TWI687200B - Optical pulse image measuring device and method for analyzing change of pulse waveform - Google Patents

Abstract

The present disclosure provides an optical pulse image measuring device including a base, a cover, an imaging module, a light source module, a structured light projection module, a circuit module, a computing module and a display module. The cover is disposed on the base. The imaging module is disposed within the cover and for capturing an image in an imaging area. The light source module is disposed on one side of the imaging module. The structured light projection module is disposed within the cover. The circuit module is electrically connected to the imaging module and the light source module. The computing module is signally connected to the circuit module. The display module is signally connected to the computing module. Therefore, the optical pulse image measuring device of the present disclosure can capture pulse images on wrists of a subject by the imaging module and visualize the pulse condition information so as to obtain pulse measurement results with high accuracy.

Description

Optical pulse wave image measuring instrument and pulse waveform variable measuring method

The invention relates to a pulse image measuring instrument, in particular to an optical pulse wave image measuring instrument which uses an optical imaging system to measure and analyze pulse wave images.

In traditional pulse control, Chinese medicine practitioners press the radial artery of the patient's wrist by touching, touching, pressing, etc. to feel the pulse of the patient's wrist, such as the floating, middle, and deep depths of the three positions of the wrist, feet, and feet. Different pressures are used to sense different pulse changes. However, the accuracy of pulse diagnosis will vary depending on the palpation position, palpation habits, and pressure of different TCM doctors, and it cannot objectively describe the pulse, which will make the result of the pulse change more significant. Variability makes it easier to issue wrong diagnosis results to patients.

In order to solve the above-mentioned problems, related technical personnel have proposed a tactile combined pulse assisting device, in which a Chinese medicine practitioner wears a pulse assisting device including a sensing unit on a finger to detect in real time that the Chinese medicine practitioner applies the pulse to the patient's wrist The size of the pressure is good for adjusting the pressure channel during the pulse process, and can digitize the obtained pulse information, thereby providing the patient with an objective pulse diagnosis result. However, the aforementioned tactile sense combined with the pulse assist device In the process, it is still necessary for the TCM doctor to judge the palpation position and apply pressure to the patient's wrist, and it is not possible to standardize the palpation position and compression force, resulting in different pulse diagnosis results issued by different TCM practitioners to the same patient.

In order to solve the above-mentioned problems, related technical personnel have also proposed to use a compression device such as a balloon to pressurize the radial artery of the patient, and to obtain a pulse diagnostic tester for analyzing the pulse pressure signal after the compression to analyze to obtain a standardized pulse diagnosis result. However, although the aforementioned pulse diagnosis instrument can avoid the result error caused by the different palpation habits of traditional Chinese medicine practitioners, it still needs to apply external force to the patient's wrist and perform contact diagnosis to obtain the relative pulse pressure signal for subsequent follow-up The judgment of the pulse diagnosis result is not only complicated in the operation method, but also may affect the accuracy of the pulse diagnosis result due to the contact pulse-taking method.

Therefore, there is an urgent need on the market for a pulse measurement instrument that combines ease of use and achieves an objective pulse result request.

One aspect of the present invention is to provide an optical pulse wave image measuring instrument, which includes a base, a cover, an imaging module, a light source module, a structured light projection device, a circuit module, and an arithmetic module And a display module. The outer cover is arranged on the base to provide a light-shielding area. The light source module is disposed on one side of the imaging module. The structured light projection device is arranged in the outer cover. The imaging module is disposed in the outer cover, and the imaging module is used to capture an image of an area to be measured. The light source module is disposed on one side of the imaging module. The circuit module is electrically connected to the imaging module and the light source module. The signal of the arithmetic module is connected to the circuit module. The display module signal is connected to the calculation module.

Another aspect of the present invention is to provide a pulse measurement method, which includes the following steps: performing a positioning adjustment step, which is to align an imaging module to one of the subjects through an image positioning assistance method The wrist area, and adjust the imaging module and a structured light projection device to a measurement position, where the wrist area includes at least one of the three parts of inch, close and ruler; perform a shooting step, which is captured by the imaging module Image information of a wrist area; performing an operation step, which uses an operation module to analyze the aforementioned image information to obtain an operation result; performing a comparison step, which uses an operation module to compare the aforementioned operation result with an The pulse classification data set is compared to output the pulse measurement result of one of the subjects.

In this way, the optical pulse wave image measuring instrument and the pulse image measuring method of the present invention use the imaging module to automatically capture the image information of the wrist area of the subject, and perform calculation and analysis through the computing module to further visualize the pulse information At the same time, it can also standardize the pulse measurement method and its results and other data at the same time, avoiding the result error caused by the conventional use of palpation or pressure pulse detection, and then provide an objective and accurate pulse measurement result.

100‧‧‧Optical pulse wave image measuring instrument

110‧‧‧Dock

111‧‧‧Relying on the wrist pulse pillow

120‧‧‧Outer cover

200‧‧‧Imaging module

202‧‧‧Imaging polarizer

204‧‧‧Imaging lens

206‧‧‧Image sensor

208‧‧‧synchronous circuit

300‧‧‧Light source module

302‧‧‧Light source polarizer

304‧‧‧Light source

308‧‧‧synchronous circuit

400‧‧‧circuit module

402‧‧‧Power circuit

404‧‧‧Control circuit

406‧‧‧Drive circuit

408‧‧‧Data transmission circuit

500‧‧‧ arithmetic module

600‧‧‧Display module

700‧‧‧Structured light projection device

702‧‧‧Light source polarizer

704‧‧‧Structured light source

708‧‧‧synchronous circuit

720‧‧‧Digital micromirror device

730‧‧‧Reflecting mirror

800‧‧‧Mobile module

900‧‧‧Pulse measurement method

910, 920, 930, 940‧‧‧ steps

11‧‧‧ wrist area

A‧‧‧ area to be tested

P‧‧‧Projection stripes

R‧‧‧beam

In order to make the above and other objects, features, advantages and embodiments of the present invention more obvious and understandable, the drawings are described as follows: FIG. 1 illustrates an optical pulse wave image measuring instrument according to an embodiment of the present invention. Schematic architecture; Figure 2 is a schematic diagram of an optical pulse wave image measuring instrument according to an embodiment of the present invention; Figure 3 is a partial cross-sectional view of the optical pulse wave image measuring instrument of the embodiment of Figure 2; Figure 4 is an imaging module and structure of the optical pulse wave image measuring instrument of the embodiment of Figure 3 An enlarged schematic diagram of the light projection device and the mobile module; FIG. 5 is an enlarged schematic diagram of the structured light projection device and the mobile module of the optical pulse wave image measuring instrument of the embodiment of FIG. 4; FIG. 6 is a schematic diagram of the first 5 is an enlarged schematic view of the structured light projection device of the optical pulse wave image measuring instrument of the embodiment of FIG. 5; FIG. 7 is a schematic view showing the operating state of the optical pulse wave image measuring instrument of the embodiment of FIG. 2; and FIG. A flowchart of a pulse measurement method according to another embodiment of the invention is shown.

Hereinafter, a plurality of embodiments of the present invention will be described with reference to the drawings. For clarity, many practical details will be explained in the following description. However, it should be understood that these practical details should not be used to limit the present invention. That is to say, in some embodiments of the present invention, these practical details are unnecessary. In addition, for the sake of simplifying the drawings, some conventionally used structures and elements will be shown in a simple schematic manner in the drawings; and repeated elements may be indicated by the same number.

Please refer to FIG. 1, FIG. 2 and FIG. 3, FIG. 1 is a schematic structural diagram of an optical pulse wave image measuring instrument according to an embodiment of the present invention. FIG. 3 is a schematic diagram of an optical pulse wave image measuring instrument 100 according to an example of an embodiment of the present invention, and FIG. 3 is a partial cross section of the optical pulse wave image measuring instrument 100 according to the example of FIG. 2. Illustration. The present invention aims to provide an optical pulse wave image measuring instrument 100 for detecting the pulse state of a region A to be measured of a subject (not shown), which includes a base 110, a cover 120, and an imaging The module 200, a light source module 300, a structured light projection device 700, a circuit module 400, an arithmetic module 500, and a display module 600.

The base 110 may include a measuring and positioning assisting device (not shown in the figure) and an auxiliary wrist fixing jig (not shown in the figure) to assist in placing the area A to be measured in an appropriate position. Preferably, the base 110 may include a wrist pillow 111 (shown in FIG. 3) to increase the efficiency of wrist fixation. The cover 120 is disposed on the base 110. Preferably, the cover 120 can be used to block all ambient light sources in the area A to be measured. Specifically, the cover 120 may be a shielding environmental interference baffle to block all interference light from the surrounding environment, and the material of the cover 120 may be a full-band non-penetrating material, but the invention is not limited thereto.

The imaging module 200 is disposed in the housing 120, and the imaging module 200 captures an image of the area A to be measured at a direction angle. The imaging module 200 may include an imaging polarizer 202, an imaging lens 204, an image sensor 206, and a synchronization circuit 208, wherein the imaging polarizer 202 may include a linear polarizer, and the imaging lens 204 may include a plurality of lenses As for the number of lenses and their arrangement, it is not the main feature of the present invention, and it will not be repeated here. The image sensor 206 can be a charge-coupled device (CCD) or a complementary metal oxide semiconductor (Complementary oxide semiconductor) metal-oxide-semiconductor (CMOS), and the invention is not limited thereto.

The light source module 300 is disposed on one side of the imaging module 200, and the light source module 300 may include a light source 304, a light source polarizer 302, and a synchronization circuit 308, wherein the light source polarizer 302 may include a linear polarizer, and the imaging module The imaging polarizer 202 of the group 200 and the light source polarizer 302 of the light source module 300 may be orthogonally arranged, but the invention is not limited thereto. Specifically, the light source module 300 may be disposed on at least one side of the imaging module 200 or coaxially with the imaging module 200. The light source 304 may be an illumination device such as a light-emitting diode (LED) flash lamp, a stroboscopic lamp (Stroboscopic lamp) or a Lamp light source. However, it should be noted that the number of light source modules 300 can be configured as two or more according to actual needs. The two light source modules 300 are arranged around the periphery of the imaging module 200, so as to provide more The brightness is good, and the present invention is not limited to the content disclosed in the foregoing description and drawings.

The structured light projection device 700 is disposed in the housing 120 to provide a structured light in the area A to be measured, and the structured light projection device 700 may include a structured light source 704, a light source polarizer 702, and a synchronization circuit 708, wherein the light source polarizer 702 may include a linear polarizer, and the imaging polarizer 202 of the imaging module 200 and the light source polarizer 702 of the structured light projection device 700 may be orthogonally arranged, but the invention is not limited thereto. Specifically, the structured light projection device 700 utilizes non-contact spatial frequency domain imaging (SFDI) for structured light projection, and captures the reflected light after the structured light is projected onto the area to be measured A, and according to Wait Change the light wave signal presented by the reflected light in the measurement area A to calculate the pulsation position, pulsation depth and other information, and then obtain the pressure waveform generated by the hemodynamic change of the blood vessel in the measurement area A to change the diameter width and height of the blood vessel A dependent variable of direction or surrounding organization. Preferably, the structured light projection device 700 may include a digital optical processing projector (DLP Projector) or a liquid crystal projector (LCD Projector), and the digital optical processing projector may include a digital micromirror device (Digital Micromirror Device) and a digital Micromirror device control module (not shown). Furthermore, the light source spectrum of the structured light projection device 700 may include a visible light band (wavelength range of about 400 nm to 700 nm) to a near infrared light band (Near InfraRed, NIR, wavelength range of about 700 nm to 1000 nm).

The circuit module 400 may be disposed in the base 110 and electrically connect the imaging module 200, the light source module 300, and the structured light projection device 700, and the circuit module 400 may include a power circuit 402, a control circuit 404, and a driver Circuit 406 and a data transmission circuit 408, wherein the control circuit 404 can be used to control the circuit power supply that may be included in the aforementioned components, and the data transmission circuit 408 can be used to transmit the information of the image captured by the imaging module 200 to the operation Module 500. In addition, the data transmission circuit 408 may include a wireless communication transmission module (not shown) or a wired communication transmission module (not shown), wherein the wireless communication transmission module may be a Bluetooth wireless communication transmission module , An infrared wireless communication transmission module or a wireless local area network module, but the invention is not limited thereto.

The signal of the arithmetic module 500 is connected to the circuit module 400, so that the data transmission circuit 408 of the circuit module 400 receives the capture of the imaging module 200 Image information, and analyze and calculate the aforementioned image information through the arithmetic module 500 to output a pulse measurement result. Preferably, the computing module 500 may include a computer processor, a mobile device computing unit, or a module that can complete the foregoing actions, such as a microcontroller (Micro Controller Unit, MCU), a central processing unit (Central Processing Unit, CPU) ), advanced reduced instruction set machine (Advanced RISC Machine, ARM), digital signal processor (Digital Signal Processor, DSP) or smart mobile device, but the invention is not limited to this. Preferably, the arithmetic module 500 can analyze the image information of the image of the area A to be measured by a non-contact spatial frequency domain image (SFDI) demodulation algorithm, such as the pressure generated by the hemodynamic changes of the blood vessels in the wrist area The waveform changes to a dependent variable of the diameter and height direction of the blood vessel or the surrounding tissue, and the measured stress and strain curves are used to observe the change of the pressure wave to the pulse structure to obtain objective and standardized pulse measurement results .

The signal of the display module 600 is connected to the arithmetic module 500 to receive and display information such as image and pulse measurement results. The display module 600 may include a display, a wired display device, or a wireless display device. Specifically, the computing module 500 can be built in a mobile device or a personal computer, or can be integrated and built on the housing 120 or the base 110, and the present invention is not limited to any embodiment or example .

In addition, as shown in FIG. 1, the optical pulse wave image measuring instrument 100 may further include a mobile module 800 connected to the imaging module 200, and the imaging module 200 and the structured light projection device 700 can pass through the mobile module 800 And synchronous displacement. Preferably, the mobile module 800 may include a motor, a pneumatic cylinder, a micro-electromechanical, etc. The moving source may include a moving mechanism (not shown) to drive the imaging module 200 and the structured light projection device 700 to move in the vertical direction, horizontal direction, and oblique direction, thereby projecting the imaging module 200 and the structured light The device 700 is adjusted to an appropriate shooting position.

Please refer to FIG. 2 and FIG. 3, the optical pulse wave image measuring instrument 100 is used to detect the pulse state at the wrist area 11 of the subject (that is, the aforementioned area A to be measured), and the optical pulse wave image volume The architecture of the measuring instrument 100 is roughly as shown in FIG. 1, which includes a base 110, a housing 120, an imaging module 200, a light source module 300, a structured light projection device 700, a circuit module 400, An arithmetic module 500 and a display module 600.

The base 110 of the optical pulse wave image measuring instrument 100 may be a rectangular base, and the cover 120 is a generally semi-circular shell disposed on the base 110 to block all ambient light. Specifically, the aforementioned shading range is located between the base 110 and the cover 120, and the area to be measured is located in the shading range of the cover 120, so as to further prevent external light sources from affecting the accurate pulse measurement of the optical pulse wave image measuring instrument 100 degree.

The imaging module 200 is disposed inside the cover 120 and captures image information of the wrist area 11 at an angle. The imaging range of the imaging module 200 is about 50 mm ² to 100 mm ² . The light source module 300 is arranged around the imaging module 200 and abuts on the cover 120, and the area to be measured (not shown) is located in the shading range of the cover 120 and is the imaging module 200, the light source module 300 and The structured light projection device 700 is surrounded to provide sufficient light when the optical pulse wave image measuring instrument 100 of the present invention measures the pulse image at the wrist area 11 of the subject. Preferably, in the embodiments of FIGS. 2 and 3, the number of the light source modules 300 may be two, the two light source modules 300 are arranged around the imaging module 200 relative to each other, and the two light source modules The 300 series respectively abut against the outer cover 120 to effectively maintain the size of the space in the outer cover 120 and provide sufficient light sources for it, but the invention is not limited thereto.

Please refer to FIG. 4, FIG. 5 and FIG. 6 at the same time. FIG. 4 illustrates the imaging module 200, structured light projection device 700 and mobile module of the optical pulse wave image measuring instrument 100 of the embodiment of FIG. 3. 800 is an enlarged schematic diagram, FIG. 5 is an enlarged schematic diagram of the structured light projection device 700 and the mobile module 800 of the optical pulse wave image measuring instrument 100 of the embodiment of FIG. 4, and FIG. 6 is a diagram showing the fifth An enlarged schematic view of the structured light projection device 700 of the optical pulse wave image measuring instrument 100 of the embodiment shown in the figure.

The structured light projection device 700 is disposed in the housing 120 and adjacent to the imaging module 200, and the structured light projection device 700 may include a structured light source 704, a digital micromirror device 720, and a reflection mirror 730, and an optical pulse wave image The measuring instrument 100 may further include a mobile module 800. In detail, the structured light source 704 will emit a light beam R, and the light beam R will be reflected by the mirror 730 into the digital micromirror device 720, and the digital micromirror device 720 will further process the optical properties of the light beam R to produce The structured light of the projection fringe P is then projected by the digital micromirror device 720 to the wrist area 11, and the imaging module 200 collects the light reflected by the wrist area 11 to facilitate subsequent analysis. The mobile module 800 is connected to the imaging module 200 and further connected to the structured light projection device 700, and the imaging module 200 and the structured light projection device 700 can be synchronously displaced through the mobile module 800. Preferably, the mobile module 800 may include a moving mechanism (not shown) to drive the imaging module 200 and the structured light projection device 700 to move in the vertical direction, horizontal direction, tilt direction, and rotation direction to project the imaging module 200 and the structured light The device 700 reaches a measurement position.

In addition, the other components of the optical pulse wave image measuring instrument 100 in FIGS. 2 and 3, such as the circuit module 400, the calculation module 500, and the display module 600, have already been described above, and will not be repeated here.

The following will refer to FIG. 7 and FIG. 8 together to explain the method of performing pulse image measurement by the optical pulse wave image measuring instrument 100 of the present invention. Please refer to FIG. 7 and FIG. 8, FIG. 7 is a schematic diagram illustrating the operation state of the optical pulse wave image measuring instrument 100 of the embodiment of FIG. 2, and FIG. 8 is another embodiment of the present invention. A flowchart of a pulse measurement method 900. The pulse measurement method 900 includes steps 910, 920, 930, and 940.

Step 910 is a positioning adjustment step, which is to align the imaging module 200 to the wrist area 11 of the subject through the image positioning assistance method, and adjust the imaging module 200 and the structured light projection device 700 to a certain amount To measure the position, the wrist area 11 includes at least one of three parts: an inch, a close, and a ruler (not shown in the figure). In detail, when the subject wants to use the optical pulse wave image measuring instrument 100 of the present invention to perform pulse image measurement, the subject will first place the palm-up position between the base 110 and the cover 120 for shading In the range, place the wrist area 11 on the pedestal 111 of the base 110 to locate the wrist area 11 to the correct measurement position, and adjust the height of the subject's wrist area 11 to be flush with the heart At this time, the optical pulse wave image measuring instrument 100 will modulate the structured light source 704 and the structure of the structured light projection device 700 at a spatial frequency, respectively. Like the module 200, to find the extension direction of the radial artery or the peripheral blood vessels in the wrist area 11, and to find the most obvious place of the pulsation of the radial artery, so as to locate the three parts of the inch, the close and the ruler.

Preferably, the positioning adjustment step can further drive the imaging module 200 and the structured light projection device 700 through the moving module 800 to perform synchronous displacement in the vertical direction, the horizontal direction, the tilt direction, and the rotation direction, so as to move the imaging module 200 and the structured light The projection device 700 moves to an optimal measurement position. In addition, the positioning adjustment step can adjust the positions of the imaging module 200 and the structured light projection device 700, so that the field of view of the imaging module 200 includes the three positions of the wrist area 11 at the same time, so that Measure the pulse at the three parts of the ruler. Preferably, the wavelength range of the light source spectrum of the aforementioned structured light projection device 700 ranges from the visible light band (wavelength range is 400nm-700nm) to the near infrared light band (wavelength range is 700nm-1000nm). Specifically, the image positioning assistance method uses the skin surface texture features and structured light modulation to calculate height information to detect the characteristics of the wrist area 11, and uses an image sensor and the light source spectrum of the structured light projection device 700 to perform image positioning. In order to find the position of the close part, the position of the close part extending about 10mm to the palm along the blood vessel extending direction is the inch part, and the position of the close part extending about 10mm to the elbow along the blood vessel extending direction is the ruler, in which the aforementioned image The sensor may be an RGB sensor, but the invention is not limited thereto.

Step 920 is a photographing step, which uses the imaging module 200 to capture image information of the wrist region 11, wherein the image information of the wrist region 11 includes the data of the diameter and width of the blood vessel and the data of the height of the blood vessel or the surrounding tissue Deformation information. In detail, the shooting step is to capture the different measurement points of the wrist area 11 in different spaces through the synchronous high-speed photography method through the structured light source 704 and the imaging module 200 whose frequency conversion rate is 0.0142mm ^-1 to 0.5mm ^-1 Frequency-modulated image, wherein the spatial frequency of structured light can include the modulated image with the lowest frequency to zero (that is, the structured light component is not included in the light source), and the spatial frequency modulation up to the resolution of the imaging module 200 image.

In addition, the synchronous high-speed photography method may include the steps of simultaneously updating the structured light source 704 and the imaging module 200, wherein the synchronous update rate of the structured light source 704 and the imaging module 200 satisfies the sampling of the Nyquist Theorem The frequency is about 120 FPS (Frame per Second) to 240 FPS or more sampling frequency to avoid aliasing of the pulse wave.

Step 930 is an operation step, which uses the operation module 500 to analyze the image information to obtain an operation result. In detail, the calculation module 500 first calculates the degree of bending of the projected fringe P of the structured light by the wrist area 11, and then uses the calculation module 500 to demodulate the projected fringe with a non-contact spatial frequency domain image demodulation algorithm The degree of curvature of P to obtain the phase information of the wrist area 11, and convert the aforementioned phase information into the diameter of the blood vessel and the deformation data of the height of the blood vessel or the deformation data of the surrounding tissue, and analyze the hemodynamic changes of the blood vessel The diameter width and height direction of the blood vessel caused by the pressure waveform change or the dependent variable of the surrounding tissue to obtain information such as the position of the radial artery or the peripheral blood vessel and the depth of the blood vessel, and then reconstruct the blood vessel distribution and unit time of the wrist area 11 The result of the operation in the situation of the change of the pulse.

Step 940 is a comparison step, which uses the calculation module 500 to compare the foregoing calculation result with a pulse classification data set to output a pulse measurement result of the subject. In detail, the pulse classification data set includes a total of 28 types of pulse characteristics in six categories: floating, sinking, virtual, real, late, and counting, and the calculation module 500 compares the calculation results with the aforementioned 28 types of pulse characteristics Compare to provide corresponding pulse measurement results.

In summary, the optical pulse wave image measuring instrument of the present invention uses the imaging module to automatically capture the image information of the wrist area of the subject, and performs calculation and analysis through the calculation module to further visualize the pulse information, and The pulse measurement technique and its results can be standardized at the same time, to avoid the result error caused by the conventional use of palpation or pressure pulse detection. Furthermore, the pulse measurement method of the present invention applies non-contact spatial frequency domain imaging technology to pulse measurement, and automatically acquires pulse image information and calculation, and compares the results with the pulse classification data set , To assist Chinese medicine practitioners to carry out pulse and diagnosis, and then provide an objective and accurate pulse measurement results.

Although the present invention has been disclosed as above in an embodiment, it is not intended to limit the present invention. Anyone who is familiar with this art can make various modifications and retouching without departing from the spirit and scope of the present invention, so the protection of the present invention The scope shall be as defined in the appended patent application scope.

200‧‧‧Imaging module

202‧‧‧Imaging polarizer

204‧‧‧Imaging lens

206‧‧‧Image sensor

208‧‧‧synchronous circuit

300‧‧‧Light source module

302‧‧‧Light source polarizer

304‧‧‧Light source

308‧‧‧synchronous circuit

400‧‧‧circuit module

402‧‧‧Power circuit

404‧‧‧Control circuit

406‧‧‧Drive circuit

408‧‧‧Data transmission circuit

500‧‧‧ arithmetic module

600‧‧‧Display module

700‧‧‧Structured light projection device

702‧‧‧Light source polarizer

704‧‧‧Structured light source

708‧‧‧synchronous circuit

800‧‧‧Mobile module

A‧‧‧ area to be tested

Claims (21)

An optical pulse wave image measuring instrument includes: a base; an outer cover, which is arranged on the base; an imaging module, which is arranged in the outer cover, and the imaging module is used to capture an area to be measured An image; a light source module, disposed on one side of the imaging module; a structured light projection device, disposed in the housing, wherein the light source spectrum of the structured light projection device includes a visible light band to a near infrared light band A circuit module that electrically connects the imaging module and the light source module; an arithmetic module that signals connect to the circuit module; and a display module that signals connect to the arithmetic module. The optical pulse wave image measuring instrument described in item 1 of the patent application scope further includes: a mobile module connected to the imaging module. The optical pulse wave image measuring instrument as described in item 2 of the patent application scope, wherein the imaging module and the structured light projection device are simultaneously displaced through the moving module. The optical pulse wave image measuring instrument as described in item 1 of the patent application scope, wherein the base includes a wrist pillow that bears the wrist. The optical pulse wave image measuring instrument as described in item 1 of the patent application scope, wherein the outer cover is used to block all surrounding ambient light of the area to be measured. The optical pulse wave image measuring instrument as described in item 1 of the patent application scope, wherein the imaging module includes an imaging polarizer, an imaging lens, an image sensor and a synchronization circuit. The optical pulse wave image measuring instrument as described in item 6 of the patent application scope, wherein the light source module includes a light source polarizer, a light source and a synchronization circuit. An optical pulse wave image measuring instrument as described in item 1 of the patent application scope, wherein the structured light projection device includes a digital optical processing projector. An optical pulse wave image measuring instrument as described in item 8 of the patent application range, wherein the digital optical processing projector includes a digital micromirror device and a digital micromirror device control module. The optical pulse wave image measuring instrument as described in item 2 of the patent application scope, wherein the moving module includes: a moving mechanism for driving the imaging module and the structured light projection device in the vertical direction, horizontal direction and tilt Direction of movement. An optical pulse wave image measuring instrument as described in item 6 of the patent application range, wherein the structured light projection device includes a light source polarizer, a structured light source, and a synchronization circuit. The optical pulse wave image measuring instrument as described in item 1 of the patent application scope, wherein the computing module includes a computer processor or a computing device of a mobile device. A pulse waveform variable measurement method includes the following steps: performing a positioning adjustment step, which is to align an imaging module to a wrist area of a subject through an image positioning assistance method, and adjust the imaging A module and a structured light projection device to a measurement position, wherein the wrist area includes at least one of three parts: an inch, a close and a ruler, wherein a light source spectrum of the structured light projection device includes a visible light band to a near infrared light band Performing a photographing step, which uses the imaging module to capture image information of the wrist area; and performing an arithmetic step, which uses an arithmetic module to analyze the image information to obtain a pulse waveform change operation result. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the positioning adjustment step is to modulate the light source spectrum of the structured light projection device and the light source spectrum of the imaging module at a spatial frequency to locate the Wrist area. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the shooting step is to acquire modulated image information of a plurality of measurement points of the wrist area by a synchronous high-speed photography method, wherein each measurement The point has a spatial frequency. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the calculation step is to use the calculation module to analyze the image information of the wrist region with a non-contact spatial frequency domain image demodulation algorithm. The pulse waveform variable measurement method as described in item 13 of the patent application range, wherein the image information of the wrist area includes a vessel diameter width deformation data and a blood vessel height direction deformation data or peripheral tissue deformation data. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the image positioning auxiliary method uses an image sensor and the light source spectrum of the structured light projection device for image positioning, and the structured light projection device The frequency band of the light source spectrum ranges from the visible light band to the near infrared light band. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the image positioning assistance method uses a skin surface texture feature and a structured light modulation to calculate height information to locate the wrist area. The pulse waveform variable measurement method as described in item 13 of the patent application scope, wherein the adjustment step is to adjust the position of the imaging module and the structured light projection device so that a field of view of the imaging module includes the wrist area , Where the wrist area contains the inch, close and ruler parts. The pulse waveform variable measurement method as described in item 16 of the patent application scope, wherein the non-contact spatial frequency domain image demodulation algorithm is to analyze the pressure waveform generated by the hemodynamic change of the blood vessel in the wrist area. It is a dependent variable on the width and height of the blood vessel or the surrounding tissue.

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