TW202241377A - Wetted dressing for use in tattoo color protection and using method thereof can reduce festering wound, showering inconvenience and ink dilution and facilitate color attachment - Google Patents

Abstract

The invention relates to a wetted dressing for use in tattoo color protection, wherein the wetted dressing has high features of high moisture content and low absorption capability of aqueous solution. The wetted dressing of the invention is used for damaged skin repair and tattoo ink color protection after fresh tattoo. It provides for medical level repair, protection isolation, moisture retaining after tattooing, and supports the deposition of tattoo ink within skin in order to increase tattoo's artistic beauty.

Description

A wet dressing for color protection of tattoos and its application method

The present invention is a moisturizing and color-protecting wet dressing, which is used for repairing damaged skin after fresh tattoos and tattoo ink color protection. It is characterized in that the wet dressing has the characteristics of high water content and low absorption capacity of aqueous solution . Therefore, the wet dressing can provide medical-grade repair of damaged skin after tattooing, protect and isolate, maintain moisture and assist the deposition of tattoo ink in the skin, so as to enhance the beauty of tattoo art.

In recent years, tattoos have leapt from subculture to popular culture. With the increase in the number of tattoos, the issue of fresh tattoo care has also begun to be taken seriously. In the past, ventilation was the main care principle for damaged skin, so after fresh tattoos, Vaseline or tattoo ointment was applied to moisturize without covering any dressings. However, just applying petroleum jelly or ointment cannot completely protect and isolate tattoo wounds, and petroleum jelly or ointment is not only easy to stain clothing and cause inconvenience and discomfort, but also requires constant replenishment to keep the skin moist.

The tattooed wound is an open wound. If it comes into contact with water (such as bathing), bacteria in the air or clothes without isolation, it may cause infection and inflammation of the wound, causing the tattoo ink to fade. If the wound is not protected by an isolation layer, it is easy to get the quilt, bed, towel or underwear when the scab forms, and the scab will be torn off, which may even cause the tattoo wound to open again, causing wound infection and ink fading. Furthermore, tattooed people tend to scratch and break the scab due to the dryness and itching of the scab. Causes wound infection and ink fading.

In order to keep the damaged skin moist after fresh tattoos, tattoo artists will also use plastic (such as plastic wrap) as an auxiliary isolation layer to wrap around the freshly tattooed skin and its surroundings, covering the wound exudate and exuded ink inside , to avoid dry skin, prevent the exudate after tattooing from sticking to the clothes, and also reduce the problem of the wound being rubbed by foreign objects. However, the fresh-keeping film is airtight and does not have medical quality. It is easy to cause wound ulceration or skin allergy due to airtightness and stuffy & wet, and it is easy to fall off. Therefore, the plastic wrap can only be used as an auxiliary isolation layer within a few hours after fresh tattoos, and the plastic wrap must be removed after a few hours.

In the past, wounds after fresh tattoos were hardly regarded as ordinary open wounds, so there was no special dressing for tattoos. In addition to possible infection of tattoo wounds, it may also cause inconvenience to life and loss of ink. Improper care detracts from the technical quality and visual beauty of tattoo art, which is highly undesirable.

US Patent Publication No. US20140200196A1 discloses that alginate hydrogel combined with mineral-containing spray solution forms a transparent film layer for wound isolation, hemostasis and repair. However, the hydrogel of this patent is gel-like, and its structural strength is insufficient to buffer the physical impact and friction of the wound site. In addition, the moisture permeability of the outer film formed by the alginate hydrogel in this patent is too high, and it needs to rely on wound exudate to maintain a moist state. If there is little/no exudate in the wound, the moisture in the hydrogel will It will become dry due to volatilization. Although the hydrogel can be easily removed due to drying, it loses the necessary factors for wound repair to keep moist, and may reabsorb tattoo ink, resulting in the loss of tattoo ink. At the same time, the alginate hydrogel in this patent does not have a waterproof effect, so that the wound cannot touch water after a fresh tattoo, such as bathing, cleaning, going out in rainy days, etc. In addition to causing the hydrogel protective layer to fall off, it is also easy to cause the wound to be infected by microorganisms due to contact with water pollution sources. Due to insufficient adhesion, patients must avoid friction between the hydrogel protective layer at the wound and clothing, and do not rub or slap the wound when they feel itchy. This will cause unnecessary pain and inconvenience to the tattooed person. In addition, the patent involves two steps. The first step is to apply a thin layer of hydrogel, and the second step is to spray a spray solution containing minerals at a specific distance, so that the spray condenses and forms a thin film on the surface of the hydrogel. The amount will also affect its structure and thickness, which shows that its use process is complicated and troublesome.

US Patent Publication No. US20170042772 A1 discloses that hydrogel patches and skin patches can be used for post-treatment after tattooing. However, the hydrogel patches described in this patent are not necessarily capable of absorbing aqueous solutions such as wound exudate. In addition, the hydrogel in this patent is made of adhesives and/or thickeners, and is not a three-dimensional network cross-linked polymer structure, so it may dissolve due to water absorption and swelling. At the same time, the patch of this patent contains multiple ingredients (eg, gelling agent, thickener, emulsifier, preservative, anti-inflammatory agent, soothing agent, cooling agent and/or analgesic, etc.), the main purpose is anti-inflammatory, soothing and anti-corrosion, the patent aims to change the dosage form of anti-inflammatory soothing lotion or ointment into a patch type, and specifies that these ingredients will not affect tattoo ink, but these ingredients are irritating, useless or harmful to wound healing and repair of.

In addition to the above-mentioned hydrogels, there are generally silicone-free hydrogels that absorb water and swell, which have good water absorption but insufficient mechanical strength. For example, Taiwan Patent Publication Nos. M419555, I267387, I429462, and I504420; Chinese Patent Publication No. No. CN204863670 and U.S. Patent Publication No. 2013/0072843 disclose the use of hydrogel combined with non-woven fabrics or fibers as a support layer to strengthen its structure; however, the structure of the hydrogel is still brittle after absorbing aqueous solution and swelling, resulting in the removal of the dressing. ,broken The cracked glue is not easy to remove, nor can it buffer the physical impact and friction of the wound site.

Wound repair is a series of complex processes that the body initiates from the moment of injury. The first stage "inflammation phase" blood needs to flow to the wound area to deliver substances such as factors, proteins and coagulation components needed for healing, while the immune system resists and swallows bacteria, foreign bodies and debris at the wound. In the second stage, "proliferative phase", new capillaries are proliferated in the wound area, and more collagen is delivered. The hyperplastic granulation tissue is deposited on the wound surface to provide the basic structure, and epidermal cells move and proliferate from the periphery of the wound to the interior to enclose and close the wound. The third stage "maturation/remodeling stage" after the wound is healed, the excess capillaries degenerate and shrink, the collagen tissue is elongated and arranged neatly, and the scar fades.

In addition, general hydrogel dressings used for wound treatment are too absorbent. For example, the hydrogel dressing disclosed in US Patent Application No. 11720912 has a water absorption of 15 g/g. If a hydrogel dressing that is too absorbent is used on a tattoo, it may absorb too much tattoo ink, which will affect the color rendering of the tattoo.

Tattoo wounds are different from ordinary wounds. Tattoos use tattoo needles to puncture the epidermis to produce micro-perforations in the skin, and deposit ink in the dermis below the epidermis to form permanent patterns and colors. The dermis contains nerve endings, sweat, sebaceous glands, blood and lymphatic vessels. It is the sensitive connective tissue layer of the skin. When the tattoo needle micro-punctures the dermis, the damaged tissue will trigger an inflammatory response, causing a small amount of blood and exudate to pass through the skin. Released in blood vessels or tissues, inflammation-provoking substances can destroy and/or metabolize tattoo ink; on the other hand, ink deposited in the dermis may also dissipate through micro-perforations in the skin, causing discoloration. Therefore, how to help the damaged skin after fresh tattoos to speed up repair and ink color protection is a problem that the industry needs to solve at present.

In order to solve the above problems, it is urgent to develop a method that can not only isolate and protect damaged skin, but also moisturize and maintain the deposition of tattoo ink in the dermis. The invention provides a waterproof and breathable wet dressing, which can be attached to the damaged skin of the affected part of the fresh tattoo and/or its surrounding skin to isolate the stimulation or pollution of the external environment; , Biological inertness, chemical stability, keep tattooed damaged skin in a moist microenvironment, in order to quickly pass the inflammation period, promote wound healing, and maintain the artistic beauty of tattoo patterns.

The term "a" or "an" herein is used to describe elements and components of the present invention. This term is only for convenience of description and to give the basic concept of the present invention. This statement should be read to include one or at least one, and the singular also includes the plural unless it is clearly stated otherwise. When used in conjunction with the word "comprising" in the claims, the word "a" may mean one or more than one.

Each of these specific embodiments may be combined with each of the above items individually or in combination unless otherwise expressly stated herein.

The word "or" in this document means "and/or".

An embodiment of the wet dressing of the present invention is a solid sheet dressing, and the solid sheet dressing includes a hydrogel dressing. In a specific embodiment, the hydrogel dressing has a sheet thickness of 0.02 to 5 mm. In a preferred embodiment, the hydrogel dressing has a sheet thickness of 0.05 to 3 mm. In a more preferred embodiment, the hydrogel dressing has a sheet thickness of 0.1 to 2 mm.

The present invention provides a wet dressing, which comprises a hydrogel (Hydrogel), which The water content of the hydrogel is greater than 50% by weight, and the absorption capacity of the aqueous solution is not greater than 5g/g.

In one embodiment, the hydrogel has an attachment surface for attachment to the tattooed area and/or its surrounding area on the skin of an individual. In addition, the hydrogel is breathable.

In another embodiment, the wet dressing further comprises a sheet adhered to the hydrogel. In a preferred embodiment, the sheet has a double-sided structure, one of which is an adhesive surface, and the adhesive surface is bonded to the non-attached surface of the hydrogel. In a more preferred embodiment, the surface area of the adhesive surface of the sheet is larger than the surface area of the hydrogel. Since the hydrogel is non-adhesive, the adhesive surface of the sheet will have an additional attachment area outside the hydrogel, which is used as a secondary dressing to make the non-adhesive hydrogel adhere to the skin. tattoo area.

In a specific embodiment, the sheet has waterproof and breathable functions. In a preferred embodiment, the sheet is made of polyurethane (Polyurethane; PU). The polyurethane sheet of the invention is composed of polyurethane materials with good biocompatibility and blood compatibility, flexibility, antibacterial property and adhesiveness. Therefore, the thin sheet of the present invention can be waterproof, transparent and breathable; thereby, not only can water or bacteria be prevented from entering the wet dressing, but also good breathability can be maintained.

In another specific embodiment, the sheet has a peel force of 50 to 1,200 g/25mm. In a preferred embodiment, the sheet has a peel force of 100 to 1,000 g/25 mm. In a more preferred embodiment, the sheet has a peel force of 200 to 800 g/25 mm.

The wet dressing provided by the invention has suitable waterproof, breathable and moisture retention properties, and can be used The moisture of the hydrogel itself or the exudate of the wound maintains the damaged skin after tattooing in a moist microenvironment without being too dry or humid, helping the damaged skin after tattooing to quickly pass through the inflammation period and enter the repairing and proliferating period To accelerate wound healing, reduce the ink in the dermis layer of the skin from being damaged by inflammatory substances, or the ink dissipate through the micro-perforation of the skin and fade. Because tattoos belong to micro-perforation, there is not much wound exudate, the wet dressing of the present invention does not need to absorb too much water-based solution, so as to avoid the ink from being adsorbed by the high-absorbency dressing through the capillary action of micro-perforation and dissipating. Therefore, the wet dressing of the present invention not only needs to accelerate wound healing, but also takes into account the artistic beauty of the tattoo pattern.

Therefore, high-absorbency foam dressings (Foam dressing), hydrophilic fiber dressings (Hydrofiber dressing) and/or alginate dressings suitable for medium/large exudates are not suitable for tattoo wounds with little or slight exudates, because Strong water-absorbing properties can easily cause excessive drying of tattoo wounds, and even back-absorb tattoo ink, causing tattoo ink to escape from the dermis of the skin. In a preferred embodiment, the aqueous solution absorption capacity of the hydrogel is not greater than 3 g/g. In a more preferred embodiment, the hydrogel has an aqueous solution absorption capacity of not greater than 2 g/g.

In a specific embodiment, the moisture permeability (Moisture Permeability) of the wet dressing is 200 to 3,500 g/M ² /24Hr. In a preferred embodiment, the moisture permeability of the wet dressing is 300 to 3,000 g/M ² /24Hr. In a more preferred embodiment, the moisture permeability of the wet dressing is 400 to 2,500 g/M ² /24Hr.

In another specific embodiment, the hydrostatic pressure (waterproof function) of the wet dressing is above 0.8M. In a preferred embodiment, the hydrostatic pressure of the wet dressing is above 1.2M. In a more preferred embodiment, the hydrostatic pressure of the wet dressing is above 1.5M.

The hydrogel of the present invention is composed of polymerizable polyunsaturated monomers and/or polymerizable Polymers are polymerized through heat, light, radiation exposure or other means of cross-linking, and finally form a solid hydrophilic polymer with a three-dimensional network structure. In one embodiment, the hydrogel is polymerized from a plurality of reactants; wherein the reactants include a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or its derivatives, and a cross-linking agent.

In one embodiment, the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group.

Herein, "amphiphilic group" refers to a molecule having both hydrophilic and hydrophobic groups, wherein the hydrophilic group can be a charged or polar hydroxyl group, an aldehyde group, a carboxyl group and/or An amine group, the hydrophobic group can be a non-polar hydrocarbon group and/or an ester group. The "polymerizable monomers and/or polymers having amphiphilic groups" mentioned in the present invention include but not limited to -β-hydroxyethyl methacrylate (HEMA) or its derivatives, methacrylamide or its derivatives, glyceryl methacrylate or its derivatives, 2-hydroxyethyl methacrylamide or its derivatives, polyethylene glycol methacrylate or its derivatives, butyl methacrylate or Its derivatives, ethylene glycol dimethacrylate or its derivatives, or a combination thereof.

The "polymerizable monomers and/or polymers having hydrophilic groups" mentioned in the present invention include but not limited to acrylic acid or its derivatives, acrylamide or its derivatives, vinylamide or its derivatives, Vinyl lactam (such as NVP) or its derivatives, polyethylene glycol or its derivatives, or combinations thereof. Because of the integrity of the crosslinked network structure of hydrogels prepared from polymerizable monomers or polymers with hydrophilic groups, they can swell and lock into aqueous solutions without dissolving.

Polyethylene glycol is a high-molecular polymer with a chemical formula of HO(CH ₂ CH ₂ O) _n H. It has many excellent properties: water solubility, non-volatility, biological inertness, lubricity and moisturizing, soft, It is widely used in various medical products or pharmaceutical preparations because of its pleasant after-use feeling; moreover, polyethylene glycol can improve the biocompatibility of copolymers polymerized with other monomers.

Siloxane (siloxane) is a kind of compound with silicon-oxygen-silicon (Si-O-Si) bond as the skeleton, which is divided into chain H(OSiH ₂ ) _n OH (chain siloxane), or ring Like (OSiH ₂ ) _n derivatives (cyclosiloxane). The functional group R ₃ Si-O- containing a single silicon atom is called siloxy. Siloxane is stable to heat and chemical reagents, biologically inert, not wetted by water, and has outstanding aging resistance. It is often used as a filler for hydrophobic fiber polymers such as rubber or plastic, endowing the polymer with excellent reinforcement and elasticity.

Therefore, the present invention modifies linear polyethylene glycol with organic siloxane (Siloxane) having good chemical stability, biological inertness, and flexible hydrophobic active groups to improve the hydrophilicity of hydrophobic siloxane, thereby forming silane Functionalized polyethylene glycol silanes, including but not limited to mercaptosilane modified polyethylene glycol (such as mercaptopolyethylene glycol silane (SH-PEG-Silane)), carboxysilane modified polyethylene glycol (such as Carboxypolyethylene glycol silane (COOH-PEG-Silane)), and methoxysilane-modified polyethylene glycol (such as methoxypolyethylene glycol silane (mPEG-Silane)). In one embodiment, the silane-functionalized polyethylene glycol comprises mercaptopolyethylene glycol silane, carboxypolyethylene glycol silane or methoxypolyethylene glycol silane. The silane-functionalized polyethylene glycol can increase the hydrophobicity of polyethylene glycol (decrease its hydrophilicity), and enhance the bioinertness, flexibility, chemical stability and low water absorption of the hydrogel of the present invention.

The hydrogel of the present invention is a water-swellable polymer with a certain degree of cross-linking, and is neither soluble in water nor soluble in organic solvents. The hydrophilic group in the hydrogel has the ability to absorb water-soluble The ability of liquid, and the water absorption rate is fast, the water retention performance is good, and it is difficult to separate the water even if it is pressurized. In one embodiment, the hydrogel is prepared from polymerizable monomers and/or polymers having amphiphilic groups. In a preferred embodiment, the hydrogel is composed of polymerizable monomers and/or polymers with amphiphilic groups and the polymerizable monomers and/or polymers with hydrophilic groups Prepared.

In another embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups (which have hydrophobic groups) in the hydrogel is greater than that of the hydrophilic groups Polymerizable monomers and/or polymers are used to prepare hydrogels with low absorption capacity of aqueous solutions. In a preferred embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percent of the polymer is 20%. In a more preferred embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percent of the polymer is 30%. Controlling the hydrogel by adjusting the composition ratio of the polymerizable monomer and/or polymer with amphiphilic groups and the polymerizable monomer and/or polymer with hydrophilic groups The absorption capacity of aqueous solution is not more than 5g/g.

In one embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. In a preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel. In a more preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.

The crosslinking agent of the present invention is not particularly limited, as long as it can react with the amphiphilic group and/or the functional group of the hydrophilic group to initiate crosslinking. "Crosslinking agent" herein includes, but is not limited to, compounds having at least two ethylenically unsaturated groups. In a specific embodiment, the crosslinking agent comprises N,N'-methylenebisacrylamide, ethylene glycol dimethacrylate, polyethylene glycol diacrylate, tetraethylene glycol Dimethacrylate, Triethylene glycol dimethacrylate, Polyethylene glycol dimethacrylate, Trimethylpropane trimethacrylate, Vinyl methacrylate, Ethylenediamine Dimethacrylamide, glycerol dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene or a combination thereof.

In another specific embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.

In one embodiment, the hydrogel comprises a soothing factor, a polishing factor or a combination thereof. The soothing factor or the embellishing factor can optionally exist in the hydrogel, and the free water of the three-dimensional network structure inside the hydrogel can be replaced with the compound aqueous solution of the soothing factor or the embellishing factor, the soothing factor or the embellishing factor The compound of the embellishment factor can be freely distributed in the hydrogel polymer. Therefore, when the wet dressing containing the soothing factor or the moisturizing factor is attached to the tattoo wound, the compound of the soothing factor or the moisturizing factor is released into the damaged skin from the hydrogel of the wet dressing, which can improve Repair damaged skin and protect the color of tattoo ink, and it will not interact with tattoo pigments.

In the present invention, the soothing factor can improve the comfort of damaged skin care, such as Soothing and calming, reducing wound odor, avoiding scabs, etc. In a specific embodiment, the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, menthol (Menthol) , Borneol, Frankincense, derivatives thereof, and combinations thereof.

In the present invention, the embellishment factor can moisturize and protect the color, such as moisturizing, brightening, embellishing and so on. In a specific embodiment, the moisturizing factor is selected from Glycyrrhizic acid, Salvia miltiorrhiza, Allantoin, Aloe, Arbutin, vitamin A, vitamin D, vitamin E. Vitamin C, Salicylic acid, Ellagic acid, Kojic acid, Chamomile ET, 5,5'-Dipropylbiphenyl-2,2 '-diol (5,5'-Dipropyl-Biphenyl-2,2'-diol), derivatives thereof, and combinations thereof.

In another specific embodiment, the soothing factor or embellishing factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.

In a specific embodiment, the toner includes Potassium Methoxysalicylate, Aloe or a combination thereof. In a preferred embodiment, the embellishment factor has moisturizing and color-protecting effects, and includes 0.2% potassium methoxysalicylate, 1% aloe (Aloe) or a combination thereof.

In a specific embodiment, the toning factor comprises arbutin, and the soothing factor comprises hyaluronic acid. In a preferred embodiment, the soothing factor or the moisturizing factor has moisturizing and color-protecting effects, wherein the moisturizing factor contains 0.1% arbutin, and the soothing factor contains 0.5% hyaluronic acid.

In another specific embodiment, the wet dressing has the functions of protection, isolation, moisturizing and embellishment, etc. for wound care and tattoo color protection. In a preferred embodiment, the hydrogel contains a soothing factor, a polishing factor or a combination thereof.

In one embodiment, the hydrogel does not contain irritating ingredients such as gelling agents, thickeners, preservatives, and/or cooling agents.

Therefore, the wet dressing of the present invention has a high water content (more than 50%), so it can replenish skin moisture when there is little or no exudate in the wound. In addition, because the wet dressing contains a relatively low weight percentage of molecules with adsorbable hydrophilic groups, the wet dressing has a low ability to absorb aqueous solutions and is suitable for tattoo wounds with little exudate . Therefore, the wet dressing of the present invention can maintain the proper moisture balance of tattooed damaged skin, accelerate the damaged skin through the inflammatory period and promote healing, contribute to the deposition of ink in the dermis of the skin, and maintain the technical quality and quality of tattoo art. Visually beautiful.

The present invention also provides a method for color protection and development of fresh tattoo designs, which includes: (a) tattooing a fresh design on the skin of an individual; and (b) attaching a wet dressing to the tattoo design Above, wherein the wet dressing contains a hydrogel (Hydrogel), wherein the water content of the hydrogel is greater than 50% by weight, and the aqueous solution absorption capacity is not greater than 5g/g. Therefore, the wet dressing can be used to maintain the shape of the tattoo pattern and the coloring effect of the tattoo pigment. In addition, before the wet dressing is attached to the tattoo, the damaged skin at the tattoo has been cleaned.

In a specific embodiment, the individual is a mammal. In a preferred embodiment, the individual is human.

In a specific embodiment, the step (b) further comprises attaching the wet dressing to the tattoo design within 2 hours after tattooing. In a preferred embodiment, the step (b) further includes attaching the wet dressing to the tattoo within 1 hour after tattooing. In a more preferred embodiment, the step (b) further includes sticking the wet dressing on the tattoo design within 30 minutes after tattooing.

In another specific embodiment, the step (b) further includes a step (b1), wherein the step (b1) includes removing the wet dressing 48 hours after the wet dressing is attached with the tattoo pattern, And reapply a new wet dressing on the tattoo design. In a preferred embodiment, the step (b) further includes a step (b1), wherein the step (b1) includes removing the wet dressing 24 hours after the wet dressing is attached with the tattoo pattern , and reapply a new wet dressing over the tattoo.

In a specific embodiment, the step (b1) is repeated 6 times. In a preferred embodiment, the step (b1) is repeated 4 times. In a more preferred embodiment, the step (b1) is repeated twice. In addition, after the step (b1) is repeated several times, the wet dressing should be completely removed from the tattoo pattern at last.

In another embodiment, the wet dressing further comprises a sheet adhered to the hydrogel. In a preferred embodiment, the surface area of the adhesive surface of the sheet is greater than the surface area of the hydrogel. Therefore, the adhesive surface of the sheet will have more attachment areas for bonding the hydrogel.

In one embodiment, the wet dressing is implemented as a solid sheet type dressing. In another specific embodiment, the sheet has waterproof and breathable functions. In a preferred embodiment, the sheet is made of polyurethane.

In a preferred embodiment, the aqueous solution absorption capacity of the hydrogel is no greater than 3 g/g. In a more preferred embodiment, the hydrogel has an aqueous solution absorption capacity of no greater than 2 g/g.

In one embodiment, the hydrogel is polymerized through the reaction of multiple reactants; wherein the multiple reactants include a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or its derivatives, and a cross-linking agent. In a preferred embodiment, the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group.

In another embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. In a preferred embodiment, the cross-linkable polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel . In a more preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.

In a specific embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percentage is 20%. In a preferred embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percent of the polymer is 30%.

In another specific embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the cross-linking agent in the hydrogel 0.05 to 5%.

In one embodiment, the hydrogel comprises a soothing agent, a toning agent or a combination thereof.

In a specific embodiment, the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, menthol, borneol, Frankincense, its derivatives and combinations thereof.

In another specific embodiment, the moisturizing factor is selected from glycyrrhizic acid, salvia miltiorrhiza, allantoin, aloe vera, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid, Chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.

In a specific embodiment, the soothing factor or the embellishing factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.

In another specific embodiment, the toning agent comprises Potassium Methoxysalicylate, Aloe or a combination thereof. In a preferred embodiment, the embellishment factor has moisturizing and color-protecting effects, and includes 0.2% potassium methoxysalicylate, 1% aloe vera or a combination thereof.

In a specific embodiment, the toning factor comprises arbutin, and the soothing factor comprises hyaluronic acid.

The present invention further provides a composition for the preparation of a pharmaceutical composition for caring for damaged skin with fresh tattoos and maintaining the tattoo pattern and its color, wherein the composition comprises a wet A dressing, wherein the wet dressing comprises a hydrogel, wherein the water content of the hydrogel is greater than 50% by weight, and the aqueous solution absorption capacity is not greater than 5g/g. Therefore, the wet dressing is used for sticking on the fresh tattooed skin after tattooing, in order to care for the damaged skin after the fresh tattooing, and contribute to the artistic beauty of tattoo patterns and pigments in the skin.

In another embodiment, the wet dressing further comprises a sheet adhered to the hydrogel. In a preferred embodiment, the surface area of the adhesive surface of the sheet is greater than the surface area of the hydrogel. Therefore, the adhesive surface of the sheet will have more attachment areas for bonding the hydrogel.

In a specific embodiment, the form of the wet dressing is a solid sheet dressing. In another specific embodiment, the sheet has waterproof and breathable functions. In a preferred embodiment, the sheet is made of polyurethane.

In a preferred embodiment, the aqueous solution absorption capacity of the hydrogel is no greater than 3 g/g. In a more preferred embodiment, the hydrogel has an aqueous solution absorption capacity of not greater than 2 g/g.

In one embodiment, the hydrogel is polymerized by reacting reactants comprising a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or its derivatives, and a cross-linking agent. In a preferred embodiment, the polymerizable monomer and/or polymer has an amphiphilic group and/or a hydrophilic group.

In another embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. In a preferred embodiment, the polymerizable monomer and/or polymer having a hydrophilic group is And the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel. In a more preferred embodiment, the polymerizable monomer and/or polymer having hydrophilic groups and the silane-functionalized polyethylene glycol or its derivatives account for 8% by weight of the hydrogel to 20%.

In a specific embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percentage is 20%. In a preferred embodiment, the proportion of the polymerizable monomer and/or polymer having an amphiphilic group in the hydrogel is greater than that of the crosslinkable monomer and/or polymer having a hydrophilic group Or the weight percentage of the polymer is 30%.

In another specific embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.

In one embodiment, the hydrogel comprises a soothing agent, a toning agent or a combination thereof.

In a specific embodiment, the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, menthol, borneol, Frankincense, its derivatives and combinations thereof.

In another specific embodiment, the moisturizing factor is selected from glycyrrhizic acid, salvia miltiorrhiza, allantoin, aloe, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, Ellagic acid, kojic acid, chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.

In a specific embodiment, the soothing factor or the embellishing factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.

In addition, the present invention provides a method for preparing a hydrogel, which comprises: mixing a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or a derivative thereof, and a cross-linking agent to obtain a mixture, and subjecting the mixture to a cross-linking polymerization reaction to obtain the hydrogel.

In one embodiment, the polymerizable monomer and/or polymer has an amphiphile and/or a hydrophilic group. In a preferred embodiment, the polymerizable monomers and/or polymers having amphiphilic groups include β-hydroxyethyl methacrylate or derivatives thereof, methacrylamide or derivatives thereof , glyceryl methacrylate or its derivatives, 2-hydroxyethyl methacrylamide or its derivatives, polyethylene glycol methacrylate or its derivatives, butyl methacrylate or its derivatives, Ethylene glycol dimethacrylate or its derivatives or combinations thereof. In another specific embodiment, the polymerizable monomer and/or polymer having a hydrophilic group comprises acrylic acid or its derivatives, acrylamide or its derivatives, acrylamide or its derivatives, vinylidene Amide (such as NVP) or derivatives thereof, polyethylene glycol or derivatives thereof, or combinations thereof.

In one embodiment, the silane-functionalized polyethylene glycol comprises mercaptopolyethylene glycol silane, carboxypolyethylene glycol silane or methoxypolyethylene glycol silane.

In another embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. In a preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 6 to 30% by weight of the hydrogel. In a more preferred embodiment, the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 8 to 20% by weight of the hydrogel.

In a specific embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percentage is 20%. In a preferred embodiment, the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer and/or polymer with hydrophilic groups The weight percent of the polymer is 30%. By adjusting the ratio of the polymerizable monomers and/or polymers with amphiphilic groups and the polymerizable monomers and/or polymers with hydrophilic groups, the hydraulic coagulation is controlled The absorption capacity of glue to aqueous solution is not more than 5g/g.

In a specific embodiment, the crosslinking agent comprises N,N'-methylenebisacrylamide, ethylene glycol dimethacrylate, polyethylene glycol diacrylate, tetraethylene glycol Dimethacrylate, Triethylene glycol dimethacrylate, Polyethylene glycol dimethacrylate, Trimethylpropane trimethacrylate, Vinyl methacrylate, Ethylenediamine Dimethacrylamide, glycerol dimethacrylate, diethylene glycol dimethacrylate, divinylbenzene or a combination thereof.

In another specific embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.01 to 10%. In a preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.02 to 8%. In a more preferred embodiment, the weight percentage of the crosslinking agent in the hydrogel is 0.05 to 5%.

In a specific embodiment, the water accounts for more than 50% by weight of the hydrogel.

In another embodiment, the preparation method further comprises adding a soothing factor, a polishing factor or a combination thereof to the mixture. In a preferred embodiment, the soothing factor or embellishing factor accounts for 0.01 to 10% by weight of the composition of the hydrogel.

In a specific embodiment, the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, menthol, borneol, Frankincense, its derivatives and combinations thereof. In another specific embodiment, the moisturizing factor is selected from glycyrrhizic acid, salvia miltiorrhiza, allantoin, aloe vera, arbutin, vitamin A, vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid, Chamomile extract, 5,5'-dipropylbiphenyl-2,2'-diol, derivatives thereof, and combinations thereof.

In one embodiment, the mixture is polymerized to form the hydrogel by cross-linking through heat, light, radiation exposure or other means.

In another embodiment, the method further comprises adhering a sheet to the hydrogel. In a preferred embodiment, the surface area of the adhesive surface of the sheet is greater than the surface area of the hydrogel.

Therefore, the present invention provides a wet dressing for post-tattoo care, so that fresh tattoos have medical-grade repair and professional artistic aesthetics; protect and isolate tattoo wounds from infection, and are not stained by daily contact items such as clothing and quilts. Sticky friction, waterproof and breathable, can reduce wound ulceration, inconvenience of bathing and ink dilution and dissipation, moisturize and protect color, promote pigment color adhesion, and perfectly display tattoo art of visual beauty.

10 and 20: Wet Dressings

101: flakes

102: Hydrogel

201: tattoo

Fig. 1 is a schematic view of the side structure of the wet dressing of the present invention.

Fig. 2 is a schematic diagram of sticking the wet dressing of the present invention on a tattoo.

A few examples of the operation mode of this application are listed hereafter, and are described in the following in conjunction with the description of the drawings, for reference during examination. The proportions and positions of the drawings in this application are not necessarily drawn according to the actual scale for the convenience of explanation, and the proportions and positions in the drawings are not intended to limit the scope of protection claimed by the present invention.

The following examples are non-limiting and represent only a few aspects and features of the invention.

Example 1

Preparation and use of wet dressings

6 grams of amphiphilic group-β-hydroxyethyl methacrylate, 2 grams of hydrophilic group acrylamide, 2 grams of mercapto polyethylene glycol silane, N,N'-methylenebisacrylamide 0.2 gram (cross-linking agent), 0.2 gram of Irgacure 2959 photoinitiator (selected from BASF BASF) and water are mixed to 100 gram, the above-mentioned solution that stirs is moved in the polymerization reaction mould, under the situation of ultraviolet light irradiation, The solution in the reaction mold undergoes a cross-linking polymerization reaction to form a solid sheet-like hydrogel with a three-dimensional network structure. The water content of the hydrogel is greater than 80% by weight, and the absorption of aqueous solution is not greater than 2g/g.

As shown in Figure 1, it is a schematic side view of the wet dressing 10 of the present invention. The wet dressing 10 includes a sheet 101 with waterproof and breathable functions and a hydrogel 102, wherein the sheet 101 has a double-sided structure, wherein One side is an adhesive surface (adhesive surface is not shown), the adhesive surface has an adhesive, and the adhesive surface will be bonded with the hydrogel 102, so that the sheet 101 and the hydrogel 102 form the wet dressing 10 . The surface area of the thin sheet 101 is larger than that of the hydrogel 102 , so the adhesive surface of the thin sheet 101 has more adhesive area than the hydrogel 102 for the wet dressing 10 to adhere to the skin.

As shown in Figure 2, the wet dressing is used as follows: within 2 hours after the tattoo, clean the affected part of the tattoo 201 with clean cold water, and then gently remove the bleeding, exudate, ink, etc. of the fresh tattoo 201 with clean gauze Material, the wet dressing 20 of this case is attached to the affected part of the tattoo 201, and the dressing is changed every 0.5 to 2 days (adjust the replacement frequency according to the amount of bleeding and exudate).

Example 2

Preparation and use of wet dressing containing arbutin/hyaluronic acid

According to the preparation method of Example 1, but add 0.5g hyaluronic acid (relaxing factor) and 0.1g arbutin (polish factor) to the 100g solution prepared in Example 1, after cross-linking polymerization reaction, a solid flake-like The arbutin hydrogel with a hyaluronic acid concentration of 0.5% in the three-dimensional network structure has a water content of more than 75% and can absorb no more than 2g/g of aqueous solution. Then combine the arbutin/hyaluronic acid hydrogel with a waterproof and breathable film to form a wet dressing containing arbutin/hyaluronic acid with self-adhesive surrounding. The method of using this wet dressing is also to clean the affected part of the tattoo with clean cold water, and then gently remove the bleeding, exudate, ink and other substances from the fresh tattoo with clean gauze, and then gently stick this wet dressing on the affected part of the fresh tattoo. 0.5~2 Change the dressing once a day (adjust the changing frequency according to the amount of bleeding and exudate).

Example 3

How to use polyurethane film dressing

Clean the tattoo affected area with clean cold water first, then gently remove the bleeding, exudate, ink and other substances from the fresh tattoo with clean gauze, and use a waterproof and breathable polyurethane film dressing that is at least 1 cm larger than the tattoo, and gently stick it on the tattoo. Change the dressing every 0.5 to 1 day (adjust the frequency according to the amount of bleeding and exudate), and repeat the above steps until the wound heals.

Example 4

Potassium methoxysalicylate or aloe vera in combination with polyurethane film dressings

First clean the affected part of the tattoo with clean cold water, then gently remove the bleeding, exudate, ink and other substances from the fresh tattoo with clean gauze, and apply a solution containing 0.2% potassium methoxysalicylate or 1% aloe vera (polishing factor) to the skin. For the tattoo, when it is in a slightly damp state, gently stick a polyurethane film dressing at least 1 cm larger than the tattoo around the tattoo, and change the dressing every 0.5 to 2 days (adjust the frequency according to the amount of bleeding and exudate), and Repeat the above steps until the wound heals.

Example 5

Compare the wet dressing of Example 1 with the non-silicon hydrogel (not containing compounds with silicon molecules) dressing (as a comparative example) on the market, and measure the wet dressing before soaking in normal saline and after soaking completely swollen. The mechanical properties are shown in Table 1.

From the results, it can be seen that adding the mercapto polyethylene glycol silane can enhance the hydrogel Strength of mechanical properties (compressive strength and elongation).

Table 1. Comparative test results of samples of the present invention and comparative examples

Example 6

Comparison of tattoo repair

The dressings of the different embodiments above, the alginate sheet dressing with high hygroscopicity (as comparative example 1), the plastic wrap commonly used in the tattoo industry (as comparative example 2) and the non-silicon hydrogel dressing on the market (as comparative example Example 3), 4 people were asked to conduct nursing experiments after fresh tattoos, and their indicators for tattoo repair were measured respectively. The test results are shown in Table 2 below.

Table 2. 28 fresh tattoos were tested according to the embodiment and comparative example described in the present invention. The results of the tattoo art were evaluated by the tattoo artist, the wound care was evaluated by the medical staff, and the water absorption was the test result of soaking in water ( Condition rating: ★★★best, ★★☆second best, ★★good, ★☆average, ★poor, ━invalid):

From the results, it can be seen that the wet dressing of the present invention is better than other groups of dressings in terms of tattoo color protection, protection and isolation, and wound repair.

The above-mentioned embodiments are only illustrative to illustrate the effect of the present invention and describe the technical features of the present invention, but are not intended to limit the scope of protection of the present invention. Any changes or arrangements that can be easily accomplished by those skilled in the art without violating the technical principle and spirit of the present invention fall within the scope of the present invention.

10: Wet dressing

101: flakes

102: Hydrogel

Claims (16)

A wet dressing comprising a hydrogel, wherein the water content of the hydrogel is greater than 50% by weight, and the aqueous solution absorption capacity is not greater than 5g/g, wherein the hydrogel is reacted by a plurality of reactants Polymerized, wherein the plurality of reactants include a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or its derivatives, and a cross-linking agent. The wet dressing as described in claim 1, wherein the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel . The wet dressing according to claim 1, wherein the polymerizable monomer and/or polymer has an amphiphilic group and/or a hydrophilic group. The wet dressing as described in claim 3, wherein the proportion of the polymerizable monomer and/or polymer with amphiphilic groups in the hydrogel is greater than that of the polymerizable monomer with hydrophilic groups The weight percentage of body and/or polymer is 20%. The wet dressing as described in claim 1, wherein the silane-functionalized polyethylene glycol comprises mercaptopolyethylene glycol silane (SH-PEG-Silane), carboxypolyethylene glycol silane (COOH-PEG-Silane) or Methoxypolyethylene glycol silane (mPEG-Silane). The wet dressing according to claim 1, wherein the hydrogel contains a soothing factor, a moisturizing factor or a combination thereof. The wet dressing as described in claim 6, wherein the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, Menthol, Borneol, Frankincense, derivatives thereof, and combinations thereof. The wet dressing as described in claim 6, wherein the moisturizing factor is selected from Glycyrrhizic acid, Salvia miltiorrhiza, Allantoin, Aloe, Arbutin, vitamin A , vitamin D, vitamin E, vitamin C, salicylic acid, ellagic acid, kojic acid, chamomile ET, 5,5'-dipropyl bismuth Benzene-2,2'-diol (5,5'-Dipropyl-Biphenyl-2,2'-diol), derivatives thereof and combinations thereof. A method for color protection and development of fresh tattoo designs, comprising: (a) tattooing a fresh design on the skin of an individual; and (b) attaching a wet dressing to the tattoo design, wherein the The wet dressing comprises a hydrogel, wherein the water content of the hydrogel is greater than 50% by weight, and the absorption capacity of the aqueous solution is not greater than 5g/g, wherein the hydrogel is polymerized through the reaction of multiple reactants , wherein the plurality of reactants include a polymerizable monomer and/or polymer, a silane-functionalized polyethylene glycol or a derivative thereof, and a crosslinking agent. The method according to claim 9, wherein the step (b) further comprises attaching the wet dressing to the tattoo within 2 hours after tattooing. The method according to claim 9, wherein the polymerizable monomer and/or polymer and the silane-functionalized polyethylene glycol or its derivatives account for 4 to 40% by weight of the hydrogel. The method as described in claim 9, wherein the polymerizable monomer and/or polymer has There is an amphiphilic group and/or a hydrophilic group. The method as claimed in claim 9, wherein the silane-functionalized polyethylene glycol comprises mercaptopolyethyleneglycolsilane (SH-PEG-Silane), carboxypolyethyleneglycolsilane (COOH-PEG-Silane) or methoxy Polyethylene glycol silane (mPEG-Silane). The method according to claim 9, wherein the hydrogel comprises a soothing factor, a polishing factor or a combination thereof. The method as described in claim 14, wherein the soothing factor is selected from collagen, hyaluronic acid, glycerin, ceramide, gelatin, antibacterial peptide, chitosan, chitosan, alginate, menthol (Menthol), Borneol, Frankincense, derivatives thereof, and combinations thereof. The method as described in claim 14, wherein the embellishing factor is selected from Glycyrrhizic acid, Salvia miltiorrhiza, Allantoin, Aloe, Arbutin, vitamin A, vitamin D. Vitamin E, Vitamin C, Salicylic acid, Ellagic acid, Kojic acid, Chamomile ET, 5,5'-dipropylbiphenyl- 2,2'-diol (5,5'-Dipropyl-Biphenyl-2,2'-diol), derivatives thereof and combinations thereof.

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