TWI626949B - Denture detergent - Google Patents
Denture detergent Download PDFInfo
- Publication number
- TWI626949B TWI626949B TW103108367A TW103108367A TWI626949B TW I626949 B TWI626949 B TW I626949B TW 103108367 A TW103108367 A TW 103108367A TW 103108367 A TW103108367 A TW 103108367A TW I626949 B TWI626949 B TW I626949B
- Authority
- TW
- Taiwan
- Prior art keywords
- denture
- weight
- detergent
- denture detergent
- present
- Prior art date
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- 239000003599 detergent Substances 0.000 title claims abstract description 118
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 51
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 25
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 20
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229940041616 menthol Drugs 0.000 claims abstract description 20
- 239000004088 foaming agent Substances 0.000 claims abstract description 19
- 229910000420 cerium oxide Inorganic materials 0.000 claims abstract description 17
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims abstract description 17
- 238000005406 washing Methods 0.000 claims description 35
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 17
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 11
- 150000008052 alkyl sulfonates Chemical class 0.000 claims description 6
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 239000004711 α-olefin Substances 0.000 claims description 2
- 125000005526 alkyl sulfate group Chemical group 0.000 claims 1
- 239000012459 cleaning agent Substances 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 49
- 238000005187 foaming Methods 0.000 description 26
- 238000004140 cleaning Methods 0.000 description 25
- 239000003826 tablet Substances 0.000 description 16
- -1 carbonic acid compound Chemical class 0.000 description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
- 239000006260 foam Substances 0.000 description 12
- 239000002253 acid Substances 0.000 description 10
- 235000017550 sodium carbonate Nutrition 0.000 description 10
- 230000009471 action Effects 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- 150000008051 alkyl sulfates Chemical class 0.000 description 7
- 239000001569 carbon dioxide Substances 0.000 description 7
- 229910002092 carbon dioxide Inorganic materials 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 6
- 239000003002 pH adjusting agent Substances 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 5
- 230000001747 exhibiting effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- 230000002035 prolonged effect Effects 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 3
- 229940043264 dodecyl sulfate Drugs 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 239000007937 lozenge Substances 0.000 description 3
- 239000001630 malic acid Substances 0.000 description 3
- 235000011090 malic acid Nutrition 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- LDMOEFOXLIZJOW-UHFFFAOYSA-N 1-dodecanesulfonic acid Chemical compound CCCCCCCCCCCCS(O)(=O)=O LDMOEFOXLIZJOW-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229960003975 potassium Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 2
- URLJMZWTXZTZRR-UHFFFAOYSA-N sodium myristyl sulfate Chemical compound CCCCCCCCCCCCCCOS(O)(=O)=O URLJMZWTXZTZRR-UHFFFAOYSA-N 0.000 description 2
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- AEQDJSLRWYMAQI-UHFFFAOYSA-N 2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline Chemical compound C1CN2CC(C(=C(OC)C=C3)OC)=C3CC2C2=C1C=C(OC)C(OC)=C2 AEQDJSLRWYMAQI-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 150000000994 L-ascorbates Chemical class 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 238000013494 PH determination Methods 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- HVWGGPRWKSHASF-UHFFFAOYSA-N Sulfuric acid, monooctadecyl ester Chemical compound CCCCCCCCCCCCCCCCCCOS(O)(=O)=O HVWGGPRWKSHASF-UHFFFAOYSA-N 0.000 description 1
- ZUBJEHHGZYTRPH-KTKRTIGZSA-N [(z)-octadec-9-enyl] hydrogen sulfate Chemical compound CCCCCCCC\C=C/CCCCCCCCOS(O)(=O)=O ZUBJEHHGZYTRPH-KTKRTIGZSA-N 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229960003563 calcium carbonate Drugs 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- CEALXSHFPPCRNM-UHFFFAOYSA-L disodium;carboxylato carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OC([O-])=O CEALXSHFPPCRNM-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 229940050411 fumarate Drugs 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- DVBDWJXHMORLMQ-UHFFFAOYSA-N hexadecanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCCCCC(O)=O DVBDWJXHMORLMQ-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- UZZYXUGECOQHPU-UHFFFAOYSA-M n-octyl sulfate Chemical compound CCCCCCCCOS([O-])(=O)=O UZZYXUGECOQHPU-UHFFFAOYSA-M 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- WLGDAKIJYPIYLR-UHFFFAOYSA-N octane-1-sulfonic acid Chemical compound CCCCCCCCS(O)(=O)=O WLGDAKIJYPIYLR-UHFFFAOYSA-N 0.000 description 1
- 229940067739 octyl sulfate Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000001139 pH measurement Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229940093956 potassium carbonate Drugs 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940048084 pyrophosphate Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 235000019265 sodium DL-malate Nutrition 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- WPUMTJGUQUYPIV-UHFFFAOYSA-L sodium malate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)CC([O-])=O WPUMTJGUQUYPIV-UHFFFAOYSA-L 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 235000019187 sodium-L-ascorbate Nutrition 0.000 description 1
- 239000011755 sodium-L-ascorbate Substances 0.000 description 1
- KZQSXALQTHVPDQ-UHFFFAOYSA-M sodium;butanedioate;hydron Chemical compound [Na+].OC(=O)CCC([O-])=O KZQSXALQTHVPDQ-UHFFFAOYSA-M 0.000 description 1
- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- UZZYXUGECOQHPU-UHFFFAOYSA-N sulfuric acid monooctyl ester Natural products CCCCCCCCOS(O)(=O)=O UZZYXUGECOQHPU-UHFFFAOYSA-N 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- MYOWBHNETUSQPA-UHFFFAOYSA-N tetradecane-1-sulfonic acid Chemical compound CCCCCCCCCCCCCCS(O)(=O)=O MYOWBHNETUSQPA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
本發明之主要課題在提供一種義齒洗淨劑,其抑制使業已投入義齒洗淨劑之水的上面形成氣泡疊合而聚集之狀態之作用,前述課題可藉由下述來解決,即:於構成為含有發泡劑、陰離子界面活性劑、薄荷腦及二氧化矽之義齒洗淨劑中,調整使該義齒洗淨劑2.65g溶解於25℃之水150ml中時的pH成為8~11。 A main object of the present invention is to provide a denture cleaning agent which suppresses the formation of a state in which bubbles are superimposed and aggregated on the water which has been put into the denture detergent, and the above problems can be solved by In the denture detergent containing a foaming agent, an anionic surfactant, menthol, and cerium oxide, the pH at which 2.65 g of the denture detergent was dissolved in 150 ml of water at 25 ° C was adjusted to 8 to 11.
Description
本發明是有關於一種義齒洗淨劑,其抑制使業已投入義齒洗淨劑之水的上面形成氣泡疊合而聚集之狀態之作用。再者,本發明是有關於一種使用該義齒洗淨劑之義齒洗淨方法。 The present invention relates to a denture detergent which suppresses a state in which bubbles are superimposed and aggregated on the water which has been put into the denture detergent. Furthermore, the present invention relates to a denture cleaning method using the denture detergent.
義齒是使用在牙齒缺損時,並按照牙齒缺損之狀態,利用全口義齒、可撤式局部義齒等各種形態者。於義齒容易附著細菌、生物膜及其他沈積物等,若未洗淨而放置,則不僅會成為口臭之原因,且有時會成為誘發齲蛀、牙周病等口腔疾病之原因之一。故,作為口腔保健之一環,將義齒洗淨並保持清潔是不可或缺的。於利用牙刷之清掃中,無法充分地除去附著於義齒之細菌或髒污,因此,利用義齒洗淨劑之洗淨是重要的。尤其是在附加配件或經常採用複雜之形狀之可撤式局部義齒中,清掃是困難的,目前檢討用以即使對於此種義齒亦可達成優異之洗淨效果之技術。 The denture is used in the case of a tooth defect and in accordance with the state of the tooth defect, and uses various forms such as a full denture and a removable partial denture. The denture is likely to adhere to bacteria, biofilms, and other deposits. If it is left unwashed, it will not only cause bad breath, but also cause one of the causes of oral diseases such as sputum and periodontal disease. Therefore, as a ring of oral health care, it is indispensable to wash and keep the denture clean. In the cleaning by the toothbrush, bacteria or dirt adhering to the denture cannot be sufficiently removed, and therefore, it is important to wash with the denture detergent. Especially in the case of additional fittings or retractable partial dentures which often use complicated shapes, cleaning is difficult, and a technique for achieving an excellent washing effect even for such dentures is currently reviewed.
一般而言,利用義齒洗淨劑之義齒之洗淨會藉由將義齒浸漬放置於業已將義齒洗淨劑投入水中而調製之義齒洗淨水中的方法來進行。以往,義齒洗淨劑是廣泛地利用以下發泡錠劑類型者,即:藉由含有界面活性劑及發泡劑,投入水中時於水中發泡,且氣泡疊合而聚集於水的上面。於發泡錠劑類型之義齒洗淨劑中,設計成藉由兼具利用界面活性作用之化學性洗淨力與利用發泡作用之物理性洗淨力,提高洗淨力。該義齒洗淨劑若投入水中,則於水中發泡,同時界面活性劑於水中溶出,因此,氣泡疊合而聚集於水的上面(以下,有時亦將前述狀態標示為「積泡」),若該積泡到達最大量,則會維持該狀態一定時間,且隨著洗淨結束,積泡逐漸消失,不久,水面上的泡沫會完全消失。 In general, the denture cleaning using the denture detergent is carried out by dipping the denture in a denture washing water prepared by putting the denture detergent into water. Conventionally, denture detergents have been widely used in the following types of foamed tablets, that is, by containing a surfactant and a foaming agent, they are foamed in water when they are put into water, and the bubbles are superposed and accumulated on the upper surface of the water. In the denture detergent type denture detergent, it is designed to improve the detergency by combining the chemical detergency using the interfacial activity with the physical detergency using the foaming action. When the denture detergent is put into water, it is foamed in water and the surfactant is dissolved in water. Therefore, the bubbles are superposed and accumulated on the water (hereinafter, the above-mentioned state may be referred to as "bubble"). If the accumulated amount reaches the maximum amount, the state is maintained for a certain period of time, and as the washing is completed, the bubble is gradually disappeared, and soon, the foam on the water surface completely disappears.
於發泡錠劑類型之義齒洗淨劑中,會要求使業已投入義齒洗淨劑之水的上面形成氣泡疊合而聚集之狀態之作用優異。為了提升發泡錠劑類型之義齒洗淨劑之洗淨效果,進行各種改良,舉例言之,目前揭示有於發泡錠劑類型之義齒洗淨劑中,藉由以3:7~7:3之重量比摻合聚乙烯吡咯啶酮與聚乙二醇,可增大起泡力(參照專利文獻1)。依此,積泡作用良好會與提高義齒洗淨劑之洗淨效果有關,再者,在提升使用者於視覺上所感受之滿足感上會變得有效。 In the denture detergent type of the foamed lozenge type, it is required to have an excellent effect of forming a state in which bubbles are superposed on the upper surface of the water which has been put into the denture detergent. In order to improve the cleaning effect of the denture detergent type of the foamed lozenge type, various improvements have been made. For example, it has been disclosed in the denture detergent type of the foaming lozenge by 3:7-7: When the weight ratio of 3 is blended with polyvinylpyrrolidone and polyethylene glycol, the foaming power can be increased (refer to Patent Document 1). Accordingly, the good foaming effect is related to the improvement of the cleaning effect of the denture detergent, and further, it is effective in improving the visual satisfaction of the user.
然而,藉由使形成積泡之作用增強,可達成優異之洗淨效果,另一方面,卻有泡沫自容器溢出,或洗淨義 齒後含有來自義齒之髒污的泡沫附著於義齒而帶給使用者反感之問題。為了避免該等問題,要求一種抑制積泡量而構成適度之積泡之技術。話雖如此,然而,義齒洗淨劑必須維持充分之洗淨效果,用以兼顧適度之積泡作用與優異之洗淨作用之相反作用之技術目前是未知的。 However, by enhancing the effect of forming the foam, an excellent washing effect can be achieved, on the other hand, there is a foam overflowing from the container, or washing the meaning The tooth behind the tooth contains the dirty foam from the denture attached to the denture and gives the user a feeling of resentment. In order to avoid such problems, a technique for suppressing the amount of foaming to constitute a moderate amount of foam is required. Having said that, however, the denture detergent must maintain a sufficient cleaning effect, and the technique for balancing the effect of moderate foaming with the excellent washing action is currently unknown.
將此種習知技術作為背景,期望能開發一種雖然可抑制積泡量但卻可發揮優異之洗淨作用之發泡義齒洗淨劑。 Against the background of such a conventional technique, it is desired to develop an expanded denture detergent which can exhibit an excellent cleaning effect while suppressing the amount of foaming.
[專利文獻1]日本專利公開公報特開2008-50323 號公報 [Patent Document 1] Japanese Patent Laid-Open Publication No. 2008-50323 Bulletin
本發明之主要目的在提供一種可抑制積泡之義齒洗淨劑。再者,本發明之其他目的在提供一種使用該義齒洗淨劑之義齒之洗淨方法。 SUMMARY OF THE INVENTION A primary object of the present invention is to provide a denture detergent which can suppress foaming. Furthermore, another object of the present invention is to provide a method of cleaning dentures using the denture detergent.
發明人為了解決前述課題進行銳意檢討之結果,發現於含有發泡劑、陰離子界面活性劑、二氧化矽及薄荷腦之義齒洗淨劑中,藉由調整使該義齒洗淨劑溶解於水中時的pH為成弱鹼性,可抑制積泡。又,此種義齒洗淨劑雖然可抑制積泡,但卻具有充分之義齒洗淨效果。再者,發 明人發現,若藉由前述義齒洗淨劑,則由於投入水中後的崩解時間會延長,因此,可長時間發泡,且利用發泡之洗淨作用會持續,同時於視覺上亦帶給使用者洗淨作用優異之印象。本發明是根據該等見識進而反覆研究之結果所完成。即,本發明提供下述所揭示之態樣之義齒洗淨劑及使用該義齒洗淨劑之義齒之洗淨方法。 In order to solve the above problems, the inventors have found that in the denture detergent containing a foaming agent, an anionic surfactant, cerium oxide, and menthol, when the denture detergent is dissolved in water, The pH is weakly alkaline and inhibits foaming. Moreover, although such a denture detergent can suppress foaming, it has a sufficient denture cleaning effect. Again, send It has been found that the above-mentioned denture cleaning agent can prolong the disintegration time after being put into water, so that it can be foamed for a long time, and the washing action by foaming continues, and also visually Give the user an impression of excellent cleaning. The present invention has been completed on the basis of these findings and the results of repeated studies. That is, the present invention provides a denture detergent according to the aspect disclosed below and a method of washing dentures using the denture detergent.
項1.一種義齒洗淨劑,其構成為含有發泡劑、陰離子界面活性劑、薄荷腦及二氧化矽,又,使該義齒洗淨劑2.65g溶解於25℃之水150ml中時的pH為8~11。 Item 1. A denture detergent comprising a foaming agent, an anionic surfactant, menthol and cerium oxide, and a pH at which 2.65 g of the denture detergent is dissolved in 150 ml of water at 25 ° C. It is 8~11.
項2.如項1之義齒洗淨劑,其中陰離子界面活性劑每100重量份之薄荷腦之含量為5~100重量份。 Item 2. The denture detergent according to Item 1, wherein the anionic surfactant is contained in an amount of 5 to 100 parts by weight per 100 parts by weight of the menthol.
項3.如項1或2之義齒洗淨劑,其中陰離子界面活性劑每100重量份之二氧化矽之含量為5~100重量份。 Item 3. The denture detergent according to Item 1 or 2, wherein the anionic surfactant is contained in an amount of 5 to 100 parts by weight per 100 parts by weight of the cerium oxide.
項4.如項1至3中任一項之義齒洗淨劑,其含有碳酸鈉10~40重量%。 The denture detergent according to any one of items 1 to 3, which contains 10 to 40% by weight of sodium carbonate.
項5.如項1至4中任一項之義齒洗淨劑,其含有陰離子界面活性劑1.5~3重量%。 The denture detergent according to any one of items 1 to 4, which contains an anionic surfactant of 1.5 to 3% by weight.
項6.如項1至5中任一項之義齒洗淨劑,其為可撤式局部義齒用。 Item 6. The denture detergent according to any one of items 1 to 5, which is a removable partial denture.
項7.一種義齒之洗淨方法,係將義齒浸漬於業已放入如項1至6中任一項之義齒洗淨劑之水中。 Item 7. A method of washing dentures by immersing dentures in water which has been placed in a denture detergent according to any one of items 1 to 6.
由於本發明之義齒洗淨劑可抑制溶解於水中時的積泡,因此,亦不會有泡沫自容器溢出,或取出所浸漬 之義齒時含有來自義齒之髒污的泡沫附著於義齒而損害使用者心情之情形。又,本發明之義齒洗淨劑雖然可抑制積泡,但卻發揮充分之洗淨效果。由於本發明之義齒洗淨劑可延長投入水中時的崩解時間,因此,洗淨作用會持續,且可帶給使用者洗淨效果提升之印象。 Since the denture detergent of the present invention can suppress the foaming when dissolved in water, there is no possibility that the foam overflows from the container or is taken out by the impregnation. In the case of a denture, the foam from the denture is attached to the denture and the user's mood is impaired. Moreover, although the denture detergent of the present invention can suppress foaming, it exhibits a sufficient washing effect. Since the denture detergent of the present invention can prolong the disintegration time when it is put into water, the washing action is continued and the user can be given the impression of improving the washing effect.
又,於義齒中,可撤式局部義齒會有以下結構上之特性,即:具有配件,且經常採用複雜之結構。另一方面,若藉由本發明之義齒洗淨劑,則由於溶解於水中時顯示弱鹼性,因此,在洗淨如可撤式局部義齒般具有配件之義齒時,不會有腐蝕配件之虞。又,本發明之義齒洗淨劑為錠劑狀時,可延長、確保崩解時間,伴隨於此,二氧化碳之氣泡與義齒接觸之時間亦會變長,且可更進一步地提高洗淨效果,因此,即使對於如可撤式局部義齒般具有複雜且難以洗淨之結構者,亦可發揮優異之洗淨效果。依此,本發明之義齒洗淨劑具有抑制可撤式局部義齒之配件之腐蝕、對於可撤式局部義齒之優異之洗淨效果等之優點,特別是可適當地使用作為可撤式局部義齒用。 Moreover, in the denture, the removable partial denture has the following structural characteristics, namely: having an accessory, and often adopting a complicated structure. On the other hand, if the denture detergent of the present invention exhibits weak alkalinity when dissolved in water, there is no corrosion of the fitting when the denture having the fitting such as the removable partial denture is washed. . Moreover, when the denture detergent of the present invention is in the form of a tablet, the disintegration time can be prolonged and ensured, and accordingly, the time during which the carbon dioxide bubbles come into contact with the denture becomes longer, and the washing effect can be further improved. Therefore, even in the case of a structure which is complicated and difficult to clean as a removable partial denture, an excellent washing effect can be exerted. Accordingly, the denture detergent of the present invention has the advantages of suppressing the corrosion of the fitting of the removable partial denture, the excellent cleaning effect for the removable partial denture, and the like, and particularly can be suitably used as the removable partial denture. use.
1.義齒洗淨劑Denture detergent
本發明之義齒洗淨劑是構成為含有發泡劑、陰離子界面活性劑、薄荷腦及二氧化矽之義齒洗淨劑,又,使該義 齒洗淨劑2.65g溶解於25℃之水150ml中時的pH為8~11。以下,詳述本發明之義齒洗淨劑。 The denture detergent of the present invention is a denture detergent containing a foaming agent, an anionic surfactant, menthol and cerium oxide, and The pH of the 2.65 g of the tooth detergent dissolved in 150 ml of water at 25 ° C was 8-11. Hereinafter, the denture detergent of the present invention will be described in detail.
使用在本發明之義齒洗淨劑之發泡劑並無特殊之限制,可廣泛地使用義齒洗淨劑中通常所使用者(即,可於水中產生二氧化碳者)。 The foaming agent to be used in the denture detergent of the present invention is not particularly limited, and a general user of the denture detergent (i.e., a carbon dioxide which can be produced in water) can be widely used.
具體而言,發泡劑可例示:碳酸鹽、碳酸氫鹽及該等之複鹽中之至少1種(以下,有時亦標示為碳酸化合物)與酸之組合。碳酸鹽並無特殊之限制,舉例言之,可列舉如:碳酸鈉、碳酸鉀等之碳酸鹼金屬鹽。碳酸氫鹽並無特殊之限制,舉例言之,可列舉如:碳酸氫鈉、碳酸氫鉀等之碳酸氫鹼金屬鹽。碳酸鹽與碳酸氫鹽之複鹽並無特殊之限制,舉例言之,可列舉如:二碳酸氫鈉等。該等碳酸化合物可單獨使用1種,又,亦可組合、使用2種以上。又,酸並無特殊之限制,舉例言之,可列舉如:檸檬酸、酒石酸、延胡索酸、蘋果酸、馬來酸、葡萄糖酸、琥珀酸、水楊酸、草酸等之有機酸;磷酸、胺磺酸等之無機酸等。該等酸可單獨使用1種,又,亦可組合、使用2種以上。 Specifically, the foaming agent may, for example, be a combination of at least one of a carbonate, a hydrogencarbonate, and a double salt thereof (hereinafter sometimes also referred to as a carbonic acid compound) and an acid. The carbonate is not particularly limited, and examples thereof include alkali metal carbonates such as sodium carbonate and potassium carbonate. The hydrogencarbonate is not particularly limited, and examples thereof include alkali metal hydrogencarbonate such as sodium hydrogencarbonate or potassium hydrogencarbonate. The double salt of the carbonate and the hydrogencarbonate is not particularly limited, and examples thereof include sodium dicarbonate and the like. These carbonic acid compounds may be used alone or in combination of two or more. Further, the acid is not particularly limited, and examples thereof include organic acids such as citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, and oxalic acid; and phosphoric acid and amines. A mineral acid such as a sulfonic acid or the like. These acids may be used alone or in combination of two or more.
構成發泡劑之碳酸化合物可列舉如:較為理想的是碳酸氫鹼金屬鹽,更為理想的是碳酸氫鈉。又,構成發泡劑之酸可列舉如:較為理想的是有機酸,更為理想的是檸檬酸及蘋果酸。 The carbonic acid compound constituting the foaming agent may, for example, be preferably an alkali metal hydrogencarbonate, more preferably sodium hydrogencarbonate. Further, the acid constituting the foaming agent may, for example, be an organic acid, more preferably citric acid or malic acid.
於發泡劑中,以兩者於水中反應而可產生二氧化碳為限度,碳酸化合物與酸之比率並無特殊之限制,舉例言之,可列舉如:碳酸化合物每100重量份,酸通常為20~120 重量份,且宜為30~100重量份,更宜為30~95重量份。又,發泡劑使用碳酸氫鹽時,碳酸氫鹽與酸之比率可列舉如:碳酸氫鹽每100重量份,酸通常為20~120重量份,且宜為30~100重量份,更宜為30~95重量份,特別是宜為70~95重量份。 In the foaming agent, the ratio of the carbonic acid compound to the acid is not particularly limited as long as the two are reacted in water, and the ratio of the carbonic acid compound to the acid is not particularly limited. For example, the carbonic acid compound is usually 20 per 100 parts by weight. ~120 The parts by weight are preferably 30 to 100 parts by weight, more preferably 30 to 95 parts by weight. Further, when the hydrogen peroxide is used as the foaming agent, the ratio of the hydrogencarbonate to the acid may be, for example, the hydrogencarbonate is usually 20 to 120 parts by weight, and preferably 30 to 100 parts by weight, more preferably 100 to 100 parts by weight, more preferably It is 30 to 95 parts by weight, particularly preferably 70 to 95 parts by weight.
只要在義齒之洗淨時可發揮發泡作用,則本發明之義齒洗淨劑中的發泡劑之含量(碳酸化合物與酸之合計量)並無特殊之限制,舉例言之,可列舉如:10~80重量%,且宜為15~75重量%,更宜為20~70重量%。又,發泡劑使用碳酸氫鹽時,舉例言之,發泡劑之含量(碳酸氫鹽與酸之合計量)可列舉如:10~80重量%,且宜為15~75重量%,更宜為20~70重量%,特別是宜為20~40重量%。 The content of the foaming agent (the total amount of the carbonic acid compound and the acid) in the denture detergent of the present invention is not particularly limited as long as it can exert a foaming action when the denture is washed. For example, for example, : 10 to 80% by weight, and preferably 15 to 75% by weight, more preferably 20 to 70% by weight. Further, when the hydrogen peroxide is used as the foaming agent, the content of the foaming agent (the total amount of the hydrogencarbonate and the acid) may, for example, be 10 to 80% by weight, and preferably 15 to 75% by weight, more preferably It is preferably 20 to 70% by weight, particularly preferably 20 to 40% by weight.
使用在本發明之義齒洗淨劑之陰離子界面活性劑並無特殊之限制,可廣泛地使用義齒洗淨劑中一般所使用者。 The anionic surfactant to be used in the denture detergent of the present invention is not particularly limited, and a general user of the denture detergent can be widely used.
具體而言,陰離子界面活性劑可列舉如:烷基硫酸鹽、烷基磺乙酸鹽、α-烯烴磺酸鹽、烷基苯磺酸鹽等。於該等中,若由發揮更優異之洗淨作用之觀點來看,則可列舉如:較為理想的是烷基硫酸鹽、烷基磺乙酸鹽,更為理想的是烷基硫酸鹽。 Specifically, examples of the anionic surfactant include an alkyl sulfate, an alkyl sulfonate, an α-olefin sulfonate, an alkylbenzenesulfonate, and the like. Among these, from the viewpoint of exhibiting a more excellent washing action, an alkyl sulfate or an alkyl sulfonate is preferable, and an alkyl sulfate is more preferable.
只要具有界面活性作用,則前述烷基硫酸鹽之烷基之碳數並無特殊之限制,舉例言之,可列舉如:10~18,且宜為12~16,更宜為12~14。又,烷基可為直鏈狀、分枝狀中之任一者,然而,宜列舉如直鏈狀。又,鹽可列舉如: 鈉、鉀等之水溶性鹽,適合之鹽可例示:鈉鹽。於前述烷基硫酸鹽中,若由發揮更優異之洗淨作用之觀點來看,則可列舉如:理想的是辛基硫酸鹽、月桂基硫酸鹽、肉豆蔻基硫酸鹽、棕櫚基硫酸鹽、硬脂醯硫酸鹽、油烯基硫酸鹽,較為理想的是月桂基硫酸鹽、肉豆蔻基硫酸鹽,更為理想的是月桂基硫酸鹽,特別理想的是月桂基硫酸鈉。 The carbon number of the alkyl group of the alkyl sulfate is not particularly limited as long as it has an interfacial activity. For example, it may be, for example, 10 to 18, and preferably 12 to 16, more preferably 12 to 14. Further, the alkyl group may be either linear or branched, but it is preferably linear. Also, the salt can be enumerated as follows: A water-soluble salt such as sodium or potassium, and a suitable salt can be exemplified by a sodium salt. In the above-mentioned alkyl sulfate, from the viewpoint of exhibiting a more excellent washing action, for example, an octyl sulfate, a lauryl sulfate, a myristyl sulfate, a palmitate sulfate is preferable. The stearyl sulphate or the oleyl sulfate is preferably a lauryl sulfate or a myristyl sulfate, more preferably a lauryl sulfate, and particularly preferably sodium lauryl sulfate.
只要具有界面活性作用,則前述烷基磺乙酸鹽之烷基之碳數並無特殊之限制,與構成前述烷基硫酸鹽之烷基之碳數相同。又,構成烷基磺乙酸鹽之鹽之種類亦可列舉如:與前述烷基硫酸鹽相同者。於前述烷基磺乙酸鹽中,若由發揮更優異之洗淨作用之觀點來看,則可列舉如:較為理想的是辛基磺乙酸鹽、月桂基磺乙酸鹽、肉豆蔻基磺乙酸鹽,更為理想的是月桂基磺乙酸鹽,特別理想的是月桂基磺乙酸鈉。 The carbon number of the alkyl group of the alkyl sulfonate is not particularly limited as long as it has an interfacial activity, and is the same as the carbon number of the alkyl group constituting the alkyl sulfate. Further, the type of the salt constituting the alkyl sulfonate may be, for example, the same as the alkyl sulfate. In the alkyl sulfonate, the octyl sulfonate, the lauryl sulfonate, and the myristyl sulfonate are preferably used from the viewpoint of exhibiting a more excellent washing action. More desirable is lauryl sulfonate, and particularly preferred is sodium lauryl sulfonate.
於本發明之義齒洗淨劑中,陰離子界面活性劑可單獨使用1種,又,亦可組合、使用2種以上。 In the denture detergent of the present invention, the anionic surfactant may be used singly or in combination of two or more.
只要具有界面活性作用,則本發明之義齒洗淨劑中的陰離子界面活性劑之含量並無特殊之限制,舉例言之,可列舉如:0.5~4重量%,且宜為1~3.5重量%,更宜為1.5~3重量%,進而宜為1.5~2.3重量%。 The content of the anionic surfactant in the denture detergent of the present invention is not particularly limited as long as it has an interfacial activity. For example, it is, for example, 0.5 to 4% by weight, and preferably 1 to 3.5% by weight. More preferably, it is 1.5 to 3% by weight, and further preferably 1.5 to 2.3% by weight.
於本發明之義齒洗淨劑中所含有的薄荷腦具有抑制藉由前述發泡劑及界面活性劑所形成的積泡之作用。又,藉由含有薄荷腦,在裝設業已洗淨之義齒時可帶給裝設者之口腔內清爽感,並具有可實際感受到洗淨效果之作 用。 The menthol contained in the denture detergent of the present invention has an effect of suppressing the accumulation of bubbles formed by the foaming agent and the surfactant. In addition, by containing menthol, it can bring the refreshing feeling in the mouth of the installer when the denture has been cleaned, and has a practical feeling of washing effect. use.
於本發明之義齒洗淨劑中,薄荷腦可使用d體、l體、dl體中之任一者。又,薄荷腦亦可於精油之形態下使用。含有薄荷腦之精油並無特殊之限制,舉例言之,可列舉如:綠薄荷油、薄荷素油、薄荷油、薄荷白油等。 In the denture detergent of the present invention, any one of a d body, a l body, and a dl body can be used for the menthol. In addition, menthol can also be used in the form of essential oils. The essential oil containing menthol is not particularly limited, and examples thereof include: spearmint oil, peppermint oil, peppermint oil, and mint white oil.
若由更加明顯地發揮積泡量之抑制效果且義齒洗淨劑維持充分之洗淨效果之觀點來看,則本發明之義齒洗淨劑中的薄荷腦之含有比率可列舉如:相對於陰離子界面活性劑100重量份之薄荷腦之含量(使用精油時為換算成薄荷腦量之含量)通常為5~100重量份,且宜為10~65重量份,更宜為21.7~43.5重量份。 The ratio of the content of menthol in the denture detergent of the present invention can be exemplified by the ratio of the inhibitory effect of the foaming amount and the sufficient cleaning effect of the denture detergent. The content of the menthol (100 parts by weight of the menthol when using the essential oil) of the surfactant is usually 5 to 100 parts by weight, and preferably 10 to 65 parts by weight, more preferably 21.7 to 43.5 parts by weight.
本發明之義齒洗淨劑中的薄荷腦之含量可根據與前述陰離子界面活性劑之摻合比率來設定,且可列舉如:通常為0.1~1.5重量%,且宜為0.25~1.5重量%,更宜為0.5~1.5重量%,特別是宜為0.5~1重量%。 The content of menthol in the denture detergent of the present invention can be set according to the blending ratio with the anionic surfactant, and is, for example, usually 0.1 to 1.5% by weight, and preferably 0.25 to 1.5% by weight. More preferably, it is 0.5 to 1.5% by weight, particularly preferably 0.5 to 1% by weight.
又,與前述薄荷腦相同,於本發明之義齒洗淨劑中所含有的二氧化矽具有抑制藉由前述發泡劑及界面活性劑所形成的積泡之作用。所謂二氧化矽是二氧化矽或藉由二氧化矽所構成的物質之總稱。 Further, similarly to the menthol, the cerium oxide contained in the denture detergent of the present invention has an effect of suppressing the accumulation of bubbles by the foaming agent and the surfactant. The so-called cerium oxide is a general term for cerium oxide or a substance composed of cerium oxide.
若由更加明顯地發揮積泡量之抑制效果且義齒洗淨劑維持充分之洗淨效果之觀點來看,則本發明之義齒洗淨劑中的二氧化矽之含有比率可列舉如:相對於陰離子界面活性劑100重量份之二氧化矽之含量通常為5~100重量份,且宜為21.7~78.3重量份,更宜為43.5~78.3重量份。 The content ratio of cerium oxide in the denture detergent of the present invention can be enumerated, for example, as compared with the viewpoint of more effectively exhibiting the effect of suppressing the amount of foaming and maintaining a sufficient washing effect of the denture detergent. The content of the anionic surfactant 100 parts by weight of cerium oxide is usually 5 to 100 parts by weight, and preferably 21.7 to 78.3 parts by weight, more preferably 43.5 to 78.3 parts by weight.
本發明之義齒洗淨劑中的二氧化矽之含量可根據與前述陰離子界面活性劑之摻合比率來設定,且可列舉如:通常為0.1~3重量%,且宜為0.5~2重量%,更宜為0.8~2重量%,特別是宜為1~1.8重量%。 The content of cerium oxide in the denture detergent of the present invention can be set according to the blending ratio with the anionic surfactant, and may be, for example, usually 0.1 to 3% by weight, and preferably 0.5 to 2% by weight. More preferably, it is 0.8 to 2% by weight, and particularly preferably 1 to 1.8% by weight.
於本發明之義齒洗淨劑中,當陰離子界面活性劑每100重量份之薄荷腦之含量為5~100重量份,且宜為10~65重量份,更宜為21.7~43.5重量份,而二氧化矽之含量為5~100重量份,且宜為21.7~78.3重量份,更宜為43.5~78.3重量份時,可發揮更加明顯之積泡抑制作用。 In the denture detergent of the present invention, when the content of the anionic surfactant per 100 parts by weight of the menthol is 5 to 100 parts by weight, and preferably 10 to 65 parts by weight, more preferably 21.7 to 43.5 parts by weight, and The content of cerium oxide is from 5 to 100 parts by weight, and preferably from 21.7 to 78.3 parts by weight, more preferably from 43.5 to 78.3 parts by weight, to exhibit a more pronounced foam suppressing effect.
本發明之義齒洗淨劑在溶解於水中時呈現pH8~11。在此,pH值是指將本發明之義齒洗淨劑2.65g作成粉末狀而將其投入25℃之水150ml中,並靜置10秒而藉由目視確認氣泡業已消失後,在業經攪拌後所測定之溶液之pH值。 The denture detergent of the present invention exhibits a pH of 8 to 11 when dissolved in water. Here, the pH value means that 2.65 g of the denture detergent of the present invention is powdered and placed in 150 ml of water at 25 ° C, and allowed to stand for 10 seconds, and it is visually confirmed that the bubble has disappeared, and after stirring The pH of the solution measured.
若本發明之義齒洗淨劑含有前述各成分,且使其溶解之溶液之pH值為前述範圍,則可避免泡沫因過度之起泡而自容器溢出,或含有髒污的泡沫附著於洗淨後之義齒之問題,且可實現不會阻礙利用發泡劑及界面活性劑之義齒之洗淨效果而亦可滿足使用者視覺上之洗淨效果感的適度之積泡量。 When the denture detergent of the present invention contains the above-mentioned respective components and the pH of the solution to be dissolved is in the above range, it is possible to prevent the foam from overflowing from the container due to excessive foaming, or the contaminated foam is attached to the washing. The problem of the latter denture can achieve an appropriate amount of foaming which does not hinder the washing effect of the denture using the foaming agent and the surfactant, and can also satisfy the user's visual sense of washing effect.
若由更明顯地發揮前述本發明之效果之觀點來看,則使本發明之義齒洗淨劑溶解於水中時的pH可列舉如:較為理想的是pH8~10,更為理想的是pH8~9.5。 The pH when the denture detergent of the present invention is dissolved in water can be, for example, preferably pH 8 to 10, more preferably pH 8~, from the viewpoint of more clearly exhibiting the effects of the present invention. 9.5.
於本發明中,為了使義齒洗淨劑之溶解液呈現前 述pH值,可依需要添加pH調整劑而調製義齒洗淨劑。pH調整劑可自以往公知者適當地選擇,具體而言,可例示:碳酸鹽、碳酸氫鹽等之無機酸鹽;檸檬酸鹽、醋酸鹽、抗壞血酸鹽、葡萄糖酸鹽、琥珀酸鹽、酒石酸鹽、乳酸鹽、焦磷酸鹽、延胡索酸鹽、蘋果酸鹽等之有機酸鹽。鹽可列舉如:鈉、鉀等之鹼金屬鹽、鈣等之鹼土類金屬鹽,較為理想的可例示:鈉鹽、鉀鹽。具體而言,pH調整劑可列舉如:碳酸鈉、碳酸氫鈉、碳酸鉀、檸檬酸鈉、醋酸鈉、L-抗壞血酸鈉、碳酸鉀、碳酸鈣、葡萄糖酸鈉、琥珀酸一鈉、L-酒石酸鈉、琥珀酸二鈉、DL-酒石酸鈉、乳酸鈉、延胡索酸一鈉、DL-蘋果酸鈉等。作為使用在本發明之義齒洗淨劑之pH調整劑,適合者可例示:碳酸鈉、碳酸氫鈉、檸檬酸、蘋果酸,更適合者可例示:碳酸鈉、檸檬酸。 In the present invention, in order to make the solution of the denture detergent present before The pH value can be adjusted by adding a pH adjuster as needed to prepare a denture detergent. The pH adjuster can be appropriately selected from those conventionally known, and specific examples thereof include inorganic acid salts such as carbonates and hydrogencarbonates; citrates, acetates, ascorbates, gluconates, succinates, and tartaric acid. An organic acid salt of a salt, lactate, pyrophosphate, fumarate, malate or the like. Examples of the salt include an alkali metal salt such as sodium or potassium, and an alkaline earth metal salt such as calcium. Preferred examples thereof include a sodium salt and a potassium salt. Specific examples of the pH adjusting agent include sodium carbonate, sodium hydrogencarbonate, potassium carbonate, sodium citrate, sodium acetate, sodium L-ascorbate, potassium carbonate, calcium carbonate, sodium gluconate, monosodium succinate, and L-. Sodium tartrate, disodium succinate, sodium DL-tartrate, sodium lactate, monosodium fumarate, sodium DL-malate, and the like. The pH adjuster used in the denture detergent of the present invention may, for example, be sodium carbonate, sodium hydrogencarbonate, citric acid or malic acid, and more preferably, sodium carbonate or citric acid.
本發明之義齒洗淨劑中的pH調整劑之含量可適當地設定成義齒洗淨劑溶解於水中時呈現前述pH值,且可例示:通常為10~70重量%,且宜為20~70重量%,更宜為25~70重量%。又,舉例言之,pH調整劑使用碳酸鈉時之含量可列舉如:通常為10~40重量%,且宜為20~40重量%,更宜為20~35重量%。 The content of the pH adjuster in the denture detergent of the present invention can be appropriately set such that the denture detergent exhibits the aforementioned pH value when dissolved in water, and can be exemplified by usually 10 to 70% by weight, and preferably 20 to 70. The weight % is more preferably 25 to 70% by weight. Further, as an example, the content of the pH adjuster in the case of using sodium carbonate may be, for example, usually 10 to 40% by weight, and preferably 20 to 40% by weight, more preferably 20 to 35% by weight.
除了前述成分外,以不妨礙本發明之效果為限度,於本發明之義齒洗淨劑中,亦可依需要含有螯合劑、酵素、著色料、甘味料、消臭劑、發泡安定化劑、保存劑、漂白劑、抗菌.殺菌劑、防腐劑、陰離子界面活性劑以外之界面活性劑、結合劑、潤滑劑、賦形劑、崩解劑、流化劑等 之添加劑。 In addition to the above-mentioned components, the denture detergent of the present invention may contain a chelating agent, an enzyme, a coloring material, a sweetener, a deodorant, and a foaming stabilizer, as needed, without impairing the effects of the present invention. , preservatives, bleach, antibacterial. Surfactants, preservatives, surfactants other than anionic surfactants, binders, lubricants, excipients, disintegrators, fluidizers, etc. Additives.
本發明之義齒洗淨劑可為錠劑、粒劑、顆粒劑等之固態狀,然而,由於投入水中時沈降的類型之義齒洗淨劑可使在水中產生的二氧化碳之氣泡以物理方式與義齒接觸並提高洗淨效果,因此,於前述劑型中,亦宜為錠劑狀。又,為錠劑狀時,藉由崩解時間之延長,可延長二氧化碳之氣泡與義齒接觸之時間,其結果,亦可更進一步地提升義齒之洗淨效果。在作成錠劑狀時,每一個錠劑之重量宜設定成一次之義齒洗淨所必須之量。 The denture detergent of the present invention may be in the form of a solid of a tablet, a granule, a granule or the like. However, since the type of denture detergent which settles when placed in water, the bubble of carbon dioxide generated in the water can be physically and dentured. The contact and the cleaning effect are improved. Therefore, in the above dosage form, it is also preferable to be in the form of a tablet. Further, in the case of a tablet, the time during which the bubbles of carbon dioxide come into contact with the denture can be prolonged by the prolongation of the disintegration time, and as a result, the cleaning effect of the denture can be further improved. In the case of a tablet form, the weight of each tablet should be set to the amount necessary for one-time denture cleaning.
本發明之義齒洗淨劑是藉由混合前述各成分及依需要含有的其他添加劑並製劑化成所期望之形狀而製造。 The denture detergent of the present invention is produced by mixing the above components and other additives as needed, and formulating them into a desired shape.
若於將本發明之義齒洗淨劑加入水中之狀態下使構成洗淨對象之義齒共存,則與含有成分之溶解同時地產生利用發泡劑之二氧化碳之氣泡,並藉由利用該氣泡與義齒接觸之物理性刺激與利用前述陰離子界面活性劑之界面活性作用而洗淨義齒。 When the denture constituting the object to be cleaned is allowed to coexist in the state in which the denture detergent of the present invention is added to water, bubbles of carbon dioxide using the foaming agent are generated simultaneously with the dissolution of the component, and the bubble and the denture are utilized. The physical stimulus of the contact is washed with the interdental action of the aforementioned anionic surfactant to wash the denture.
使用本發明之義齒洗淨劑而洗淨義齒時所使用的水並無特殊之限制,可列舉如:自來水、精製水、蒸餾水、生理食鹽水等。 The water to be used for washing the denture using the denture detergent of the present invention is not particularly limited, and examples thereof include tap water, purified water, distilled water, and physiological saline.
使用本發明之義齒洗淨劑而洗淨義齒時,可於將義齒浸漬於水中後加入本發明之義齒洗淨劑,又,亦可於加入本發明之義齒洗淨劑後使義齒浸漬於水中。 When the denture is washed by using the denture detergent of the present invention, the denture detergent of the present invention may be added after immersing the denture in water, or the denture may be immersed in water after adding the denture detergent of the present invention. .
又,於義齒之洗淨中,本發明之義齒洗淨劑與水 之比率可按照本發明之義齒洗淨劑之組成、構成洗淨對象之義齒之髒污程度等適當地設定,舉例言之,可相對於水100重量份,將義齒洗淨劑作成通常為1~10重量份,且宜為1~5重量份。更具體而言,於一次之義齒之洗淨中,可準備水100~200mL,並於其中加入本發明之義齒洗淨劑1~20g,較為理想的是1~10g,更為理想的是1~5g。 Moreover, in the washing of the denture, the denture detergent of the present invention and water The ratio can be appropriately set according to the composition of the denture detergent of the present invention, the degree of soiling of the denture constituting the object to be cleaned, and the like. For example, the denture detergent can be usually made 1 with respect to 100 parts by weight of water. ~10 parts by weight, and preferably 1 to 5 parts by weight. More specifically, in the washing of the denture once, 100 to 200 mL of water can be prepared, and 1 to 20 g of the denture detergent of the present invention is added thereto, preferably 1 to 10 g, more preferably 1 ~5g.
義齒洗淨時之水溫可作成5~30℃。又,將義齒浸漬於業已加入本發明之義齒洗淨劑之水中的時間可列舉如:通常為5分~12小時,較為理想的是通常為5分~8小時,更為理想的是通常為5分~6小時。 The temperature of the water when the denture is washed can be made 5~30 °C. Further, the time during which the denture is immersed in the water to which the denture detergent of the present invention has been added is, for example, usually 5 minutes to 12 hours, more preferably 5 minutes to 8 hours, and more preferably, usually 5 minutes to 6 hours.
藉由本發明之義齒洗淨劑洗淨的義齒之種類或形狀並無特殊之限制,無關全口義齒、可撤式局部義齒等之差別而可廣泛地應用。於本發明之義齒洗淨劑中,由於調整為溶解於水中時呈現pH8~11,因此,即使在洗淨具有配件之可撤式局部義齒時,亦不會有腐蝕金屬之虞。又,可撤式局部義齒通常採用複雜之形狀,然而,即使對於此種形狀,亦可發揮充分之洗淨效果。故,本發明之義齒洗淨劑尤其適合作為可撤式局部義齒用。 The type or shape of the denture to be washed by the denture detergent of the present invention is not particularly limited, and can be widely applied regardless of the difference of the complete denture, the removable partial denture or the like. In the denture detergent of the present invention, since it is adjusted to be pH 8 to 11 when dissolved in water, there is no possibility of corroding the metal even when the removable partial denture having the fitting is washed. Further, the removable partial denture usually has a complicated shape, but even for such a shape, a sufficient washing effect can be exerted. Therefore, the denture detergent of the present invention is particularly suitable for use as a removable partial denture.
2.義齒洗淨方法2. Denture cleaning method
本發明之義齒洗淨方法是使用前述義齒洗淨劑而洗淨義齒之方法。即,本發明之義齒洗淨方法是將義齒浸漬於業已放入前述義齒洗淨劑之水中而洗淨義齒之方法。本發明之義齒洗淨方法之具體實施態樣是如前述「1.義齒洗淨劑」欄中所揭示。 The denture cleaning method of the present invention is a method of washing dentures using the aforementioned denture detergent. That is, the denture cleaning method of the present invention is a method in which a denture is immersed in water which has been placed in the denture detergent to wash the denture. A specific embodiment of the denture cleaning method of the present invention is as disclosed in the column "1. Denture Detergent" described above.
以下顯示實施例等,並具體地說明本發明。然而,本發明並不限於該等。 The embodiments and the like are shown below, and the present invention will be specifically described. However, the invention is not limited to these.
調製表1及2所示之組成之錠劑狀之義齒洗淨劑。具體而言,使用直徑25Φ之模具,以7MPa將混合有表1及2所示之成分之組成物打錠成型,藉此,調製每一個2.65g之錠劑狀之義齒洗淨劑。另,表1及2中,「碳酸鈉(輕質)」表示粉末狀之碳酸鈉,「碳酸鈉(緻密)」表示「碳酸鈉(輕質)」之造粒物。 A tablet-shaped denture detergent having the composition shown in Tables 1 and 2 was prepared. Specifically, each of 2.65 g of a tablet-shaped denture detergent was prepared by ingot molding a composition in which the components shown in Tables 1 and 2 were mixed at 7 MPa using a mold having a diameter of 25 Φ. In addition, in Tables 1 and 2, "sodium carbonate (light)" means powdery sodium carbonate, and "sodium carbonate (dense)" means "sodium carbonate (light)" granule.
積泡量之計測Measurement of the amount of foam
將25℃之蒸餾水75mL注入容量200mL之量筒,並輕輕地投入所製得之各義齒洗淨劑1個。然後,計測藉由使氣泡疊合而聚集於水的上面所形成的氣泡層之量(積泡量)。於表1及2中顯示所計測之最大積泡量。 75 mL of distilled water at 25 ° C was injected into a measuring cylinder having a capacity of 200 mL, and one of the denture detergents prepared was gently put into operation. Then, the amount (bubble amount) of the bubble layer formed by accumulating the bubbles on the upper surface of the water by superimposing the bubbles was measured. The measured maximum foaming amount is shown in Tables 1 and 2.
又,積泡之減低效果是在表2中以%表示依據下述式(1)所評價之結果。 Further, the effect of reducing the bubble generation is expressed by % in Table 2 in terms of the results evaluated by the following formula (1).
積泡之減低效果(%)=100×(比較例之最大積泡-含有與比較例同量之陰離子界面活性劑、薄荷腦及二氧化矽之實施例之最大積泡)/比較例之最大積泡……式(1) Decrease effect of foaming (%) = 100 × (maximum foaming of the comparative example - maximum foaming of the same amount of anionic surfactant, menthol and cerium oxide as in the comparative example) / maximum of comparative examples Accumulation bubble...(1)
錠劑之崩解時間Disintegration time of tablets
將25℃之蒸餾水75mL注入容量200mL之量筒,並輕輕地投入所製得之各義齒洗淨劑1個。然後,計測直到錠劑崩解為止之時間。錠劑之崩解是藉由目視來確認,並將直到無法確認錠劑之形狀為止之時間作成崩解時間。又,自實 施例之義齒洗淨劑之崩解時間減去對應之比較例之義齒洗淨劑之崩解時間而求取崩解時間差,並根據下述基準來評價。 75 mL of distilled water at 25 ° C was injected into a measuring cylinder having a capacity of 200 mL, and one of the denture detergents prepared was gently put into operation. Then, the time until the tablet disintegrates is measured. The disintegration of the tablet was confirmed by visual observation, and the time until the shape of the tablet could not be confirmed was made into a disintegration time. Again, self-real The disintegration time of the denture detergent of the comparative example was subtracted from the disintegration time of the denture detergent of the comparative example, and the disintegration time difference was calculated, and it evaluated based on the following criteria.
[評價基準] [evaluation benchmark]
---:錠劑之崩解時間縮短 ---: The disintegration time of the tablet is shortened
--:延長時間為10秒以上、小於50秒 --: The extension time is 10 seconds or more and less than 50 seconds.
-:延長時間為50秒以上、小於100秒 -: The extension time is 50 seconds or more and less than 100 seconds.
+:延長時間為100秒以上、小於150秒 +: The extension time is 100 seconds or more and less than 150 seconds.
++:延長時間為150秒以上、小於170秒 ++: The extension time is 150 seconds or more and less than 170 seconds.
+++:延長時間為170秒以上。 +++: The extension time is 170 seconds or more.
pH值測定pH determination
將25℃之蒸餾水150mL注入容量200mL之量筒,並輕輕地投入業已將所製得之各義齒洗淨劑1個粉碎而作成粉末狀者,且靜置10秒而藉由目視確認氣泡業已消失後,在輕輕地攪拌後,使用pH計F52(型號9615)((股)堀場製作所製),測定溶液之pH值。 150 mL of distilled water at 25 ° C was poured into a measuring cylinder having a capacity of 200 mL, and one of the denture detergents prepared was pulverized and powdered, and allowed to stand for 10 seconds to visually confirm that the bubble had disappeared. Thereafter, after gently stirring, the pH of the solution was measured using a pH meter F52 (Model 9615) (manufactured by Horiba, Ltd.).
義齒之洗淨效果Denture cleaning effect
利用以下方法,藉由偵察者10人,依據以下判定基準評價洗淨效果,即:於業已注入蒸餾水(25℃)之杯中投入各義齒洗淨劑後,投入業已使用1日之可撤式局部義齒,並放置10分鐘後,以流水洗淨而藉由目視確認洗淨效果。另,於下述判定基準中,若為△以上,則表示義齒洗淨劑發揮實用上不成問題之洗淨效果。 The following method was used to evaluate the washing effect by the scouts in accordance with the following criteria: that, after the denture detergent was put into the cup which had been filled with distilled water (25 ° C), the one-day disposable type was used. The partial denture was placed and allowed to stand for 10 minutes, and then washed with running water to visually confirm the washing effect. Further, in the following criterion, if it is Δ or more, it means that the denture detergent has a cleaning effect which is not practically problematic.
10人滿意洗淨效果:○ 10 people satisfied with the washing effect: ○
8~9人滿意洗淨效果:△ 8~9 people satisfied with the washing effect: △
滿意洗淨效果者為7人以下:× Satisfactory cleaning effect is less than 7 people: ×
依據表1及2所示之結果,相較於對應之比較例1~12(pH值皆為中性),pH值顯示弱鹼性之實施例1~12之義齒洗淨劑皆可抑制積泡量,又,錠劑之崩解時間亦延長。另一方面,各實施例之義齒洗淨劑之洗淨效果與對應之比較例之洗淨效果並無變化,義齒洗淨劑雖然可維持充分之 洗淨效果,但卻可抑制積泡量。又,於實施例2~11之義齒洗淨劑中,可確認更優異之積泡量之抑制效果及崩解時間之延長效果。 According to the results shown in Tables 1 and 2, the denture detergents of Examples 1 to 12 which showed a weakly alkaline pH compared with the corresponding Comparative Examples 1 to 12 (the pH values were all neutral) were able to suppress the product. The amount of foam, in addition, the disintegration time of the tablet is also prolonged. On the other hand, the cleaning effect of the denture detergent of each of the examples and the washing effect of the corresponding comparative example did not change, and the denture detergent could be maintained sufficiently. Washing effect, but it can suppress the amount of foaming. Moreover, in the denture detergents of Examples 2 to 11, the effect of suppressing the more excellent foaming amount and the effect of prolonging the disintegration time were confirmed.
於義齒中,可撤式局部義齒經常採用複雜之結構,為了充分地洗淨其複雜之結構部分,必須延長使二氧化碳之氣泡以物理方式接觸之時間。對此,如實施例1~12所示,本發明之義齒洗淨劑由於錠劑之崩解時間長,且伴隨於此,可延長、維持使二氧化碳之氣泡以物理方式接觸之時間,因此,可說是特別適合於可撤式局部義齒之洗淨。 In dentures, retractable partial dentures often employ complex structures, and in order to adequately clean their complex structural parts, the time for the carbon dioxide bubbles to physically contact must be extended. On the other hand, as shown in Examples 1 to 12, the denture detergent of the present invention has a long disintegration time of the tablet, and along with this, the time for the carbon dioxide bubbles to physically contact can be prolonged and maintained. It can be said that it is especially suitable for the cleaning of removable partial dentures.
[處方例] [Prescription example]
調製下表3~5所示之組成之本發明之義齒洗淨劑(錠劑)。具體而言,使用直徑25Φ之模具,以7MPa將混合有表3~5所示之成分之組成物打錠成型,藉此,調製每一個2.65g之錠劑狀之義齒洗淨劑。針對所製得之義齒洗淨劑,依據前述「pH值測定」欄所揭示之方法測定溶液之pH值之結果,皆為pH8~11之範圍內。又,任一者之義齒洗淨劑皆可有效地抑制積泡量,且錠劑之崩解時間變長,並發揮充分之洗淨效果。 The denture detergent (tablet) of the present invention having the composition shown in the following Tables 3 to 5 was prepared. Specifically, a composition in which the components shown in Tables 3 to 5 were mixed was molded at 7 MPa using a mold having a diameter of 25 Φ, whereby each of 2.65 g of a tablet-shaped denture detergent was prepared. For the prepared denture detergent, the pH of the solution was measured in accordance with the method disclosed in the "pH measurement" column described above, and all were in the range of pH 8-11. Further, any of the denture detergents can effectively suppress the amount of foaming, and the disintegration time of the tablet becomes long, and a sufficient washing effect is exerted.
Claims (7)
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JP2013049583A JP6088301B2 (en) | 2013-03-12 | 2013-03-12 | Denture cleaning agent |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US5015408A (en) * | 1988-03-19 | 1991-05-14 | Reckitt Gmbh | Denture cleaning tablet containing a bleach activator and an organic phosphonic acid stabilizer |
JPH09110665A (en) * | 1995-10-18 | 1997-04-28 | Lion Corp | Denture cleaning agent |
US20020122775A1 (en) * | 2000-11-03 | 2002-09-05 | Clariant Gmbh | Cleaning compostion for dental prostheses |
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GB9513694D0 (en) * | 1995-07-05 | 1995-09-06 | Procter & Gamble | Oral compositions |
JPH1017454A (en) * | 1996-07-02 | 1998-01-20 | Kobayashi Pharmaceut Co Ltd | Foamable composition for washing artificial tooth |
JP6067296B2 (en) * | 2011-10-18 | 2017-01-25 | 小林製薬株式会社 | Denture cleaning agent |
-
2013
- 2013-03-12 JP JP2013049583A patent/JP6088301B2/en active Active
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2014
- 2014-03-04 WO PCT/JP2014/055404 patent/WO2014141938A1/en active Application Filing
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Publication number | Priority date | Publication date | Assignee | Title |
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US5015408A (en) * | 1988-03-19 | 1991-05-14 | Reckitt Gmbh | Denture cleaning tablet containing a bleach activator and an organic phosphonic acid stabilizer |
JPH09110665A (en) * | 1995-10-18 | 1997-04-28 | Lion Corp | Denture cleaning agent |
US20020122775A1 (en) * | 2000-11-03 | 2002-09-05 | Clariant Gmbh | Cleaning compostion for dental prostheses |
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