and generate the evaluation result. A blood flow assessment system for performing the blood return flow assessment method described in claim 6, comprising: an inverted device, including a carrier suitable for carrying the at least one subject, the carrier is in a first position and a first Rotate between two positions, in the first position, the carrier is perpendicular to a plane, and is suitable for carrying the at least one subject in a standing state; in the second position, the carrier is parallel to the plane, and is suitable for carrying Carrying the at least one subject in a lying state; an oxygen saturation measuring device, adapted to the inverted device, and used to acquire the first deoxygenation data, the second deoxygenation data, and the third deoxygenation data , the first oxygen data, the second oxygen data, the third oxygen data and an evaluation device, which is adapted to the inversion device and communicates with the oxygen saturation measurement device, and obtains the blood pressure difference according to the height of the subject, and is used to calculate the percentage change of the venous return flow , the arterial blood input resistance, and generate the evaluation result.

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