CN106102706A - O/W emulsion composition - Google Patents

Abstract

The problem of the present invention is to provide a kind of cosmetics or skin preparations for extenal use, and described cosmetics or skin preparations for extenal use are the O/W emulsion compositions that the pH containing allantoin is 3～6, the problem that there is not allantoin crystallization under low temperature, and emulsion stability is excellent.The present invention is a kind of O/W emulsion composition for using as cosmetics or skin preparations for extenal use, described O/W emulsion composition contains the allantoin as composition (a), long acyl methyl tauride as composition (b), polyalcohol as composition (c), and when 25 DEG C, the pH of described O/W emulsion composition is 3～6, preferably, composition (a) is 0.002～0.05 relative to the mass ratio of composition (c), further preferably, b the content of () is 0.2～3%, more preferably, described O/W emulsion composition contains polyoxyalkylene addition glycerin ether, polyoxyalkylene addition diglycerol ether is as composition (d).

Description

O/W emulsion composition

Technical field

The present invention relates to a kind of O/W emulsion composition for using as cosmetics or skin preparations for extenal use, described O/W emulsion composition contains allantoin (allantoin), long acyl methyl tauride and polyalcohol, in more detail and Speech, relates to oil-in-water emulsion type cosmetic preparation or the skin of crystallization and the stability having preparation concurrently that can prevent allantoin External preparation.

Background technology

Allantoin has cel l proliferation, antiinflammation, in cosmetic field, for improving the mesh such as pachylosis , allantoin is widely used.It is well known, however, that allantoin pH higher than 6 when by hydrolyzing (seeing patent document 1), be Guarantee stability, need under conditions of pH is below 6, contain allantoin.In addition, there is also following problem: allantoin self Dissolubility in water is low, especially at low temperatures, easily separates out crystallization.

On the other hand, as O/W emulsion composition, the emulsion employing various surfactant is being studied, But when the acid range that pH is less than 6, the easy aggegation of emulsion droplet, it is difficult to guarantee good emulsified state, ageing stability.

As the composition containing allantoin, it is known that following composition: a kind of washing agent, described washing agent is to cooperate with long-chain The triethanolamine salt of acylalkyl taurine salt form anion surfactant or the three of ether carboxylic acid type anion surfactant Ethanolamine salt, urea, allantoin etc. and formed, at high temperature, the long-term storing stability under illumination is good (sees patent literary composition Offer 2)；A kind of O/W emulsion composition, described O/W emulsion composition is will to comprise allantoin, beeswax and lauryl The pH of the emulsification system of the anion surfactants such as sodium sulphate is adjusted to (see patent document 3) obtained from 3～6；A kind of Topical composition, is combined with enoxolone, mono fatty acid macrogol ester, lauroyl methyl ox sulphur in described topical composition Acid sodium, allantoin etc., the antiphlogistic effects of described topical composition is improved (seeing patent document 4).Furthermore it is known that a seed coat Skin external preparation, described skin preparations for extenal use contains higher alcohol, long acyl sulfonate type anion surfactant and tranexamic acid, And pH is 3～6 (seeing patent document 5).

Patent document 1: Japanese Unexamined Patent Publication 2013-1651 publication

Patent document 2: Japanese Unexamined Patent Publication 10-36886 publication

Patent document 3: Japanese Unexamined Patent Application Publication 2003-505404 publication

Patent document 4: Japanese Unexamined Patent Publication 2012-144490 publication

Patent document 5: Japanese Unexamined Patent Publication 2011-84551 publication

Content of the invention

Invent problem to be solved

The problem of the present invention is to provide a kind of cosmetics or skin preparations for extenal use, under described cosmetics or skin preparations for extenal use are State O/W emulsion composition, although described O/W emulsion composition is containing allantoin, but especially at low temperatures not There is crystallization, and, even if under conditions of below the pH6 of allantoin energy stable existence, ageing stability is also good.

For solving the means of problem

Emulsion stability when crystallizing and guarantee that pH is less than 6 to suppress allantoin to separate out at low temperatures, the application Inventor conduct in-depth research, it was found that by by allantoin and polyhydric alcohol conjugate, thus allantoin and polyalcohol Interact and preferentially carry out than allantoin interaction each other, thus will easily maintain the hydration of allantoin, therefore, can Substantially reduce crystallization.In addition, it has been found that for the effect above, by combination polyoxyalkylene addition glycerin ether (polyoxyalkylene-added glycerin), polyoxyalkylene addition diglycerol ether (polyoxyalkylene-added Diglyceryl), effect improves further.And then discovery, when using long acyl methyl tauride as surfactant, Even if not only can get at the also good oil-in-water emulsion of the low pH ranges internal stability that pH is 3～6, and by with urine Ionic interaction between Bursin, can suppress crystallization synergistically, complete the present invention based on above-mentioned discovery.

That is, the present invention provides: [1] is used for the O/W emulsion composition using as cosmetics or skin preparations for extenal use, It contains the allantoin as composition (a), the long acyl methyl tauride as composition (b), polynary as composition (c) Alcohol, when 25 DEG C, the pH of described O/W emulsion composition is 3～6.Also provide: the oil-in-water type described in [2] above-mentioned [1] Emulsification composition, it is characterised in that composition (a) is 0.002～0.05 relative to the mass ratio of composition (c).Also provide: on [3] State the O/W emulsion composition described in [1] or [2], it is characterised in that the content of composition (b) is 0.2～3 mass %.Separately Outer offer: the O/W emulsion composition according to any one of [4] above-mentioned [1]～[3], it is characterised in that composition (c) is choosing In propane diols, 1,3-BDO, glycerine, DPG, diglycerol, polyethylene glycol, D-sorbite, maltitol a kind or 2 More than Zhong；And provide: [5] O/W emulsion composition, it is double sweet that it contains polyoxyalkylene addition glycerin ether, polyoxyalkylene addition Oil ether is as composition (d).

The effect of invention

The present invention can provide a kind of O/W emulsion composition, the warp of allantoin in described O/W emulsion composition When have good stability, there is not crystallization especially at low temperatures.And then, it is possible to provide a kind of cosmetics or skin preparations for extenal use, Described cosmetics or skin preparations for extenal use are following O/W emulsion compositions, even if described O/W emulsion composition is at urine Bursin does not occur in there is not the low pH ranges of below the pH6 of hydrolysis to separate or the deterioration such as the aggegation of emulsion droplet, polymerization, breast yet Change state, ageing stability are good.

Detailed description of the invention

Hereinafter, the present invention is described in detail.It should be noted that in this specification, use～represent number range When, this scope includes the numerical value at two ends.

The composition (a) using in the present invention is the chemistry entitled allantoin (5-of allantoin Ureidehydantoin), activating cell function, promote that cell proliferation, anti-inflammatory, hemostasis, the action effect such as sterilization are known 's.Allantoin in the present invention is not particularly limited, can from common cosmetics or skin preparations for extenal use spendable allantois Arbitrarily select in Su to use.

The composition (a) of the present invention is that the content of allantoin is not particularly limited, from the effect improving pachylosis and suppression From the viewpoint of crystallization, in O/W emulsion composition total amount be preferably 0.05～0.5 mass % (hereinafter referred to as For " % "), more preferably 0.05～0.3%.

The composition (b) i.e. using in present invention long acyl methyl tauride is anion surfactant, and it is not only Emulsion stability in low pH ranges is excellent, and is played suppression crystallization by the ionic interaction between allantoin Effect.In cosmetic field, it is known to the anion surfactant of various chemical constitutions, but or be not suitable for low pH model Emulsification in enclosing, or the effect of the crystallization of suppression allantoin is insufficient, and in the present invention, as meeting both effects Anion surfactant, have selected long acyl methyl tauride.

It is long acyl methyl tauride as the composition (b) using in the present invention, can arbitrarily use commonization Spendable long acyl methyl tauride in cosmetic or skin preparations for extenal use.For example, N-stearyl-N-methyl ox can be enumerated Sodium sulfonate, N-myristoyl-N methyl taurine sodium, coconut oil fat acid methyl taurine sodium, lauryl methyl taurine Sodium etc., can use one kind or two or more.

The composition (b) of the present invention is that the content of long acyl methyl tauride is not particularly limited, from suppression allantoin Crystallization and emulsion stability from the viewpoint of, be preferably 0.2～3.0% in O/W emulsion composition total amount, More preferably 0.3～2.0%.

The composition (c) using in the present invention is that polyalcohol can maintain the hydration of allantoin, significantly inhibits especially under low temperature The crystallization of allantoin.It is polyalcohol as the composition (c) using in the present invention, can arbitrarily use in common cosmetics Spendable polyalcohol.For example, can enumerate dihydroxylic alcohols (for example, ethylene glycol, propane diols, 1,3-PD, 1,2-butanediol, 1, 3-butanediol, BDO, 2,3-butanediol, 1,5-PD, 2-butene-1,4-glycol, hexylene glycol, ethohexadiol etc.)；Three Unit's alcohol (for example, glycerine, trimethylolpropane etc.)；Tetrahydroxylic alcohol (for example, 1, the pentaerythrite etc. of 2,6-hexanetriols etc.)；Pentabasis alcohol (for example, xylitol etc.)；Hexahydroxylic alcohols (for example, D-sorbite, mannitol etc.)；Polyhydric alcohol polymer (for example, diethylene glycol, DPG, triethylene glycol, polypropylene glycol, TEG, diglycerol, polyethylene glycol, triglycerin, four glycerine, polyglycereol etc.)； (for example, D-sorbite, maltitol, maltotriose, mannitol, sucrose, erythrite, glucose, fructose, starch divide sugar alcohol Solution sugar, maltose, xylitol, starch decompose sugar and go back carbinol etc.), can use one kind or two or more.

In above-mentioned polyalcohol, from the viewpoint of hydratability and use feeling, preferably propane diols, 1,3-BDO, glycerine, DPG, diglycerol, polyethylene glycol, D-sorbite, maltitol, further preferred 1,3-BDO, propane diols, glycerine, Polyethylene glycol.

The composition (c) of the present invention is that the content of polyalcohol is not particularly limited, preferably total at O/W emulsion composition Amount is 4～36%, more preferably 10～30%, it is still more preferably 12～25%.In addition, from suppression allantoin From the viewpoint of the effect of crystallization and emulsion stability, composition (a) is preferably 0.002 relative to the mass ratio of composition (c) ～0.05, more preferably 0.004～0.04.

The O/W emulsion composition of present invention pH when 25 DEG C is 3～6.It is properly added pH adjusting agent to regulate pH, So that the pH of final O/W emulsion composition becomes above-mentioned scope.As pH adjusting agent, such as lactic acid, lemon can be enumerated Lemon acid, hydroxyacetic acid, butanedioic acid, tartaric acid, dl-malic acid, potassium carbonate, sodium acid carbonate, ammonium hydrogen carbonate etc., can use a kind or 2 More than Zhong.In addition, to control method it is not also specifically limited, be dissolvable in water in the operation manufacturing O/W emulsion composition In emulsification aqueous phase, the continuous water adding, it is possible to do not dissolve and add.Additionally, it is possible to after manufacturing O/W emulsion composition, Confirm pH while adding.

In the present invention, when pH is less than 3, having problems in terms of the security in emulsion stability with to skin, pH is higher than 6 When, there is the hydrolysis of allantoin, it is difficult to obtain the effect improving pachylosis, the antiphlogistic effects of this composition steadily in the long term.

In the present invention, in order to form O/W emulsion composition, in addition to above-mentioned each composition, it is necessary to containing water and Oil components.

It as water, as long as be generally used for manufacturing the water of cosmetics, be just not particularly limited, ordinary water, purifying can be enumerated Water, thermal water, deep water or lavender liquid, rose water, aqua aurantii florum etc. derive from the steam distillation water etc. of plant, can use 1 Plant or two or more.

For oil components spendable in the present invention, as long as be generally used for cosmetics or skin preparations for extenal use Finish, is just not particularly limited, and any source, solid oil, lard, the liquid oil such as animal oil, vegetable oil, artificial oil, waves Send out the finishes of any proterties such as property oil, can arbitrarily select to use one kind or two or more.As oil components, hydrocarbon can be enumerated Class, grease class, wax class, hydrogenated oils, ester oil class, fatty acid, higher alcohols, silicone oil, fluorine system oils, lanolin derivative The finishes such as class.If specific example, can enumerate atoleine, saualane (squalane), vaseline, polyisobutene, polybutene, The hydro carbons such as paraffin, ceresine, microwax, Fischer-Tropsch wax (Fischer Tropsch Wax)；Haze tallow, olive oil, castor oil, ermine oil, Australia The grease classes such as continent macadamia nut oil；The wax classes such as lignite wax, beeswax, Brazil wax, candelila wax, spermaceti；Isooctyl acid cetyl ester, Isopropyl myristate, isopropyl palmitate, myristic acid octyldodecyl, tricaprylin, two isostearic acids are double Glyceride, three isostearic acid double glycerides, tribehenin acid glyceride, citronellic acid pentaerythritol ester, two octanoic acid DOPCPs, courage The esters such as solid polyol fatty acid ester, N-lauroyl-Pidolidone two (cholest behenyl base octyldodecyl) ester；Stearic The fatty acids such as acid, laurate, myristic acid, behenic acid, isostearic acid, oleic acid, citronellic acid, 12-hydroxy stearic acid；Stearic Alcohol, cetanol, cetostearyl alcohol (cetostearyl alcohol), myristyl alcohol, laruyl alcohol, oleyl alcohol, different tristearin The higher alcohols such as alcohol, docosyl alcohol；Low polymerization degree dimethyl polysiloxane, high polymerization degree dimethyl polysiloxane, aminomethyl phenyl gather Siloxanes, decamethylcyclopentaandoxane (decamethylcyclopentasiloxane), octamethylcy-clotetrasiloxane, fluorine richness Polysiloxanes etc. are polysiloxane-based；The fluorine system finish classes such as PFPE, perfluoro decane, PFO；Lanolin, acetic acid wool The lanolin derivative classes such as fat, lanolin fatty isopropyl propionate, lanolin alcohol；Etc., can use a kind in them or 2 kinds with On.In addition, for the amount of oil components spendable in the present invention, in O/W emulsion composition total amount be preferably 0.1～10%, more preferably 0.5～8%, particularly preferably 1.5～6%.

Additionally, in the present invention, containing polyoxyalkylene addition glycerin ether, polyoxyalkylene addition diglycerol ether as composition (d) When, the effect of the crystallization of suppression composition (a) improves further, is preferred.Polyoxyalkylene addition glycerin ether, polyoxyalkylene Addition diglycerol ether is that epoxyalkane (alkylene oxide) addition polymerization is in product obtained from glycerine or diglycerol.Epoxy The carbon number of alkane is not particularly limited, and preferably 2～4, more preferably 2～3.In addition, the degree of polymerization of epoxyalkane It is not particularly limited, preferably 3～30, more preferably 9～26.Epoxyalkane can use two or more, in the case of being somebody's turn to do, and can Use with block-wise, random shape etc. be arbitrarily polymerized obtained by product.

As composition (d), specifically, for example, polyoxyethylene (26) glycerin ether (trade name: LIPONIC EG-can be enumerated 1, LIPO CHEMICALS INC company system), (trade name: SY-DP9, this pharmaceutical industries of slope is public for polyoxypropylene (9) diglycerol ether Department system), polyoxyethylene (24) polyoxypropylene (24) glycerin ether (trade name: UNILUBE 50TG-32, Japan Oil Co's system), Polybutylene (3) polyoxyethylene (8) polyoxypropylene (5) glycerin ether (trade name: WILBRIDE S-753, Japan Oil Co's system) Deng can use suitably.

In addition to above-mentioned required composition, can be in the range of not damaging the effect of the present invention, containing generally at cosmetics In the composition that can contain, i.e. can optionally contain the surface-active beyond composition (b) in the range of not hindering the effect of the present invention Agent, water soluble polymer, moisturizing ingredient, ultra-violet absorber, pH adjusting agent, antioxidant, metal-chelator, preservative, powder Body, pigment, spices, various medicaments etc..As described composition, following such material can be enumerated.

As the anion surfactant beyond composition (b), for example, soap base, sodium laurate, palmitic acid can be enumerated Alkyl ether sulphate salts, the sodium lauroyl sarcosines such as the fatty acid soaps such as sodium, POE (polyoxyethylene, lower same) sodium laureth sulfate Deng phosphate ester salt, two-2-ethylhexyls such as N-acyl sarcosinates, POE oleyl ether phosphoric acid sodium, POE stearyl ether sodium phosphates Sodium sulfosuccinate (Sodium di-2-ethylhexyl sulfoSuccinate), single lauroyl single ethanol amide polyoxy Sulfosuccinate, the linear dodecylbenzene sulfonic acid such as ethene sodium sulfosuccinate, lauryl polypropylene glycol sodium sulfosuccinate Alkylbenzenesulfonate, N-lauroyl glutamate list sodium, the N-stearyl glutamic acid two such as sodium, linear dodecylbenzene potassium sulfonate N-acyl glutamate, the hydrogenated coconut oil fatty glyceride sodium sulphate such as sodium, N-myristoyl-Pidolidone list sodium are contour Level hydrosulphate, POE alkyl ether carboxy acid salt, the POE polyoxyethylene base ether carboxylic acid such as fatty acid ester sulfuric acid, turkey red oil Salt, alpha-alkene sulfonate, higher fatty acids sulfonated ester, secondary alcohol sulphates salt, higher fatty acid alkanol amide sulfuric acid (higher fatty acid alkylol amide sulfate ester salts), lauroyl single ethanol amide amber Hydrochlorate, N-palmityl aspartate, casein-sodium etc., can use one kind or two or more.

As lipophile nonionic surfactant, for example, sorbitan monooleate, sorbitan list can be enumerated Isostearate, Span-20, sorbitan monopalmitate, sorbitan monostearate, mountain Pears sugar alcohol acid anhydride sesquioleate, sorbitan trioleate, diglycerol sorbitan five-2 ethyl hexanoic acid ester (diglycerol sorbitan penta-2-ethylhexylate), diglycerol sorbitan four-2 ethyl hexanoic acid ester etc. Sorbitan fatty acid ester class, single cottonseed oil fatty acid glyceride, single erucic acid glyceride, sesquialter olein, single tristearin Acid glyceride, α, the glycerine polyglyceryl fatty acid ester class such as α '-oleic acid pyroglutamic acid glyceride, malic acid glycerin monostearate, Methyl glycol fatty acid ester class, the rilanit special derivatives etc. such as propylene glycol monostearate, can use one kind or two or more.

As hydrophilic non-ionic surfactant, for example, POE sorbitan monooleate, POE sorbose can be enumerated The POE sorbitan esters of fatty such as alcohol acid anhydride monostearate, POE sorbitan monooleate, POE sorbitan four oleate Esters of gallic acid, POE D-sorbite monolaurate, POE sorbitol monooleate, POE D-sorbite five oleate, POE sorb The POE sorbitan fatty acid esters such as sugar alcohol monostearate, POE glyceryl monostearate, POE glycerol monoisostearate, POE glycerine fatty acid esters, polysorbate 80, POE distearate, mono-two oleic acid of POE such as POE glyceryl triisostearate The POE fatty acid esters such as ester (POE monodioleate), diglycol stearate, POE lauryl ether, POE oleyl ether, POE alkyl ether, the POE such as POE stearyl ether, POE behenyl base ether, POE2-octyldodecyl ether, POE cholestane alcohol ether are pungent The POE alkyl phenyl ethers such as base phenyl ether, POE nonylplenyl ether, POE dinonyl phenyl ether, POE POP cetyl ether, POE POP2-decyl myristyl ether, POE POP single-butyl ether, POE POP hydrogenated lanolin, POE POP glycerin ether etc. POE POP alkyl ether, TETRONIC etc. four POE tetra-POP ethylenediamine condensation species, POE castor oil, POE hydrogenated castor Oil, the burnt paddy ammonia of POE rilanit special list isostearate, POE rilanit special three isostearate, POE rilanit special list POE castor oil rilanit special derivative, the POE D-sorbites such as monooctyl acid stearic acid diester, POE rilanit special maleate POE beeswax lanolin derivative, cocoanut fatty acid diethanolamide, lauric monoethanolamide, the aliphatic acid such as beeswax are different Alkanolamide, POE methyl glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty ester, the POE nonyls such as propyl alcohol acid amides Base phenyl formaldehyde condensation products, alkyl ethoxy dimethylamine oxide, tricresyl phosphate oleyl ester (trioleyl phosphate) Deng can use one kind or two or more.

As amphoteric surfactant, for example, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolines beet can be enumerated The glycine betaine system surfaces such as alkali, lauryl dimethyl oxyneurine, alkyl betaine, amide betaine, sulfobetaines Activating agent, lecithin etc., can use one kind or two or more.

As cationic surfactant, for example, stearyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride can be enumerated Deng the dialkyl dimethyl ammonium salt such as alkyl trimethyl ammonium salt, VARISOFT TA100, chlorination poly-(N, N '-dimethyl-3, 5-methylenepiperidines), the Fixanol such as cetylpyridinium chloride, alkyl quaternary ammonium salts, alkyl dimethyl benzyl ammonium salt, Alkyl isoquinolinium salt, dialkylmorpholinum salts, POE alkylamine, alkylamine salt, polyamines derivative of fatty acid, amylalcohol aliphatic acid Derivative, benzalkonium chloride, benzethonium chloride etc., can use one kind or two or more.

As water soluble polymer, can enumerate Arabic gum, bassora gum, galactan, tragon, guar gum, sun from Sonization guar gum, karaya, carrageenan, pectin, agar, lemon seed (marmelo), starch (rice, corn, potato, Wheat), the microorganisms such as department of botany's macromolecule, glucan, succinoglucan, pulullan polysaccharide such as algin (brown alga extract) It is animal system macromolecule, CMS, the methylhydroxypropyl starch such as macromolecule, collagen, casein, albumin, gelatin Deng starch-series macromolecule, methylcellulose, NC Nitroncellulose, ethyl cellulose, methylhydroxypropylcellulose, hydroxy ethyl fiber Element, cellulose sodium sulfate, hydroxypropyl cellulose, cationization hydroxyethyl cellulose, sodium carboxymethylcellulose, avicel cellulose, The alginic acid system macromolecules such as the cellulose polymer such as cellulose powder, mosanom, propylene glycol alginate, polyvinyl methyl ether, Carboxyl vinyl polymer (CARBOPOL (trade name) etc.), alkyl-modified carboxyl group polyvinyl (PEMULEN (trade name) Deng) etc. ethene base system macromolecule, polyoxyethylene system macromolecule, poloxalkol system macromolecule, polyacrylic acid The organic systems such as acrylic acid series macromolecule, ethylene imine, cation property copolymer such as sodium, polyethyl acrylate, polyacrylamide The nothings such as water soluble polymer, bentonite, Magnesiumaluminumsilicate, hectorite (laponite), hectorite (hectorite), silicic acid anhydride Machine system water soluble polymers etc., can use one kind or two or more.

As moisturizing ingredient, carbohydrate, amino acid and derivative thereof, peptides, plant extraction liquid etc. can be enumerated, a kind can be used Or two or more.

As carbohydrate, D-sorbite, erythrite, maltose, maltitol, xylitol, wood sugar, trehalose, flesh can be enumerated Alcohol, glucose, mannitol, pentaerythrite, fructose, sucrose and ester thereof, dextrin and derivative thereof, honey, brown sugar extract etc.. As amino acids, can enumerate for example glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, Glutamic acid, asparagine, glutamine, lysine, oxylysine, arginine, cystine, cysteine, mucolyticum Acid, methionine, phenylalanine, tyrosine, proline, hydroxyproline, ornithine, citrulling, theanine, creatine, kreatinin Deng.As amino acid derivativges, glutathione, 2-pyrrolidone-5-carboxylic acid, N-lauroyl-Pidolidone two (phytosterol can be enumerated Base 2-octyldodecyl) ester, N-lauroyl-Pidolidone two (cholest behenyl base octyldodecyl) ester, N- Lauroyl-Pidolidone two (cholest octyldodecyl) ester, N-lauroyl-Pidolidone two (phytosterol Ji Shan Yu base 2-octyldodecyl) ester, N-lauroyl-Pidolidone two (2-octyldodecyl) ester, N-acyl glutamic acid rely Propylhomoserin condensation product etc..As peptides, any peptides of animal, fish, shellfish, plant can be derived from, specifically can enumerate collagen egg Its derivative of bletilla or their hydrolysate, elastin and derivative thereof or their hydrolysate, keratin and derivative thereof Or they analyte, wheat gluten and derivative thereof or their hydrolysate, soybean protein and derivative thereof or their water Solve thing etc..As plant extracts, for example, can enumerate: use golden cypress, the coptis, alkanet, Chinese herbaceous peony, when medicine, birch, Salvia japonica, Loquat, ginseng, aloe, high mallow, iris, grape, coix seed, sponge gourd, lily, safflower, Ligusticum wallichii, ginger, hypericum erectum, awns handle Flower, garlic, capsicum, dried orange peel, Radix Angelicae Sinensis, marine alga etc., utilize water, organic solvent suitably extract obtained from material.

As ultra-violet absorber, ESCALOL 567,2,4,6-triphenylamine bases-p-(carbonyl can be enumerated (carbo)-2 '-ethylhexyl-1 '-epoxide)-1,3,5-triazines, salicylic acid-2-Octyl Nitrite, to dihydroxypropyl benzoic acid Ethyl ester, 2-ethylhexylpmethoxycinnamate, 4-tert-4 '-methoxy dibenzoylmethane, 2-[4-(diethyl amino Base)-2-hydroxy benzoyl] hexyl-benzoate, dimethoxybenzylidenegroup group (benzylidene) dioxoimidazolidin alkyl propionic acid 2- Octyl Nitrite, 2,2 '-di-2-ethylhexylphosphine oxide [6-(2H-BTA-2-base)-4-(1,1,3,3-tetramethyl butyl) phenol], (1,3, 5)-triazine-2, double [{ 4-(2-ethyl hexyl oxy)-2-hydroxyl }-phenyl]-6-(4-the methoxyphenyl)-1,3,5-triazines of 4-, poly- Dimethyl siloxane benzal propylmalonic acid diethylester (dimethicodiethylbenzal malonate), 2-hydroxyl-4-methoxy Base benzophenone-5-sulfonic acid and sodium salt etc. thereof.

As antioxidant, ascorbic acid, alpha-tocopherol, dibutyl hydroxy toluene, butylated hydroxyanisole (BHA) etc. can be enumerated.

As metal-chelator, for example, 1-hydroxyl ethane-1 can be enumerated, 1-di 2 ethylhexyl phosphonic acid, 1-hydroxyl ethane-1,1-di 2 ethylhexyl phosphonic acid Tetrasodium salt, disodium ethylene diamine tetraacetate, sodium versenate, tetrasodium ethylenediamine tetraacetate, sodium citrate, sodium polyphosphate, Sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, butanedioic acid, ethylenediamine tetra-acetic acid, ethylenediamine ethoxy triacetic acid three Sodium etc..

As preservative, benzoic acid, salicylic acid, phenol, sorbic acid, p-hydroxybenzoate, benzalkonium chloride, chlorine can be enumerated Oneself is fixed, Trichlorocarbanilide (trichlorocarbanilide), photosensitive element, phenoxetol etc..

As powder and pigment, for example, can enumerate talcum, kaolin, mica, sericite (sericite), muscovite, Phlogopite, synthetic mica, rubellan, biotite, vermiculite, magnesium carbonate, calcium carbonate, alumina silicate, barium silicate, calcium silicates, magnesium silicate, Strontium silicate, metal salt, magnesium, silica, zeolite, barium sulfate, calcined calcium sulfate hemihydrate (calcined gypsum), calcium phosphate, fluor-apatite The inorganic powder such as metallic soap, boron nitride such as (fluoride apatite), hydroxyapatite, ceramic powders, Zinc tetradecanoate；Poly- Amide resin powder (nylon powder), polyethylene powders, polymethylmethacrylate powder, Polystyrene powder, styrene with The organic dusts such as acrylic acid copolymer resin powder, benzoguanamine resin powder, polytetrafluorethylepowder powder, cellulose powder； The inorganic white pigment such as titanium dioxide, zinc oxide；Iron oxide red, gamma-iron oxide, iron oxide yellow, iron oxide black, chromium oxide, group The inorganic colored pigments such as blue or green, Prussian blue；Pearlescent pigment, metallic powdery pigment, organic pigment, natural colouring matter etc..

As various medicaments, can for such as moisturizing, anti-inflammatory, stimulate circulation, cell activation, the mesh such as antibacterial, analgesia And contain, such as antiphlogistic (for example, glycyrrhizin derivative, Enoxolone derivative, salicyclic acid derivatives, Japan cypress can be enumerated Phenol (hinokitiol), zinc oxide etc.)；Whitening agent (for example, vitamin C derivatives, intacellin, Herba Saxifragae extract, bear Really glycosides etc.)；Activator (for example, royal jelly, photosensitive element, cholesterol derivative etc.)；(for example, n-nonanoic acid is fragrant for blood circulation accelerant Oxamides, nicotinic acid benzyl ester, nicotinic acid Beta-Butoxy ethyl ester, capsicim, zingerone, cantharides tincture (Japanese: power Application タ リ ス チ Application キ), Ammonium ichthosulfonate, tannic acid, α-borneol, tocopherol nicotinate, hexanicotinate, cyclandelate, cinnarizine, Tolazoline, acetyl Choline, Verapamil, cepharanthine, gamma oryzanol etc.)；Lipotropism bleeding (for example, sulphur, thianthol etc.)；Antiinflammatory (example Such as tranexamic acid, thiolaurine, hypotaurine etc.) etc., can use one kind or two or more.

The manufacture method of the O/W emulsion composition of the present invention is not particularly limited, prepared by available conventional method. For example, can be prepared by the following method: in product obtained from by composition (a)～(c) heating for dissolving in water, add heating Product obtained from oil components, and carry out mixing, emulsify, it is then cooled near room temperature.

For the O/W emulsion composition of the present invention, as cosmetics, can be applicable to emulsion, creams, beauty treatment Liquid, hair-care agent, hair mousse, end adornment, foundation emulsion etc., as skin preparations for extenal use, can be applicable to liquid for external use, external-use gel Agent, creme, ointment, liniment, lotion, cataplasm etc..In addition, be used for as cosmetics or skin preparations for extenal use for the present invention For the proterties of the O/W emulsion composition using, can be with solid-like, gel, creams shape, the various property such as liquid The form of the cosmetics of shape is implemented.

Embodiment

It follows that enumerate embodiment, further illustrate the present invention.It should be noted that these embodiments are not to the present invention Carry out any restriction.

Embodiment 1～16 and comparative example 1～6；Emulsion oil-in-water

Prepare emulsion oil-in-water according to the composition shown in table 1 and table 2 and following preparation method, utilize method shown below, Carry out the evaluation of the crystallization inhibition under<1>low temperature, emulsion stability under<2>high temperature.Result is recorded in the lump table 1 and Table 2.

<1>the crystallization inhibition under low temperature

Each sample is put in vial, preserves 24 hours in the thermostat of-10 DEG C.Then, visualization just from After taking out in thermostat, (-10 DEG C) and this sample recover to the state of crystallization during room temperature, judge according to following benchmark.

[metewand]

◎ :-10 DEG C, room temperature when, have no crystallization all completely

When zero :-10 DEG C, confirm crystallization slightly, but recover to disappear to room temperature

Δ: when-10 DEG C, confirms crystallization slightly, even if recovering to room temperature, crystallization does not disappears yet

×: when-10 DEG C, confirming crystallization, even if recovering to room temperature, crystallization does not disappears yet

<2>emulsion stability under high temperature

Each sample is put in vial, is saved in the thermostat of 50 DEG C, the sample after preserving 1 month and 5 DEG C Preservation product compare, and by visual observation and microscope is observed, carry out the emulsion stability after 1 month according to following benchmark Judge.

[metewand]

◎: do not change completely

Zero: confirm particle diameter and somewhat increase, but unconfirmed to discharge opeing

Δ: confirm particle diameter and increase, and confirm discharge opeing slightly

×: confirm particle diameter and increase, and confirm obvious discharge opeing

[table 2]

(%)

(preparation method)

A. composition (1)～(19) are heated to 70 DEG C so that it is uniform dissolution.

B. composition (20)～(23) are heated to 70 DEG C so that it is add in A under uniform dissolution, stirring.

C. make B cool down under stirring, obtain emulsion.

From the result of table 1 and table 2, for the emulsion of embodiment 1～16, the effect of suppression crystallization is excellent Different, emulsion stability is also good.Composition (a) is less relative to the mass ratio of composition (c), is less susceptible to separate out crystallization, as one-tenth The long acyl methyl tauride dividing (b) is more, more can obtain the effect of better suppression crystallization.In addition, contain As in the embodiment 16 of " the polyoxyalkylene addition glycerin ether " of composition (d), obtain the effect of more preferable suppression crystallization.

On the other hand, in comparative example 1～4, without the long acyl methyl tauride as composition (b), but use Different types of surfactant, result there occurs allantoin crystallization, emulsion stability is also poor.In comparative example 5, do not contain As the polyalcohol of composition (c), it can not suppress crystallization, even if at room temperature also been observed crystallization.Additionally, comparative example In 6, change into simple containing monohydric alcohol without the polyalcohol as composition (c), even if but its at room temperature also observe Crystallization, fails to suppress crystallization.

Embodiment 17 oil-in-water type creams

According to following shown composition and preparation method, prepare oil-in-water type creams.

(preparation method)

A. composition (1)～(9) are heated to 80 DEG C so that it is uniform dissolution.

B. composition (10)～(13) are heated to 80 DEG C so that it is add in A under uniform dissolution, stirring.

C. B is made to cool down under stirring, then adding ingredient (14)～(16).

D. it is again stirring for C, obtain creams.

The pH of the creams of the embodiment 17 obtaining according to the method described above is 5, and effect and the emulsification of suppression crystallization are steady Qualitative very good.

Embodiment 18 oil-in-water type hair mousse

According to following shown composition and preparation method, prepare hair mousse.

(preparation method)

A. composition (1)～(9) are heated to 70 DEG C so that it is uniform dissolution.

B. composition (10)～(13) are heated to 70 DEG C so that it is add in A under uniform dissolution, stirring.

C. B is made to cool down under stirring, then adding ingredient (14)～(16).

D. it is again stirring for C, obtain hair mousse.

The pH of the hair mousse of the embodiment 18 obtaining according to the method described above is 6, and prevents effect and the emulsification of crystallization Stability is very good.

Embodiment 19 oil-in-water foundation liquid

According to following shown composition and preparation method, prepare oil-in-water foundation liquid.

(preparation method)

A. composition (1)～(8) are heated to 90 DEG C so that it is uniform dissolution.

B. composition (9)～(12) are heated to 70 DEG C so that it is add in A under uniform dissolution, stirring.

C. make B cool down under stirring, then, add composition (13)～(18) processing through roller in advance.

D. it is again stirring for C, obtain foundation emulsion.

The pH of the foundation emulsion of the embodiment 19 obtaining according to the method described above is 5.5, and prevents effect and the breast of crystallization Change stability very good.

Claims (5)

1. the O/W emulsion composition for using as cosmetics or skin preparations for extenal use, described oil-in-water type emulsion combines Thing contains following compositions (a)～(c),

Composition (a): allantoin,

Composition (b): long acyl methyl tauride,

Composition (c): polyalcohol；

When 25 DEG C, the pH of described O/W emulsion composition is 3～6.

2. O/W emulsion composition as claimed in claim 1, it is characterised in that composition (a) is relative to the matter of composition (c) Amount ratio is 0.002～0.05.

3. O/W emulsion composition as claimed in claim 1 or 2, it is characterised in that the content of composition (b) is 0.2～3 Quality %.

4. the O/W emulsion composition as according to any one of claims 1 to 3, it is characterised in that composition (c) for selected from In propane diols, 1,3 butylene glycol, glycerine, DPG, diglycerol, polyethylene glycol, D-sorbite, maltitol a kind or 2 More than Zhong.

5. the O/W emulsion composition as according to any one of Claims 1 to 4, it is characterised in that possibly together with polyoxygenated Alkene addition glycerin ether, polyoxyalkylene addition diglycerol ether are as composition (d).