TWI672152B - Oil-in-water emulsion composition - Google Patents

Abstract

An object of the present invention is to provide a cosmetic or skin external preparation comprising an oil-in-water emulsion composition having a pH of 3 to 6 of allantoin, which is emulsified without the problem of crystal precipitation of allantoin at a low temperature. Excellent stability. The oil-in-water emulsion composition of the present invention is used as a cosmetic or external preparation for skin, which comprises the component (a) allantoin, the component (b) long-chain mercaptomethyltaurate, and the component ( c) the polyol, preferably having a mass ratio of the component (a) to the component (c) of 0.002 to 0.05, more preferably (b) of 0.2 to 3%, more preferably containing polyoxyalkylene The base is added to glycerin, polyoxyalkylene alkyl diglyceride as component (d), and has a pH of 3-6 at 25 °C.

Description

Oil-in-water emulsion composition

The present invention relates to an oil-in-water emulsion composition comprising allantoin, long-chain mercaptomethyltaurate and a polyhydric alcohol for use as a cosmetic or external preparation for skin, and more particularly, to prevent An oil-in-water emulsion cosmetic or an external preparation for skin which precipitates crystals of allantoin and which has the stability of the preparation.

Allantoin has a cell proliferative action or an anti-inflammatory action, and is widely used for the purpose of improving skin roughness in the field of cosmetic materials. However, it is known that allantoin is hydrolyzed when the pH exceeds 6 (refer to Patent Document 1), and in order to ensure stability, it is necessary to contain allantoin at a pH of 6 or less. Further, there is also a problem that allantoin itself has low solubility in water, and is particularly likely to precipitate crystals at a low temperature.

On the other hand, as an oil-in-water emulsion composition, an emulsion using various surfactants has been studied, but in an acidic region having a pH of 6 or less, the emulsified droplets tend to aggregate, and it is difficult to ensure a good emulsified state or stabilized over time. Sex.

As a composition containing allantoin, a triethanolamine salt prepared with a long-chain mercaptoalkyl taurate type anionic surfactant or a triethanolamine salt of an ether carboxylic acid type anionic surfactant is known. A cleaning agent having good long-term storage stability under high temperature or light irradiation, such as urea or allantoin (refer to Patent Document 2); an emulsifying system containing an anionic surfactant such as allantoin, beeswax, and sodium lauryl sulfate The oil-type emulsified composition adjusted to a pH of 3 to 6 (refer to Patent Document 3); and the glycyrrhetinic acid, the mono-fatty acid polyethylene glycol ester, the lauryl methyl taurate, the allantoin, etc. Anti-inflammatory effect (refer to Patent Document 4). Further, an external preparation for skin containing a higher alcohol, a long-chain mercaptosulfonate-type anionic surfactant, and a tranexamic acid and having a pH of 3 to 6 is known (see Patent Document 5).

[Patent Document 1] Japanese Patent Laid-Open Publication No. 2013-1651

[Patent Document 2] Japanese Patent Laid-Open No. Hei 10-36886

[Patent Document 3] Japanese Patent Laid-Open Publication No. 2003-505404

[Patent Document 4] Japanese Patent Laid-Open Publication No. 2012-144490

[Patent Document 5] Japanese Patent Laid-Open Publication No. 2011-84551

An object of the present invention is to provide an oil-in-water type which contains allantoin and, in particular, crystal precipitation without low temperature, and allantoin can be stably present and has good stability over time even under a pH of 6 or less. A cosmetic or skin external preparation for emulsifying the composition.

The inventors of the present invention have diligently studied to suppress the precipitation of allantoin at a low temperature and to ensure the emulsion stability of pH 6 or less, and as a result, it has been found that the allantoin is combined with the polyol and the allantoin The interaction between the element and the polyol preferentially acts on the interaction of the allantoin with each other, whereby the hydration of the allantoin is easily maintained, so that the crystallization is remarkably lowered. Further, the following findings have been obtained: With regard to this effect, the effect is further improved by combining a polyoxyalkylene group-added glycerin and a polyoxyalkylene group-added diglycerin. Further, it has been found that when a long-chain mercaptomethyltaurate is used as a surfactant, an oil-in-water emulsion having good stability can be obtained even in a low pH region of pH 3 to 6, and not only The ionic interaction with allantoin can also synergistically inhibit crystallization; based on these findings, the present invention has been completed.

That is, the present invention provides [1] an oil-in-water emulsion composition for use as a cosmetic or an external preparation for skin, which comprises the component (a) allantoin, component (b) long-chain mercaptomethyl taurine Salt, and component (c) polyol, and the pH is 3-6 at 25 °C. Further, the present invention provides [2] the oil-in-water emulsion composition according to [1] above, characterized in that the content ratio of the component (a) to the component (c) is 0.002 to 0.05. Further, the present invention provides the oil-in-water emulsion composition according to any one of the above [1], wherein the content of the component (b) is 0.2 to 3% by mass. The present invention provides the oil-in-water emulsion composition according to any one of the above [1] to [3] wherein the component (c) is selected from the group consisting of propylene glycol, 1,3-butylene glycol, and glycerin. And one or more of dipropylene glycol, diglycerin, polyethylene glycol, sorbitol, and maltitol; and provide [5] an oily emulsion type composition containing polyoxyalkylene alkyl addition glycerin, Polyoxyalkylene addition diglycerin is used as component (d).

The present invention can provide an oil-in-water emulsion composition having good stability over time, particularly no precipitation of crystals at low temperatures. Further, according to the present invention, it is possible to provide a low pH region having a pH value of 6 or less which does not cause hydrolysis of allantoin, and there is no deterioration such as aggregation or aggregation of separation or emulsified droplets, and the emulsified state or the stability with time is good. A cosmetic or skin external preparation of an oily emulsified composition in water.

Hereinafter, the present invention will be described in detail. Furthermore, in the present specification, when the range of values is used, the range is set to include the values of both ends.

The chemical name of the allantoin of the component (a) used in the present invention is 5-ureido-sodium carbazide, which is known to activate the function of cells and has an effect of promoting cell proliferation, anti-inflammatory, hemostasis, sterilization, and the like. The allantoin in the present invention is not particularly limited, and a user of a usual cosmetic or external preparation for skin can be arbitrarily selected and used.

The content of the component (a) allantoin of the present invention is not particularly limited, and is preferably in the total amount of the oily emulsified composition in water from the viewpoint of the skin roughness improving effect and the inhibition of crystal precipitation. It is 0.05 to 0.5% by mass (hereinafter referred to as "%"), and more preferably 0.05 to 0.3%.

The long-chain mercaptomethyltaurine salt of the component (b) used in the present invention is an anionic surfactant, which is excellent in emulsion stability in a low pH region, and is ionic with allantoin. The crystallization effect is exerted by interaction. In the field of cosmetics, anionic surfactants of various chemical structures are known, but they are not suitable for emulsification in low pH regions or insufficient crystallization inhibition effects of allantoin. In the present invention, long chain thiol groups are selected. Base taurates are used as those satisfying both effects.

As the long-chain mercaptomethyltaurate salt of the component (b) used in the present invention, a long-chain mercaptomethyltaurine salt which is usually used for a cosmetic or an external preparation for skin can be used arbitrarily. For example, sodium N-stearyl-N-methyltaurate, sodium N-myristyl-N-methyltaurate, sodium coconut oil fatty acid methyl taurate, lauryl methyl One or two or more kinds of sodium taurate or the like can be used.

The content of the component (b) long-chain mercaptomethyltaurate salt of the present invention is not particularly limited, and the total amount of the oil-type emulsified composition in water is from the viewpoint of inhibition of crystallization of the allantoin and emulsion stability. Preferably, it is 0.2 to 3.0%, and more preferably 0.3 to 2.0%.

The polyol of the component (c) used in the present invention maintains the hydration of allantoin, and particularly inhibits the crystallization of allantoin at a low temperature. As the polyol of the component (c) used in the present invention, a polyol which is usually used for a cosmetic can be used arbitrarily. For example, a glycol (for example, ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2, 3-butyl) Glycol, 1,5-pentanediol, 2-butene-1,4-diol, hexanediol, octanediol, etc.); triol (eg glycerol, trimethylolpropane, etc.); quaternary Alcohol (e.g., pentaerythritol such as 1,2,6-hexanetriol, etc.); pentavalent alcohol (e.g., xylitol, etc.); hexahydric alcohol (e.g., sorbitol, mannitol, etc.); polyol polymer (e.g., diethyl Glycol, dipropylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol, diglycerin, polyethylene glycol, triglycerin, tetraglycerin, polyglycerol, etc.; and sugar alcohols (eg sorbitol, maltitol, Maltotriose, mannitol, sucrose, erythritol, glucose, fructose, starch-decomposing sugar, maltose, xylose, starch-decomposing sugar As the raw alcohol or the like, one type or two or more types can be used.

Among the above polyols, from the viewpoints of hydration ability and feeling of use, propylene glycol, 1,3-butylene glycol, glycerin, dipropylene glycol, diglycerin, polyethylene glycol, sorbitol, and maltitol are preferable. Further, preferred are 1,3-butanediol, propylene glycol, glycerin, and polyethylene glycol.

The content of the component (c) of the present invention is not particularly limited, and is preferably from 4 to 36%, more preferably from 10 to 30%, still more preferably from 12 to 25, based on the total amount of the oily emulsion composition in water. %. In addition, the mass ratio of the component (a) to the component (c) is preferably from 0.002 to 0.05, and more preferably from 0.004 to 0.04, from the viewpoint of the effect of suppressing the crystal precipitation of allantoin and the emulsion stability.

The oil-in-water emulsion composition of the present invention has a pH of 3 to 6 at 25 °C. The pH value is adjusted by appropriately adding a pH adjuster so that the pH of the final oil-based emulsified composition becomes the above range. Examples of the pH adjusting agent include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, dl-malic acid, potassium carbonate, sodium hydrogencarbonate, and ammonium hydrogencarbonate. One type or two or more types may be used. Further, the adjustment method is not particularly limited, and it can be dissolved in the emulsified aqueous phase in the step of producing the oil-based emulsified composition in water or added to the water, or added without being dissolved. Further, after the oily emulsified composition in water is produced, it can be added while confirming the pH.

In the present invention, if the pH value is less than 3, there is a concern of emulsion stability and safety to the skin. If the pH exceeds 6, hydrolysis of allantoin occurs, and it is difficult to obtain the component in a long-term and stable manner. Rough skin improvement or anti-inflammatory effect.

In the present invention, in order to prepare the oil-in-water emulsion composition, water and oily components are required in addition to the above components.

The water is not particularly limited as long as it is used for the manufacture of ordinary cosmetic materials, and examples thereof include ordinary water, purified water, hot spring water, deep water or lavender water, rose water, orange blossom water, and the like. One type or two or more types may be used for the steam distilled water or the like.

The oily component used in the present invention may be any ordinary cosmetic or external preparation for skin. The oil agent to be used is not particularly limited, and may be arbitrarily selected and used in one or two or more types depending on the nature of the animal oil, the vegetable oil, the synthetic oil, or the like, the solid oil, the semi-solid oil, the liquid oil, and the volatile oil. Examples of the oil component include oils such as hydrocarbons, oils and fats, waxes, hydrogenated oils, ester oils, fatty acids, higher alcohols, polyoxyxides, fluorine-based oils, and lanolin derivatives. . Specific examples thereof include hydrocarbons such as liquid paraffin, squalane, petrolatum, polyisobutylene, polybutene, paraffin wax, ceresin wax, microcrystalline wax, and Fischer-Tropsch wax; wood wax and olive oil; Oils such as oil, castor oil, eucalyptus oil, macadamia oil; waxes such as montan wax, beeswax, carnauba wax, canary wax, and cetyl wax; cetyl isooctanoate, isopropyl myristate, palmitic acid Isopropyl ester, octyl dodecyl myristate, tricaprylin, diisostearic acid diglyceride, triisostearic acid diglyceride, tribehenic acid glyceride, pentaerythritol rosinate, neopentyl Esters such as diol dicaprylate, cholesterol fatty acid ester, N-lauroside-L-glutamic acid bis(cholesteryl, behenyl, octyldodecyl) ester; stearic acid, lauric acid, Fatty acids such as myristic acid, behenic acid, isostearic acid, oleic acid, rosin acid, 12-hydroxystearic acid; stearyl alcohol, cetyl alcohol, cetearyl alcohol, myristyl alcohol, lauryl alcohol Higher alcohols such as oleyl alcohol, isostearyl alcohol, behenyl alcohol; low polymerization degree dimethyl polyoxane, high polymerization degree dimethyl polyoxyl , methylphenyl polyoxyalkylene, decamethylcyclopentaoxane, octamethylcyclotetraoxane, fluorine-modified polyfluorene oxide, etc.; perfluoropolyether, perfluorodecane, Fluorine-based oils such as perfluorooctane; and lanolin derivatives such as lanolin, lanolin acetate, lanolin fatty acid isopropyl ester, and lanolin, etc., may be used alone or in combination of two or more. Further, the amount of the oil component used in the present invention is preferably from 0.1 to 10%, more preferably from 0.5 to 8%, even more preferably from 1.5 to 6%, based on the total amount of the oily emulsion composition in water.

Furthermore, in the present invention, when the polyoxyalkylene group-added glycerin and the polyoxyalkylene group-added diglycerin are contained as the component (d), the effect of suppressing the crystallization of the component (a) is further increased, which is preferable. The polyoxyalkylene group-added glycerin and the polyoxyalkylene group-added diglycerin are obtained by adding propylene oxide or diglycerin to form an alkylene oxide. The carbon number of the alkylene oxide is not particularly limited, Preferably, it is 2 to 4, and more preferably 2 to 3. Further, the degree of polymerization of the alkylene oxide is not particularly limited, but is preferably 3 to 30, and more preferably 9 to 26. Two or more types of alkylene oxides can be used, and in this case, a block form, a random form, or the like can be arbitrarily polymerized.

Specific examples of the component (d) include polyoxyethylene (26) glycerin (sale name: LIPONIC EG-1, manufactured by LIPO CHEMICALS INC), and polyoxypropylene (9) diglycerin (sales name: SY) -DP9, manufactured by Sakamoto Pharmaceutical Co., Ltd.), polyoxyethylene (24) polyoxypropylene (24) glyceryl ether (sale name: Unilube 50TG-32, manufactured by Nippon Oil Co., Ltd.), polyoxybutylene (3) polyoxygen Ethylene (8) polyoxypropylene (5) glyceryl ether (trade name: WILBRIDE S-753, manufactured by Nippon Oil Co., Ltd.) or the like can be preferably used.

In addition to the above-mentioned essential components, it may be a component contained in a general cosmetic, and may contain a surfactant other than the component (b) and water-soluble in a range that does not impair the effects of the present invention, within a range that does not impair the effects of the present invention. A polymer, a moisturizing component, a UV absorber, a pH adjuster, an antioxidant, a metal chelating agent, a preservative, a powder, a color, a fragrance, various chemicals, and the like. The following may be mentioned as this component.

Examples of the anionic surfactant other than the component (b) include a fatty acid soap such as a green body for soap, sodium laurate or sodium palmitate, and an alkyl ether such as sodium lauryl sulfate as POE (polyoxyethylene, the same applies hereinafter). Sulfate salt; N-mercapto sarcosinate such as sodium laurate; sodium phosphate such as POE oil ether sodium phosphate, POE stearyl ether sodium phosphate; sodium di-2-ethylhexyl sulfosuccinate , succinic acid monoethanolamine polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, sulfosuccinate; linear sodium dodecyl benzene sulfonate, linear dodecyl benzene sulfonate Alkylbenzenesulfonate such as potassium acid; N-lauric acid glutamic acid monosodium, N-stearyl glutamate disodium, N-myristyl-L-glutamic acid monosodium, etc. Amino acid salt; higher fatty acid ester sulfate salt such as hydrogenated coconut oil fatty acid sodium glycerate; sulfur oxide such as Turkish red oil; and POE alkyl ether carboxylate, POE alkyl allyl ether carboxylate, α- Olefin sulfonate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkanolamine sulfate, lauryl monoethanol amide amber Salts, N- palmitoyl acyl aspartic acid salt, casein One type or two or more types can be used for sodium or the like.

Examples of the lipophilic nonionic surfactant include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, and sorbitan monopalmitate. , sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycol sorbitan penta-2-ethylhexanoate, diglycerin sorbose Sorbitol fatty acid esters such as alcoholic anhydride tetra-2-ethylhexanoate; glycerol monocotton seed oil fatty acid ester, glycerol monoerucate, glycerol sesquioleate, glyceryl monostearate, glycerol alpha , glycerol polyglycerol fatty acid such as α'-oleic acid glutamate, monostearic acid glyceryl malic acid; propylene glycol fatty acid ester such as propylene glycol monostearate; and hydrogenated castor oil derivative, etc. Or two or more.

Examples of the hydrophilic nonionic surfactant include POE sorbitan monooleate (oleate), POE sorbitan monostearate, and POE sorbitan monooleate (olete). POE sorbitan fatty acid esters such as POE sorbitan tetraoleate; POE sorbitol monolaurate, POE sorbitol monooleate, POE sorbitol pentoxide, POE sorbitol POE sorbitan fatty acid esters such as monostearate; POE glycerol monostearate, POE glycerol monoisostearate, POE glyceryl triisostearate, etc. POE glycerol fatty acid ester; POE monooleic acid POE fatty acid esters such as ester, POE distearate, POE mono-dioleate, ethylene glycol distearate; POE lauryl ether, POE oleyl ether, POE stearyl ether, POE behenyl ether POE alkyl ethers such as POE2-octyl lauryl ether and POE dihydrocholesterol ether; POE alkyl phenyl ethers such as POE octyl phenyl ether, POE nonyl phenyl ether, POE dinonyl phenyl ether POE‧POP alkyl ether, POE‧POP cetyl ether, POE‧POP2-decyltetradecyl ether, POE‧POP monobutyl ether, POE‧POP hydrogenated lanolin, POE‧POP glyceryl ether Class; Tetronic and other four POE‧ four POP ethylene diamine condensates; POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate, POE hydrogenated hydrazine Sesame oil monopoly glutamic acid monoisostearic acid diester, POE hydrogenated castor oil maleic acid and other POE castor oil hydrogenation Castor oil derivatives; POE beeswax, lanolin derivatives such as POE sorbitol beeswax; coconut oil fatty acid diethanolamine, lauric acid monoethanolamine, fatty acid isopropanolamine and the like, and POE propylene glycol fat Acid ester, POE alkylamine, POE fatty decylamine, sucrose fatty acid ester, POE nonylphenyl formaldehyde condensate, alkyl ethoxy dimethyl amine oxide, trioleyl phosphate, etc., can be used in one or two More than one species.

Examples of the amphoteric surfactant include 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl dimethylaminoacetate betaine, alkyl betaines, and decylamine. A betaine-based surfactant such as betaine or sulphobetaine; and lecithin or the like may be used alone or in combination of two or more.

Examples of the cationic surfactant include an alkyltrimethylammonium salt such as stearyltrimethylammonium chloride or lauryltrimethylammonium chloride; and distearyldimethylammonium chloride; Alkyldimethylammonium salt; alkyl (pyridinium salt) such as poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; cetylpyridinium chloride; and alkyl group Quaternary ammonium salt, alkyl dimethyl benzyl ammonium salt, alkyl isoquinolinium salt, dialkyl morpholinium salt, POE alkyl amine, alkyl amine salt, polyamine fatty acid derivative, pentanol fatty acid The derivative, the benzalkonium chloride, the benzethonium chloride, etc. may be used alone or in combination of two or more.

Examples of the water-soluble polymer include gum arabic, tragacanth, polygalactose, locust bean gum, guar gum, cationized guar gum, karaya gum, carrageenan, pectin, agar, and alfalfa seeds. (榅桲), plant-based polymers such as starch (rice, corn, potato, wheat), seaweed gum (hay algae extract); microbial polymers such as dextran, amber turmeric, and pullulan; collagen , animal products such as casein, albumin, gelatin; starch-based polymers such as carboxymethyl starch and methyl hydroxypropyl starch; methyl cellulose, nitrocellulose, ethyl cellulose, methyl hydroxypropyl a cellulose-based polymer such as cellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, cationized hydroxyethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, or cellulose powder; Alginic acid polymer such as sodium alginate or propylene glycol alginate; polyvinyl methyl ether, carboxyvinyl Ethylene polymer such as polymer (CARBOPOL (sale name), etc.), alkyl-modified carboxyvinyl polymer (PEMULEN (sales name), etc.); polyoxyethylene polymer, polyoxyethylene polyoxypropylene copolymer Acrylic polymers such as molecules, sodium polyacrylate, polyethyl acrylate, and polyacrylamide; organic water-soluble polymers such as polyethylenimine and cationic polymers; and bentonite, aluminum magnesium silicate, and lithium silicate soap One or two or more kinds of inorganic water-soluble polymers such as stone, lithium bentonite, and phthalic anhydride can be used.

Examples of the hydrating component include a saccharide, an amino acid and a derivative thereof, a peptide, and a plant extract, and one type or two or more types can be used.

Examples of the saccharide include sorbitol, erythritol, maltose, maltitol, xylitol, xylose, trehalose, inositol, glucose, mannitol, pentaerythritol, fructose, sucrose and esters thereof, and dextrin and the like. Derivatives, honey, black granulated sugar extracts, etc. Examples of the amino acid include glycine, alanine, lysine, isoleucine, serine, threonine, aspartic acid, glutamic acid, aspartame, and glutamine. , aminic acid, hydroxy lysine, arginine, cystine, cysteine, acetylcysteine, methionine, phenylalanine, tyrosine, valine, hydroxyguanamine Acid, ornithine, citrulline, theanine, creatine, creatinine, and the like. Examples of the amino acid derivative include glutathione, pyrrolidone carboxylic acid, N-lauroside-L-glutamic acid bis (phytosterol, 2-octyldodecyl) ester, and N- Laurel-L-glutamic acid bis(cholesteryl, behenyl, octyldodecyl) ester, N-lauroside-L-glutamic acid bis(cholesteryl, octyldodecyl) ester, N-laurel-L-glutamic acid bis (phytosterol, behenyl, 2-octyldodecyl) ester, N-lauroside-L-glutamic acid bis(2-octyldodecane Ester), N-methyl glutamic acid lysine condensate, and the like. The peptide may be derived from any one of animals, fish, shellfish, and plants, and specific examples thereof include hydrolysis of collagen, a derivative thereof, or the like thereof, hydrolyzate, a derivative thereof, or the like. a substance, a keratin and a derivative thereof or a decomposition product thereof, a wheat protein and a derivative thereof or a hydrolyzate thereof, a soy protein and a derivative thereof or a hydrolyzate thereof or the like. Examples of the plant extract include the use of cork, berberine, purple root, peony, medicine, birch, sage, scorpion, human scorpion, Aloe, mallow, iris, grape, coix seed, loofah, lily, saffron, Chuanxiong, ginger, small forsythia, stalk flower, garlic, pepper, dried tangerine peel, angelica, seaweed, etc. and extracted with water or organic solvent By.

Examples of the ultraviolet absorber include 2-hydroxy-4-methoxybenzophenone and 2,4,6-triphenylamino-p-(carbonyl-2'-ethylhexyl-1'-oxy). -1,3,5-triazine, 2-ethylhexyl salicylate, ethyl p-dihydroxypropyl benzoate, 2-ethylhexyl p-methoxycinnamate, 4-third- 4'-Methoxydibenzofuranium methane, 2-[4-(diethylamino)-2-hydroxybenzimidyl]benzoic acid hexyl ester, dimethoxybenzylidene dioxazimidazole 2-ethylhexyl propionate, 2,2'-methylenebis[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl) Phenol], (1,3,5)-triazine-2,4-bis[{4-(2-ethylhexyloxy)-2-hydroxy}-phenyl]-6-(4-methoxy Phenyl)-1,3,5-triazine, dimethoxane diethylbenzylidene malonate, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and Sodium salt, etc.

Examples of the antioxidant include ascorbic acid, α-tocopherol, dibutylhydroxytoluene, and butylhydroxyanisole.

Examples of the metal chelating agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium ethylenediaminetetraacetate, and ethylene. Trisodium aminotetraacetate, tetrasodium ethylenediaminetetraacetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, ethylenediaminetetraacetic acid, ethylenediamine hydroxyethyl Trisodium triacetate and the like.

Examples of the preservative include benzoic acid, salicylic acid, phenol, sorbic acid, paraben, benzalkonium chloride, chlorhexidine dichloride, trichloro symmetrical diphenylurea, and photoreceptor. , phenoxyethanol, and the like.

Examples of the powder and the coloring matter include talc, kaolin, mica, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, vermiculite, magnesium carbonate, calcium carbonate, and aluminum citrate. Barium citrate, calcium citrate, magnesium citrate, barium strontium citrate, metal tungstate, magnesium, cerium oxide, zeolite, barium sulfate, calcined calcium sulfate (calcined gypsum), phosphoric acid Metal soap such as calcium, fluoroapatite, hydroxyapatite, ceramic powder, zinc myristic acid, inorganic powder such as boron nitride; polyamidamide resin powder (nylon powder), polyethylene powder, polymethyl methacrylate Powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, organic powder such as benzoquinone resin powder, polytetrafluoroethylene powder, cellulose powder; inorganic white pigment such as titanium dioxide and zinc oxide; iron oxide, γ-oxidation Inorganic coloring pigments such as iron, iron oxide yellow, iron oxide black, chromium oxide, ultramarine blue, iron blue; and pearl pigments, metal powder pigments, organic pigments, natural pigments, and the like.

Examples of the various agents include, for example, moisturizing, anti-inflammatory, blood flow promoting, cell activation, antibacterial, analgesic, and the like, and examples thereof include anti-inflammatory agents (for example, glycyrrhizic acid derivatives, glycyrrhetic acid derivatives, salicylic acid derivatives, and the like). Alkali, zinc oxide, etc.; whitening agents (such as vitamin C derivatives, placenta extract, saxifrage extract, arbutin, etc.); activators (such as royal jelly, photoreceptors, cholesterol derivatives, etc.); blood flow Promoters (such as undecylamine decanoate, benzyl nicotinic acid, β-butoxyethyl nicotinic acid, capsaicin, zingerone, canthax, fish fat, tannic acid, α-borneol, Tocopherol nicotinic acid ester, phytallyl nicotinic acid ester, cyclomandelic acid ester, cinnamyl piperazine, torazoline, acetylcholine, verapamil, cephalosporin, γ-oryzanol Etc.); anti-lipid leakage agents (such as sulfur, dimethyl sulfonium, etc.); and anti-inflammatory agents (such as tranexamic acid, thiotaurine, secondary bovine cholesterol, etc.), one or more types may be used. .

The method for producing the oil-in-water emulsion composition of the present invention is not particularly limited and can be produced by a usual method. For example, it can be prepared by heating and mixing the oily component until the components (a) to (c) are dissolved in water and emulsified, and then cooled to room temperature. nearby.

The oil-in-water emulsion composition of the present invention can be used as a cosmetic, and can be applied to an emulsion, a cream, a beauty liquid, a conditioner, a hair styling, a makeup foundation, a liquid foundation, etc., and can be applied to an external liquid agent as an external preparation for skin. , topical gel, cream, ointment, coating agent, lotion, plaster, and the like. Further, regarding the oil used in the cosmetic or skin external preparation of the present invention The properties of the emulsified composition can be carried out in the form of a cosmetic such as a solid, a gel, a cream or a liquid.

[Examples]

The invention will now be further illustrated by the examples. Furthermore, these are not intended to limit the invention in any way.

Examples 1 to 16 and Comparative Examples 1 to 6: Oil-in-water emulsion

The oil-in-water emulsion was prepared according to the compositions shown in Tables 1 and 2 and the following production method, and the crystallization inhibition effect at <1> low temperature and the emulsion stability at high temperature were evaluated by the method shown below. The results are shown together in Tables 1 and 2.

<1> Crystallization inhibition effect at low temperature

Each sample was placed in a glass bottle and stored in a thermostat at -10 ° C for 24 hours. Thereafter, the state of the crystal immediately after the removal from the constant temperature bath (-10 ° C) and the sample was returned to room temperature was visually observed, and the judgment was made based on the following criteria.

[evaluation benchmark]

◎: No crystals were observed at -10 ° C at room temperature.

○: A little crystal precipitation was observed at -10 ° C, but disappeared when it returned to room temperature.

△: A slight crystal precipitation was observed at -10 ° C, and the crystal did not disappear even after returning to room temperature.

×: Crystallization was confirmed at -10 ° C, and the crystal did not disappear even after returning to room temperature.

<2>Emulsification stability at high temperature

Each sample was placed in a glass bottle and stored in a thermostat at 50 ° C, and the emulsion stability after one month was compared with the stored product at 5 ° C, and observed by visual observation and microscope, and according to the following The basis is judged.

[evaluation benchmark]

◎: Not changed at all

○: It was confirmed that the particle size slightly increased, but the liquid discharge was not confirmed.

△: It was confirmed that the particle size was increased, and a little drainage was confirmed.

×: It was confirmed that the particle size was increased, and it was confirmed that the discharge was remarkable.

(method of law)

A. The components (1) to (19) were heated to 70 ° C to be uniformly dissolved.

B. The components (20) to (23) were heated to 70 ° C to be uniformly dissolved, and the mixture was added to A while stirring.

C. An emulsion is obtained by cooling while facing B.

As is clear from the results of Tables 1 and 2, the emulsions of Examples 1 to 16 were excellent in crystal precipitation suppressing effect and excellent in emulsion stability. It is more difficult to precipitate crystals when the component (a) has a smaller mass ratio than the component (c), and the long chain mercaptomethyltaurate of the component (b) More people get better crystallization precipitation inhibition effect. Further, in Example 16 containing "polyoxyalkylene group-added glycerol" of the component (d), a higher crystal precipitation suppressing effect was obtained.

On the other hand, in Comparative Examples 1 to 4 which did not contain the long-chain mercaptomethyltaurate of the component (b) and different types of surfactants, crystallinity of allantoin was observed, and the emulsion stability was also inferior. In Comparative Example 5, which did not contain the polyol of the component (c), crystal precipitation was not inhibited, and crystallization was observed also at room temperature. Further, in Comparative Example 6, the polyol of the component (c) was not contained, and instead of containing a monohydric alcohol, crystals were observed at room temperature, and precipitation was not inhibited.

Example 17 Oil-in-water cream

An oil-in-water cream was prepared according to the composition and method described below.

(method of law)

A. The components (1) to (9) were heated to 80 ° C to be uniformly dissolved.

B. The components (10) to (13) were heated to 80 ° C to be uniformly dissolved, and added to A while stirring.

C. Add the ingredients (14) to (16) after stirring in the face of B.

D. Stir C again to obtain a cream.

The cream of Example 17 obtained as described above had a pH of 5, and the crystallization precipitation inhibiting effect and the emulsion stability were extremely excellent.

Example 18 Oil-in-water type hair styling material

The hair styling material was prepared according to the composition and preparation method shown below.

(16) vinylpyrrolidone-vinyl acetate copolymer 0.3

(method of law)

A. The components (1) to (9) were heated to 70 ° C to be uniformly dissolved.

B. The components (10) to (13) are heated to 70 ° C to be uniformly dissolved, and these are added to A while stirring.

C. Add the ingredients (14) to (16) after stirring in the face of B.

D. Stir C again to obtain a whole hair.

The whole hair powder of Example 18 obtained as described above had a pH of 6, and the crystallization prevention and emulsion stability were extremely excellent.

Example 19 Oily liquid foundation in water

An oily liquid foundation was prepared according to the composition and method described below.

(method of law)

A. The components (1) to (8) are heated to 90 ° C to be uniformly dissolved.

B. The components (9) to (12) are heated to 70 ° C to be uniformly dissolved, and these are added to A while stirring.

C. After cooling with agitation in the face of B, add the components (13) to (18) which have been subjected to the drum treatment beforehand.

D. Stir C again to obtain a liquid foundation.

The liquid foundation of Example 19 obtained as described above had a pH of 5.5, and the crystallization prevention and the emulsion stability were extremely excellent.

Claims (4)

An oil-in-water emulsion composition for use as a cosmetic or external preparation for skin, which comprises the following components (a) to (d): component (a) allantoin, component (b) long-chain mercaptomethyl bovine The sulfonate, component (c) polyol, and component (d) polyoxyalkylene addition glycerol and/or polyoxyalkylene addition diglycerin, and having a pH of 3-6 at 25 °C. The oil-in-water emulsion composition of claim 1, wherein the content ratio of the component (a) to the component (c) is 0.002 to 0.05. The oil-in-water emulsion composition according to any one of claims 1 to 2, wherein the content of the component (b) is 0.2 to 3% by mass. The oil-in-water emulsion composition according to any one of claims 1 to 2, wherein the component (c) is selected from the group consisting of propylene glycol, 1,3-butylene glycol, glycerin, dipropylene glycol, diglycerin, polyethylene glycol, and sorbus One or two or more of a sugar alcohol and a maltitol.