TWM559888U - Hydrogel structure - Google Patents

Abstract

The present invention provides a hydrogel structure comprising a hydrophilic substrate layer and a film layer, wherein the film layer is disposed above the hydrophilic substrate layer, wherein the hydrophilic substrate layer is composed of a hydrophilic polymer The hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent and an inorganic phosphonium compound, wherein the hydrophilic substrate layer comprises a plurality of molecular particles, and the plurality of molecular particles are for promoting wounds Healing compound.

Description

Hydrogel structure

The present invention relates to a hydrogel structure characterized in that the hydrogel structure is a solid hydrophilic polymer having a high-strength three-dimensional network structure of a compound that promotes wound healing.

In the past, keeping the wound dry was the main principle of care, so dry gauze dressings were used to protect the wound. However, it often happens that the wound is stuck to the gauze, causing the wound to be healed and causing secondary damage and pain to the wound when the dressing is removed. In recent years, related studies have shown that keeping the wound moist helps the movement and proliferation of epidermal cells and accelerates wound healing, thus producing various wet dressings such as Hydrocolloids and Hydrogels dressings.

However, hydrocolloid dressings are mainly carboxymethylcellulose, which are susceptible to bacterial decomposition and odor generation; therefore, hydrocolloids are not used for infectious wounds.

Another water-swellable hydrogel, the existing product has insufficient mechanical strength, for example, the patents of Taiwan Patent Publication No. M419555, I267387, I429462, and I504420; the patent of the Chinese Patent Publication No. CN204863670 and the US Patent Publication No. The patent of 2013/0072843 discloses the use of a hydrogel in combination with a non-woven fabric or fiber as a support layer to strengthen it. Structure; however, the structure of the hydrogel after absorbing the aqueous solution is still fragile, resulting in the removal of the residual glue, which is difficult to remove.

In order to accelerate the healing of chronic wounds, in addition to maintaining the wound moist and blocking the external injury dressing, it is also necessary to promote wound healing factors. For example, U.S. Patent Nos. 5,489,304 and 5,716,411 disclose collagen-glycosaminoglycan on a wound surface and a layer of cultured animal or human epidermal cells to promote skin. regeneration. U.S. Patent No. 5,977,088 discloses a pharmaceutical composition containing a medicament for treating or promoting skin irritation and hyaluronic acid, which utilizes hyaluronic acid to promote or cause delivery of a medicament into the skin of a wound. It can accumulate and extend the agent to stay in the area.

However, the above-mentioned effective factors for accelerating wound healing or wet dressings need to be coated with an effective factor and then covered with the second step of dressing protection, so the care process is cumbersome; further, if the wound healing factor is excessively applied, it is not only wasteful. Easy to fix the dressing. Although the patent of Taiwan Patent Publication No. I264306 discloses a collagen-hyaluronic acid mixture coated gauze dressing, it is a composite material of dry gauze which is unfavorable for wound healing.

Therefore, how to effectively combine the effective factors of accelerated wound healing with wet dressing to strengthen wound care and healing is currently a problem solved by the industry.

Therefore, in view of this, the creator of this creator and the idea of creation, designed with many years of experience, after many discussions and trials of sample tests, and many revisions and improvements, is the creation of this creation. To solve the above problems.

In view of this, the present invention provides a hydrophilic dressing having appropriate mechanical strength, comprising a composite material and a film, most particularly the composite material is composed of a hydrophilic polymer and a compound for promoting wound healing. Composed of. The hydrophilic polymer is a polymer having a combination of characteristics of high strength and hydrophilicity; therefore, the hydrophilic polymer has a high hydrophilicity polymer in addition to maintaining wound wetting and accelerating the movement and proliferation of epidermal cells. The solid three-dimensional network structure of the solid hydrophilic polymer overcomes the situation that the hydrogel is swelled and fragrant after absorbing the aqueous solution. In addition, the hydrophilic polymer utilizes an adsorbing hydrophilic group to adsorb a compound which promotes wound healing such as water-soluble collagen or hyaluronic acid, and adsorbs to a three-dimensional network structure inside the hydrophilic polymer in the wound. Slow release promotes wound healing factors during treatment and accelerates wound healing. In addition, at present wound treatment, the wound needs to be coated with the wound healing compound and then covered with the dressing, so a two-step care process is required, but the hydrophilic dressing of the present invention can achieve the above-mentioned treatment purpose in one step, and the wound can be healed. Time can be shortened more effectively.

To achieve the above object, the present invention provides a composite material comprising a hydrophilic substrate and a compound for promoting wound healing, wherein the hydrophilic substrate is a reaction product of a hydrophilic polymer, wherein the hydrophilic polymerization The composition comprises a hydrophilic monomer, a crosslinking agent and an inorganic oxo compound, wherein the compound for promoting wound healing is distributed in the hydrophilic substrate.

The term "a" or "an" is used herein to describe the elements and ingredients of this creation. This term is only for the convenience of description and the basic concept of giving this creation. This description is to be construed as inclusive of the singular When used in conjunction with the word "including" in the scope of the patent application, the term "a" may mean one or super. One more.

The term "or" in this document means "and/or".

The "hydrophilic monomer" herein contains a reactive monomer having a hydrophilic group. A hydrophilic monomer useful in the preparation of a hydrophilic polymer according to the present invention having at least one polymerizable double bond and at least one hydrophilic functional group. A functional group having a polymerizable double bond, and examples thereof include: acrylic acid, methacrylic acid, acrylamide, methacrylamido, fumaric acid, maleic acid, styryl, isopropenylphenyl O-ethylene carbonate, O-vinyl urethane, allyl, O-ethylene ethyl sulfonyl, double bond with N-vinyl decylamine, and N-vinyl guanamine.

Types of hydrophilic monomers suitable for the present invention include monomers containing acrylic or vinyl groups. The term "acrylic" or "acrylic-containing" monomer is a monomer containing the following acrylic groups: (CH ₂ =CRCOX), wherein R is H or CH ₃ and X is O or N, which is also known to be Rapid polymerization, such as N,N-dimethyl methacrylate (DMA), 2-hydroxyethyl methacrylate (HEMA), glyceryl methacrylate, 2-hydroxyethyl methacryl oxime Amines, polyethylene glycol monomethacrylates, methacrylic acid, mixtures thereof and the like. The term "vinyl" or "vinyl-containing" single system refers to a monomer containing a vinyl group (-CH=CH ₂ ) and capable of undergoing polymerization. Vinyl containing monomers including, but not limited to, monomers such as N-vinylamine, N-vinyl lactam (eg NVP), N-vinyl-N-methylacetamide, N-vinyl-N- Ethyl acetamide, N-vinyl-N-ethylformamide, N-vinylformamide.

Other hydrophilic monomers useful in the present invention include, but are not limited to, polyoxyethylene polyols having one or more terminal hydroxyl groups substituted with a functional group containing a polymerizable double bond. Examples include polyethylene glycol, ethoxylated alkyl glucosides and ethoxylated bisphenol A, which react with one or more molar equivalent end-capping groups, such as methacrylic acid Isocyanoethyl ester (IEM), methacrylic anhydride, methacrylium fluorene chloride, vinyl benzamidine chloride or the like to produce a polyethylene glycol having one or more terminal polymerizable alkenyl groups, and The one or more terminally polymerizable alkenyl groups are bonded to the polyethylene glycol via a linking moiety, such as a urethane ester group.

The hydrophilic monomer of the present invention can be any hydrophilic monomer known to be useful in the manufacture of hydrogels. In one embodiment, the hydrophilic monomer comprises a double bond acrylic acid or a derivative thereof, a acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or a salt, a polyethylene glycol or a derivative thereof or a combination thereof.

In another embodiment, the hydrophilic monomer comprises from 8 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the hydrophilic monomer comprises from 10 to 50% by weight of the hydrophilic polymer.

The crosslinking agent of the present invention is not particularly limited as long as it can react with a functional group of the hydrophilic polymer to initiate crosslinking. As used herein, "crosslinking agent" includes, but is not limited to, compounds having at least two ethylenically unsaturated groups. In one embodiment, the crosslinking agent comprises a N,N'-methylenebisacrylamide, monoethylene glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol. Dimethacrylate, triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, monomethacrylate, monoethylenediamine Dimethyl methacrylate, glyceryl dimethacrylate, diethylene glycol dimethacrylate, monovinyl benzene or a combination thereof.

In another embodiment, the crosslinking agent comprises from 0.1 to 20% by weight of the hydrophilic polymer. In a preferred embodiment, the crosslinking agent comprises from 0.2 to 10% by weight of the hydrophilic polymer. In a more preferred embodiment, the crosslinking agent comprises from 0.5 to 5% by weight of the hydrophilic polymer.

The present invention provides a high-strength three-dimensional network structure by adding an inorganic siloxane compound to the hydrophilic polymer to increase the strength of the reaction product of the hydrophilic polymer, that is, the hydrophilic substrate. Therefore, the structure of the hydrogel has been overcome by the fact that the structure of the hydrogel is swelled and fragrant after absorbing the aqueous solution. In one embodiment, the inorganic oxime compound is a compound having a ruthenium chain as a main chain. The basic structural unit of the 矽oxygen chain is a ruthenium-oxygen bond structure having a reactive group capable of chemically bonding with an inorganic material and capable of chemically bonding with an organic material. Therefore, the structure of the inorganic oxime compound has both "organic group" binding ability and "inorganic structure". The specific composition and structure of the reactive group, when reacted with the organic polymerizable monomer, its special physical and chemical properties The coupling reaction is effective to improve the mechanical strength, water resistance, cold resistance and adhesion of the polymeric material.

The inorganic anthracene compound of the present invention comprises an inorganic bismuth salt. The inorganic citrate refers to a compound composed of hydrazine and oxygen (SixOy), which can be represented by a salt produced by cerium oxide or ceric acid. In one embodiment, the inorganic oxonium compound is cerium oxide or a metal cerate. The term "metal citrate" is a generic term for compounds consisting of bismuth, oxygen and metal elements. The metal citrate refers to a cerium oxide bond of cerium oxide replaced by a metal salt, which produces a metal citrate having a small particle size and a large specific surface area, the original single particle is 0.02 μm, and the aggregated particle is 5 μm. The aggregate particles were 30 μm and the specific surface area was 20-800 m ² /g. When the specific surface area of the metal citrate is more than 50 m ² /g, the sterol group on the surface causes interaction between the particles, and when it is used as a filler of a hydrophobic plastic polymer such as rubber or plastic, it imparts an excellent reinforcing effect to the plastic. In a preferred embodiment, the metal citrate is magnesium aluminosilicate.

The specific surface area of a particle refers to the total surface area per unit mass (or volume) of particulate matter and can be used as one of the important parameters for evaluating the performance of catalysts, adsorbents and other porous materials. Therefore, the specific surface area of the particles is increased, and the adsorption area thereof can be increased, thereby increasing the adsorption capacity. In one embodiment, the inorganic oxirane particles have a specific surface area greater than 50 m ² /g. In a preferred embodiment, the inorganic siloxane compound has a specific surface area greater than 100 m ² /g. In a more preferred embodiment, the inorganic oxirane particles have a specific surface area greater than 150 m ² /g.

In another embodiment, the inorganic siloxane compound comprises from 2 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the inorganic oxo compound comprises from 4 to 50% by weight of the hydrophilic polymer. In a more preferred embodiment, the inorganic oxo compound comprises from 6 to 40% by weight of the hydrophilic polymer.

In one embodiment, the inorganic oxo compound is an inorganic compound having a hafnium tetrahedral structure or a polyxamethylene tetrahedral structure. Therefore, the strength of the hydrophilic polymer can be improved by polymerizing the inorganic siloxane compound into the three-dimensional network structure in the hydrophilic polymer.

The hydrophilic polymer further comprises one or more polymerization initiators. The polymerization initiator is used in an effective amount in the hydrophilic polymer to initiate photopolymerization of the hydrophilic polymer. The polymerization of the hydrophilic polymer can be initiated using heat, visible light, ultraviolet light or other suitable means depending on the polymerization initiator used. Or, can be cited without a photoinitiator Hair, for example, using an electron beam (e-beam).

Examples of the polymerization initiator include, but are not limited to, lauryl peroxide, benzhydryl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which are at moderately elevated temperatures. Produces free radicals, as well as photoinitiator systems such as aromatic avatar hydroxy ketone, alkoxy benzoin, acetophenone, decylphosphine oxide, bis-decylphosphine oxide and tertiary amine plus diketone, Mixtures of the foregoing are similar. The UV photopolymerization initiator contained Irgacure 1173 and Irgacure 2959 (Ciba Specialty Chemicals).

Therefore, the polymerization initiator can cause the other components of the hydrophilic polymer to undergo polymerization reaction with each other to obtain a reaction product of a hydrophilic polymer as the hydrophilic substrate.

After the hydrophilic substrate is cured, the water-soluble promoting wound healing factor is adsorbed to the three-dimensional network structure inside the hydrophilic substrate by using the hydrophilic group having adsorptivity, thereby forming the composite material. Therefore, when the composite material is made into a hydrophilic dressing, when it is attached to the wound, the promoting wound healing factor is released from the composite material, which accelerates wound healing.

The "wound" herein may be an open wound and a closed wound. Open wounds can be divided into many types, including cuts (caused by clean sharp objects such as knives or razors), cracks (rough irregular wounds caused by pressure or tear), and scratches (usually due to slipping over rough surfaces) A very surface injury is caused, the uppermost skin is rubbed off) and a stab wound (caused by an object such as a nail or needle piercing the skin). Closed wounds are classified much less, but are as dangerous as open wounds. They are contused or injured (injury to the underlying tissues caused by hard forces), hematomas (caused by blood vessels that cause blood to collect under the skin), and bruises (due to long-term application or Great external force is caused).

As used herein, "a compound that promotes wound healing" includes, but is not limited to, a compound having an effect of promoting wound healing. In one embodiment, the compound that promotes wound healing comprises a water soluble compound that promotes wound healing. In a preferred embodiment, the compound that promotes wound healing comprises a factor that promotes wound healing. In a more preferred embodiment, the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, a few Butanose or a combination thereof. As used herein, "cytokine" includes, but is not limited to, interleukins and interferons. Herein, "growth factor" includes, but is not limited to, epidermal growth factor (EGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), connective tissue growth. Connective tissue growth factor, platelet-derived growth factor (PDGF), insulin-like growth factor, nerve growth factor, cell colony stimulating factor (colony) -stimulating factor), stem cell factor, keratinocyte growth factor, granulocyte colony-stimulating factor, granulocyte macrophage colony- Stimulating factor), glial-derived neurotropic factor, endothelial-monocyte activating polypeptide, epithelial neutrophil activating peptide, red Ball erythropoietin (rythropoietin), BRAK and transforming growth factor -β (transforming growth factor beta).

In another embodiment, the compound that promotes wound healing is from 0.01 to 20% by weight of the total weight of the hydrophilic polymer. In a preferred embodiment, the compound that promotes wound healing is from 0.05 to 18% of the total weight of the hydrophilic polymer. In a more preferred embodiment, the compound that promotes wound healing is from 0.1 to 15% of the total weight of the hydrophilic polymer.

The composite material of the present invention is further bonded to a film to form a hydrophilic dressing. In one embodiment, the film has a two-sided structure, one of which is an adhesive surface that is bonded to the composite material. In another embodiment, the film is a film having the effect of waterproofing and venting. In a preferred embodiment, the film is a polyurethane (PU) film.

In one embodiment, the surface area of the film is greater than the surface area of the composite material. Therefore, the adhesive surface of the film may have a bonding area outside the composite material to provide adhesion of the hydrophilic dressing to the skin. In another embodiment, the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to bond the composite material and the skin of one body.

The present invention also provides a method for preparing a composite material, the steps comprising: (1) crosslinking and polymerizing a hydrophilic polymer to obtain a hydrophilic substrate, wherein the hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent and an inorganic oxo compound; and (2) adding a compound for promoting wound healing to the hydrophilic substrate to obtain the composite material, wherein the compound for promoting wound healing is treated by the hydrophilic substrate Adsorbed and distributed in the hydrophilic substrate.

In one embodiment, the hydrophilic monomer comprises a double bond acrylic acid or a derivative thereof, a acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or salt a class, a polyethylene glycol or a derivative thereof or a combination thereof.

In another embodiment, the hydrophilic monomer comprises from 8 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the hydrophilic monomer comprises from 10 to 50% by weight of the hydrophilic polymer.

In one embodiment, the crosslinking agent comprises a N,N'-methylenebisacrylamide, monoethylene glycol dimethacrylate, a polyethylene glycol diacrylate, and a tetraethylene glycol. Dimethacrylate, triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, monomethacrylate, monoethylenediamine Dimethyl methacrylate, glyceryl dimethacrylate, diethylene glycol dimethacrylate, monovinyl benzene or a combination thereof.

In another embodiment, the crosslinking agent comprises from 0.1 to 20% by weight of the hydrophilic polymer. In a preferred embodiment, the crosslinking agent comprises from 0.2 to 10% by weight of the hydrophilic polymer. In a more preferred embodiment, the crosslinking agent comprises from 0.5 to 5% by weight of the hydrophilic polymer.

In one embodiment, the inorganic oxooxide comprises an inorganic bismuth salt. In a preferred embodiment, the inorganic oxonium compound is cerium oxide or a metal cerate. In a more preferred embodiment, the metal silicate is magnesium aluminosilicate.

In another embodiment, the inorganic oxime compound is an inorganic compound having a hafnium tetrahedral structure or a polyxamethylene tetrahedral structure. In another embodiment, the inorganic siloxane compound has a specific surface area greater than 50 m ² /g. In a preferred embodiment, the inorganic siloxane compound has a specific surface area greater than 100 m ² /g. In a more preferred embodiment, the inorganic oxirane particles have a specific surface area greater than 150 m ² /g.

In one embodiment, the inorganic oxonium compound is from 2 to 80% by weight of the hydrophilic polymer. In a preferred embodiment, the inorganic oxo compound comprises from 4 to 50% by weight of the hydrophilic polymer. In a more preferred embodiment, the inorganic oxo compound comprises from 6 to 40% by weight of the hydrophilic polymer.

The hydrophilic polymer of the step (1) in the production method of the present invention further contains a polymerization initiator. The polymerization initiator is used in an effective amount in the hydrophilic polymer to initiate photopolymerization of the hydrophilic polymer. Examples of the polymerization initiator include, but are not limited to, lauryl peroxide, benzhydryl peroxide, isopropyl peroxycarbonate, azobisisobutyronitrile, and the like, which are at moderately elevated temperatures. Produces free radicals, as well as photoinitiator systems such as aromatic avatar hydroxy ketone, alkoxy benzoin, acetophenone, decylphosphine oxide, bis-decylphosphine oxide and tertiary amine plus diketone, Mixtures of the foregoing are similar. In one embodiment, the polymerization initiator is a UV photopolymerization initiator. The UV photopolymerization initiator is irradiated with UV light to initiate a polymerization reaction. In a preferred embodiment, the UV photopolymerization initiator is Irgacure 1173 or Irgacure 2959.

In one embodiment, the method of cross-linking the hydrophilic polymer comprises causing the hydrophilic polymer to produce a cross-linking polymerization using heat, visible light or ultraviolet light.

In another embodiment, the compound that promotes wound healing comprises a water soluble compound that promotes wound healing. In a preferred embodiment, the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, and a cytokine. (cytokine), monoalginate, a silver ion, a chitosan or a combination thereof.

In one embodiment, the compound that promotes wound healing is from 0.01 to 20% of the total weight of the hydrophilic polymer. In a preferred embodiment, the compound that promotes wound healing is from 0.05 to 18% of the total weight of the hydrophilic polymer. In a more preferred embodiment, the compound that promotes wound healing is from 0.1 to 15% of the total weight of the hydrophilic polymer.

Since the hydrophilic substrate itself has a hydrophilic group, it can adsorb a compound that promotes wound healing; and the hydrophilic substrate is a solid hydrophilic polymer having a three-dimensional network structure, so the three-dimensional network structure can be sustained-released. A wound healing compound that enhances the wound healing effect of the composite material.

The composite material prepared by the present invention can be further bonded to a film to obtain a hydrophilic dressing for wound healing.

The film of the present invention can be waterproof, transparent and breathable, thereby not only preventing water or bacteria from entering the hydrophilic dressing, but also maintaining good gas permeability. In one embodiment, the film is a film having the effect of waterproofing and venting. In a preferred embodiment, the gas permeable membrane layer can be made of polyurethane (PU).

In addition, the film of the present invention is a film of a single-sided adhesive, and in addition to bonding with the composite material, it also provides adhesion to a skin of a body. Therefore, in one embodiment, the film has a two-sided structure, one of which is an adhesive surface, and the adhesive surface is bonded to the composite material. In a preferred embodiment, the bonding surface is an acrylic adhesive bonding surface. The acrylic adhesive surface is used to bond the composite material and the skin of one body. Another specific embodiment The surface area of the film is greater than the surface area of the composite material. Therefore, the adhesive surface of the film may have a bonding area other than the composite material to provide adhesion between the hydrophilic dressing and the skin of the body; and the skin bonding area is a seal for oxygen supply and moisture exchange. Environment, insulting microorganisms and contaminants into the wound to promote the wound to be wet without excessive infiltration or drying.

In one embodiment, the individual is an animal, preferably a mammal, and more preferably a human.

The present invention further provides a hydrogel structure comprising a hydrophilic substrate layer and a plurality of molecular particles, wherein the hydrophilic substrate layer is composed of a hydrophilic polymer, wherein the hydrophilic polymer comprises a hydrophilic property a monomer, a crosslinking agent, and an inorganic oxo compound, wherein the plurality of molecular particles are distributed in the hydrophilic substrate layer, wherein each of the plurality of molecular particles is a compound that promotes wound healing.

In one embodiment, the hydrophilic substrate layer has a three-dimensional network structure, and the plurality of molecular particles adhere to the three-dimensional network structure.

In another embodiment, the plurality of molecular particles are in the shape of a sphere.

In one embodiment, the hydrophilic monomer comprises a double bond acrylic acid or a derivative thereof, a acrylamide or a derivative thereof, a 2-acrylamido-2-methylpropanesulfonic acid or a salt, a polyethylene glycol or a derivative thereof or a combination thereof.

In another embodiment, the crosslinking agent comprises an N,N'-methylenebispropene Indamine, monoethylene glycol dimethacrylate, polyethylene glycol diacrylate, tetraethylene glycol dimethacrylate, triethylene glycol dimethacrylate, polyethylene glycol Methacrylate, trimethylolpropane trimethacrylate, monomethacrylate, monoethylenediamine dimethyl decylamine, glyceryl dimethacrylate, diethylene glycol dimethacrylate Alcohol ester, monovinylbenzene or a combination thereof.

In one embodiment, the inorganic oxo compound is an inorganic compound having a hafnium tetrahedral structure or a polyxamethylene tetrahedral structure.

In another embodiment, the hydrophilic polymer further comprises a polymerization initiator. In a preferred embodiment, the polymerization initiator is an Irgacure 2959.

In a specific embodiment, the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, a growth factor, a cytokine, an alginate, a silver ion, and a chitosan. Sugar or a combination thereof.

In another embodiment, the hydrogel structure further adheres to a film layer disposed over the hydrogel structure, and the film layer has a surface area greater than a surface area of the hydrogel structure. In a preferred embodiment, the film layer has a two-sided structure, one of which is an adhesive surface that is bonded to the hydrogel structure. In a more preferred embodiment, the film layer is made of a polyurethane (PU).

Therefore, the main purpose of this creation is to provide a solid hydrophilic polymer with appropriate strength, elasticity and three-dimensional network structure. The hydrophilic polymer has a hydrophilic group, so it has moisture absorption and hydrolysis resistance, can absorb wound exudate and maintain wound moist; and suitable strength The three-dimensional network solid structure covers the wound, which not only isolates the external environment to protect the wound, but also accelerates the proliferation and movement of the epidermal cells of the wound and accelerates the healing of the wound.

Another object of the present invention is that the solid polymer of suitable strength can be used to enhance the wound healing factor by using a hydrophilic group which does not require non-woven fabric or fiber as a support layer for strengthening the structure, and utilizes the hydrophilic polymer. The three-dimensional network structure in the hydrophilic polymer achieves the effect of sustained release promoting wound healing factor and accelerates wound healing.

100, 220‧‧‧ hydrogel structure

110‧‧‧Hydrophilic substrate layer

120‧‧‧Molecular particles

200‧‧‧Hydrophilic dressing

210‧‧‧film layer

Figure 1 is a schematic view showing the structure of the hydrogel structure of the present invention.

Figure 2 is a schematic view showing the side structure of the hydrophilic dressing of the present invention.

This creation may be implemented in different forms and is not limited to the examples mentioned below. The following examples are merely representative of the different aspects and features of the present invention. The described embodiments are not intended to limit the scope of the present invention as described in the claims.

The present invention is a hydrophilic monomer having a hydrophilic group, a reactive monomer, a crosslinking agent and a hydrogen tetrahedral structure, and is formed into a water-insoluble high-strength solid hydrophilic polymer, and then a hydrophilic polymer substrate. The adsorption property of its own hydrophilic group, the wound healing effective factor, is adsorbed in the hydrophilic polymer of the solid three-dimensional network structure.

Example 1

Preparation of hydrophilic polymer

3 g of acrylamide (hydrophilic monomer), 7 g of 2-acrylamido-2-methylpropanesulfonic acid (hydrophilic monomer), 2 g of cerium oxide, N, N'-methylene Bisacrylamide (added in an amount of 1% by weight based on the total weight of the hydrophilic polymer) (crosslinking agent) was mixed with water to 100 g and stirred well.

After the above solution was deoxidized, an initiator Irgacure 2959 (added in an amount of 2% by weight based on the total weight of the hydrophilic polymer) was added to the solution and stirred well. The solution is transferred to a reaction mold, and under the irradiation of ultraviolet light, the solution in the reaction mold starts to undergo cross-linking polymerization, and the liquid oligomer in the solution gradually forms a hydrophilic polymerization of a three-dimensional network structure which is insoluble in water and solid. As a hydrophilic substrate.

Example 2

Preparation of composite materials

10 grams of a 10% collagen solution, which is a wound healing effective factor, is added to the above solid hydrophilic polymer. After the solid hydrophilic polymer completely adsorbs the collagen solution, a composite material, that is, a hydrogel structure, can be obtained.

As shown in FIG. 1 , it is a schematic structural view of a hydrogel structure 100 . The hydrogel structure 100 comprises a hydrophilic substrate layer 110 and a plurality of molecular particles 120 . The hydrophilic substrate layer 110 is composed of a hydrophilic polymer having a three-dimensional network structure, wherein the hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent and an inorganic phosphonium compound. The plurality of molecular particles 120 are distributed in the three-dimensional network structure of the hydrophilic substrate layer 110. Since the plurality of molecular particles 120 comprise a wound healing effective factor, the hydrogel is used When the structure 100 is used to treat a wound, the plurality of molecular particles 120 release a wound healing effective factor from the hydrogel structure 100 to accelerate wound healing. A specific embodiment of the wound healing effective factor is collagen.

Example 3

Efficacy testing of composite materials

According to the preparation method of the above composite material, only the amount of the cerium oxide in the hydrophilic polymer is adjusted or the cerium oxide is replaced by other components, that is, the original 3 gram of acrylamide, 7 gram of 2-propene. The component and the amount of addition of guanamine-2-methylpropanesulfonic acid and N,N'-methylenebisacrylamide (which is added in an amount of 1% by weight based on the total weight of the hydrophilic polymer) do not change, Samples of four different composite materials were prepared. The differences in the preparation methods of each sample are as follows: Sample 1: cerium oxide is added in an amount of 2 g; sample 2: cerium oxide is added in an amount of 6 g; and sample 3: cerium oxide is replaced by magnesium silicate, and added The amount was 2 g; and the sample 4: cerium oxide was replaced with magnesium aluminum silicate, and the amount thereof was 6 g.

The above composite materials samples with different ratios were compared with commercially available hydrogel dressings (as a comparison group), and the mechanical properties of the composite materials before and after impregnation were measured. The results are shown in Table 1.

Example 4

Preparation of hydrophilic dressings

A film of a single-sided adhesive (for example, a commercially available "supplement coating" having a waterproof and breathable function) is bonded to the composite material described above, that is, the side having the adhesive on the film is bonded to the composite material. A hydrophilic dressing is obtained.

As shown in FIG. 2, it is a side view of the hydrophilic dressing 200 of the present invention. The hydrophilic dressing 200 comprises a film layer 210 and a hydrogel structure 220, wherein the film layer 210 is disposed on the hydrogel structure. Above 220. The film layer 210 has a two-sided structure, wherein one side is an adhesive surface (not shown), and the adhesive surface has an adhesive, and the adhesive surface is bonded to the hydrogel structure 220 to make the film layer 210 and The hydrogel structure 220 constitutes the hydrophilic dressing 200. In addition, the surface area of the film layer 210 is greater than the surface area of the hydrogel structure 220. Therefore, the bonding surface of the film layer 210 may have a bonding area outside the hydrogel structure 220 to provide the hydrophilic dressing. 200 adheres to the skin of a body, and the skin adhesion area is a sealed environment for oxygen and moisture exchange, which insulates microorganisms and contaminants into the wound to promote the wound to be wet without excessive infiltration or drying.

The above embodiments are merely illustrative of the effects of the present invention, and illustrate the technical features of the present invention, and are not intended to limit the scope of protection of the present invention. Any change or arrangement that can be easily accomplished by anyone familiar with the technology without departing from the technical principles and spirit of the creation is within the scope of this creation. Therefore, the scope of protection of the present invention is as set forth in the appended claims.

Claims (9)

A hydrogel structure comprising a hydrophilic substrate layer and a film layer, wherein the film layer is disposed above the hydrophilic substrate layer, wherein the hydrophilic substrate layer is composed of a hydrophilic polymer. Wherein the hydrophilic polymer comprises a hydrophilic monomer, a crosslinking agent and an inorganic phosphonium compound, wherein the hydrophilic substrate layer comprises a plurality of molecular particles and a three-dimensional network structure, wherein the plurality of molecular particles Adhered to the three-dimensional network structure. The hydrogel structure according to claim 1, wherein the hydrophilic monomer comprises a double bond acrylic acid or a derivative thereof, a acrylamide or a derivative thereof, and a 2-propenylamine group- 2-methylpropanesulfonic acid or a salt thereof, a polyethylene glycol or a derivative thereof or a combination thereof. The hydrogel structure according to claim 1, wherein the crosslinking agent comprises an N,N'-methylenebisacrylamide, monoethylene glycol dimethacrylate, and a polyethylene glycol. Diacrylate, tetraethylene glycol dimethacrylate, triethylene glycol dimethacrylate, polyethylene glycol dimethacrylate, trimethyl propane trimethacrylate, one Vinyl acrylate, ethylenediamine dimethyl acrylamide, glyceryl dimethacrylate, diethylene glycol dimethacrylate, monovinylbenzene or a combination thereof. The hydrogel structure according to claim 1, wherein the inorganic oxime compound is an inorganic compound having a siloxane tetrahedral structure or a polyxamethylene tetrahedral structure. The hydrogel structure according to claim 1, wherein the plurality of molecular particles are compounds for promoting wound healing, wherein the compound for promoting wound healing comprises a collagen, a hyaluronic acid, a gelatin, and a A growth factor, a cytokine, an alginate, a silver ion, a chitosan or a combination thereof. The hydrogel structure of claim 1, wherein the hydrophilic polymer further comprises a polymerization initiator. The hydrogel structure of claim 1, wherein the film layer has a surface area greater than a surface area of the hydrophilic substrate layer. The hydrogel structure according to claim 1, wherein the film layer has a two-sided structure, one of which is an adhesive surface, and the adhesive surface is bonded to the hydrophilic substrate layer. The hydrogel structure according to claim 1, wherein the film layer is made of a polyurethane (PU).