TWI691319B - Partial processing method for bio absorbable stent - Google Patents

Abstract

A partial processing method for bio absorbable sent is provided, which includes the following steps: provide a bio absorbable stent, wherein the bio absorbable sent is made of polymer materials; disposing a mask on the bio absorbable stent; positioning a plurality of target positions of the bio absorbable sent by a positioning system to make the target positions expose from the mask; and executing a partial processing to process the target positions in order to increase the degradation rate thereof.

Description

Local treatment method of degradable biomedical stent

The invention relates to an improved technique of biomedical stent, in particular to a local treatment method of degradable biomedical stent.

Existing absorbable biomedical stents (vascular stents) are mostly made of a single polymer material, which can be slowly decomposed after a period of time after being implanted in a blood vessel. However, the fracture elongation rate of the polymer biomedical stent is lower than that of the metal stent. Therefore, when implanted in a blood vessel with a high bending angle, the biomedical stent may have a large deformation and cause poor expansion, resulting in reduced strength and treatment. The effect is therefore reduced, and therefore medical disputes are prone to occur.

Therefore, how to propose an improved technique for biomedical stents that can effectively improve the limitations of the conventional skills has become an urgent issue.

In view of the above-mentioned problems of the conventional art, one of the objects of the present invention is to provide a local treatment method of the degradable biomedical stent to solve various limitations of the conventional art.

According to one of the objectives of the present invention, a local treatment method for a degradable biomedical stent is proposed, which includes the following steps: providing a biomedical stent, the biomedical stent is made of a polymer material; and setting a mask on the biomedical stent; Positioning a plurality of target positions of the biomedical stent with a positioning system and exposing the target positions to masks; and executing local processing procedures to process the target positions to increase the degradation speed of the target positions.

In a preferred embodiment, the step of performing a local processing procedure to process the target positions to increase the degradation speed of the target positions further includes the following steps: heating the target positions through a heating rod to increase the degradation of the target positions speed.

In a preferred embodiment, the temperature of the heating rod to heat the target positions is 40-70°C.

In a preferred embodiment, the heating rod heats the target positions for 10 to 120 minutes.

In a preferred embodiment, the step of performing a local processing procedure to process the target locations to increase the degradation speed of the target locations further includes the following steps: hydrophilizing the target locations through plasma to enhance the target locations The degradation rate of the target location.

In a preferred embodiment, the temperature of the plasma is 20~70°C.

In a preferred embodiment, the contact angle of the plasma is 25 degrees to 35 degrees.

In a preferred embodiment, the power of the plasma is 100-150 watts.

In a preferred embodiment, the flow rate of the plasma is 6-10 slm.

In a preferred embodiment, the step of performing a local processing procedure to process the target positions to increase the degradation speed of the target positions further includes the following steps: processing the target positions through ultraviolet light to make the target positions The molecular links are broken to increase the degradation rate of these target locations.

In a preferred embodiment, the wavelength of ultraviolet light is 270-400 nm.

In a preferred embodiment, the irradiation time of ultraviolet light is 0.5-50 hours.

In a preferred embodiment, the biomedical stent includes a plurality of ring-shaped layers and a plurality of connection portions connecting the ring-shaped layers, and the target positions are the connection portions.

As mentioned above, the local treatment method of the degradable biomedical stent according to the present invention may have one or more of the following advantages:

(1) In one embodiment of the present invention, the local treatment method of the degradable biomedical stent improves the degradation speed of the target position of the biomedical stent through specially designed local processing procedures and parameters, so the target position can be degraded in a short time It enables the biomedical stent to support blood vessels independently in sections, so it will not be distorted when implanted in blood vessels with high bending angles. It has a good expansion effect and has strength, which greatly improves its therapeutic effect.

(2) In one embodiment of the present invention, the local treatment method of the degradable biomedical stent greatly improves the therapeutic effect of the biomedical stent, so it can effectively reduce medical disputes.

(3) In one embodiment of the present invention, the local treatment method of the degradable biomedical stent can improve the degradation rate of the biomedical stent at different positions according to the situation, so that it can meet various clinical conditions, so it can be more applied For wide.

(4) In one embodiment of the present invention, the local processing method of the degradable biomedical stent has a simple manufacturing process, so the desired effect can be achieved without greatly increasing the cost.

The following will describe an embodiment of the local treatment method of the degradable biomedical stent according to the present invention with reference to the related drawings. For the sake of clarity and convenience of the illustration, the components in the drawings may be exaggerated in size and proportion Or present it in a reduced size. In the following description and/or patent application, when an element is referred to as being "connected" or "coupled" to another element, it may be directly connected or coupled to the other element or intervening elements may be present; and when the element is mentioned When "directly connected" or "directly coupled" to another element, there are no intervening elements, and other words used to describe the relationship between the elements or layers should be interpreted in the same manner. For ease of understanding, the same elements in the following embodiments are described with the same symbols.

Please refer to FIG. 1, which is a structural diagram of a degradable biomedical stent according to the first embodiment of the present invention. As shown in the figure, the biomedical stent 1, such as a vascular stent, is made of a polymer material and includes a plurality of ring-shaped layers 11 and a plurality of connecting portions 12; the ring-shaped layers 11 are connected to each other through the connecting portions 12 . Each annular layer 11 includes a plurality of crown portions 111 and a plurality of support portions 112.

First, the mask is placed on the biomedical support 1. Then, locate a plurality of target positions of the biomedical stent 1 through the positioning system and expose the target positions to the mask; in an embodiment, the target positions may be the connection portions 12 described above. Next, a local processing procedure is performed to process the target positions to increase the degradation rate of the target positions. This local processing procedure can change the properties of the target positions, such as lowering the molecular weight or breaking the molecular bonds, so it can be improved The degradation rate; in one embodiment, the local treatment procedure may be a heat treatment method; in another embodiment, the local treatment procedure may be a plasma method; in yet another embodiment, the local treatment procedure may be an ultraviolet method.

Through the above-mentioned local processing method, the degradation speed of the target positions of the biomedical stent 1 can be effectively increased, so after implantation of the blood vessel, the target positions, that is, the connecting portions 12, can be rapidly degraded; therefore, the The medical stent 1 can support blood vessels independently segmented from each other, and if implanted in a blood vessel with a high bending angle, since the biomedical stent 1 already supports the blood vessels in segments, there will be no severe deformation, which results in a good expansion effect and strength Improve, so it can achieve better treatment effect.

In other embodiments, the target positions may also be the crown portions 111 or the support portions 112 to meet different requirements.

Please refer to FIG. 2, which is a flowchart of the first embodiment of the present invention. As shown in the figure, the manufacturing method of the biomedical stent 1 of this embodiment includes the following steps:

Step S21: Provide a biomedical stent made of polymer materials.

Step S22: Set the mask on the biomedical support.

Step S23: use the positioning system to locate a plurality of target positions of the biomedical stent and expose the target positions to the mask.

Step S24: Perform a local processing procedure to process the target positions to increase the degradation speed of the target positions.

It is worth mentioning that most of the existing absorbable biomedical stents are made of a single polymer material, which can be slowly decomposed after a period of time. However, the fracture elongation rate of the polymer biomedical stent is lower than that of the metal stent. Therefore, when implanted in a blood vessel with a high bending angle, the biomedical stent may have a large deformation, which may result in poor expansion, resulting in a decrease in strength, and its therapeutic effect It is therefore reduced. On the contrary, according to the embodiment of the present invention, the local treatment method of the degradable biomedical stent improves the degradation speed of the target position of the biomedical stent through specially designed local processing procedures and parameters, so the target position can be degraded in a short time, The biomedical stent can support blood vessels independently and segmentally. Therefore, it can solve the problem of large deformation when implanted in blood vessels with high bending angles. The expansion effect is good and has strength, which greatly improves the therapeutic effect and can effectively reduce medical disputes. .

In addition, according to the embodiments of the present invention, the local treatment method of the biodegradable biomedical stent can improve the degradation rate of the biomedical stent at different positions according to the situation, so that it can meet various clinical conditions, so it can be more widely used .

Furthermore, according to the embodiments of the present invention, the local processing method of the degradable biomedical stent has a simple manufacturing process, so it can achieve the desired effect without significantly increasing the cost. It can be seen from the above that the local treatment method of the degradable biomedical stent of the present invention can indeed achieve excellent technical effects.

Please refer to FIG. 3, which is a flowchart of a second embodiment of the present invention. The local processing procedure adopted in this embodiment is a heat treatment method to perform local processing on the target positions of the biomedical stent 1, that is, the connecting portions 12.

The heat treatment method heats the connecting portions 12 below the glass transition temperature (Tg point) through a heating rod to increase the degradation rate of the connecting portions 12; in one embodiment, the heating rod heats the temperature of the connecting portions 12 40~70°C, time is 10~120 minutes; in one embodiment, the temperature of the heating rod to heat the connecting portions 12 is 40~60°C, time is 10~60 minutes; in another embodiment In this case, the heating rod heats the connecting portions 12 at a temperature of 45°C for 30 to 60 minutes.

The heat treatment method can crystallize the connection portions 12, thereby increasing the degradation speed of the connection portions 12, so that after the biomedical stent 1 is implanted into the blood vessel, the connection portions 12 can be rapidly degraded, so that the biomedical stent 1 can Support blood vessels segmented independently of each other.

As shown in the figure, the manufacturing method of the biomedical stent 1 of this embodiment includes the following steps:

Step S31: Provide a biomedical stent made of a polymer material.

Step S32: Set the mask on the biomedical support.

Step S33: use the positioning system to locate a plurality of target positions of the biomedical stent and expose the target positions to the mask.

Step S34: heating the target positions at 40~70°C for 10~120 minutes through a heating rod to increase the degradation rate of the target positions.

Please refer to FIG. 4, which is a flowchart of a third embodiment of the present invention. The local processing procedure adopted in this embodiment is the plasma method to perform local processing on the target positions of the biomedical stent 1, that is, the connecting portions 12.

Plasma method hydrophilizes these connection parts through normal temperature plasma to increase the degradation rate of these connection parts 12; in one embodiment, the temperature of the plasma is 20 ~ 70 °C, the contact angle is 25 degrees ~ 35 degrees, the power is 100~150 watts, the flow rate is 6-10 slm, the transfer speed is 100 mm/s, and the spacing is 10 mm; in another embodiment, the contact angle is 30 degrees and the power of the plasma is 100 watts, The flow rate is 10 slm.

The room temperature plasma used in the plasma method does not produce a hot-melt effect on polymer materials and can be hydrophilically treated, so it can accelerate the decomposition rate; therefore, after the biomedical stent 1 is implanted into the blood vessel, the connection portions 12 can The rapid degradation allows the biomedical stent 1 to support blood vessels independently of each other.

As shown in the figure, the manufacturing method of the biomedical stent 1 of this embodiment includes the following steps:

Step S41: Provide a biomedical stent made of a polymer material.

Step S42: Set the mask on the biomedical support.

Step S43: use the positioning system to locate a plurality of target positions of the biomedical stent and expose the target positions to the mask.

Step S44: Hydrophilizing the connection parts through the plasma to increase the degradation speed of the target positions, wherein the temperature of the plasma is 20~70°C, the temperature power of the plasma is 100~150 watts, the electricity The flow rate of the pulp is 6-10 slm, and the contact angle of the plasma is 25 degrees to 35 degrees.

Please refer to FIG. 5, which is a flowchart of a fourth embodiment of the present invention. The local processing procedure used in this embodiment is the ultraviolet method to perform local processing on the target positions of the biomedical stent 1, that is, the connecting portions 12.

The ultraviolet method uses ultraviolet light to process the connection portions 12, so that the molecular links of the connection portions 12 are broken to increase the degradation rate of the connection portions 12. In one embodiment, the wavelength of the ultraviolet light is 270~ 400nm, irradiation time is 0.5~50 hours; in another embodiment, the wavelength of ultraviolet light is 315~385nm, the irradiation time is 0.5~24 hours; in yet another embodiment, the wavelength of ultraviolet light is 365nm, irradiation time For 12 hours.

Ultraviolet method can reduce the molecular weight of the connection parts 12 by about 70% to increase the degradation rate, so it can produce excellent effects, so that after the biomedical stent 1 is implanted in the blood vessel, the connection parts 12 can be rapidly degraded, so that The biomedical stent 1 can support blood vessels independently of each other in sections.

As shown in the figure, the manufacturing method of the biomedical stent 1 of this embodiment includes the following steps:

Step S51: Provide a biomedical stent made of polymer materials.

Step S52: Set the mask on the biomedical support.

Step S53: Locate a plurality of target positions of the biomedical stent with the positioning system and expose the target positions to the mask.

Step S54: irradiate the target positions with ultraviolet light with a wavelength of 270-400 nm for 0.5-50 hours to break the molecular links of the target positions to increase the degradation rate of the target positions.

In summary, according to the embodiment of the present invention, the local treatment method of the degradable biomedical stent improves the degradation speed of the target position of the biomedical stent through the specially designed local processing procedures and parameters, so the target position can be shortened in a short time The degradation allows the biomedical stents to support blood vessels independently of each other. Therefore, when implanted in a blood vessel with a high bending angle, there will be no large deformation. The expansion effect is good and it has strength, which greatly improves its therapeutic effect.

In addition, according to the embodiments of the present invention, the local treatment method of the degradable biomedical stent greatly improves the therapeutic effect of the biomedical stent, so it can effectively reduce medical disputes.

In addition, according to the embodiments of the present invention, the local treatment method of the biodegradable biomedical stent can improve the degradation rate of the biomedical stent at different positions according to the situation, so that it can meet various clinical conditions, so it can be more widely used .

Furthermore, according to the embodiments of the present invention, the local processing method of the degradable biomedical stent has a simple manufacturing process, so it can achieve the desired effect without significantly increasing the cost.

It can be seen that the present invention has achieved the desired enhancement effect by breaking through the previous technology, and it is not easy to think about by those who are familiar with the art. Its progress and practicality have obviously met the patent application requirements. I filed a patent application in accordance with the law, and urge your office to approve this application for a patent for invention to encourage creation and to feel virtuous.

The above is only exemplary, and not restrictive. Any other equivalent modifications or changes made without departing from the spirit and scope of the present invention should be included in the scope of the attached patent application.

1: Biomedical stent

11: Ring layer

111: Crown

112: Support

12: Connection

S21~S24, S21~S34, S41~S44, S51~S54: Step flow

Figure 1 is a structural diagram of a degradable biomedical stent according to the first embodiment of the present invention.

Figure 2 is a flowchart of the first embodiment of the present invention.

Figure 3 is a flowchart of a second embodiment of the invention.

Figure 4 is a flowchart of a third embodiment of the invention.

Figure 5 is a flowchart of a fourth embodiment of the present invention.

S21~S24: Step flow

Claims (10)

A local treatment method for a degradable biomedical stent includes: providing a biomedical stent made of a polymer material; placing a mask on the biomedical stent; positioning the biomedical stent with a positioning system Plural target positions of the medical stent and expose the masks to the target positions; and execute a local processing procedure to process the target positions to increase the degradation speed of the target positions, thereby implanting the biomedical stent into a blood vessel Afterwards, it is decomposed into a plurality of sections, and the sections are independently supported to support the blood vessel, so as to maintain the later dilation effect and strength. The local treatment method for a degradable biomedical stent as described in item 1 of the patent application scope, wherein the step of performing the local treatment procedure to process the target positions to increase the degradation speed of the target positions further includes: heating through a heating rod The target positions increase the degradation rate of the target positions. The local treatment method of the degradable biomedical stent as described in Item 2 of the patent application scope, wherein the temperature of the heating rod to heat the target positions is 40~70°C. The local treatment method of the degradable biomedical stent as described in Item 2 of the patent application scope, wherein the heating rod heats the target positions for 10 to 120 minutes. The local processing method of the degradable biomedical stent as described in item 1 of the patent application scope, wherein the step of performing the local processing procedure to process the target positions to increase the degradation speed of the target positions further includes: through a plasma pair The target positions are hydrophilized to increase the degradation rate of the target positions. The local treatment method of the degradable biomedical stent as described in item 5 of the patent scope, wherein the temperature of the plasma is 20~70℃. The local treatment method of the biodegradable biomedical stent as described in item 5 of the patent scope, wherein the power of the plasma is 100-150 watts, the flow rate of the plasma is 6-10 slm, and the contact angle of the plasma is 25 Degrees ~ 35 degrees. The local treatment method for a degradable biomedical stent as described in item 1 of the patent application scope, wherein the step of performing the local treatment procedure to process the target positions to increase the degradation speed of the target positions further includes: passing an ultraviolet light pair The target positions are processed to break the molecular links of the target positions, so as to increase the degradation rate of the target positions. The local treatment method of the degradable biomedical stent as described in item 8 of the patent application scope, wherein the wavelength of the ultraviolet light is 270~400nm, and the irradiation time of the ultraviolet light is 0.5~50 hours. The local treatment method for a degradable biomedical stent as described in item 1 of the patent application scope, wherein the biomedical stent includes a plurality of ring-shaped layers and a plurality of connection portions connecting the ring-shaped layers, and the target positions are the These connections.

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