TWI677286B - A herbicidal composition and method of controlling plant growth - Google Patents

Abstract

和組分(B)為化合物五氟磺草胺，其分子式(II)為：

The present invention provides a herbicide composition, the composition comprising components (A) and (B), wherein component (A) is the compound promethazine and its molecular formula (I) is

And component (B) is the compound penoxsulam, whose molecular formula (II) is:

A method for controlling plant growth using components (A) and (B) is also provided.

Description

Weeding composition and method for controlling plant growth

The present invention relates to a herbicidal composition. The invention also relates to a method for preventing and controlling the growth of harmful plants.

There are many types of weeds in rice fields, and weeding in rice fields is a major problem in rice production. Chemical methods have been the main means of controlling weeds in paddy fields. However, in recent years, many weed varieties have developed resistance to herbicides, especially due to long-term application and the use of a single active ingredient herbicide mixture.

In addition, different kinds of weeds, such as grass weeds, broad-leaved weeds, and sedges, are mixed in the same rice field. Due to the limitation of the herbicidal spectrum of the single active ingredient in the herbicidal mixture, the herbicide mixture of the single active ingredient may not be able to remove all the weeds in the target rice field.

Sulfonylurea herbicides are selective systemic conductive herbicides, which can be absorbed by the roots and leaves of weeds, and are quickly conducted in the plant to inhibit cell division and growth. After the sensitive weeds absorb the sulfonylurea herbicide, the shoots and roots stop growing quickly, the young tissues turn yellow, and then die. However, the difficulty in the application of sulfonylurea herbicides is that its toxicity to beneficial plants and weeds develop resistance to sulfonylurea herbicides.

Therefore, it is necessary to develop an improved herbicide composition, especially to be able to control a variety of weeds or certain types of weeds which are difficult to control with the currently known compositions and preparations. Compositions that can be applied to crop fields, especially rice fields, in one or several portions are useful.

Propyrisulfuron (Propyrisulfuron) is a known pyrimidinyl sulfonylurea herbicide developed by Sumitomo Chemical in Japan. It is mainly used to prevent and control grass weeds (such as yarrow) and broadleaf weeds. Grass can be widely used in rice fields. Although the required amount of prosulfuron is low, it is effective in preventing and controlling weeds that are resistant to some known sulfonylurea herbicides.

Promethazine, with a molecular formula of C ₁₆ H ₁₈ O ₅ N ₇ SCl, has the chemical structure shown below:

Penoxsulam is a post-emergent herbicide developed by Dow AgroSciences. Penoxsulam is a compound of the triazolopyrimidine sulfonamide group and is an acetamidine lactate synthase inhibitor. Penoxsulam is absorbed by plant leaves, shoots and roots and is transmitted to meristems. Penoxsulam treatment caused cell division and subsequent growth cessation, yellowing, and death in the treated plants. Penoxsulam is used to prevent and control annual weeds in corn fields. It has specific effects on weeds, but it is not effective on some grass weeds, sedges and broadleaf weeds.

Penoxsulam, chemical name is 3- (2,2-difluoroethoxy) -N- (5,8-dimethoxy- [1,2,4] triazolo [1 , 5-C] pyrimidin-2-yl) -α, α, α-trifluorotolyl-2-sulfonamide, its structural formula is:

It has now been found that a very advantageous and required level of weed control can be achieved by combining promethazuron and penoxsulam. The combination of prosulfuron and penoxsulam is effective in controlling many types of harmful plants, including even certain weeds that are difficult to control with known herbicidal compositions.

Surprisingly, compared with the single use, the simultaneous use of prosulfuron and penoxsulam can significantly reduce the application rate and has a high herbicidal effect. That is to say, the synergistic effect of promethazuron and penoxsulam can be synergistic, while the synergism of promethazuron and penoxsulam is not expected or expected before. Therefore, this finding can enhance the use of prosulfuron and penoxsulam and reduce costs.

Promethazol and penoxsulam can be prepared into a single composition and used simultaneously in a single composition. In addition, prosulfuron and penoxsulam can also be applied together in separate locations to control the growth of harmful plants.

組分(B)為具有結構式(II)的化合物五氟磺草胺：

One aspect of the present invention is to provide a herbicidal composition comprising components (A) and (B), wherein component (A) is a compound prazosulfuron with a structural formula (I):

Component (B) is the compound penoxsulam, having the structural formula (II):

Any suitable amount of components (A) and (B) may be present in the composition to provide the desired plant growth control. Preferably, the amounts of components (A) and (B) in the composition are capable of producing the synergistic effect described above. The weight ratio of components (A) to (B) in the composition is preferably from about 100: 1 to about 1: 100. More preferably, the weight ratio of components (A) to (B) is from about 50: 1 to about 1:50, and the weight ratio of components (A) to (B) is more preferably from about 25: 1 to about 1:25, More preferably, the weight ratio is from about 10: 1 to about 1:10. In many embodiments of this composition, the weight ratio of components (A) to (B) is from about 5: 1 to about 1: 5.

Components (A) and (B) may be present in the composition in any total dose suitable to provide the control required for plant growth. In the herbicidal composition, preferably, the total amount of components (A) and (B) accounts for about 5 to about 90% by weight of the herbicidal composition, and more preferably about 10 to about 10% by weight of the herbicidal composition. About 80% by weight, more preferably about 20% to about 60% by weight of the herbicidal composition, and still more preferably about 30% to 50% by weight of the herbicidal composition.

The herbicidal composition of the present invention can be formulated into a variety of dosage forms. For example, the composition can be formulated as a wettable powder (WP), an emulsifiable concentrate (EC), a suspending agent (SC), a microcapsule suspension Flotation (CS), microemulsion (ME), emulsions, such as water emulsion (EW), or suspension emulsion (SE), water-dispersible granules (WDG), ultra-low-volume liquid (ULV), or mixed preparations such as micro Blended formulation of vesicle suspension and suspension (ZC).

The above formulations can be prepared by existing methods known in the art, including mixing the active ingredient with other components such as one or more fillers, one or more surfactants, one or more dispersants, and one or more Multiple carriers.

When water is used as a filler, organic solvents can be used to help dissolve the components in the formulation. Suitable solvents include aromatic hydrocarbon solvents such as xylene, toluene or alkyl naphthalene; chloroaromatic hydrocarbons and aliphatic chlorinated hydrocarbons such as chlorobenzene, vinyl chloride or dichloromethane; aliphatic hydrocarbons such as cyclohexane or paraffin, mineral oil Fractions, mineral and vegetable oils; alcohols such as butanol or ethylene glycol and their ethers and esters; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone; polar solvents such as Methylformamide and dimethylmethane and water.

Suitable carriers include ammonium salts and ground natural minerals such as kaolin, clay, talc, chalk, quartz, diatomite, montmorillonite or diatomaceous earth; and ground synthetic minerals such as highly dispersed silica , Alumina and silicate. Suitable solid particulate carriers include ground natural minerals such as calcite, marble, pumice, sepiolite, and dolomite, as well as synthetic particles of inorganic and organic powders, and particles of organic materials such as sawdust, coconut shell, corn cobs, and Tobacco straw.

Suitable surfactants include nonionic and anionic emulsifiers such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, alkylaryl polyethylene glycol ethers, alkylsulfonates, alkyl sulfates, aromatics Sulfonate, and protein hydrolysates.

Suitable dispersants include lignin-sulfite and methyl cellulose.

The composition may contain tackifiers, such as carboxymethyl cellulose; natural and synthetic polymers in powder, granular or latex form, such as gum arabic, polyvinyl alcohol, and polyvinyl acetate; and natural phospholipids, such as brain phospholipids And lecithin, and synthetic phospholipids.

Other possible additives included in the composition are mineral and vegetable oils.

Colorants such as inorganic pigments such as iron oxide, titanium oxide, and Prussian blue; organic colorants such as alizarin colorants, azo colorants, and metal phthalocyanine colorants may be included in the formulation.

The composition may also include one or more micronutrients such as iron, manganese, and boron, copper, cobalt, molybdenum, and zinc salts.

The content of components (A) and (B) is about 5% to about 90% by weight of the herbicidal composition, preferably about 10% to about 80% by weight, and more preferably about 20% to about 60% by weight , More preferably about 30% to 50% by weight.

The herbicidal composition is capable of controlling, in particular, preventing the growth of many types of harmful plants or weeds, including monocotyledonous and dicotyledonous weeds.

The herbicidal composition can be used to control unwanted plant growth in a variety of crops including wheat, corn, soybeans, sugar beet, sugar cane, cotton, rice, beans, flax, barley, oats, rye, Triticale, rapeseed, potato and millet, as well as controlling plant growth in other applications, such as pastures, green spaces or lawns, fruit plantations or non-crop areas.

It has now been found that a composition comprising the components (A) prosulfazuron and (B) penoxsulam exhibits an unexpected synergistic effect, i.e. a synergistic effect. The observed activity is significantly stronger than when the active ingredients (A) and (B) are applied alone.

The herbicidal composition of the present invention comprising the active ingredients (A) and (B) may further comprise one or more components known in the art of formulating herbicidal compositions, such as one or more fillers and / or one or more surfactants.

The herbicidal composition of the present invention may further contain one or more other herbicidally active compounds different from the components (A) and (B). In addition, the herbicidal composition of the present invention may further comprise one or more selected from safeners, fungicides, insecticides, acaricides, nematicides, repellents Bird liquor, soil conditioners, plant nutrients (fertilizers) and herbicides (different from components (A) and (B)), and compounds of plant growth regulators.

One or more other active compounds preferably present in the composition are selected from the group consisting of acetochlor, acibenzolar, acibenzolar-S-methyl, acifluorfen ), Aclofen, alachlor, allidochlor, alloxydim, ametryn, amcarbazone, asulfuron (amidosulfuron), aminopyralid, amomile, ammonium sulfamate, ancymidol, anilofos, asulam, dehydration Atrazine, azafenidin, azimsulfuron, benfuresate, bensulfuron, bentazone, dibenoxazone ( benzfendizone, benzobicyclon, benzofenap, benzofluor, bicyclopyrone, bispyribac-sodium, bromoxynil, butan Butachlor, butafenacil, butralin, cafenstrole, diamidine Carbamide, carfentrazone, chlorimuron (chlorimuron-ethyl), chlormequat chloride, chlorotoluron, chlorsulfuron, cycloheptan Cinmethylin, cinosulfuron, clethodim, clomazone, clomeprop, clopyralid, cyanazine, Cyclanilide, cyclosulfamuron, cycloxydim, cyprazole, daimuron / dymron, dicamba, grass Diclofop-methyl, diclofop-P-methyl, diclosulam, diethatyl (diethatyl-ethyl), flufenoxamine (diflufenican), diflufenzopyr (diflufenzopyr-sodium), dimefuron, dimepiperate, dimethachlor, dimethametryn, diphenacetin Diphenamid, dipropetryn, diquat, diuron, ethametsulfuron, ethametsulfuron-methyl, ethephon, ethidimuron , Ethoxysulfuron, ethoxysulfuron, etobenzanid, fenoxaprop, fenoxaprop-P, fenoxaprop-ethyl , Fentrazamide, flazasulfuron, florasulam, fluazifop, fluazifop-P, pyrfluramine Fluazifop-butyl, fluazifop-P-butyl, fluazolate, flucarbazone (flucarbazone-sodium), flupyramid Flucetosulfuron, flufenacet, flumetralin, flumetsulam, fluflutol mioxazin), flumipropyn, fluometuron, fluorodifen, fluoroglycofen (fluoroglycofen-ethyl), flupoxam, fluoxan Flupyrsulfuron, fluridone, flurochloridone, fluroxypyr, flurtamone, fluthiamide, flusulfuron (fomesafen), glufosinate (glufosinate-ammonium), glufosinate-P (glufosinate-P-ammonium), glufosinate-P-sodium, glyphosate Glyphosate, glyphosate-isopropylammonium, halosafen, halosulfuron (halosulfuron-methyl), haloxyfop, refined fluorine Haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-ethoxyethyl (haloxyfop-P-ethoxyethyl), haloxyfop-methyl, haloxyfop-P-methyl, hexazinone, imazamethabenz, imazamethabenz-methyl, Imazamox (imazamox-ammonium), imazamox (imazapic), imazapyr (imazapyr-isopropylammonium), imazaquin (imazaquin-ammonium), imazethapyr , Imazethapyr-ammonium), imazosulfuron, inabenfide, indanofan, iodosulfuron (iodosulfuron-methyl-sodium), ioxynil, Isoproturon, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, lactofen , Lenacil, 2-methyl-4-chlorophenoxyacetic acid (MCPA), 2-methyl-4-chlorophenoxybutyric acid (MCPB), 2-methyl-4-chlorophenoxybutane Methyl ester (MCPB-methyl), ethyl 2-methyl-4-chlorophenoxybutyrate (MCPB-ethyl), sodium 2-methyl-4-chlorophenoxybutyrate (MCPB-sodium), phenothiazine Humulide enacet), mefluidide, mepiquat-chloride, mesosulfuron (mesosulfuron-methyl), mesobione, methabenzthiazuron , Metamifop, metamitron, metazachlor, methazole, methiopyrsulfuron, methoxyphenone, methyl Methyldymron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, Metsulfuron (metsulfuron-methyl), grasses (molinate), monosulfuron (monosulfuron), monosulfuron ester (monosulfuron ester), monuron, napropamide, Nicosulfuron, oxadiargyl, Oxadiazon, oxasulfuron, oxaziclomefone, oxyfluorfen, paclibutrazol, paraquat, paraquat dichloride, dimethylpentazone Pendimethalin, pentoxazone, pethoxamid, picloram, picolinafen, pinoxaden, and phoxant piperophos, pretilachlor, probenazole, profluazol, prifluraline, profoxydim, prometryn, and Propanil, propazine, propham, propisochlor, propyrisulfuron, propyzamide, prosulfocarb, fluoride Prosulfuron, prynachlor, pyraclonil, pyraflufen (pyraflufen-ethyl), pyrazosulfuron (pyrazosulfuron-ethyl), isoprofen Ether (pyribambenz-isopropyl), pyribambenz-propyl, pyrimoxime (pyr ibenzoxim), piributicarb, pyriftalid, pyriminobac (pyriminobac-methyl), pyrimisulfan, pyrithiobac (pyrithiobac-sodium), pyroxasulfone, Pyroxsulam, quinchlorac, quinmerac, quizalofop, quizalofop-P, quinoxaline ethyl ester quizalofop-P-ethyl), rimsulfuron, saflufenacil, secbumeton, sethoxydim, siduron, sulcotrione ), Sulfentrazone, sulfometuron (sulfometuron-methyl), thidiazuron, thifensulfuron (thifensulfuron-methyl), thiobencarb, paraquat (tiocarbazil), triasulfuron, triaziflam, tribenuron (tribenuron-methyl), trichloroacetic acid (TCA), trichloropyroxy Triclopyr, tridiphane, trifloxysulfuron (trifloxysulfuron-sodium), trifluralin, triflusulfuron, triflusulfuron-methyl ), Trimeturon, trinexapac (trinexapac-ethyl), tritosulfuron, tsitodef, and uniconazole.

Although the combination of components (A), prosulfazuron and (B) penoxsulam, shows high selectivity for many plants, making them useful for protecting some crops, the active compounds may have plants in some crops Toxic, especially when the active compound is mixed with other herbicides of lower selectivity. Therefore, it is preferable to add one or more safeners to the composition of the present invention. Safeners are compounds that reduce or eliminate the effects of phytotoxicity on important economic crops. Important cash crops include cereals (wheat, barley, rye, oats, corn, rice and millet), sugar beets, sugar cane, rapeseed, cotton and soybeans, preferably cereals, and still more preferably rice.

Suitable safeners include benoxacor, cloquintocet (-mexyl), cyometrinil, cyprosulfamide, dichlormid, and dicycline dicyclonon), O-phenylthiophosphoric acid O, O-diethyl ester (dietholate), fenchlorazole (-ethyl), fenclorim, flurazole, fluroxime (fluxofenim), furilazole, isoxadifen (-ethyl), mefenpyr (-diethyl), methyl carbamate 4-chlorophenyl ester (methyl carbamate 4-mephenate), naphthalenedicarboxylic anhydride, and oxabetrinil. The safener may be one or more possible stereoisomers, esters or salts commonly used in the preparation of herbicidal composition preparations in this field.

The weight ratio of the herbicidal active ingredient to the safener can be determined through routine experimentation, which depends on factors such as the rate of application of the herbicide and the efficiency of the safener. Herbicidal compounds and The weight ratio of the safener can vary widely, usually about 90,000: 1 to about 1: 5000, preferably about 7000: 1 to about 1: 1600, more preferably about 3000: 1 to about 1: 500, and then It is preferably about 1: 100 to about 20: 1.

One or more safeners may be mixed with components (A) and (B) in a single dose, or applied and used with a herbicidal composition in a tank mix.

The herbicidal composition of the present invention can be prepared by methods known in the art, that is, the individual components (A) and (B) (if applicable) are mixed with other active compounds, additives and / or auxiliaries to form a mixed preparation, The formulation is then diluted by conventional methods before application. In addition, components (A) and (B) may be separately formulated to form a tank-mixed preparation.

The herbicide composition of the present invention has high-efficiency and broad-spectrum herbicidal activity, and can control monocotyledonous and dicotyledonous economic crops, including controlling broad-leaved weeds, grass weeds, and sedges, and herbicidally active compounds such as glyphosate , Glufosinate, atrazine, imidazolinone and sulfonylurea herbicides).

The herbicide composition of the present invention can be used to control monocotyledonous and dicotyledonous plants. Target monocotyledonous weeds include Echinochloa spp., Panicum spp., Poa spp, Leptochloa spp., Brachiaria spp., And Horse Digitaria spp., Setaria spp., Cyperus, Monochoria spp., Fimbristylis, Sagittaria spp., Eleocharis spp .), Scirpus spp., Alisma spp., Aneilema spp., Blyxa spp., Eriocaulon spp., And Potamogeton spp., Such as Echinochloa oryzicola, Monochoria vaginalis, Eleocharis acicularis, Eleocharis kuroguwai, Cyperus difformis, Cyperus serotinus), Sagittaria pygmaea, Alisma canaliculatum and Scirpus juncoides. Target dicotyledonous weeds Polygonum spp., Rotala spp., Lindernia spp., Bidens spp., Sphenoclea spp., Dopatrium spp.), Eclipta spp., Elatine spp., Gratiola spp., Lindernia spp., Ludwigia spp., Cress Oenanthe spp., Ranunculus spp. And Deinostema spp., Such as Rotala indica, Sphenoclea zeylanica, Lindernia procumbens, Lidwigia prostrate, Potamogeton distinctus, Elatine triandra and Oenanthe javanica.

The invention also relates to a method for preventing and controlling harmful plants by applying the components (A) promethazuron and (B) penoxsulam at the location.

其中組分(B)是化合物五氟磺草胺，其結構式為(II)：

Therefore, another aspect of the present invention provides a method for controlling plant growth at a location, the method comprising applying components (A) and (B) at the location, wherein the component (A) is the compound prazisulfuron, Its structural formula is (I):

Wherein component (B) is the compound penoxsulam and its structural formula is (II):

There is a synergistic effect when components (A) promethazuron and (B) penoxsulam are applied in combination. When components (A) and (B) are applied simultaneously or continuously, a synergistic effect can be observed.

Components (A) and (B) can be applied to the target plant before and / or after germination. Components (A) and (B) can be applied to the early, middle or late germination stages of the target plant in need of control. The components (A) prosulfazuron and (B) penoxsulam can be applied to the location before planting or sowing by treating plants or plant materials such as seeds.

It is preferred to apply the components (A) promethazuron and (B) penoxsulam before the germination of the target plant to prevent harmful plant growth.

Components (A) and (B) may be administered simultaneously and / or separately. The simultaneous or almost simultaneous application is preferred, and the simultaneous application is more preferred. In a preferred embodiment, components (A) and (B) are applied as a composition as described above.

The components (A) prosulfuron and (B) penoxsulam can be applied in a range of weight ratios. A suitable weight ratio is as described above. Therefore, the weight ratio of components (A) and (B) ranges from about 100: 1 to about 1: 100. Preferably, the weight ratio of components (A) and (B) ranges from about 50: 1 to about 1:50, more preferably from about 25: 1 to about 1:25, and still more preferably from about 10: 1 to about 1 : 10, and more preferably about 5: 1 to about 1: 5.

As described above, when the active compounds promethazuron and penoxsulam are used together, it is possible to reduce the application rate while improving or at least maintaining the efficacy of the active compound. The use of a combination of components (A), prosulfuron and (B) penoxsulam, can also control unprotected plant varieties, plant varieties that are resistant to single or multiple herbicides, or to one or more Herbicide-resistant plant varieties. In addition, the use of a combination of components (A), prosulfuron, and (B) penoxsulam can extend the application period and / or reduce the application time.

The application rate of component (A) promethazine can be varied within a wide range, and its application rate is generally 0.1 to 1000 g / ha. When the application rate of component (A) is in the range of 0.1 to 1000 g / ha, component (A) has a wide spectrum of control for controlling harmful plant growth, such as seeding Or before planting, before germination or after germination. Its broad spectrum makes it suitable for treating multi-plants, such as annual and perennial monocotyledonous or dicotyledonous, broad-leaved weeds, gramineous weeds or sedges.

The application rate of the active ingredient (B) penoxsulam can be varied within a wide range, and its application rate is generally 1 to 5000 g / ha. Similarly, penoxsulam has a broad control spectrum for controlling harmful plant growth.

Suitable ratios of the active ingredients (A) and (B) can be determined with reference to the application rates of the individual compounds described above. However, the present invention has the advantage of using a combination of components (A), prosulfuron and (B) penoxsulam, which can reduce the application rate of one or two active ingredients.

In the method of the present invention, components (A) and (B) may be applied simultaneously or separately to harmful plants or areas where harmful plants are grown. The harmful plants that can be treated and controlled by this method include monocotyledonous and dicotyledonous plants.

If the components (A) prosulfuron and (B) penoxsulam are applied to the ground before weeds germinate, the target weeds can be significantly reduced or prevented from germinating. If the target weed is in the cotyledon stage, the present invention can reduce or prevent further growth of the target weed. It has now been found that the present invention is capable of preventing the growth and killing of target weeds within two to four weeks.

If the components (A) prosulfazuron and (B) penoxsulam are applied to the green part after the harmful plants germinate, the harmful plants will slow down after the application and stop growing in a short time. Plants will remain at this growth stage, or harmful plants will die after a limited time. Therefore, the present invention can continuously eliminate the competition of harmful plants at an early stage and protect the required crops.

As mentioned above, the present invention has now been found to be particularly useful for protecting rice crops, especially rice fields. In paddy fields, the components (A), prosulfuron and (B) penoxsulam, can be applied to water and absorbed by the soil, buds and roots of the target plants.

The invention also provides a method for selectively preventing and controlling the growth of harmful plants. Is selected to prevent and control harmful plants in crops, especially in rice, wherein the method includes the simultaneous or separate application of components (A) and (B) to plants (e.g. monocotyledonous and dicotyledonous broadleaf weeds, grasses Harmful plants or crops such as grasses and sedges), seeds (e.g. caryopsis, seeds or asexual reproduction organs, shoots, tubers or auxiliary buds), or application of herbicidal compositions (e.g. cultivated land or waters) , Such as rice crops).

Harmful or target plants are all plants that do not want to grow there. These plants include harmful plants such as monocotyledonous and dicotyledonous broadleaf weeds, gramineous weeds, and sedges or harmful crops, and these plants are resistant to certain herbicides such as glyphosate, glufosinate, Atrazine, imidazolinone and sulfonylurea herbicides.

When the crop is harvested, or when it is necessary to prevent the growth of a certain crop, the components (A) promethazuron and (B) penoxsulam can be used to prevent and control the growth of harmful plants, thereby cleaning the planting area, Prepare for the next planting season. The components (A) promethazuron and (B) penoxsulam can be selectively used to prevent and control a variety of harmful plants to protect various crops, such as monocotyledon crops, including cereals (e.g. wheat, barley , Rye, oats, rice, corn, and millet), or dicotyledonous crops, such as sugar beet, sugar cane, flax, triticale, rapeseed, cotton, sunflower, and leguminous plants, such as soybeans (such as Glycine max. ), Non-GMO soybeans (such as conventional cultivars and STS cultivars), genetically modified soybeans (such as RR soybeans or LL soybeans and their hybrids), Phaseolus, Pisum, Vicia Arachis, or vegetable crops of various botanical categories, such as potato, leek, cabbage, carrot, tomato, onion. The components (A) prosulfuron and (B) penoxsulam can also be applied to orchards (horticultural planting), green fields, lawns and pastoral areas, especially pastures. The components (A) prosulfuron and (B) penoxsulam can also be used in non-crop areas, such as residential or industrial areas. The components (A) prosulfuron and (B) penoxsulam are particularly effective when applied to rice crops.

As described above, the herbicidal composition and method of the present invention are particularly suitable for selectively preventing and controlling harmful plants in rice crops. The rice crop includes all possible forms of rice crop cultivation under the most diverse conditions, such as dry field cultivation, dry land cultivation, or paddy field cultivation, where the irrigation of the rice crop can be natural (rainfall) and / or artificial (irrigated, flooded) ). The rice crop may be a conventionally cultivated seed, a hybrid seed, or a resistant-at least tolerant seed (obtained from a mutation or transgene), which may be derived from an indica or japonica variety or a hybrid thereof.

The components (A) prosulfuron and (B) penoxsulam can be applied to rice in a number of ways commonly used and known in the art. The components (A) promethazuron and (B) penoxsulam are preferably applied in a spray and / or dipping manner. When applied by immersion, the highest water level in the rice field is preferably 3 to 20 cm. The components (A) promethazuron and (B) penoxsulam can be applied directly to the water of a rice field, for example in the form of a composition according to the invention.

The components (A) promethazuron and (B) penoxsulam may be applied simultaneously or separately, or multiple consecutive applications. For example, it can be used before sowing / planting, seed dressing with the components (A) promethazuron and (B) penoxsulam, and / or before and / or after the germination of the target plant, and / Or in one or more of the early, middle or late stages of plant germination.

Preference is given to the simultaneous application of component (A) prosulfuron and (B) penoxsulam.

Components (A) and (B) can be applied simultaneously or separately via traditional dosage forms, such as wettable powders (WP), emulsifiable concentrates (EC), suspensions (SC), microcapsule suspensions (CS), microemulsions (ME ), Water emulsion (EW), suspoemulsion (SE), water-dispersible granules (WDG), ZC or ultra-low-volume liquid (ULV), natural and synthetic materials and polymer materials coated or impregnated with active compounds Natural and synthetic materials in microcapsules.

Components (A) and (B) can be used with other pesticide chemically active compounds to prevent and control harmful plants, such as weeds or harmful crop plants.

The components (A) prosulfazuron and (B) penoxsulam can be applied using techniques known in the art And form application. Traditional methods of using active ingredients include irrigation, spraying, atomizing or spreading.

In another aspect, the present invention provides the use of the components (A) prosulfazuron and (B) penoxsulam for controlling plant growth at the location.

As mentioned above, it has now been found that in the combined use of components (A) promethazuron and (B) penoxsulam, certain specific safeners can be used.

Accordingly, the present invention also provides the use of a safener in reducing the toxicity of the combination of components (A) promethazuron and (B) penoxsulam.

To prevent and control various types of beneficial plants, especially weeds in rice, the use of safeners in the combination of components (A) promethazuron and (B) penoxsulam has many advantages.

Suitable safeners include benoxacor, fenclorim, dichlormid, mefenpyr (-diethyl)), and bisoxazol (ethyl) ) (isoxadifen (-ethyl))). The composition containing the safener and the components (A) prosulfuron and (B) penoxsulam can effectively protect beneficial plants (except weeds) from poisoning by active herbicides.

The embodiments of the present invention will be illustrated by the following examples, but for illustrative purposes only.

Composition Examples

In the following examples, Examples 1 to 25 are examples relating to the composition of the present invention.

Unless otherwise stated, the percentages in the following examples are weight ratios of the composition.

Example 1

An oil suspension containing 25% prosulfazuron + 1% penoxsulam is prepared from the following ingredients:

After mixing these ingredients, 25% promethazine + 1% penoxsulam oil suspension is obtained after grinding and high-speed shearing.

Example 2

Wettable powder containing 10% prosulfazuron + 2% penoxsulam is prepared from the following ingredients:

The above components are mixed and pulverized by an ultrafine pulverizer to obtain 10% promethazine + 2% penoxsulam wettable powder.

Example 3

A wettable powder containing 1% prosulfazuron + 50% penoxsulam is prepared from the following ingredients:

The above components are mixed and pulverized by an ultrafine pulverizer to obtain a wettable powder of 1% promethazine + 50% penoxsulam.

Example 4

The water-dispersible granules containing 0.1% prosulfazuron + 1% penoxsulam are composed of the following ingredients:

The above ingredients are mixed, and after uniform stirring, grinding, wetting with water, extrusion and drying, water-dispersible granules containing 0.1% prosulfazuron + 1% penoxsulam are obtained.

Example 5

An emulsifiable concentrate containing 5% promethazine + 0.1% penoxsulam is prepared from the following ingredients:

The above ingredients are mixed and stirred to obtain a uniform phase.

Example 6

An oil suspension emulsion containing 10% prosulfazuron + 0.1% penoxsulam is prepared from the following ingredients:

Grinding and / or high-speed shearing of prosulfazuron and methylnaphthalenesulfonate formaldehyde condensate to obtain prosulfazuron oil suspension agent; pentosufuracil, SOLVESSO ^TM 200, ethoxylation Castor oil is mixed and stirred to obtain the pentaflusulfa EC emulsifiable concentrate; the obtained pentaflusulfa EC is added to the prosulfazuron oil suspension agent, and mixed to obtain 10% promethazuron + 0.1% pentasulfuron Glufamide oil suspension emulsion.

Example 7:

Wettable powder containing 25% prosulfazuron + 1% penoxsulam is prepared from the following ingredients: prosulfuron 25%

The mixture of the above components is pulverized and ground to prepare a wettable powder.

Example 8:

The water-dispersible granules containing 40% prosulfazuron + 4% penoxsulam are prepared from the following ingredients:

The above components are uniformly mixed, ground, wetted with water, squeezed and air-dried to obtain a water-dispersible granule containing 40% prosulfazuron + 4% penoxsulam.

Example 9:

Suspension formulations containing 2% prosulfazuron + 50% penoxsulam are prepared from the following ingredients: oil phase:

water box:

Dissolve promethazine in N-methylpyrrolidone, and add ethoxylated castor oil to N-methylpyrrolidone to obtain an oil phase; pentasusulfuron, SOPROPHOR ^® 4D384, and water sand mill to obtain pentafluoro Aqueous suspension of sulfachlor; the oil phase is added to the water phase with stirring to obtain a suspending agent.

Example 10:

Wettable powder containing 10% prosulfazuron + 10% penoxsulam is prepared from the following ingredients:

The above components are pulverized and ground to prepare a wettable powder.

Example 11:

The coated granules containing 1% prosulfazuron + 25% penoxsulam are prepared from the following ingredients:

The components are added to a mixer, and the finely divided active ingredient is uniformly coated on a calcium carbonate carrier wetted with polyethylene glycol in the mixer to obtain a dust-free coated granule.

Example 12:

Wettable powder containing 1% prosulfazuron + 5% penoxsulam is prepared from the following ingredients:

The above components are ground and pulverized to prepare a wettable powder.

Example 13:

Extruded granules containing 5% promethazine + 5% penoxsulam are prepared from the following ingredients:

The above ingredients are mixed and ground. The resulting powder is wetted with water to form a extrudable paste. The paste is then extruded to form granules and then dried in air.

Example 14:

The mixed dosage form (ZC) of prosulfazuron microcapsule suspension + penoxsulam suspension is prepared from the following ingredients: microencapsulated prosulfuron:

Suspensions of penoxsulam:

An oil phase was prepared from polymethylene polyphenyl polyisocyanate (PAPI), promethazine, SOLVESSO ^TM 200. The oil phase is added to the aqueous phase containing ATLOX ^™ 4913 to form an emulsion. The emulsion was then heated to 50 ° C, a catalyst was added, and the resulting mixture was reacted for 2 hours. After cooling, promethazine-containing microcapsule suspension (CS) was obtained.

ATLOX ^™ 4913, antifoam, urea, penoxsulam and water were mixed and ground to prepare a suspension of penoxsulam (SC).

Promethazuron microcapsule suspension was added to the suspension of penoxsulam to obtain a mixed formulation (ZC) containing prosulfazuron + 10% penoxsulam.

Example 15:

Suspension emulsion containing 2% prosulfazuron + 3% penoxsulam is prepared from the following ingredients:

Dissolve penoxsulam in SOLVESSO ^TM 200, and add ethoxylated castor oil to the resulting solution to obtain an emulsion of penoxsulam; mix and grind prosulfuron, SOPROPHOR ^® 4D384, and grind in The resulting mixture was added with water to prepare a suspending agent.

The oil phase was added to the suspension to obtain a suspension emulsion containing 2% penoxsulam and 3% prosulfuron.

Embodiment 16:

An emulsifiable concentrate containing 10% prosulfazuron + 2% penoxsulam is prepared from the following ingredients:

The above components are mixed and stirred until a homogeneous phase is obtained.

Example 17:

Suspensions containing 20% prosulfazuron + 40% penoxsulam are prepared from the following ingredients:

The components are uniformed and ground to prepare a suspension.

Embodiment 18:

Wettable powder containing 40% prosulfazuron + 50% penoxsulam is prepared from the following ingredients:

The above ingredients are mixed, pulverized and ground to prepare a wettable powder.

Example 19:

Water-dispersed granules containing 20% prosulfazuron + 60% penoxsulam are prepared from the following ingredients:

The active ingredients, dispersant, wetting agent, disintegrant and filler are combined, mixed uniformly, ground and wetted with water to form a paste. The paste was extruded and air-dried to obtain a water-dispersed granule containing 20% prosulfazuron + 60% penoxsulam.

Example 20:

A mixture containing 40% prosulfazuron + 60% penoxsulam is prepared from the following ingredients:

Promethazine and penoxsulam are mixed uniformly in the above proportion.

Example 21:

A mixture containing 20% prosulfazuron + 60% penoxsulam + 20% dibenzoxazole acid is prepared from the following ingredients:

Mix promethazine, penoxsulam, and dibenzoxazole acid according to the above ratios and mix well.

Example 22:

A mixture containing 60% promethazuron + 20% penoxsulam + 20% chlorpromazine is prepared from the following ingredients:

Promethazine, penoxsulam, and acetochlor are mixed uniformly according to the above ratio.

Example 23:

A mixture containing 15% promethazuron + 5% penoxsulam + 80% acetochlor is prepared from the following ingredients:

Promethazine, penoxsulam, and acetochlor are mixed uniformly according to the above ratio.

Example 24:

A mixture containing 10% prosulfazuron + 5% penoxsulam + 85% dichloropropenylamine is prepared from the following ingredients:

Promethazine, penoxsulam, and dichloropropenylamine are mixed uniformly according to the above ratio.

Example 25:

A mixture containing 5% promethazine + 1% penoxsulam + 94% mefenpyr-diethyl is prepared from the following ingredients:

Mix promethazine, penoxsulam, and pyraclostrobin according to the above ratios and mix well.

Biological example

Examples 26 to 28 illustrate examples of the methods and uses of the present invention and demonstrate the effect of the composition of the present invention in controlling plant growth.

Example 26-Pre-emergence treatment:

The test plants are grown indoors in greenhouse conditions in a standard soil cultivation substrate. Before the test plants germinate, the herbicide group containing prosulfuron and penoxsulam The composition was applied to the soil surface on which the test plants were grown.

For comparison purposes, a control composition containing promethazine and penoxsulam was applied to the soil surface on which the test plants were grown.

Test plants are evaluated 2-4 weeks after planting and application. In the test, the combination of prosulfuron and penoxsulam was significantly more capable of controlling and preventing plant growth than the control test group. Specifically, the results of this test show that the combination of prosulfuron and penoxsulam has a significant synergistic effect.

This test shows that when the active ingredient in the present invention is applied to the cultivation substrate before germination, the method and composition of the present invention using the combination of prosulfuron and penoxsulam can completely prevent the emergence of test plants.

Similar test results were obtained when the same tests were performed after the test plants had germinated and the cotyledon stage. In these tests, these plants stopped growing after the cotyledon stage after application and died 3 to 4 weeks after application.

Example 27-Post-emergence treatment

Post-emergence treatment tests were performed on the following plants (Gramineous weeds, broadleaf weeds, sedges): Leptochloachinensis, Stellaria media, Amaranthus retroflexus, Setaria viridis, Vol. Fallopia (ex Polygonum) Convolvulus, Echinochloa crusgalli, Abuthilon theophrasti, Oryza sativa, Sagittariatrifolia, Oriental Waterplantain Rhizome, Herba of Pygmy Arrowhead), Monochoria korsakowii, Lindernia procumbens, Scirpus juncoides Roxb, and Cyperus diffomis L. The above plants are considered to be harmful plants in crops, especially rice.

Seeds or rhizomes of harmful plants and rice are planted in sandy soil in peat pots (4 cm in diameter) and covered with soil. Place peat pots in a greenhouse and keep the temperature right.

In addition, harmful plants are individually planted in peat pots.

Keep the water level in the pot 2 cm above the soil.

After 3 weeks of incubation, the plants will develop from the one-leaf stage to the three-leaf stage. At this time, the plants are treated with the following formulations: 1. promethazuron; 2. penoxsulam; and 3. promethazuron + pentafluoro Sulfachlor

The formulation was diluted with water and applied to plants.

After the application, the peat pots were placed in a greenhouse to maintain the optimal temperature for further cultivation.

21 days after application, the effectiveness of the herbicide was visually inspected.

The visual scores represent the comparison of the treated plants with the control plants. A score of 0% means no herbicidal activity. A score of 100% means that there is complete herbicidal activity (weeds are completely eliminated).

When the herbicidal activity of a composition comprising two active compounds is greater than the total activity of the two active compounds applied alone, the combination of the two active compounds can produce a synergistic effect. The expected activity of a particular combination of two active compounds can be calculated using the so-called "Colby formula" (see S.R.Colby, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15, 20-22): where: A = Percent activity of compound A when the application rate of active compound A is mg / ha; B = Percent activity of compound B when the application rate of active compound B is ng / ha; E = When compound A and B use Expected percentage of simultaneous application rates of mg / ha and ng / ha; then: E = A + B- (A × B / 100)

If the actual activity of the combination of compounds A and B observed is greater than the calculated result, the activity of the combination shows a superadditive effect, that is, a synergistic effect exists.

The above test results are summarized in Table 1 below.

From the results in Table 1, it can be seen that the combination of prosulfuron and penoxsulam can effectively control a variety of weeds, including annual grasses, sedges, and broadleaf weeds, especially Growth in rice fields. According to the test results, it can be seen that the herbicidal effect of application of prosulfuron and penoxsulam in combination is obviously better than that of application of prosulfuron or penoxsulam alone. Specifically, the results show that the combination of prosulfuron and penoxsulam has a synergistic effect. In addition, the combination of active ingredients maintains high herbicidal activity at low application rates. The combination of probenesulfuron and penoxsulam has a broader range of herbicidal spectrum than any one of them, and can be used for the comprehensive management of a variety of weeds. Using a combination of active ingredients can control herbicide-resistant weeds and reduce resistance to the target weeds.

Example 28-Toxicity test

Test plants wheat, corn, soybean, sugar beet, sugarcane, cotton, rice, beans, flax, barley, oats, rye, triticale, rape, potatoes and millet grew to four-leaf stage in plastic pots in a greenhouse. Propargazuron, a composition comprising prazosulfuron and a safener, a mixture of prazosulfuron and penoxsulam, were separately applied to the test plants, And a mixture of prazosin, penoxsulam and a safener.

Three weeks after application, the toxicity of the application to the test plants was evaluated. 100% means strong toxicity (all test plants died). 0% means non-toxic.

It was found that after adding safeners (especially fenoxacillin, acetaminophen, dichloropropenylamine, pyroxapyr, and dibenzoxazole acid (ethyl)), prosulfazuron and penesulfuron The combination of amines significantly reduced the toxicity to the test plants.

Claims (35)

A herbicidal composition comprising components (A) and (B), wherein component (A) is the compound promethazine and its molecular formula (I) is: Component (B) is the compound penoxsulam, whose molecular formula (II) is: The herbicide composition according to claim 1, wherein the weight ratio of the component (A) to the component (B) is 100: 1 to 1: 100. The herbicide composition according to claim 2, wherein the weight ratio of the component (A) to the component (B) is 5: 1 to 1: 5. The herbicide composition according to claim 1, wherein the total amount of component (A) and component (B) accounts for 5 to 90% by weight of the composition. The herbicide composition according to claim 4, wherein the total amount of component (A) and component (B) accounts for 30 to 50% by weight of the composition. The herbicide composition of claim 1, wherein the formulation of the composition is selected from the group consisting of a wettable powder (WP), an emulsifiable concentrate (EC), a suspending agent (SC), a microcapsule suspending agent (CS), and a microemulsion (ME), emulsion, such as water emulsion (EW), or suspension emulsion (SE), water-dispersible granules (WDG), ultra-low-volume liquid (ULV), or mixed dosage form. The herbicide composition of claim 1, further comprising one or more compounds selected from the group consisting of safeners, fungicides, insecticides, acaricides, nematicides, bird repellents, soil conditioners, plants Nutrients (fertilizers), plant growth regulators, micronutrients and herbicides different from components (A) and (B). A herbicide composition as claimed in claim 7, wherein the composition comprises a safener. The herbicide composition of claim 8, wherein the safener is effective to reduce the toxicity of the agent to one or more crops selected from wheat, barley, rye, oats, corn, rice, millet, sugar beet, sugar cane, Canola, cotton and soybeans. The herbicide composition according to claim 8, wherein the safener is selected from the group consisting of benoxacor, cloquintocet (-mexyl), cyometrinil, cyprosulfamide, Dichlormid, dicyclonon, O-phenylthiophosphoric acid O, O-diethyl ester (dietholate), fenchlorazole (-ethyl), fenclorim , Flurazole, fluofenim, furilazole, isoxadifen (-ethyl), mefenpyr (-diethyl), formazan Methyl carbamate 4-mephenate, naphthalenedicarboxylic anhydride, oxabetrinil, and mixtures thereof. The herbicide composition according to claim 8, wherein the weight ratio of the herbicidally active compound to the safener is 90,000: 1 to 1: 5000. The herbicide composition according to claim 11, wherein the weight ratio of the herbicidally active compound to the safener is 20: 1 to 1: 100. A method for controlling growth at a plant location, the method comprising applying components (A) and (B) at the location, wherein the component (A) is a compound promethazine and its molecular formula (I) is: Component (B) is the compound penoxsulam, whose molecular formula (II) is: The method of claim 13, wherein the weight ratio of the component (A) to the component (B) is 100: 1 to 1: 100. The method of claim 14, wherein the weight ratio of the component (A) to the component (B) is 5: 1 to 1: 5. The method of claim 13, wherein the component (A) and the component (B) are administered in a dosage form selected from the group consisting of a wettable powder (WP), an emulsifiable concentrate (EC), a suspending agent (SC), and a microcapsule suspending agent (CS), microemulsions (ME), emulsions, such as water emulsion (EW), or suspension emulsion (SE), water-dispersible granules (WDG), ultra-low-volume liquid (ULV), or mixed dosage forms. The method of claim 13, further comprising applying, at the location, one or more compounds selected from the group consisting of: a safener, a fungicide, an insecticide, an acaricide, a nematicide, a bird repellent, soil Regulators, phytonutrients (fertilizers), plant growth regulators, micronutrients and herbicides different from components (A) and (B). The method of claim 16 wherein the method includes using a safener. The method of claim 17, wherein the safener is effective to reduce the toxicity of the agent to one or more crops selected from wheat, barley, rye, oats, corn, rice, millet, sugar beet, sugar cane, rapeseed, cotton And soy. The method according to claim 18, wherein the safener is selected from the group consisting of chlorpromazine, toxicoxamine, chlorpromazine, ciprofloxacin, dichloropropenylamine, bicyclouron, O-phenylthiophosphoric acid O, O- Diethyl ester, oxaprazole, acetaminophen, acetaminophen, fluoxoxime, oxamethoxazole, bisoxazolic acid, oxamethoxam, 4-chlorophenyl methylcarbamate, naphthalene Dicarboxylic anhydride, oxalonitrile, and mixtures thereof. The method of claim 18, wherein the weight ratio of the herbicidally active compound to the safener is 90,000: 1 to 1: 5000. The method according to claim 21, wherein the weight ratio of the herbicidally active compound to the safener is 20: 1 to 1: 100. The method according to claim 13, wherein the plant is a monocotyledonous and dicotyledonous plant, wherein the monocotyledonous plant includes Polygonum, Polygonum, Poa, Eugenia, Brachiaria, Crassula, Salmonella , Sedge, genus Pucciniella, Puccinia spp., Aquilaria, Polygonum spp., Genus Alisma, Phyllostachys sp Polygonum, Corydalis, Moss, Hydrangea, Spikes, Snake Eyes, Eclipta, Grossula, Water Anise, Moss, Syringa, Cress, Ranunculus The genus Heze pepper. The method according to claim 23, wherein the monocotyledonous plant comprises one or more of a sedge, duck tongue, ox felt, sassafras, sedge, sedge, dwarf mushroom, diarrhea, and firefly. The method according to claim 23, wherein the dicotyledonous plant comprises one or more of Arthropoda chinensis, cuspid flower, Moshangcai, Lilac coriander, Eyeweed, Sanyaogoufan and Cress. The method of claim 13, wherein the components (A) and (B) are administered simultaneously and / or sequentially. The method of claim 13, wherein the components (A) and (B) are applied before and / or after the plant has germinated. The method of claim 13, wherein the components (A) and (B) are applied to the plant material. The method of claim 28, wherein the plant material is a seed. The method of claim 13, wherein the components (A) and (B) are administered in the form of a composition according to any one of claims 1 to 12. The method of claim 13, wherein the location comprises a member selected from the group consisting of flax, triticale, wheat, barley, rye, oats, rice, corn, millet, sugar beet, cane, rapeseed, cotton, sunflower, tobacco, soybean, potato , Leek, cabbage, carrot, tomato and onion crops, or the location includes pastures, green spaces or lawns, or the location is a fruit plantation, or the location is a non-farming area. The use of a combination of components (A) and (B) in controlling plant growth, wherein component (A) is the compound promethazine and its molecular formula (I) is: Component (B) is the compound penoxsulam, whose molecular formula (II) is: Use as claimed in claim 32 for protecting crops selected from the group consisting of flax, triticale, wheat, barley, rye, oats, rice, corn, millet, sugar beet, sugar cane, rapeseed, cotton, sunflower, tobacco, soybeans , Potatoes, leeks, cabbage, carrots, tomatoes, onions, or to protect crops in pastures, green areas, lawns, fruit plantations or non-farm areas. The use of a safener to reduce the toxicity of the combination of components (A) and (B) in controlling the growth of plants, wherein component (A) is the compound prosulfuron and its molecular formula (I) is: Component (B) is the compound penoxsulam, whose molecular formula (II) is: Wherein the safener is selected from the group consisting of chlorpromazine, quintoxin, chlorprozamide, ciprofloxacin, dichloropropenylamine, dicyclonon, O-phenylthiophosphoric acid O, O-diethyl ester , Oxamethoxazole, acetaminophen, acetaminophen, fluoxoxime, oxamethoxazole, bisoxazolic acid, pyroxapyr, 4-chlorophenyl methylcarbamate, naphthalenedicarboxylic anhydride, Oxalonitrile and their mixtures. The use according to claim 34, wherein the safener is effective to reduce toxicity to one or more crops selected from wheat, barley, rye, oats, corn, rice, millet, sugar beet, sugar cane, rapeseed, cotton and soybean.