TWI735998B - Antimicrobial kit and article - Google Patents

Abstract

An antimicrobial kit is provided. The antimicrobial kit includes an antimicrobial agent and a cloth. The antimicrobial agent includes chlorhexidine gluconate, and the cloth can carry 0.025 to 0.075 milliliter of the antimicrobial agent per square centimeter to topically deliver 0.1 to 1.25 milligrams of chlorhexidine gluconate to a square centimeter of skin. The cloth is not preloaded with antimicrobial agent. An antibacterial article is also provided. The antibacterial article comprises a cloth. The cloth can carry 0.025 to 0.075 milliliter of the antimicrobial agent per square centimeter, and the antimicrobial agent includes chlorhexidine gluconate, wherein the cloth is used to topically deliver 0.1 to 1.25 milligrams of chlorhexidine gluconate to a square centimeter of skin.

Description

Anti-microbial kits and supplies

The present invention relates to an antimicrobial kit and product, and more particularly to an antimicrobial kit and product with an antimicrobial agent and a fabric carrier.

Medical infection is a major issue in global disease management. Infection of the surgical site, in addition to increasing medical expenses and lengthening the length of hospital stay, also increases the risk of sepsis and death in patients. "Promoting Combined Care Measures to Reduce Surgical Site Infections" The 2016 research report pointed out that the implementation rate of preoperative bathing measures is low. There are a variety of microorganisms fixed on human skin, which are the main source of infection when wounds on the skin surface. If the surface of the skin is not completely disinfected, microorganisms in the epidermal cell layer of the skin will enter the body through medical operations, invasive medical treatments or wound treatments, causing medical infections. Therefore, improving the rate of preoperative bathing and strengthening the preoperative skin preparation should be one of the ways to effectively reduce the infection rate of the surgical site.

In recent years, as the population has become aging and there are more and more patients suffering from special diseases such as AIDS, uremia, and traumatic sequelae that require special care or long-term care, there are requirements for infection control in special care or long-term care institutions. Increase, and the implementation of infection control within the organization also has More and more attention. In particular, the elderly and patients who require long-term care are weaker, and there is a higher risk of skin contact infectious diseases and respiratory infectious diseases in the institution "group infection". Therefore, it is necessary to strengthen the infection surveillance and infection control in the institution. Protective measures and caregiver knowledge are very important.

In addition, when medical staff perform clinical medical measures, especially emergency medical measures, such as disinfecting the patient’s skin in an ambulance or emergency department, they often directly immerse cotton swabs and gauze towels in the disinfectant bottle, and then apply it to the skin. Wipe and disinfect the surface. However, in an emergency, the operation of bottles and cans is relatively inconvenient, and cross-infection is prone to occur. After the disinfection operation is completed, the remaining disinfectant may not be able to be used again, which also causes a waste of resources.

In view of this, how to reduce the risk of infection after the implementation of invasive medical treatment, strengthen clinical emergency measures and infection control in long-term care institutions, and at the same time use disinfectants in an effective, appropriate amount and convenient way, the existing technology needs to be improved.

In order to solve the problems described in the prior art, the purpose of the present disclosure is to provide an antimicrobial kit and an antimicrobial product to reduce the risk of infection after the implementation of invasive medical treatment, strengthen clinical medical emergency measures and long-term care Infection control in the institution, and it is convenient for users to use antimicrobial agents in an effective and appropriate amount.

The present disclosure provides an antimicrobial kit, including an antimicrobial agent and a fabric carrier. The antimicrobial agent contains chlorhexidine gluconate (CHG), and the fabric carrier can carry 0.025 ml to 0.075 milliliters (mL/cm ² ) of the antimicrobial agent per square centimeter for topical administration of 0.1 per square centimeter of skin To 1.25 mg of chlorhexidine gluconate, and the fabric carrier does not pre-load the antimicrobial agent.

In some embodiments, the antimicrobial agent is an aqueous solution of chlorhexidine gluconate with a weight volume percentage of 0.1% to 10% (w/v%).

In some embodiments, the antimicrobial agent is packaged in a container, and the material of the container includes, but is not limited to, polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof .

In some embodiments, the textile support has a porous network structure.

In some embodiments, the thickness of the fabric carrier is 30 to 100 grams per square meter (g/m ² ). In some embodiments, the thickness of the fabric carrier is 95 g/m ² .

In some embodiments, the fabric carrier system is square or rectangular.

In some embodiments, the fabric carrier system can release the carried antimicrobial agent onto the skin without residue.

In some embodiments, the material of the fabric carrier includes, but is not limited to, polyester fiber, rayon or a combination thereof.

In some embodiments, the material of the fabric carrier is 100% polyester fiber, which can carry 0.045 to 0.065 milliliters (mL/cm ² ) of antimicrobial per square centimeter.

The present disclosure also provides an antimicrobial product, which comprises a fabric carrier, the fabric carrier carries an antimicrobial agent of 0.025 ml to 0.075 ml per square centimeter, and the antimicrobial agent includes chlorhexidine gluconate. Among them, the fabric carrier system is used to locally give 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, the antimicrobial product is packaged in a container, and the material of the container includes, but is not limited to, polyethylene, polyethylene terephthalate, or a combination thereof.

The present disclosure also provides an antimicrobial product, which includes a plurality of fabric carriers, each fabric carrier carries an antimicrobial agent of 0.025 ml to 0.075 ml per square centimeter, and the antimicrobial agent includes chlorhexidine gluconate. Among them, each fabric carrier system is used to locally administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, each fabric carrier carries 30 milliliters of antimicrobial agent, and the antimicrobial agent is an aqueous solution of 2% by weight and volume of chlorhexidine gluconate.

In some embodiments, the number of these fabric carriers is 8 and they are packaged in a container, the material of which is polyethylene.

The present disclosure also provides an antimicrobial product, comprising at least one textile carrier, at least one textile carrier carrying 0.025 ml to 0.075 ml of antimicrobial per square centimeter, the antimicrobial agent comprises chlorhexidine gluconate, wherein, at least one textile The carrier system is used to locally administer 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter to the skin.

In some embodiments, at least one textile carrier Soaked in the antimicrobial agent, so that at least one fabric carrier after soaking carries 0.025ml to 0.075ml of antimicrobial agent per square centimeter.

In some embodiments, the material of the fabric carrier is polyester fiber, which carries 0.045 to 0.065 milliliters of antimicrobial agent per square centimeter.

In some embodiments, eight fabric carriers are included, and eight fabric carrier systems are used for shoulder and neck position, chest, arms to palms, front of legs, lower abdomen, lower neck to back, back of legs, and From the back waist to the buttocks.

In some embodiments, eight fabric carrier systems are used in sequence for shoulder and neck position, chest, arms to palms, front of legs, lower abdomen, lower neck to back, back of legs and back waist. To the hips.

In some embodiments, the antimicrobial product is used before invasive medical treatment is performed.

In some embodiments, bathing is performed before the invasive medical treatment is performed, and then antimicrobial products are used.

In some embodiments, the antimicrobial product is used once a day on the day of the invasive medical treatment and the first three days.

In some embodiments, the antimicrobial product is used daily after the invasive medical treatment is performed until the invasive medical treatment is healed.

In summary, the antimicrobial kits and antimicrobial products of the present disclosure all include an antimicrobial agent containing chlorhexidine gluconate and a fabric carrier. The antimicrobial kit and antimicrobial products of the present disclosure are more convenient to use due to the larger area of the fabric carrier that can be wiped, and the antimicrobial agent can be used in an appropriate amount, while still achieving an effective amount of disinfection. In some embodiments, the antimicrobial kit or antimicrobial product contains eight fabric carriers The body can be used for shoulder and neck position, chest, arms to palms, front of legs, lower abdomen, lower neck to back, back of legs and waist to buttocks to avoid cross-contamination and achieve disinfection effect. If the antimicrobial kit and antimicrobial products are used in patients undergoing invasive medical treatment, the risk of infection after the implementation of invasive medical treatment can be reduced; if they are used in patients in special care institutions or long-term care institutions, they can Reduce the risk of infection in the institution to strengthen the infection control in the institution; if used in the implementation of clinical medical measures, it can be convenient for users to use antimicrobial agents in an effective and appropriate amount.

10‧‧‧Shoulder and neck position

20‧‧‧Chest

30‧‧‧Arms to palm

40‧‧‧Front of the legs

50‧‧‧Lower abdomen

60‧‧‧Lower neck to back

70‧‧‧The back of the legs

80‧‧‧From waist to hip

The above and other aspects, features and other advantages of the present invention can be understood more clearly by referring to the contents of the specification and with the accompanying drawings. Among them:

Figure 1 is a schematic diagram of the fabric carrier of the present disclosure in the area where the front skin of the human body is wiped.

Figure 2 is a schematic diagram of the fabric carrier of the present disclosure on the skin wiping area on the back of the human body.

In order to make the description of the present disclosure more detailed and complete, the embodiments and specific embodiments of the present invention will be described below with reference to the accompanying drawings; but this is not the only way to implement or use the specific embodiments of the present disclosure. The embodiments disclosed below can be combined or substituted with each other under beneficial circumstances, and other embodiments can also be added to an embodiment without further description or description.

As used herein, "include", "include", "have" and similar words indicate the recorded features, regions, integers, steps, operations, elements and/or components, but do not exclude other features, regions, Integers, steps, operations, elements, components, and/or groups thereof.

As used herein, the term "container" means including, but not limited to, fixed shapes and non-fixed shapes, such as bags, cans, bottles, or tubes.

The antimicrobial kit of various embodiments of the present invention includes an antimicrobial agent and a fabric carrier. The antimicrobial agent includes chlorhexidine gluconate, which can be 0.1% to 10% (w/v) chlorhexidine gluconate aqueous solution by weight and volume, preferably 1.6% to 2.4% (w/v) gluconate chloride An aqueous solution of hexidine, more preferably a 2% (w/v) aqueous solution of chlorhexidine gluconate.

The fabric carrier has a porous network structure, and the pores of the porous network structure can absorb the antimicrobial agent, thereby effectively carrying and carrying the antimicrobial agent, and can completely release the antimicrobial agent carried by the fabric carrier during use. Taking a fabric carrier with an area of 600 cm² as an example, it can carry 15 to 45 ml of antimicrobial agent, that is, every square centimeter of fabric carrier can carry antimicrobial agent from 0.025 ml to 0.075 ml, preferably 0.045 ml to 0.065 ml, more Preferably, it is 0.05 ml, and 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter is administered locally. The thickness of the fabric carrier is 30 g/m ² to 100 g/m ² , preferably 95 g/m ² . If the chlorhexidine gluconate aqueous solution carried by the fabric carrier is less than 0.025mL/cm ² , the chlorhexidine gluconate aqueous solution released to the skin surface is not enough to achieve the disinfection effect; 0.075mL/cm ² is the fabric carrier can carry The upper limit of the chlorhexidine gluconate aqueous solution, exceeding the upper limit, the chlorhexidine gluconate aqueous solution will drip, increasing the difficulty of operation.

In one embodiment, the size of the fabric carrier is 20x30 cm, which can hold 30 ml of antimicrobial agent, wherein the antimicrobial agent is a 2% (w/v) aqueous solution of chlorhexidine gluconate. According to the statistics of the Ministry of Health and Welfare and the calculation formula of body surface area: body surface area (square meters) = (weight (kg) x height (cm) / 3600) ^1/2 , the average body surface area range from 2 years old to adult Chinese can be calculated It ranges from 5812 square centimeters to 18641 square centimeters. If 8 pieces of fabric carrier are used to wipe the skin of the whole body, it can be calculated that each piece of fabric carrier carrying 600 mg of chlorhexidine gluconate can locally give 0.25 mg to 0.83 mg of antimicrobial agent per square centimeter of skin.

The fabric carrier has the characteristic of releasing the carried antimicrobial agent onto the skin without leaving any residue. In some embodiments, the material of the fabric carrier is 100% polyester non-woven fabric. In some embodiments, the material of the fabric carrier may be a non-woven fabric composed of polyester fiber and Rayon, such as a non-woven fabric made of 50% polyester fiber and 50% Rayon. The present invention does not limit the shape of the fabric carrier, and the fabric carrier may preferably be rectangular, including square, rectangular and other shapes. In some embodiments, when used for large-area wiping, the fabric carrier can be designed to be rectangular, such as 20x30 cm. The square fabric carrier is prone to curling during large-area wiping and disinfection, while the rectangular fabric carrier is used for large-area wiping and disinfection. It is not easy to curl and is easy to apply force.

The fabric carrier of the present invention has a porous network structure and thickness, which can protect the skin from excessive physical friction damage during clinical wiping. Therefore, in a preferred embodiment, the antimicrobial agent in the antimicrobial kit is a 2% (w/v) chlorhexidine gluconate aqueous solution, and the antimicrobial agent can be used without protection. It can maintain a comfortable skin touch even with moisturizing ingredients.

The antimicrobial kit is a combined product. The fabric carrier and the antimicrobial agent are in separate compartments and are in the same or different packaging. The fabric carrier and the antimicrobial agent are mixed during use. The number of fabric carriers in the antimicrobial kit can be one piece of fabric carrier or a plurality of pieces of fabric carrier. The antimicrobial agent in the antimicrobial kit can be contained in the bottle body, and the bottle body can be made of materials that will not react with chlorhexidine gluconate to cause precipitation, and will not affect the efficacy of the antimicrobial agent. The aforementioned material can be, for example, polyethylene (PE), polyethylene terephthalate (PET), or a combination thereof. Among them, polyethylene may include high-density polyethylene and low-density polyethylene. In a specific embodiment, the antimicrobial kit may include a 2% (w/v) chlorhexidine gluconate aqueous solution contained in a bottle and a fabric carrier contained in a bag. When in use, pour all the chlorhexidine gluconate aqueous solution into the bag body, so that the fabric carrier is immersed in the chlorhexidine gluconate aqueous solution, and then take it out for use after the fabric carrier carries a sufficient amount of the chlorhexidine gluconate aqueous solution.

The antimicrobial product contains an antimicrobial agent and a fabric carrier, and is a pre-combined product, that is, the fabric carrier preloads the antimicrobial agent. The antimicrobial agent and fabric carrier are the same as the antimicrobial agent and fabric carrier of the aforementioned antimicrobial kit, and will not be repeated here.

In a specific embodiment, the production process of antimicrobial products is to first add 20% (w/v) chlorhexidine gluconate aqueous solution to pure water to dilute to 2% (w/v), and then dilute the 2% (w/v) ) The aqueous solution of chlorhexidine gluconate is poured into a bag containing at least one piece of non-woven fabric, preferably 8 pieces of non-woven fabric, and it will be obtained after sealing Get anti-microbial supplies. Among them, the material of the bag body is polyethylene. In addition to good sealing performance, the polyethylene bag body will not interact with chlorhexidine gluconate and cause precipitation of the antimicrobial agent after prolonged contact with the antimicrobial agent, and does not affect the antimicrobial agent The effect of.

In some embodiments, antimicrobial kits or antimicrobial products can be applied to the skin before invasive medical treatments are performed to reduce the risk of medical infections. Invasive medical treatments can be, for example, scalpel incision surgery, puncture, insertion of a catheter or drainage tube, and so on. Take the knife incision operation as an example: the patient will take a 2% (w/v) chlorhexidine gluconate aqueous solution from the antimicrobial kit or antimicrobial supplies every day after bathing the whole body three days before the operation to the night before The soaked fabric carrier wipes the whole body; on the day of the operation, wipe the whole body again with an anti-microbial kit or anti-microbial products. After invasive medical treatment, antimicrobial kits or antimicrobial products can also be used to wipe the whole body or receive invasive medical treatment until the invasive medical treatment is healed.

In one embodiment, the anti-microbial kit or anti-microbial product can be used to clean and disinfect the skin or utensils, and it does not need to be washed with water after use. For example: patients in the intensive care unit and patients in long-term care can wipe the whole body with antimicrobial kits or antimicrobial products daily to reduce the risk of nosocomial infection; patients after receiving invasive medical treatment can also use antimicrobial kits Or use anti-microbial products to wipe the whole body or the affected parts under invasive medical treatment to reduce the risk of postoperative infection; during clinical treatment, especially in emergencies, such as emergency use of anti-microbial kits or anti-microbial products in an ambulance It is used for the disinfection of patients’ skin. A combination of multiple pieces of fabric carriers impregnated with 2% (w/v) chlorhexidine gluconate aqueous solution is used in a package to achieve convenient use and avoid waves. The effectiveness of antimicrobial agents is expensive; medical equipment such as catheters can also be disinfected with antimicrobial kits or antimicrobial products before invasive medical treatment.

In one embodiment, when the antimicrobial kit or antimicrobial product is in use, a fabric carrier carrying an antimicrobial agent is locally applied to the skin for disinfection and sterilization, and the single fabric carrier system is partitioned for single use to prevent cross-infection. . For example: Establish an eight-step clinical use sequence based on the disinfected parts of the human body. Wipe in this order to avoid cross-infection. According to Figure 1 and Figure 2, the body is divided into eight areas, which are the shoulder and neck positions on the front of the human body. , Chest 20, arms to palm 30, front of legs 40, lower abdomen 50, lower neck of the back of the human body to back 60, back of legs 70, back waist to buttocks 80. Among them, the chest 20 may further include the chest and the peripheral parts of the chest, from the back waist to the buttocks 80 including the waist to the back side of the connection between the hips and the thighs. When using anti-microbial kits or anti-microbial products, use a piece of fabric carrier with anti-microbial agent in each of the above eight zones to wipe the skin that needs to be cleaned and disinfected, and ensure that the skin is fully wiped with the anti-microbial agent, and wait for 30 seconds Let the skin dry naturally. After wiping with the microbial agent, the skin will appear shiny, and it can be judged that the skin has been fully wiped with the anti-microbial agent. In other embodiments, when the antimicrobial kit or antimicrobial product is used, a single sheet of fabric carrier carrying the antimicrobial agent can also be used for application to the local skin, and is not limited to the above usage.

In summary, the antimicrobial kits and antimicrobial products of the present disclosure all include an antimicrobial agent containing chlorhexidine gluconate and a fabric carrier. The antimicrobial kit and antimicrobial products of the present disclosure are more convenient to use due to the larger area of the fabric carrier that can be wiped, and the antimicrobial agent can be used in an appropriate amount, while still achieving an effective amount of disinfection. In some In an embodiment, the antimicrobial kit or antimicrobial product contains eight fabric carriers, which can be used for shoulder and neck position, chest, arms to palms, front of legs, lower abdomen, lower neck to back, and back of legs. From the side and back waist to the buttocks, avoid cross-contamination and realize the disinfection effect. If the antimicrobial kit and antimicrobial products are used in patients undergoing invasive medical treatment, the risk of infection after the implementation of invasive medical treatment can be reduced; if they are used in patients in special care institutions or long-term care institutions, they can Reduce the risk of infection in the institution to strengthen the infection control in the institution; if used in the implementation of clinical medical measures, it can be convenient for users to use antimicrobial agents in an effective and appropriate amount.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention. Anyone familiar with the art can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection of the present invention The scope shall be subject to the scope of the attached patent application.

10‧‧‧Shoulder and neck position

20‧‧‧Chest

30‧‧‧Arms to palm

40‧‧‧Front of the legs

50‧‧‧Lower abdomen

Claims (16)

An antimicrobial kit, comprising: an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; and a fabric carrier having a porous network structure, wherein the fabric carrier can carry the antimicrobial per square centimeter The chlorhexidine gluconate of 0.1 to 1.25 mg per square centimeter is locally administered to the skin from 0.025 ml to 0.075 ml, and the fabric carrier does not carry the antimicrobial agent in advance. The antimicrobial kit according to claim 1, wherein the antimicrobial agent is an aqueous solution of chlorhexidine gluconate with a weight volume percentage of 0.1% to 10%, and the antimicrobial agent is packaged in a container, and the container is The material includes polyethylene, polyethylene terephthalate or a combination thereof. The antimicrobial kit according to claim 1, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. An antimicrobial product, comprising: an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; and a fabric carrier, the fabric carrier having a porous network structure, wherein the fabric carrier can carry 0.025 ml to 0.075 per square centimeter One milliliter of the antimicrobial agent is locally administered to the skin at 0.1 to 1.25 mg of chlorhexidine gluconate per square centimeter, wherein the fabric carrier carries the antimicrobial agent. The antimicrobial product according to claim 4, wherein the antimicrobial agent is an aqueous solution of chlorhexidine gluconate with a weight volume percentage of 0.1% to 10%. The antimicrobial article according to claim 4, wherein the fabric carrier system is square or rectangular. The antimicrobial product according to claim 4, wherein the material of the fabric carrier comprises polyester fiber, rayon or a combination thereof. The antimicrobial product according to claim 7, wherein the fabric carrier is made of 100% polyester fiber, and can carry 0.045 to 0.065 milliliters of antimicrobial per square centimeter. The antimicrobial article according to claim 4, wherein the antimicrobial article is packaged in a container, and the material of the container includes polyethylene, polyethylene terephthalate or a combination thereof. An antimicrobial product, comprising: an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; and a plurality of fabric carriers, each fabric carrier has a porous network structure, wherein each of the fabric carriers can carry 0.025 ml to 0.075 ml of this antimicrobial agent is administered locally from 0.1 to 1.25 per square centimeter of the skin Milligrams of the chlorhexidine gluconate, wherein the fabric carriers carry the antimicrobial agent. The antimicrobial article according to claim 10, wherein the material of each fabric carrier is 100% polyester fiber and can carry 30 ml of antimicrobial agent, and the antimicrobial agent is 2% by weight and volume of gluconate chloride Hexidine aqueous solution. The antimicrobial article according to claim 10, wherein the number of the textile carriers is 8 and they are packaged in a container, and the material of the container is polyethylene. An antimicrobial product, comprising: an antimicrobial agent, the antimicrobial agent comprising chlorhexidine gluconate; and at least one fabric carrier, the at least one fabric carrier has a porous network structure, wherein the at least one fabric carrier can be Carrying 0.025 ml to 0.075 ml of the antimicrobial agent, and locally administering 0.1 to 1.25 mg of the chlorhexidine gluconate per square centimeter to the skin, wherein the at least one fabric carrier carries the antimicrobial agent. The antimicrobial article according to claim 13, wherein the at least one fabric carrier is soaked in the antimicrobial agent, so that the at least one fabric carrier after soaking can carry 0.025 ml to 0.075 ml of the antimicrobial agent per square centimeter . The antimicrobial product according to claim 13 or 14, wherein the fabric carrier is made of 100% polyester fiber, and can carry 0.045 to 0.065 ml of the antimicrobial agent per square centimeter. The antimicrobial article according to claim 13 or 14, comprising eight textile carriers.

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