TWI693071B - 硫化寡醣在製備治療手術後肝細胞癌病患之藥物的用途 - Google Patents

硫化寡醣在製備治療手術後肝細胞癌病患之藥物的用途 Download PDF

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Publication number
TWI693071B
TWI693071B TW107106359A TW107106359A TWI693071B TW I693071 B TWI693071 B TW I693071B TW 107106359 A TW107106359 A TW 107106359A TW 107106359 A TW107106359 A TW 107106359A TW I693071 B TWI693071 B TW I693071B
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Taiwan
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hepatocellular carcinoma
patients
tumor
invasion
liver
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TW107106359A
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Chinese (zh)
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TW201840324A (zh
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張世忠
賴冠郎
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基亞生物科技股份有限公司
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
TW107106359A 2017-03-01 2018-02-26 硫化寡醣在製備治療手術後肝細胞癌病患之藥物的用途 TWI693071B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201762465170P 2017-03-01 2017-03-01
US62/465,270 2017-03-01
US201762504552P 2017-05-11 2017-05-11
US62/504,552 2017-05-11
US201762551770P 2017-08-29 2017-08-29
US62/551,770 2017-08-29

Publications (2)

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TW201840324A TW201840324A (zh) 2018-11-16
TWI693071B true TWI693071B (zh) 2020-05-11

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TW107106359A TWI693071B (zh) 2017-03-01 2018-02-26 硫化寡醣在製備治療手術後肝細胞癌病患之藥物的用途

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US (1) US10842804B2 (https=)
JP (1) JP6948080B2 (https=)
KR (1) KR102265159B1 (https=)
CN (1) CN110381953A (https=)
TW (1) TWI693071B (https=)
WO (1) WO2018157762A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN113160911A (zh) * 2021-02-26 2021-07-23 杭州臻合健康科技有限公司 一种用于术前肝功能耐受性分析的评估系统
CN117476246B (zh) * 2023-12-25 2024-04-19 福建大数据一级开发有限公司 基于多类型复发事件的患者生存分析方法、介质及装置

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CN103788141B (zh) * 2004-03-04 2016-08-17 普罗吉恩制药有限公司 硫酸化寡聚糖衍生物
KR20140050605A (ko) 2011-06-09 2014-04-29 메디젠 바이오테크놀로지 코프 간암의 재발, 악화 또는 전이 억제용 의약조성물

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Liu, Chun-Jen, et al. "Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence." World Journal of Gastroenterology: WJG 20.32 (2014): 11384.
Liu, Chun-Jen, et al. "Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence." World Journal of Gastroenterology: WJG 20.32 (2014): 11384. Liu, Chun-Jen, et al. "Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage." Journal of hepatology 50.5 (2009): 958-968. Wang, Gui-Bo, Xin-Yu Zhou, and Xiao-Qin Wang. "Relationship between serum heparanase and microscopic venous invasion in patients with hepatocellular carcinoma." American journal of clinical pathology 134.2 (2010): 242-248. *
Liu, Chun-Jen, et al. "Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: a randomized phase II trial for safety and optimal dosage." Journal of hepatology 50.5 (2009): 958-968.
Wang, Gui-Bo, Xin-Yu Zhou, and Xiao-Qin Wang. "Relationship between serum heparanase and microscopic venous invasion in patients with hepatocellular carcinoma." American journal of clinical pathology 134.2 (2010): 242-248.

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Publication number Publication date
JP6948080B2 (ja) 2021-10-13
TW201840324A (zh) 2018-11-16
WO2018157762A1 (en) 2018-09-07
KR102265159B1 (ko) 2021-06-17
KR20190120339A (ko) 2019-10-23
JP2020509035A (ja) 2020-03-26
CN110381953A (zh) 2019-10-25
US10842804B2 (en) 2020-11-24
US20180250317A1 (en) 2018-09-06

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