CN207085001U - A kind of degradable overlay film frame - Google Patents
A kind of degradable overlay film frame Download PDFInfo
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- CN207085001U CN207085001U CN201621376500.6U CN201621376500U CN207085001U CN 207085001 U CN207085001 U CN 207085001U CN 201621376500 U CN201621376500 U CN 201621376500U CN 207085001 U CN207085001 U CN 207085001U
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- Prior art keywords
- overlay film
- degradable
- support
- film frame
- area
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Abstract
The utility model discloses a kind of degradable overlay film frame, a kind of degradable overlay film frame, including support, support are divided into overlay film area and bare bracket, and wherein overlay film area is that overlay film is set on support；Overlay film is provided with visual indication in area；Support is curled into tubular or frustum-like shape, and overlay film is located at the inner or outer side of tubular or frustum-like shape.The utility model provides a kind of new degradable overlay film frame, has good radial support power, for rupture or dilatancy vascular lesion, effectively can repair blood vessel, isolation knurl body by endovascular graft；For Stenotic pathologic change, pathological lumen is can support, is released narrow.With good biocompatibility and blood vessel compatibility, can gradually it degrade, after vascular lesion improves or cures, degradable overlay film frame is degradable, the integrality of blood vessel and functional rehabilitation to nature.
Description
Technical field
It the utility model is related to medical instruments field, more particularly to a kind of degradable overlay film frame.
Background technology
Angiocardiopathy is the main reason for currently causing human death, is also the first cause of the death in China, every 5 death is just
There are 2 to die from cardiovascular disease.At present, in the treatment of arteries lesion, stenter to implant is most important conventional therapy.
Overlay film frame type artificial blood vessel is by bare metal stent（Mostly Nitinol）And overlay film artificial blood vessel attached thereto
（Mostly PTEF, PUT）Composition, vascular lesion position and closed sandwich cut and knurl body can be fixed on very well.In the broken of blood vessel
Split, in dilatancy lesion, especially dissection of aorta, aortic aneurysm, using the endovascular graft of overlay film frame type artificial blood vessel
（TEVAR,EVAR）The first-line treatment scheme of the suitable aortic disease of anatomical structure is turned into.But current overlay film frame type is artificial
Blood vessel makes by non-degradable material, even if lesion has healed, is still permanently present intravascular adversely affect.Including：1.
Support radial support power can cause sustainer is inverse to tear or distally rupture；2. chronic inflammatory can be caused to react, may be with interior leakage, support
Displacement and the rupture of knurl body are related；3. the stiffness index increase of stenter to implant aorta posterior, causes contracts last pressure to increase, induces left room
Plump and diastolic dysfunction, so as to be adversely affected to the long-term prognosis of patient.
In Coronary Artery Disease Intervention Treatment, overlay film frame be mainly used in the rescue of coronary arterial perforation in art, coronary aneurysm,
The PCI of coronary artery fistula and saphenous vein graft.Polytetrafluoroethylene (PTFE) (PTFE) overlay film frame mainly has two kinds at present:One kind is
JOSTENT Graftmaster (Abbott Laboratories Vascular, Red- wood City, CA) balloon expandable stent, support by 316 L not
Rust Steel material is made, mono- layer of PTFE film of embedded PT between two layers of support.Another kind be Symbiot supports (ripple ten times scientific ＆ technical corporation,
Natick, MA), surrounded by a double-deck PTFE film around nickel titanium stents.Its stent restenosis at a specified future date and incidence of thrombus
Height, restenosis rate reached up to the thrombus in stents incidence of 50%, 6 month after being treated after research display coronary artery perforation with overlay film frame
33%, it is relatively high compared with BMS, DES.May be related to the endothelialization delay of overlay film frame endangium（The retardance of PTEF overlay films
Effect）.
Peripheral vascular（Artery of extremity, neck, Visceral artery）Overlay film frame is applied to angiorrhoxis, aneurysm, also more comes
It is used for Stenotic pathologic change.In Stenotic pathologic change, because of the inhibition of film, it may prevent in the damaged blood vessels at lesion vesselses
Migrate caused by wall macrophages secrete inflammatory mediators, help to reduce and ISR related cell factor, metalloprotein again
Enzyme, growth factor etc. are acted on vascular wall, and reduce ISR relative to bare metal stent.Overlay film frame has and bare metal stent
Compared to there is less restenosis rate, long-term patency rates are high, but its bracket edge still has ISR, long-term existence, needs long-term
Antiplatelet drug is taken, there is thrombosis risk, after the acute ischemia caused by thrombus is more serious compared with occlusion generation
Fruit.
Degradable coronary artery bracket has been used for coronary heart disease treatment, and shows good clinical effectiveness.FDA approveds
Absorb GT1 biological absorbable intravascular stent systems（BVS）Type blood is fully absorbed as first treatment coronary artery disease
Pipe holder.But the overlay film frame people in dissection of aorta and the endovascular graft of active knurl, used in coronary artery and peripheral vascular disease
Work blood vessel, lacking at present can degradable overlay film frame.After overlay film frame artificial blood vessel completes its function, overlay film frame people
Work blood vessel it is degradable, to reduce vascular inner body residual, reduce its inflammatory reaction, thrombogenicity and other it is related and
Send out disease, make blood vessel structure and systolic and diastolic function return to nature be treatment ideal scheme.
Degradable overlay film frame advantage：1. blood vessel recovers normal function;2. environment restoration is normal in;3. patient need not
Long-term use of antiplatelet, medicine for treating thrombus thing；4. reduce overlay film frame correlation late complication；5. provided for the processing of late lesions
Further processing may.
Therefore, it is necessary to develop can degradable film-coated vascular support, when overlay film frame completes its treatment function, angiosis
After becoming healing, film-coated vascular support is degradable, and vascular function returns to nature, improves long-term prognosis.
The content of the invention
The technical problem of solution：The application provides a kind of new overlay film frame that can be degradable, applied to sustainer
The endovascular graft of interlayer, aortic aneurysm；The rescue of coronary arterial perforation, coronary aneurysm, coronary artery fistula, saphenous vein graft and
The PCI of coronary stenosis；And for peripheral vascular lesion（Neck, ilium, femoral artery etc.）Artery dissection, aneurysm and narrow
The treatment of lesion.Both overlay film frame treatment lesion vesselses had been reached, and can is solved at present because of non-degradable overlay film frame Preserving time
The problems such as causing to be difficult to poor complete endothelialization, anti-bolt, later stage thrombus, edge restenosis in vivo, after reaching blood vessel recovery from illness, overlay film
Mounting system is degradable, vascular integrity and functional rehabilitation to nature, reduces the purpose of late complication.
Technical scheme：A kind of degradable overlay film frame, including support, support are divided into overlay film area and bare bracket, wherein overlay film
Area is that overlay film is set on support；Overlay film is provided with visual indication in area；Support is curled into tubular or frustum-like shape, and overlay film is located at
The inner or outer side of tubular or frustum-like shape.
Further, described degradable overlay film frame, there is the medication coat of controlled release on the overlay film in overlay film area.
Further, described degradable overlay film frame, the overlay film in overlay film area are located at the inner side or outer of tubular or frustum-like shape
Side.
Further, described degradable overlay film frame, the overlay film in overlay film area is by suture or compression molding on support.
Further, described degradable overlay film frame, the material of support for degradable biocompatibility metal or can drop
Solve high molecular polymer or its mixture.
Further, described degradable overlay film frame, medication coat are thin with anti-inflammatory, anti-bolt or rush blood vessel endothelium
The medication coat that born of the same parents repair.
Further, described degradable overlay film frame, the proximal part that support is curled into tubular are identical with distal end diameter；
The proximal part diameter that support is curled into frustum-like shape is more than distal end diameter.
Further, described degradable overlay film frame, support are shaped as waveform or grid-shaped.
Further, described degradable overlay film frame, the material of the overlay film in overlay film area is degradable biological compatibility
Material or degradable macromolecule polymer or mixture film.
Further, described degradable overlay film frame, visual indication are located at covering for overlay film area and bare bracket intersection
In film area.
Beneficial effect：
The utility model provides a kind of new degradable overlay film frame, has good radial support power, for rupture
Or dilatancy vascular lesion, blood vessel, isolation knurl body effectively can be repaired by endovascular graft；For Stenotic pathologic change, can prop up
Pathological lumen is supportted, is released narrow.With good biocompatibility and blood vessel compatibility, overlay film outer layer can increase medication coat,
With anti-inflammatory, promote the effect such as blood vessel endothelium reparation, resisting vascular smooth muscle hyper-proliferative；Or without medication coat.With the extension of time,
After lesion vesselses recover, overlay film frame type artificial blood vessel is degradable, and vascular function, interior environment return to nature, reduces
Late complication caused by overlay film frame remains.The gradual disappearances of degrading of overlay film 1-2；The support told continues 1-3 and gradually said
Solution is to degradable disappearance.
Brief description of the drawings
Fig. 1 is the structural representation for the degradable overlay film frame that the utility model embodiment 1 provides；Wherein 1 is support, 2
It is bare bracket for overlay film area, 3,4 be visual indication.
Embodiment
Following examples further illustrate content of the present utility model, but should not be construed as to limitation of the present utility model.
In the case of without departing substantially from the utility model spirit and essence, the modification made to the utility model method, step or condition and
Replace, belong to the scope of the utility model.
Unless otherwise specified, the conventional meanses that technological means used in embodiment is well known to those skilled in the art.
Embodiment of the present utility model is explained in detail below in conjunction with the accompanying drawings, but the utility model is not limited to
The embodiment, in those of ordinary skill in the art's possessed knowledge, the utility model can also not departed from
Made a variety of changes on the premise of objective.
Embodiment 1
The present embodiment provides a kind of degradable overlay film frame of sustainer, for treating dissection of aorta and aortic aneurysm.Such as
Shown in Fig. 1, the structural representation of the degradable overlay film frame provided for the present embodiment, including support 1, support 1 divide for overlay film area 2
With bare bracket 3, wherein overlay film area 2 is to set overlay film on support 1；Visual indication 4 is provided with overlay film area 2；Support 1 crimps
Into tubular or frustum-like shape, overlay film 2 is located at the outside of tubular or frustum-like shape（Can also be in inner side）.There is control on the overlay film in overlay film area 2
The medication coat released（Also can be without medication coat）；Medication coat can be selected as with anti-inflammatory, anti-bolt or rush vascular endothelial cell
The medication coat of reparation；The overlay film in overlay film area 2 is located at the inner or outer side of tubular or frustum-like shape；The overlay film in overlay film area 2 passes through seam
Close or compression molding is on support 1；The material of support 1 be degradable biocompatibility metal or degradable high polymer or
Its mixture；The proximal part that support 1 is curled into tubular is identical with distal end diameter, diameter 24-50mm, length 80-200mm；
The proximal part diameter that support 1 is curled into frustum-like shape is more than distal end diameter about 4-6mm；Support 1 is shaped as waveform（Can also
For grid-shaped）, bending can be better achieved；Visual indication 4 is located at overlay film area 2 and the overlay film area 2 of the intersection of bare bracket 3
On.
Degradable overlay film frame is released to lesion by seal wire, induction system by self-expanding mode in the present embodiment.
The material of the degradable overlay film frame 1 of the present embodiment is that degradable biocompatibility metal or degradable macromolecule polymerize
Thing, can select the alloys such as magnesium, iron, zinc and other degradable metal alloys or as PLA, polyglycolic acid, poe,
Polycaprolactone, polymerization L- lactides and other high molecular polymers or mixture.The material of overlay film is that degradable biological is compatible
Property material, such as may be selected degradable polymer film, degradable PLA, polyglycolic acid and polycaprolactone, poly- dioxy
Six cyclic ketones etc. or/and its mixture, can reach good degradation effect during specifically used.And degradable polymer is thin
Film may be selected as PLA, PLLA, the lactide copolymer fibre of glycolide one and polyacetylglutamic acid or other it is new can
Degradable material；Can also be by degradable PLA, polyglycolic acid and polycaprolactone, polydioxanone etc. and blending
Body, or other new degradation material compositions.The degradable polymer film is the platform that medicine carries controlled release, passes through control
The degradation speed of matrix, insoluble drug release can be with continued for several weeks, several months, even more than 1 year.The medicine of selection include probucol,
The effect such as CD34 antibody, promotion blood vessel endothelium is quickly repaired, anti-inflammatory.Wherein overlay film is degradable in lasting 1-2；The branch told
Frame is in the degradable disappearances of 1-3.
Embodiment 2
The present embodiment provides a kind of for coronary artery, the degradable overlay film frame of peripheral vascular, for cylinder, proximal part and original
Heart end diameter is identical, coronary artery overlay film frame a diameter of 4-6mm, length 20-30mm；The a diameter of 5-14mm of periphery overlay film frame, it is long
Spend 30-80mm.Overlay film frame composition characteristic is same as Example 1.Degradable overlay film frame is delivered to disease by seal wire, induction system
At change, the overlay film frame for coronary artery is by sacculus mode, the degradable overlay film frame of peripheral vascular by balloon expandable or from swollen
Swollen mode is released to lesion.The overlay film frame for stenotic lesion told, there are rapamycin, taxanes, liver on overlay film
The medication coats such as element, resisting vascular smooth muscle, which increases, plants, promotees inner membrance reparation, anti-inflammatory, antithrombotic.The biodegradable stent and overlay film told have
Different degradation times, overlay film are degradable in 1-2；The support told is degradable in 1-3.Overlay film frame is degradable
Afterwards, vascular function and interior environment restoration are to nature.
Degradable overlay film frame provided by the utility model has good biological degradability and internal compatibility, completes
After its mission, the degradable absorption of energy, vascular function and interior environment return to nature, caused by reducing overlay film frame residual
Late complication.
Claims (6)
1. a kind of degradable overlay film frame, it is characterised in that including support（1）, support（1）It is divided into overlay film area（2）And bare bracket
（3）, wherein overlay film area（2）For in support（1）Upper setting overlay film；Overlay film area（2）On be provided with visual indication（4）；Support（1）
It is curled into tubular or frustum-like shape, overlay film area（2）Positioned at the inner or outer side of tubular or frustum-like shape；Overlay film area（2）Overlay film on have
The medication coat of controlled release；Visual indication（4）Positioned at overlay film area（2）And bare bracket（3）The overlay film area of intersection（2）On.
2. degradable overlay film frame according to claim 1, it is characterised in that overlay film area（2）Overlay film be located at tubular or
The inner or outer side of frustum-like shape.
3. degradable overlay film frame according to claim 1, it is characterised in that overlay film area（2）Overlay film by suture or
Compression molding is in support（1）On.
4. degradable overlay film frame according to claim 1, it is characterised in that medication coat be with anti-inflammatory, anti-bolt or
Promote the medication coat of vascular endothelial cell reparation.
5. degradable overlay film frame according to claim 1, it is characterised in that support（1）It is curled into the proximal part of tubular
It is identical with distal end diameter；Support（1）The proximal part diameter for being curled into frustum-like shape is more than distal end diameter.
6. degradable overlay film frame according to claim 1, it is characterised in that support（1）Be shaped as waveform or net
Trellis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621376500.6U CN207085001U (en) | 2016-12-15 | 2016-12-15 | A kind of degradable overlay film frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201621376500.6U CN207085001U (en) | 2016-12-15 | 2016-12-15 | A kind of degradable overlay film frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207085001U true CN207085001U (en) | 2018-03-13 |
Family
ID=61546853
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201621376500.6U Expired - Fee Related CN207085001U (en) | 2016-12-15 | 2016-12-15 | A kind of degradable overlay film frame |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207085001U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875735A (en) * | 2019-03-08 | 2019-06-14 | 王翔宇 | A kind of Wholly-degradable overlay film frame and overlay film frame system |
| CN112472360A (en) * | 2020-11-25 | 2021-03-12 | 四川大学华西医院 | Vena cava stent |
| WO2022076686A1 (en) | 2020-10-07 | 2022-04-14 | Canary Medical Switzerland Ag | Providing medical devices with sensing functionality |
-
2016
- 2016-12-15 CN CN201621376500.6U patent/CN207085001U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109875735A (en) * | 2019-03-08 | 2019-06-14 | 王翔宇 | A kind of Wholly-degradable overlay film frame and overlay film frame system |
| CN109875735B (en) * | 2019-03-08 | 2023-11-21 | 王翔宇 | Completely degradable tectorial membrane support and tectorial membrane support system |
| WO2022076686A1 (en) | 2020-10-07 | 2022-04-14 | Canary Medical Switzerland Ag | Providing medical devices with sensing functionality |
| CN112472360A (en) * | 2020-11-25 | 2021-03-12 | 四川大学华西医院 | Vena cava stent |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180313 Termination date: 20191215 |