TWI683676B - Antimicrobial kit and article - Google Patents

Abstract

An antimicrobial kit is provided. The antimicrobial kit includes an antimicrobial agent and a cloth. The antimicrobial agent includes chlorhexidine gluconate, and the cloth can carry 0.025 to 0.075 milliliter of the antimicrobial agent per square centimeter to topically deliver 0.1 to 1.25 milligrams of chlorhexidine gluconate to a square centimeter of skin. The cloth is not preloaded with antimicrobial agent. An antibacterial article is also provided. The antibacterial article comprises a cloth. The cloth can carry 0.025 to 0.075 milliliter of the antimicrobial agent per square centimeter, and the antimicrobial agent includes chlorhexidine gluconate, wherein the cloth is used to topically deliver 0.1 to 1.25 milligrams of chlorhexidine gluconate to a square centimeter of skin.

Description

Antimicrobial kits and supplies

The invention relates to an antimicrobial kit and supplies, and in particular to an antimicrobial kit and supplies with an antimicrobial agent and a fabric carrier.

Medical infection is a major issue in global disease management. Infection at the surgical site, in addition to increasing medical costs and length of hospital stays, also increases the risk of sepsis and death. "The Pioneer Research Project to Promote Combined Care Measures to Reduce Surgical Site Infections" 2016 research report pointed out that the implementation rate of preoperative bathing measures is low. A variety of microorganisms are fixed on the human skin, which is the main source of infection when wounds are generated on the skin surface. If the disinfection of the skin surface is incomplete, the microorganisms in the skin epidermal cell layer will enter the body through medical surgery, invasive medical treatment or wound treatment, causing medical infections. Therefore, improving the execution rate of preoperative bathing and strengthening the preoperative skin preparation should be one of the ways to effectively reduce the infection rate at the surgical site.

In recent years, as the population is aging, and there are more and more patients who need special care or long-term care due to special diseases such as AIDS, uremia, and traumatic sequelae, infection control requirements for special care or long-term care institutions Increased, and the implementation of infection control within the organization More and more attention. In particular, the elderly and patients in need of long-term care are weak, and there is a higher risk of skin-contact infectious diseases and respiratory tract infectious diseases "group infection" incidents. Therefore, it is necessary to strengthen the monitoring and control of infections in the organization. Protective measures and caregiver awareness are very important.

In addition, when medical personnel perform clinical medical measures, especially emergency medical measures, such as disinfecting the patient's skin in an ambulance or in an emergency department, they often directly dip cotton swabs and gauze towels into the disinfectant bottle and then on the skin Wipe the surface for disinfection. However, under emergency conditions, bottles and cans are less convenient to operate and are prone to cross-infection. The disinfectant remaining after the disinfection operation may not be used again, which also wastes resources.

In view of this, how to reduce the risk of infection after the implementation of invasive medical treatment, strengthen clinical emergency medical measures and infection control in long-term care institutions, and at the same time effectively, appropriately and conveniently use disinfectants, the existing technology needs to be improved.

In order to solve the problems described in the prior art, the purpose of the present disclosure is to provide an antimicrobial kit and an antimicrobial article to reduce the risk of infection after implementing invasive medical treatment, strengthen clinical emergency medical measures and long-term care Infection control within the organization, and it is convenient for users to effectively and appropriately use the effect of antimicrobial agents.

The present disclosure provides an antimicrobial kit comprising an antimicrobial agent and a fabric carrier. The antimicrobial agent contains chlorhexidine gluconate (CHG), and the fabric carrier can carry the antimicrobial agent from 0.025 ml to 0.075 ml (mL/cm ² ) per square centimeter, for topical administration of the skin 0.1 per square centimeter To 1.25 mg of chlorhexidine gluconate, and the fabric carrier does not carry antimicrobial agents in advance.

In some embodiments, the antimicrobial agent is an aqueous solution of chlorhexidine gluconate from 0.1% to 10% (w/v%) by weight.

In some embodiments, the antimicrobial agent is packaged in a container, and the material of the container includes, but is not limited to polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof .

In some embodiments, the fabric carrier has a porous network structure.

In some embodiments, the thickness of the fabric carrier is 30 grams to 100 grams per square meter (g/m ² ). In some embodiments, the thickness of the fabric carrier is 95 g/m ² .

In some embodiments, the fabric carrier is square or rectangular.

In some embodiments, the fabric carrier can release the carried antimicrobial agent onto the skin without residue.

In some embodiments, the material of the fabric carrier includes, but is not limited to polyester fiber, rayon, or a combination thereof.

In some embodiments, the fabric carrier is made of 100% polyester fiber and can carry 0.045 to 0.065 milliliters (mL/cm ² ) of antimicrobial agent per square centimeter.

The disclosure also provides an antimicrobial article comprising a fabric carrier, the fabric carrier carrying 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate. Among them, the fabric carrier is used to locally administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter of skin.

In some embodiments, the antimicrobial product is packaged in a container, and the material of the container includes, but is not limited to, polyethylene, polyethylene terephthalate, or a combination thereof.

The disclosure also provides an antimicrobial article, comprising a plurality of fabric carriers, each fabric carrier carrying 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate. Among them, each fabric carrier is used to locally administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter of skin.

In some embodiments, each fabric carrier carries 30 milliliters of antimicrobial agent, and the antimicrobial agent is an aqueous solution of chlorhexidine gluconate 2% by weight.

In some embodiments, the number of these fabric carriers is eight, and they are packed in a container, and the material of the container is polyethylene.

The disclosure also provides an antimicrobial article comprising at least one fabric carrier, at least one fabric carrier carrying 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate, wherein at least one fabric The carrier is for topical administration of 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter of skin.

In some embodiments, at least one fabric carrier is attached Soaking in the antimicrobial agent, so that at least one fabric carrier after soaking carries 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter.

In some embodiments, the fabric carrier is made of polyester fiber and carries 0.045 to 0.065 milliliters of antimicrobial agent per square centimeter.

In some embodiments, eight fabric carriers are included, and the eight fabric carriers are used for shoulder and neck positions, chest, arms to palms, front sides of legs, lower abdomen, lower neck to back, back sides of legs, and From waist to hip.

In some embodiments, the eight fabric carriers are used in order for shoulder and neck positions, chest, arms to palms, front of legs, lower abdomen, lower neck to back, back of legs, and back waist To the buttocks.

In some embodiments, the antimicrobial article is used before performing an invasive medical treatment.

In some embodiments, an antimicrobial article is used before bathing before performing an invasive medical treatment.

In some embodiments, the antimicrobial article is used once daily on the day of the invasive medical treatment and the first three days.

In some embodiments, the antimicrobial article is used daily to heal where the invasive medical treatment is performed after the invasive medical treatment.

As mentioned above, the antimicrobial kits and antimicrobial supplies of the present disclosure all include antimicrobial agents containing chlorhexidine gluconate and fabric carriers. The anti-microbial kit and anti-microbial supplies of the present disclosure, because the fabric carrier can wipe a larger area, it is more convenient to use, and an appropriate amount of anti-microbial agent can be used while still achieving an effective amount of disinfection. In some embodiments, the antimicrobial kit or antimicrobial article contains eight fabric carriers The body can be used for shoulder, neck, chest, arms to palm, front of legs, lower abdomen, lower neck to back, back of legs, and back waist to buttocks, to avoid cross-contamination and implement disinfection effect. If the antimicrobial kit and antimicrobial supplies are used in patients undergoing invasive medical treatment, the risk of infection after invasive medical treatment can be reduced; if it is used in patients in special care institutions or long-term care institutions, it can be Reduce the risk of infection in the organization to strengthen the infection control in the organization; if it is used in the implementation of clinical medical measures, it can facilitate the user to effectively and appropriately use antimicrobial agents.

10‧‧‧ shoulder and neck

20‧‧‧ chest

30‧‧‧ arms to palm

40‧‧‧front of legs

50‧‧‧ lower abdomen

60‧‧‧ Lower neck to back

70‧‧‧Back of legs

80‧‧‧ from waist to hip

The above and other aspects, features and other advantages of the present invention can be more clearly understood with reference to the description and the accompanying drawings, in which: Figure 1 shows a schematic diagram of the fabric carrier of the present disclosure on the frontal skin wiping area of the human body.

FIG. 2 is a schematic diagram of the fabric carrier of the disclosure in the skin wiping area on the back of the human body.

In order to make the description of the present disclosure more detailed and complete, the embodiments and specific embodiments of the present invention will be described below with reference to the drawings; however, this is not the only form for implementing or using specific embodiments of the present disclosure. The embodiments disclosed below can be combined or replaced with each other under beneficial circumstances, and other embodiments can be added to an embodiment without further description or description.

The words "include", "include", "have" and similar words used in this article indicate the features, regions, integers, steps, operations, elements and/or components described therein, but do not exclude other features, regions, Integers, steps, operations, elements, components, and/or groups thereof.

Herein, the term "container" is used herein to mean including, but not limited to, fixed shapes and non-fixed shapes, such as bags, cans, bottles or tubes.

The antimicrobial kit of various embodiments of the present invention includes an antimicrobial agent and a fabric carrier. The antimicrobial agent comprises chlorhexidine gluconate, which may be an aqueous solution of chlorhexidine gluconate 0.1% to 10% (w/v) by weight, preferably 1.6% to 2.4% (w/v) chlorine gluconate The hexidine aqueous solution is more preferably a 2% (w/v) chlorhexidine gluconate aqueous solution.

The fabric carrier has a porous network structure, and the pores of the porous network structure can absorb the antimicrobial agent, thereby effectively carrying and carrying the antimicrobial agent, and the antimicrobial agent carried by the fabric carrier can be completely released during use. Taking a fabric carrier with an area of 600 square centimeters as an example, it can carry 15 to 45 milliliters of antimicrobial agent, that is, each square centimeter of fabric carrier can carry 0.025 milliliters to 0.075 milliliters of antimicrobial agent, preferably 0.045 milliliters to 0.065 milliliters. Preferably, it is 0.05 ml, and chlorhexidine gluconate 0.1 to 1.25 mg per square centimeter is applied topically to the skin. The thickness of the fabric carrier is 30 g/m ² to 100 g/m ² , preferably 95 g/m ² . If the chlorhexidine gluconate aqueous solution carried by the fabric carrier is less than 0.025mL/cm ² , the chlorhexidine gluconate aqueous solution released to the skin surface is not enough to achieve the disinfection effect; 0.075mL/cm ² is the fabric carrier can carry The upper limit of the chlorhexidine gluconate aqueous solution exceeds the upper limit and the chlorhexidine gluconate aqueous solution will drip, increasing the difficulty of operation.

In one embodiment, the size of the fabric carrier is 20x30 cm and can carry 30 ml of antimicrobial agent, wherein the antimicrobial agent is 2% (w/v) chlorhexidine gluconate in water. According to the statistics of the Ministry of Health and Welfare and the calculation formula of body surface area: body surface area (square meters) = (weight (kg) x height (cm)/3600) ^1/2 , the average body surface area range from 2 years old to adult Chinese can be calculated From 5812 square centimeters to 18641 square centimeters. If 8 pieces of fabric carrier are used to wipe the whole body skin, it can be calculated that the fabric carrier carrying 600 mg of chlorhexidine gluconate per tablet can be locally administered with 0.25 mg to 0.83 mg of antimicrobial agent per square centimeter of skin.

The fabric carrier has the property of releasing the carried antimicrobial agent onto the skin without residue. In some embodiments, the material of the fabric carrier is a 100% polyester non-woven fabric. In some embodiments, the material of the fabric carrier may be a non-woven fabric composed of polyester fiber and Rayon, such as a non-woven fabric blended by fifty percent polyester fiber and fifty percent Rayon. The present invention does not limit the shape of the fabric carrier. The fabric carrier may preferably be rectangular, including square, rectangular and other shapes. In some embodiments, when used for large-area wiping, the fabric carrier may be designed to be rectangular, for example, 20x30 cm. A square-shaped fabric carrier is liable to curl when wiped and disinfected in a large area, and is unfavorable for wiping, while a rectangular fabric carrier is wiped and disinfected in a large area. It has the advantages of not easy to curl and easy to apply force.

The fabric carrier of the present invention has a porous network structure and thickness, which can protect the skin from excessive physical friction damage during clinical wiping. Therefore, in a preferred embodiment, the antimicrobial agent in the antimicrobial kit is 2% (w/v) chlorhexidine gluconate aqueous solution, and antimicrobial agent can maintain comfortable skin touch without moisturizing emollient ingredients.

The antimicrobial kit is a combined product. The fabric carrier and the antimicrobial agent are in separate compartments and in the same or different packaging. When used, the fabric carrier and the antimicrobial agent are mixed. The number of fabric carriers in the antimicrobial kit may be one fabric carrier or a plurality of fabric carriers. The antimicrobial agent in the antimicrobial kit can be contained in the bottle body, and the bottle body can be selected from materials that will not react with chlorhexidine gluconate to cause precipitation, without affecting the effectiveness of the antimicrobial agent. The aforementioned material may be, for example, polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof. Among them, polyethylene may include high-density polyethylene and low-density polyethylene. In a specific embodiment, the antimicrobial kit may include a 2% (w/v) chlorhexidine gluconate aqueous solution contained in the bottle and a fabric carrier contained in the bag. When in use, all the chlorhexidine gluconate aqueous solution is poured into the bag body, so that the fabric carrier is infiltrated in the chlorhexidine gluconate aqueous solution, and the fabric carrier carries a sufficient amount of chlorhexidine gluconate aqueous solution before taking it out for use.

The antimicrobial article contains an antimicrobial agent and a fabric carrier, and is a pre-bonded product, that is, the fabric carrier carries an antimicrobial agent in advance. The antimicrobial agent and the fabric carrier are the same as the antimicrobial agent and the fabric carrier of the aforementioned antimicrobial kit, which will not be repeated here.

In a specific embodiment, the manufacturing process of the antimicrobial article is to first dilute the 20% (w/v) chlorhexidine gluconate aqueous solution to pure water to 2% (w/v), and then 2% (w/v) ) The chlorhexidine gluconate aqueous solution is poured into At least one piece of nonwoven fabric is preferably 8 pieces of nonwoven fabric, and the antimicrobial article is obtained after sealing. Among them, the material of the bag body is polyethylene. In addition to the good sealing performance, the polyethylene bag body will not interact with chlorhexidine gluconate under long-term contact with the antimicrobial agent and cause the antimicrobial agent to precipitate, and does not affect the antimicrobial agent. Effect.

In some embodiments, an antimicrobial kit or antimicrobial article can be applied to the skin before performing an invasive medical treatment to reduce the risk of medical infections. The invasive medical treatment may be, for example, scalpel incision operation, puncture, insertion of catheter or drainage tube, and so on. Take the scalpel incision operation as an example: the patient takes a full body bath three days before the operation to the night before, and removes from the antimicrobial kit or antimicrobial supplies daily with 2% (w/v) chlorhexidine gluconate aqueous solution Wipe the whole body with the infiltrated fabric carrier; wipe the whole body again with antimicrobial kit or antimicrobial supplies on the day of surgery. After the invasive medical treatment, the antimicrobial kit or antimicrobial supplies can also be used to wipe the whole body or receive the invasive medical treatment until the invasive medical treatment is healed.

In one embodiment, the anti-microbial kit or anti-microbial article can be used for cleaning and disinfecting skin or utensils, and no need to wash with water after use. For example, patients in the intensive care unit and long-term care can wipe the whole body with antimicrobial kits or antimicrobial supplies daily to reduce the risk of nosocomial infection; patients after receiving invasive medical treatment can also use antimicrobial kits Or antimicrobial supplies to wipe the whole body or the affected area undergoing invasive medical treatment to reduce the risk of postoperative infection; during clinical treatment, especially in an emergency, such as emergency use of antimicrobial kits or antimicrobial supplies in ambulances For the disinfection of the patient's skin, with a package of multiple tablets containing 2% (w/v) chlorohexyl gluconate The combination of fabric carrier impregnated with a fixed aqueous solution to achieve the effect of convenient use and avoid wasting antimicrobial agents; medical equipment such as catheters can also be disinfected with antimicrobial kits or antimicrobial supplies before invasive medical treatment.

In one embodiment, when the antimicrobial kit or antimicrobial article is used, the fabric carrier carrying the antimicrobial agent is applied locally to the skin for disinfection and sterilization, and the single fabric carrier is used in a single partition to prevent cross infection . For example: establish an eight-step clinical use sequence according to the disinfection site required by the human body, wipe in this order to avoid cross infection, and divide the body into eight areas according to Figure 1 and Figure 2, which are the shoulder and neck positions on the front of the body 10 , Chest 20, arms to palm 30, front legs 40, lower abdomen 50, lower neck to back 60 on the back of the human body, back 70 legs, back waist to hip 80. The chest 20 may further include the chest and peripheral parts of the chest, and the back waist to the hip 80 may include the waist to the back of the joint between the hips and the thigh. When using anti-microbial kits or anti-microbial products, use a piece of fabric carrier carrying anti-microbial agents to wipe the skin to be cleaned and disinfected, and ensure that the skin is fully wiped with anti-microbial agents for 30 seconds Allow skin to dry naturally. After wiping with a microbial agent, the skin will show a sense of luster, and it can be judged that the skin has been sufficiently wiped with antimicrobial agent. In other embodiments, when the antimicrobial kit or antimicrobial article is used, a single sheet of fabric carrier carrying the antimicrobial agent can also be used in a single application to the local skin, which is not limited to the above usage.

As mentioned above, the antimicrobial kits and antimicrobial supplies of the present disclosure all include antimicrobial agents containing chlorhexidine gluconate and fabric carriers. The anti-microbial kits and anti-microbial articles of the present disclosure are more convenient to use because of the larger area that the fabric carrier can wipe. Appropriate use of antimicrobial agents while still achieving an effective amount of disinfection. In some embodiments, the antimicrobial kit or antimicrobial article includes eight fabric carriers, which can be used for shoulder and neck positions, chest, arms to palms, front legs, lower abdomen, lower neck to back, double The back side of the legs and the back waist to the buttocks, to avoid cross-contamination, and implement the disinfection effect. If the antimicrobial kit and antimicrobial supplies are used in patients undergoing invasive medical treatment, the risk of infection after invasive medical treatment can be reduced; if it is used in patients in special care institutions or long-term care institutions, it can be Reduce the risk of infection in the organization to strengthen the infection control in the organization; if used in the implementation of clinical medical measures, it can facilitate the user to effectively and appropriately use antimicrobial agents.

Although the present invention has been disclosed as above in the embodiments, it is not intended to limit the present invention. Any person who is familiar with this art can make various changes and modifications within the spirit and scope of the present invention, so the protection of the present invention The scope shall be determined by the scope of the attached patent application.

10‧‧‧ shoulder and neck

20‧‧‧ chest

30‧‧‧ arms to palm

40‧‧‧front of legs

50‧‧‧ lower abdomen

Claims (24)

An antimicrobial kit comprising: an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; and a fabric carrier, the fabric carrier can carry the antimicrobial agent from 0.025 ml to 0.075 ml per square centimeter for local administration The skin is 0.1 to 1.25 milligrams per square centimeter of the chlorhexidine gluconate, and the fabric carrier does not previously carry the antimicrobial agent, wherein the thickness of the fabric carrier is 30 to 100 grams per square meter. The antimicrobial kit according to claim 1, wherein the antimicrobial agent is a 0.1% to 10% by weight aqueous solution of chlorhexidine gluconate, and the antimicrobial agent is packaged in a container of the container The material includes polyethylene, polyethylene terephthalate or a combination thereof. The antimicrobial kit according to claim 1, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. An antimicrobial article, comprising: a fabric carrier carrying 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate; wherein the fabric carrier is used for local administration to the skin The chlorhexidine gluconate is 0.1 to 1.25 milligrams per square centimeter, wherein the thickness of the fabric carrier is 30 to 100 grams per square meter. The antimicrobial article according to claim 4, wherein the antimicrobial agent is an aqueous solution of chlorhexidine gluconate of 0.1% to 10% by weight. The antimicrobial article according to claim 4, wherein the fabric carrier has a porous network structure. The antimicrobial article according to claim 4, wherein the thickness of the fabric carrier is 95 grams per square meter. The antimicrobial article according to claim 4, wherein the fabric carrier is square or rectangular. The antimicrobial article according to any one of claims 4 to 8, wherein the fabric carrier discharges the antimicrobial agent without leaving the antimicrobial agent in the fabric carrier. The antimicrobial article according to claim 9, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. The antimicrobial article according to claim 10, wherein the fabric carrier is made of 100% polyester fiber and carries 0.045 to 0.065 ml of antimicrobial agent per square centimeter. The antimicrobial article according to claim 4, wherein the antimicrobial article is packaged in a container, and the material of the container comprises polyethylene, polyethylene terephthalate, or a combination thereof. An antimicrobial article, comprising: a plurality of fabric carriers, each fabric carrier carrying 0.025 ml to 0.075 ml of an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; wherein each of the fabric carriers is for local administration Chlorhexidine gluconate 0.1 to 1.25 mg per square centimeter of skin, wherein the thickness of the fabric carrier is 30 to 100 grams per square meter. The antimicrobial article according to claim 13, wherein each of the fabric carriers is made of 100% polyester fiber and carries 30 ml of antimicrobial agent, and the antimicrobial agent is chlorohexyl gluconate 2% by weight定Water solution. The antimicrobial article according to claim 13, wherein the number of the fabric carriers is 8 and they are packed in a container whose material is polyethylene. An antimicrobial article, comprising: at least one fabric carrier carrying 0.025 ml to 0.075 ml of antimicrobial agent per square centimeter, the antimicrobial agent comprising chlorhexidine gluconate; Wherein, the at least one fabric carrier is used to locally administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter of skin, wherein the thickness of the fabric carrier is 30 to 100 grams per square meter. The antimicrobial article according to claim 16, wherein the at least one fabric carrier is soaked in the antimicrobial agent such that the soaked at least one fabric carrier carries 0.025 ml to 0.075 ml of the antimicrobial agent per square centimeter. The antimicrobial article according to claim 16 or 17, wherein the fabric carrier is made of 100% polyester fiber and carries 0.045 to 0.065 ml of the antimicrobial agent per square centimeter. The antimicrobial article according to claim 16 or 17, comprising eight fabric carriers, which are used for shoulder and neck positions, chest, arms to palms, front sides of legs, lower abdomen, lower neck, respectively To the back, the back of the legs, and the waist to the hips. The antimicrobial article as described in claim 16 or 17 is used before invasive medical treatment. The antimicrobial article according to claim 20 is to be bathed before the invasive medical treatment, and then use the antimicrobial article. The antimicrobial article as described in claim 20 is used once a day on the day of the invasive medical treatment and on the first three days. The antimicrobial article as described in claim 20 is used daily after the invasive medical treatment has been carried out until the invasive medical treatment is received. The antimicrobial article according to claim 20, comprising eight fabric carriers, which are used for shoulder and neck positions, chest, arms to palms, front sides of legs, lower abdomen, lower neck to back, respectively , The back of the legs and the waist to the hips.

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