TWI662072B - Composite material - Google Patents

Abstract

The present invention relates to a composite material comprising a hydrophilic substrate and a compound for promoting wound healing, wherein the hydrophilic substrate is a reaction product of a hydrophilic polymer, wherein the hydrophilic polymer includes a hydrophilic A monomer, a cross-linking agent, and an inorganic silicone compound, wherein the wound healing promoting compound is distributed in the hydrophilic substrate.

Description

   Composite material   

The invention relates to a composite material, which is characterized in that the composite material is a solid hydrophilic polymer with a high-strength three-dimensional network structure containing a compound that promotes wound healing.

In the past, keeping wounds dry was the main nursing principle, so dry gauze dressings were used to protect the wounds. However, adhesion of the wound to the gauze often occurs, which leads to secondary injury and pain of the wound when the dressing is removed, causing adhesion to the newly healed wound. In recent years, related studies have shown that keeping the wound moist helps to promote the movement and proliferation of epidermal cells, and can accelerate wound healing. Therefore, various wet dressings, such as hydrocolloids and hydrogels dressings, are produced.

However, hydrocolloid dressings are mainly carboxymethylcellulose, and bacteria that are susceptible to infected wounds break down and produce odors; therefore, hydrocolloids cannot be used for infectious wounds.

Another water-absorbing and swellable hydrogel has insufficient mechanical strength of existing products, for example, Taiwan Patent Publication Nos. M419555, I267387, I429462, I504420; Chinese Patent Publication No. CN204863670; and US Patent Publication No. The patent No. 2013/0072843 discloses that the structure is reinforced with a hydrogel combined with a non-woven fabric or fibers as a support layer; however, the structure is still brittle after the hydrogel absorbs the aqueous solution and swells, which results in that the chipping residue is not easily removed when the dressing is removed.

Generally, in order to accelerate the healing of chronic wounds, in addition to dressings that keep the wound moist and blocked, it also needs to promote wound healing factors. For example, U.S. Patent Publication Nos. 5,489,304 and 5,716,411 are a mixture of collagen-glycosaminoglycan covering the surface of a wound, and then coating a layer of cultured animal or human epidermal cells to promote skin regeneration. U.S. Patent No. 5,977,088 discloses a pharmaceutical composition containing an agent for treating or promoting the relief of skin diseases and hyaluronic acid. The pharmaceutical composition uses hyaluronic acid to promote or cause the delivery of the agent to the skin of an injured patient. It can accumulate and prolong the stay of medicine in this area.

However, the above-mentioned effective factors or wet dressings to accelerate wound healing need to be coated with the effective factors first, and then cover the two steps of dressing protection, so the care process is cumbersome. Furthermore, if excessive application of the factors promoting wound healing is not only wasteful but also Easy to make dressing poorly fixed. Although Taiwan Patent Publication No. I264306 discloses a collagen-hyaluronic acid-coated gauze dressing, it is a composite material of dry gauze that is not good for wound healing.

Therefore, how to effectively combine the effective factors that accelerate wound healing with wet dressings to strengthen wound care and healing is a problem currently solved by the industry.

In view of this, the present invention provides a hydrophilic dressing with appropriate mechanical strength, which comprises a composite material and a thin film. The most special thing is that the composite material consists of a hydrophilic polymer and a compound that promotes wound healing. Composed of. The hydrophilic polymer is a polymer having a combination of high strength and favorable hydrophilic properties; therefore, in addition to maintaining a wet wound and accelerating the movement and proliferation of epidermal cells, the hydrophilic polymer is highly hydrophilic A solid hydrophilic polymer with a strong three-dimensional network structure, which overcomes the previous situation that hydrogels are brittle after swelling due to absorption of aqueous solutions. In addition, the hydrophilic polymer utilizes its hydrophilic hydrophilic group to adsorb water-soluble collagen or hyaluronic acid-promoting compounds to the wound to the three-dimensional network structure inside the hydrophilic polymer and to the wound. During the treatment, it can release the wound healing factors slowly and accelerate the wound healing. In addition, in the current wound treatment, wound patients need to be coated with a wound healing compound before covering the dressing, so a two-step care process is needed, but the hydrophilic dressing of the present invention can achieve the above-mentioned treatment objective in one step, which can make the wound heal. Time can be shortened more effectively.

To achieve the above object, the present invention provides a composite material comprising a hydrophilic substrate and a compound for promoting wound healing, wherein the hydrophilic substrate is a reaction product of a hydrophilic polymer, wherein the hydrophilic polymer The material includes a hydrophilic monomer, a cross-linking agent, and an inorganic silicon oxide compound, wherein the wound healing promoting compound is distributed in the hydrophilic substrate.

The terms "a" or "an" are used herein to describe the elements and ingredients of the invention. This term is used merely for convenience of description and to give the basic idea of the present invention. This description should be understood to include one or at least one, and unless explicitly stated otherwise, the singular also includes the plural. When used with the term "comprising" in the scope of a patent application, the term "a" may mean one or more than one.

The term "or" in this text means "and / or".

The "hydrophilic monomer" herein includes a reactive monomer having a hydrophilic group. The hydrophilic monomer which can be used for preparing the hydrophilic polymer according to the present invention has at least one polymerizable double bond and at least one hydrophilic functional group. Functional group having a polymerizable double bond, examples of which include: acrylic acid, methacrylic acid, acrylamino, methacrylamido, fumaric acid, maleic acid, styryl, isopropenylphenyl , O-ethylene carbonate, O-vinyl carbamate, allyl, O-ethylene ethylfluorenyl, and double bonds with N-ethylene lactam, and N-vinyl amine.

Suitable types of hydrophilic monomers of the present invention include acrylic or vinyl-containing monomers. The term "acrylic" or "acrylic-containing" monomer is a monomer containing the following acrylic groups: (CH ₂ = CRCOX), where R is H or CH ₃ and X is O or N, which is also known as possible Those who undergo rapid polymerization, such as N, N-dimethylacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), glyceryl methacrylate, 2-hydroxyethylmethacryl Amine, polyethylene glycol monomethacrylate, methacrylic acid, mixtures thereof and the like. The term "vinyl" or "vinyl-containing" monomers refers containing vinyl groups (-CH = CH ₂₎ and capable of a polymerization reaction of the monomer. Vinyl-containing monomers, including, but not limited to, monomers such as N-vinylamine, N-vinyllactam (such as NVP), N-vinyl-N-methylacetamide, N-vinyl-N- Ethylacetamide, N-vinyl-N-ethylformamide, N-vinylformamide.

Other hydrophilic monomers useful in the present invention include, but are not limited to, polyoxyethylene polyols having one or more terminal hydroxyl groups substituted with a polymerizable double bond-containing functional group. Examples include polyethylene glycol, ethoxylated alkyl glucosides and ethoxylated bisphenol A, which react with one or more mole equivalent end-capping groups, such as methacrylic acid Isocyanatoethyl (IEM), methacrylic anhydride, methacryl chloride, vinyl benzyl chloride, or the like to produce a polyethylene polyol having one or more terminal polymerizable alkenyl groups, and The one or more terminal polymerizable alkenyl groups are bonded to the polyethylene polyol through a linking moiety, such as a urethane or ester group.

The hydrophilic monomer of the present invention may be any hydrophilic monomer known to be useful in the manufacture of hydrogels. In a specific embodiment, the hydrophilic monomer comprises an acrylic acid or a derivative thereof having a double bond, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid, or Salts, a polyethylene glycol or a derivative thereof, or a combination thereof.

In another embodiment, the weight percentage of the hydrophilic monomer in the hydrophilic polymer is 8 to 80%. In a preferred embodiment, the weight percentage of the hydrophilic monomer in the hydrophilic polymer is 10 to 50%.

The crosslinking agent of the present invention is not particularly limited as long as it can react with the functional group of the hydrophilic polymer to initiate a crosslinking effect. The "crosslinking agent" herein includes, but is not limited to, compounds having at least two ethylenically unsaturated groups. In a specific embodiment, the cross-linking agent includes an N, N'-methylenebispropenamide, a glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol. Dimethacrylate, Triethylene glycol dimethacrylate, Monoethylene glycol dimethacrylate, Trimethylpropane trimethacrylate, Vinyl methacrylate, Monoethylene diamine Methacrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene, or combinations thereof.

In another embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.1 to 20%. In a preferred embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.2 to 10%. In a more specific embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.5 to 5%.

In the present invention, the inorganic polymer is added to the hydrophilic polymer to increase the strength of the reaction product of the hydrophilic polymer, that is, the hydrophilic substrate, so that the hydrophilic substrate has a high-strength three-dimensional network structure. Therefore, the situation that the structure of the conventional hydrogel swells due to absorption of the aqueous solution is easily overcome. In a specific embodiment, the inorganic silicon oxide compound is a compound having a silicon oxide chain as a main chain. The basic structural unit of the silicon-oxygen chain is a silicon-oxygen bond structure, and has a reactive group capable of chemically bonding with inorganic materials and chemically bonding with organic materials. Therefore, the structure of the inorganic silicon oxide compound not only has the "organic group" binding ability, but also contains the "inorganic structure". The structure of this special composition and reactive group has special physical and chemical properties when reacting with organic polymerized monomers. Coupling reaction, effectively improve the mechanical strength, water resistance, cold resistance, adhesion of polymer materials.

The inorganic siloxane compound of the present invention includes an inorganic silicate. Inorganic silicate refers to a compound (SixOy) composed of silicon and oxygen, and can be represented by a salt produced by silicon dioxide or silicic acid. In a specific embodiment, the inorganic silicon oxide compound is silicon dioxide or a metal silicate. The term "metal silicate" is a general term for compounds composed of silicon, oxygen and metal elements. The metal silicate refers to the replacement of the silicon oxygen bond of silicon dioxide with a metal salt. The metal silicate produced has a small particle size and a large specific surface area. The original single particle is 0.02 μm, and the aggregated particle is 5 μm. The aggregate particles are 30 μm and the specific surface area is 20-800m ² / g. When the specific surface area of the metal silicate is greater than 50 m ² / g, the silanol groups on the surface cause interaction between the particles, and when used as a filler for a hydrophobic plastic polymer such as rubber or plastic, it gives the plastic an excellent reinforcing effect. In a preferred embodiment, the metal silicate is magnesium aluminum silicate.

The specific surface area of particles refers to the total surface area of particulate matter per unit mass (or volume), which can be used as one of the important parameters for evaluating the performance of catalysts, adsorbents and other porous substances. Therefore, the specific surface area of the particles increases, which can increase their adsorption area, thereby increasing their adsorption capacity. In a specific embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 50 m ² / g. In a preferred embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 100 m ² / g. In a more specific embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 150 m ² / g.

In another specific embodiment, the weight ratio of the inorganic silicon oxide compound to the hydrophilic polymer is 2 to 80%. In a preferred embodiment, the weight ratio of the inorganic silicon oxide compound to the hydrophilic polymer is 4 to 50%. In a more specific embodiment, the weight ratio of the inorganic silicon oxide compound to the hydrophilic polymer is 6 to 40%.

In a specific embodiment, the inorganic silicon oxide compound is an inorganic compound having a silicon oxide tetrahedron structure or a polysiloxane tetrahedron structure. Therefore, the strength of the hydrophilic polymer can be increased by polymerizing the inorganic silicon oxide compound into a three-dimensional network structure in the hydrophilic polymer.

The hydrophilic polymer further includes one or more polymerization initiators. The polymerization initiator is used in the hydrophilic polymer in an effective amount to initiate photopolymerization of the hydrophilic polymer. Polymerization of the hydrophilic polymer may be initiated using heat, visible light, ultraviolet light, or other suitable choices, depending on the polymerization initiator used. Alternatively, it can be initiated in the absence of a photoinitiator, such as using an electron beam (e-beam).

Examples of the polymerization initiator include, but are not limited to, lauryl peroxide, benzamyl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which are at a moderately elevated temperature Generates free radicals, as well as photoinitiator systems such as aromatic atorvazone, alkoxyoxybenzoin, acetophenone, fluorenylphosphine oxide, bisfluorenylphosphine oxide and tertiary amines plus diketones, Mixtures of the foregoing are similar. The UV photopolymerization initiator includes Irgacure 1173 and Irgacure 2959 (Ciba Specialty Chemicals).

Therefore, the polymerization initiator can promote other components of the hydrophilic polymer to undergo a polymerization reaction with each other. After the reaction, a reaction product of the hydrophilic polymer is obtained as the hydrophilic substrate.

After the above-mentioned hydrophilic substrate is cured, a water-soluble promoting wound healing factor is adsorbed to the three-dimensional network structure inside the hydrophilic substrate by using the adsorbable hydrophilic group to form the composite material. Therefore, when the composite material is made into a hydrophilic dressing and attached to a wound, the wound healing promoting factor is released from the composite material, which can accelerate wound healing.

A "wound" in this context can be an open wound and a closed wound. Open wounds can be divided into many types, including cuts (caused by clean sharp objects such as knives or razors), cracks (rough and irregular wounds caused by pressure or tear), and abrasions (usually caused by sliding over rough surfaces) Causes very superficial injuries, with the top layer of skin being rubbed off) and stab wounds (caused by an object such as a nail or needle piercing the skin). Closed wounds are much less classified, but are just as dangerous as open wounds. They are bruises or bruises (injury to the tissue under the skin caused by hard forces), hematomas (caused by damage to blood vessels that cause blood to accumulate under the skin), and bruises (caused by long-term application of large or great external forces).

A "wound healing promoting compound" herein includes, but is not limited to, a compound having the effect of promoting wound healing. In a specific embodiment, the wound healing promoting compound comprises a water-soluble compound promoting wound healing. In a preferred embodiment, the wound healing promoting compound comprises a wound healing promoting factor. In a more specific embodiment, the wound healing promoting compound comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, a few Butan or a combination thereof. "Cytokines" herein include but are not limited to interleukins and interferons. "Growth factors" as used herein include but are not limited to epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and connective tissue growth Connective tissue growth factor, platelet-derived growth factor (PDGF), insulin-like growth factor, nerve growth factor, colony-stimulating factor -stimulating factor), stem call factor, keratinocyte growth factor, granulocyte colony-stimulating factor, granulocyte macrophage colony- stimulating factor, glial-derived neurotropic factor, endothelial-monocyte activating polypeptide, epithelial neutrophil activating peptide, red Ball erythropoietin (rythropoietin), BRAK and transforming growth factor -β (transforming growth factor beta).

In another specific embodiment, the wound healing promoting compound is 0.01 to 20% of the total weight of the hydrophilic polymer. In a preferred embodiment, the wound healing promoting compound is 0.05 to 18% of the total weight of the hydrophilic polymer. In a more preferred embodiment, the wound healing promoting compound is 0.1 to 15% of the total weight of the hydrophilic polymer.

The composite material of the present invention is further bonded to a film to form a hydrophilic dressing. In a specific embodiment, the film has a two-sided structure, one of which is a bonding surface, and the bonding surface is bonded to the composite material. In another embodiment, the film is a film with waterproof and breathable effects. In a preferred embodiment, the film is a Polyurethane (PU) film.

In a specific embodiment, the surface area of the film is larger than the surface area of the composite material. Therefore, the adhesive surface of the film will have more adhesive areas that adhere to the outside of the composite material to provide the hydrophilic dressing with the skin. In another embodiment, the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to adhere the composite material and a body's skin.

The present invention also provides a method for preparing a composite material. The steps include: (1) cross-linking and polymerizing a hydrophilic polymer to obtain a hydrophilic substrate, wherein the hydrophilic polymer includes a hydrophilic monomer, a A cross-linking agent and an inorganic silicon oxide compound; and (2) adding a compound for promoting wound healing to the hydrophilic substrate to obtain the composite material, wherein the compound for promoting wound healing is covered by the hydrophilic substrate Adsorbed and distributed in the hydrophilic substrate.

In a specific embodiment, the hydrophilic monomer comprises an acrylic acid or a derivative thereof having a double bond, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid, or Salts, a polyethylene glycol or a derivative thereof, or a combination thereof.

In another embodiment, the weight percentage of the hydrophilic monomer in the hydrophilic polymer is 8 to 80%. In a preferred embodiment, the weight percentage of the hydrophilic monomer in the hydrophilic polymer is 10 to 50%.

In a specific embodiment, the cross-linking agent includes an N, N'-methylenebispropenamide, a glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol. Dimethacrylate, Triethylene glycol dimethacrylate, Monoethylene glycol dimethacrylate, Trimethylpropane trimethacrylate, Vinyl methacrylate, Monoethylene diamine Methacrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene, or combinations thereof.

In another embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.1 to 20%. In a preferred embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.2 to 10%. In a more specific embodiment, the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.5 to 5%.

In a specific embodiment, the inorganic silicon oxide compound includes an inorganic silicate. In a preferred embodiment, the inorganic silicon oxide compound is silicon dioxide or a metal silicate. In a more preferred embodiment, the metal silicate is magnesium aluminum silicate.

In another specific embodiment, the inorganic silicon oxide compound is an inorganic compound having a silicon oxide tetrahedron structure or a polysiloxane tetrahedron structure. In another specific embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 50 m ² / g. In a preferred embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 100 m ² / g. In a more specific embodiment, the specific surface area of the particles of the inorganic silicon oxide compound is greater than 150 m ² / g.

In a specific embodiment, the weight percentage of the inorganic silicon oxide compound to the hydrophilic polymer is 2 to 80%. In a preferred embodiment, the weight ratio of the inorganic silicon oxide compound to the hydrophilic polymer is 4 to 50%. In a more specific embodiment, the weight ratio of the inorganic silicon oxide compound to the hydrophilic polymer is 6 to 40%.

The hydrophilic polymer of step (1) in the preparation method of the present invention further comprises a polymerization initiator. The polymerization initiator is used in the hydrophilic polymer in an effective amount to initiate photopolymerization of the hydrophilic polymer. Examples of the polymerization initiator include, but are not limited to, lauryl peroxide, benzamyl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which are at a moderately elevated temperature Generates free radicals, as well as photoinitiator systems such as aromatic atorvazone, alkoxyoxybenzoin, acetophenone, fluorenylphosphine oxide, bisfluorenylphosphine oxide and tertiary amines plus diketones, Mixtures of the foregoing are similar. In a specific embodiment, the polymerization initiator is a UV photopolymerization initiator. The UV photopolymerization initiator is irradiated with UV light to initiate a polymerization reaction. In a preferred embodiment, the UV photopolymerization initiator is Irgacure 1173 or Irgacure 2959.

In a specific embodiment, the method of cross-linking and polymerizing the hydrophilic polymer includes using a heat, visible light, or ultraviolet light to cause the hydrophilic polymer to undergo a cross-linking polymerization reaction.

In another embodiment, the wound healing promoting compound comprises a water-soluble compound that promotes wound healing. In a preferred embodiment, the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, a few Butan or a combination thereof.

In a specific embodiment, the wound healing promoting compound is 0.01 to 20% of the total weight of the hydrophilic polymer. In a preferred embodiment, the wound healing promoting compound is 0.05 to 18% of the total weight of the hydrophilic polymer. In a more specific embodiment, the wound healing promoting compound is 0.1 to 15% of the total weight of the hydrophilic polymer.

Because the hydrophilic substrate itself has hydrophilic groups, it can adsorb compounds that promote wound healing; and the hydrophilic substrate is a solid hydrophilic polymer with a three-dimensional network structure, so the three-dimensional network structure can be slowly released and promoted. A wound healing compound to enhance the wound healing effect of the composite material.

The composite material prepared by the present invention can be further adhered to a film to obtain a hydrophilic dressing for wound healing.

The film of the invention can have the characteristics of waterproofness, transparency and breathability; thereby, it can not only prevent water or bacteria from entering the hydrophilic dressing, but also maintain good breathability. In a specific embodiment, the film is a film with a waterproof and breathable effect. In a preferred embodiment, the breathable film layer may be made of Polyurethane (PU).

In addition, the film of the present invention is a film with a single-sided adhesive, and in addition to adhering to the composite material, it also provides the function of adhering to the skin of a body. Therefore, in a specific embodiment, the film has a two-sided structure, in which one side is a bonding surface, and the bonding surface is bonded to the composite material. In a preferred embodiment, the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to adhere the composite material and a body's skin. In another embodiment, the surface area of the film is larger than the surface area of the composite material. Therefore, the adhesive surface of the film will have more adhesive areas than the composite material to provide the hydrophilic dressing with the skin of a body; and the skin adhesive area is a seal for oxygen and moisture exchange The environment, isolates microorganisms and pollutants from entering the wound to promote the wound to be moist without excessive infiltration or drying.

In a specific embodiment, the individual is an animal, preferably a mammal, and more preferably a human.

The present invention further provides a hydrogel structure comprising a hydrophilic substrate layer and a plurality of molecular particles, wherein the hydrophilic substrate layer is composed of a hydrophilic polymer, and the hydrophilic polymer includes a hydrophilic property. A monomer, a cross-linking agent, and an inorganic silicon oxide compound, wherein the plurality of molecular particles are distributed in the hydrophilic substrate layer, and each of the plurality of molecular particles is a compound that promotes wound healing.

In a specific embodiment, the hydrophilic substrate layer has a three-dimensional network structure, and the plurality of molecular particles are adhered to the three-dimensional network structure.

In another specific embodiment, the shape of the plurality of molecular particles is spherical.

In a specific embodiment, the hydrophilic monomer comprises an acrylic acid or a derivative thereof having a double bond, an acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid, or Salts, a polyethylene glycol or a derivative thereof, or a combination thereof.

In another embodiment, the cross-linking agent includes N, N'-methylenebispropenamide, ethylene glycol dimethacrylate, polyethylene glycol diacrylate, and tetraethylene glycol. Alcohol dimethacrylate, monoethylene glycol dimethacrylate, monopolyethylene glycol dimethacrylate, monotrimethylpropane trimethacrylate, vinyl methacrylate, ethylene glycol Amine dimethylacrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene, or a combination thereof.

In a specific embodiment, the inorganic silicon oxide compound is an inorganic compound having a silicon oxide tetrahedron structure or a polysiloxane tetrahedron structure.

In another embodiment, the hydrophilic polymer further includes a polymerization initiator. In a preferred embodiment, the polymerization initiator is an Irgacure 2959.

In a specific embodiment, the wound healing promoting compound includes a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, and a chitin polymer. Sugar or a combination thereof.

In another specific embodiment, the hydrogel structure is further adhered to a thin film layer, which is disposed above the hydrogel structure, and the surface area of the thin film layer is larger than the surface area of the hydrogel structure. In a preferred embodiment, the film layer has a two-sided structure, one of which is a bonding surface, and the bonding surface is bonded to the hydrogel structure. In a more specific embodiment, the material of the film layer is a polyurethane (PU).

Therefore, the main object of the present invention is to provide a solid hydrophilic polymer with appropriate strength, elasticity, and three-dimensional network structure. The hydrophilic polymer has hydrophilic groups, so it has hygroscopicity and anti-hydrolysis properties. It can absorb wound exudate and keep the wound moist; while a solid structure with a proper strength of the three-dimensional network covers the wound, which not only isolates the external environment to protect the wound, but also Can accelerate the proliferation and movement of wound epidermal cells and accelerate wound healing.

Another object of the present invention is that the solid hydrophilic polymer of appropriate strength does not need non-woven fabrics or fibers as a supporting layer for strengthening its structure, and also uses the hydrophilic groups it possesses to adsorb and promote wound healing factors, and to use the The three-dimensional network structure in the hydrophilic polymer achieves the effect of slow-release promoting wound healing factors, and accelerates wound healing.

100, 220‧‧‧ composite materials

110‧‧‧ hydrophilic substrate

120‧‧‧ Effective factors for wound healing

200‧‧‧ Hydrophilic Dressing

210‧‧‧ film

FIG. 1 is a schematic structural diagram of a composite material according to the present invention.

FIG. 2 is a schematic side structural view of a hydrophilic dressing of the present invention.

The following examples are non-limiting and represent only a few aspects and features of the invention.

The invention uses a reactive monomer having a hydrophilic group, a cross-linking agent, and a compound of siloxane tetrahedron structure to solidify and polymerize to form a high-strength solid water-insoluble hydrophilic polymer, and then uses a hydrophilic polymer substrate. The adsorption characteristics of its own hydrophilic group will adsorb the effective factor of wound healing into the hydrophilic polymer with solid three-dimensional network structure.

    Example 1         Preparation of hydrophilic polymers    

3 g of acrylamide (hydrophilic monomer), 7 g of 2-acrylamido-2-methylpropanesulfonic acid (hydrophilic monomer), 2 g of silica, N, N'-methylene Dipropenamide (addition amount is 1% of the total weight of the hydrophilic polymer) (crosslinking agent) is mixed with water to 100 grams, and stirred evenly.

After the above solution was deoxygenated, an initiator Irgacure 2959 (addition amount was 2% of the total weight of the hydrophilic polymer) was added to the solution and stirred evenly. Move the solution to the reaction mold. Under the condition of ultraviolet light irradiation, the solution in the reaction mold begins to undergo cross-linking polymerization, and the liquid oligomer in the solution gradually forms a water-soluble solid three-dimensional network structure. Hydrophilic polymerization Material as a hydrophilic substrate.

    Example 2         Preparation of composite materials    

Add 10 grams of 10% collagen solution, which is an effective factor for wound healing, in the solid hydrophilic polymer described above. After the collagen solution is completely adsorbed by the solid hydrophilic polymer, a composite material can be obtained.

As shown in FIG. 1, it is a schematic structural diagram of a composite material 100 according to the present invention. The composite material 100 includes a hydrophilic substrate 110 and a wound healing effective factor 120. The hydrophilic substrate 110 is a reaction product of a hydrophilic polymer and has a solid substance with a three-dimensional network structure. The hydrophilic polymer includes a hydrophilic monomer, a cross-linking agent, and an inorganic silicon oxide compound. The wound healing effective factor 120 is distributed in the three-dimensional network structure of the hydrophilic substrate 110. When the composite material 100 is used to treat a wound, the wound healing effective factor 120 may be in the composite material 100. Released to accelerate wound healing. A specific example of the wound healing effective factor 120 is collagen.

    Example 3         Efficacy testing of composite materials    

According to the method for preparing the composite material, the present invention only adjusts the amount of silicon dioxide in the hydrophilic polymer or replaces the silicon dioxide with other components, that is, 3 g of acrylamide and 7 g of 2-propylene The composition and addition amount of fluorenylamino-2-methylpropanesulfonic acid and N, N'-methylenebispropenesulfonamide (the addition amount is 1% of the total weight of the hydrophilic polymer) are not changed. Samples of four different composite materials were prepared. The preparation methods of each sample are as follows: Sample 1: The amount of silica added is 2 grams; Sample 2: The amount of silica added is 6 grams; Sample 3: The silicon dioxide is replaced by magnesium aluminum silicate, and its addition The amount was 2 g; and sample 4: the silicon dioxide was replaced by magnesium aluminum silicate, and the added amount was 6 g.

Compare the four composite material samples with the above-mentioned different ratios with commercially available hydrogel dressings (as a comparison group), and measure the mechanical properties before immersion in physiological saline and after immersion in full swelling. The results are shown in Table 1.

    Example 4         Preparation of hydrophilic dressings    

Adhesive a single-sided adhesive film (such as a commercially available "Shutai", which has the function of waterproof and breathable) and the above-mentioned composite material, that is, the side with the adhesive on the film is bonded to the composite material , You can get a hydrophilic dressing.

As shown in FIG. 2, it is a schematic side structural diagram of a hydrophilic dressing 200 according to the present invention. The hydrophilic dressing 200 includes a film 210 and a composite material 220, and the film 210 is disposed above the composite material 220. The film 210 has a two-sided structure, one of which is an adhesive surface (the adhesive surface is not shown), and the adhesive surface has an adhesive, and the adhesive surface is adhered to the composite material 220 to make the film 210 and the composite The material 220 constitutes the hydrophilic dressing 200. In addition, the surface area of the film 210 is greater than the surface area of the composite material 220, so the bonding surface of the film 210 will have an additional bonding area that bonds outside the composite material 220 to provide the hydrophilic dressing 200 and a body Skin adhesion, and the skin adhesion area is a sealed environment for oxygen and moisture exchange, to isolate microorganisms and pollutants from entering the wound, so as to promote the wound to be moist without excessive infiltration or dryness.

The above-mentioned embodiments are merely for illustrative purposes to explain the effects of the present invention, and to explain the technical features of the present invention, but not for limiting the protection scope of the present invention. Any change or arrangement that can be easily accomplished by those skilled in the art without departing from the technical principles and spirit of the present invention is within the scope of the present invention. Therefore, the scope of protection of the rights of the present invention is as listed in the attached patent application.

Claims (7)

A composite material comprising a hydrogel and a compound for promoting wound healing, wherein the hydrogel is a reaction product of a hydrophilic polymer, wherein the hydrophilic polymer is composed of a hydrophilic monomer, A crosslinking agent, a polymerization initiator, and a metal silicate, wherein the wound healing promoting compound is distributed in the hydrogel, and the hydrogel releases the wound healing promoting compound, wherein the crosslinking agent is A compound having at least two ethylenically unsaturated groups, wherein the weight percentage of the metal silicate to the hydrophilic polymer is 4 to 50%, and the compound for promoting wound healing comprises a collagen, a hyaluronic acid , A gelatin, a growth factor, a cytokine, an alginate, a silver ion, a chitosan, or a combination thereof. The composite material according to item 1 of the patent application scope, wherein the hydrophilic monomer comprises an acrylic acid or a derivative thereof having a double bond, an acrylamide or a derivative thereof, and a 2-acrylamido-2 -Methylpropanesulfonic acid or a salt thereof, polyethylene glycol or a derivative thereof, or a combination thereof. The composite material according to item 1 of the scope of the patent application, wherein the weight percentage of the hydrophilic monomer in the hydrophilic polymer is 8 to 80%. The composite material according to item 1 of the scope of the patent application, wherein the cross-linking agent comprises N, N'-methylenebispropenamide, ethylene glycol dimethacrylate, and polyethylene glycol di Acrylate, Tetraethylene glycol dimethacrylate, Triethylene glycol dimethacrylate, Monoethylene glycol dimethacrylate, Trimethylolpropane trimethacrylate, Monomethyl Vinyl acrylate, ethylenediamine dimethylacrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene, or a combination thereof. The composite material according to item 1 of the scope of the patent application, wherein the weight percentage of the cross-linking agent in the hydrophilic polymer is 0.1 to 20%. The composite material according to item 1 of the scope of patent application, wherein the compound for promoting wound healing is 0.01 to 20% of the total weight of the hydrophilic polymer. For example, the composite material described in the scope of application for the patent, further bonded a film, wherein the film has a two-sided structure, one of which is a bonding surface, the bonding surface is bonded to the composite material, and the surface area of the film is greater than The surface area of the composite material.