TWI664968B - 使用tor激酶抑制劑之癌症治療 - Google Patents

Info

Publication number

TWI664968B

TWI664968B TW106122809A TW106122809A TWI664968B TW I664968 B TWI664968 B TW I664968B TW 106122809 A TW106122809 A TW 106122809A TW 106122809 A TW106122809 A TW 106122809A TW I664968 B TWI664968 B TW I664968B

Authority

TW

Taiwan

Prior art keywords

substituted

unsubstituted

pyrazine

dihydropyrazino

methyl

Prior art date

2012-03-15

Links

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• Global Dossier
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• 206010028980 Neoplasm Diseases 0.000 title claims description 69
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• 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims abstract description 376
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims abstract description 376
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• 238000000034 method Methods 0.000 claims abstract description 37
• -1 6- (2-hydroxyprop-2-yl) pyridin-3-yl Chemical group 0.000 claims description 417
• HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical compound OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 claims description 110
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• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims description 8
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• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 13
• 125000001624 naphthyl group Chemical group 0.000 description 13
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• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 11
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