JP2007269633A - False tooth-cleansing agent composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a false tooth-cleansing agent composition excellent in sterilizing power and cleansing false tooth in a short time. <P>SOLUTION: The false tooth-cleansing agent composition comprises an antibacterial metal salt of N-stearoyl-L-glutamic acid in a formulation amount of >0.0025 wt.% based on total weight. The antibacterial metal is preferably at least one kind of metal selected from silver and copper. The false tooth-cleansing agent composition comprises, further, at least one of (A) 5 wt.% at least one kind of bleaching agent selected from a group consisting of sodium percarbonate, sodium perborate, sodium persulfate and hydrogen potassium permonosulfate, (B) 0.1-10 wt.% at least one kind of anionic surfactant, (C) 1-60 wt.% at least one kind of organic acid and (D) 1-60 wt.% at least one kind of salt selected from a group consisting of an alkali metal carbonate and alkali metal hydrogencarbonate and the false tooth-cleansing agent composition may have expandability. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a denture cleaning composition used for sterilization and cleaning of dentures.

  Denture stains are caused by food residues, denture plaques, colored substances such as tea astringents and tobacco crabs, tartar, etc. To clean these, brushing and / or cleaning with a denture cleaner is performed. Is called.

  Of these denture stains, denture plaques are biofilms that contain a large amount of microorganisms. If left untreated, denture plaques form tartar, which is caused by the propagation of microorganisms from denture plaques in dentures to the remaining teeth. Risks to various diseases such as the occurrence of dental caries, promotion of periodontal disease, denture stomatitis, candidiasis, and infections to the digestive and respiratory systems have been pointed out. In addition, denture plaque microorganisms enter the resin part of the denture and cause deterioration of the resin part of the denture. Therefore, it is very important to sufficiently remove the denture plaque in order to maintain the health of the denture user and prevent the denture from deteriorating. However, once the microorganisms have entered the resin part of the denture, the cleaning with the cleaning agent does not reach the resin part, making it more difficult to clean the denture.

  Usually, denture cleaning agents used for denture cleaning are mainly composed of bleaching agents such as percarbonate and perboric acid, and surfactants, enzymes, excipients, lubricants, etc. are added, and carbonates. And an organic acid is added, and is of an effervescent tablet type that foams when dissolved. In addition, bleaching agents such as percarbonate and perboric acid have a bactericidal action per se, but their effects are not sufficient. Instead, those using enzymes or bactericides that have a bactericidal action are used. Often done.

  As a denture cleaning agent containing a bactericidal agent, Patent Document 1 discloses a denture cleaning agent containing an inorganic carrier carrying an antibacterial metal ion.

However, in the above-mentioned denture cleaning agent in which an antibacterial metal is supported on an inorganic carrier, it takes a relatively long time for sterilization, and depending on the blending concentration, white particles of the disinfectant remain adsorbed on the resin part of the denture. There was a problem. Denture cleaning time with denture cleaning agents varies depending on the user, but it tends to be preferred that denture cleaning can be performed in a shorter time than cleaning for a long time that must be left all day and night. .
WO99 / 56714 pamphlet

  This invention is made | formed in order to solve the said problem, and it aims at providing the denture cleaning composition which is excellent in bactericidal power and can wash | clean a denture in a short time.

  In order to solve the above-mentioned problems, the present inventors have intensively studied, and as a result, have found a denture cleaning composition that is excellent in sterilizing power and that can clean a denture in a short time.

  That is, the denture cleaning composition of the present invention is characterized in that it contains an antibacterial metal salt of N-stearoyl-L-glutamic acid in an amount exceeding 0.0025% by weight based on the total weight. .

  The antibacterial metal salt of N-stearoyl-L-glutamic acid retains the antibacterial metal in the form of ionic bonds, so it is easy to release metal ions. Can be washed. Moreover, since the antibacterial metal salt is excellent in dispersion stability when dispersed in water, no particles are deposited on the denture resin.

  In the denture cleaning composition of the present invention, the antibacterial metal is preferably at least one selected from the group consisting of silver and copper.

The denture cleaning composition of the present invention preferably further includes at least one of the following (A) to (D) and is foamable:
(A) at least one bleach selected from the group consisting of sodium percarbonate, sodium perborate, sodium persulfate, potassium monohydrogen persulfate: 5% by weight;
(B) at least one anionic surfactant: 0.1 to 10% by weight;
(C) at least one organic acid: 1 to 60% by weight;
(D) At least one selected from the group consisting of alkali metal carbonates and alkali metal hydrogen carbonates: 1 to 60% by weight.

  If the denture cleaning composition of the present invention is made foamable in this way, it is preferable because the dirt can be dispersed by foaming.

  The denture cleaning composition of the present invention may be made into tablets by using excipients such as saccharides such as polyethylene glycol and lactose and magnesium aluminate metasilicate in order to improve convenience in use.

  Alternatively, the denture cleaning composition of the present invention may be powdered by further adding at least one selected from the group consisting of silicon dioxide, magnesium aluminate metasilicate and magnesium aluminate silicate.

  The denture cleaning composition of the present invention contains an antibacterial metal salt of N-stearoyl-L-glutamic acid, which is highly dispersible in water, in an amount exceeding 0.0025% by weight based on the total weight. It can be sterilized in a very short time of 5 minutes or less against fungi, especially Gandida bacteria that are likely to cause oral diseases.

  Hereinafter, the denture cleaning composition of the present invention will be described in detail.

  In the present invention, the denture cleaning composition contains an antibacterial metal salt of N-stearoyl-L-glutamic acid (hereinafter referred to as an “antibacterial metal salt” for simplicity) as an antibacterial agent. The antibacterial metal is preferably at least one selected from the group consisting of silver and copper.

  As an antibacterial metal salt, what is available as a 5% aqueous dispersion containing silver and copper as an antibacterial metal is commercially available (SS-5 manufactured by Sangi Co., Ltd.). Alternatively, a salt containing silver and / or copper in a desired ratio may be produced by performing an ion exchange reaction between commercially available N-stearoyl-L-glutamate disodium and silver and / or copper.

  The antibacterial metal salt needs to be added in an amount exceeding 0.0025% by weight based on the total weight of the composition. When the amount is 0.0025% by weight or less, a sufficient bactericidal effect cannot be obtained. On the other hand, from the viewpoint of the stability of the preparation, the blending amount of the antibacterial metal salt is preferably set to 0.25% by weight or less.

  In addition to the antibacterial metal salt, the denture cleaning composition of the present invention comprises (A) a bleaching agent, (B) an anionic surfactant, (C) an organic acid, and (D) an alkali metal carbonate and / or an alkali metal carbonate. It may further include at least one selected from the group consisting of hydrogen salts.

  (A) Examples of the bleaching agent include sodium percarbonate, sodium perborate, sodium persulfate, and potassium monohydrogen persulfate, and these can be added singly or in combination. The blending amount is preferably 5% by weight or more in order to appropriately obtain a plaque dispersing effect. Moreover, it is preferable that the compounding quantity is 70 weight% or less from the point of storage stability. When the composition of the present invention is used as a tablet, from the viewpoint of the storage stability of the tablet, as a bleaching agent, (C) an organic acid, (D) an alkali metal carbonate and / or an alkali metal bicarbonate is used. It is desirable to use a product coated with an inert component such as sodium sulfate.

  Examples of (B) anionic surfactants include alkyl sulfates, alkyl sarcosine salts, alkylaminodiacetic acid salts, acylmethyl tauric acid, and alkyl sulfoacetic acid salts in terms of detergency. These may be used alone or in combination of two or more. Among these, in particular, dodecyl sulfate which is an alkyl sulfate is preferably blended from the viewpoint of foamability and detergency. The blending amount of the anionic surfactant is preferably 0.1 to 10% by weight from the viewpoint of foamability and detergency and not requiring a long time to dissolve in water. In order to shorten the dissolution time, dodecyl sulfate is preferably made into flakes or coarse particles rather than powder.

  (C) Examples of the organic acid include citric acid, succinic acid, maleic acid, fumaric acid, and malic acid. These may be used alone or in combination of two or more. The blending amount is preferably 1 to 60% by weight, and the pH of the final product is adjusted to 5 to 9. When the composition of the present invention is used as a tablet, from the viewpoint of storage stability of the tablet, the organic acid may be (A) a bleaching agent, (D) an alkali metal carbonate and / or an alkali metal bicarbonate. It is desirable to use a material coated with an inert sodium sulfate component.

  (D) Alkali metal carbonate and / or alkali metal bicarbonate is a foaming agent, and its blending amount is preferably 1 to 60% by weight, and the pH of the final product is adjusted to 5 to 9. The Sodium and / or potassium is used as the alkali metal. When the composition of the present invention is used as a tablet, it is particularly desirable to add 10% by weight or more of potassium carbonate in order to increase the storage stability of the tablet.

  The composition of the present invention is used as a tablet or powder.

  When the composition of the present invention is used as a tablet, the excipient used is not particularly limited, and examples thereof include saccharides such as polyethylene glycol and lactose, and magnesium aluminate metasilicate.

  When the composition of the present invention is powdered, the powdered composition is obtained by mixing each component of the composition of the present invention with a powder raw material and stirring it well. The powder raw material needs to have a property of adsorbing liquid components, and examples of such properties include silicon dioxide, magnesium aluminate metasilicate, and magnesium aluminate silicate. These may be used alone or in combination of two or more. Moreover, it is necessary to add the compounding quantity only by the quantity which fully pulverizes the final product, and the quantity is equivalent to 10 times the weight of the antibacterial metal salt used. When the blending amount is less than an equal amount, it becomes difficult to powder. Moreover, since about 10 times as much powder raw material can be added, it can be pulverized sufficiently, and the addition of a powder raw material in an amount larger than that is excessive and meaningless.

  In addition to the above components, the composition of the present invention may further contain components such as a lubricant, a fragrance, a disintegrant, a dye, a cleaning aid, and a bulking agent as long as the stability of the final product is not impaired. .

  There are no particular limitations on the lubricant, and examples include suitable alkaline earth metal salts of fatty acids and sucrose fatty acid esters.

  There is no particular limitation on the fragrance, and powdered one is preferable from the viewpoint of workability.

  The enzyme is not particularly limited, and examples thereof include protease, amylase, glucanase, mutanase, and lipase.

  There is no limitation in particular in a disintegrating agent, For example, a cellulose, a hydroxypropyl cellulose, dextrin etc. are mentioned.

  There are no particular limitations on the cleaning aid, such as those that act as solubilizers such as polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, polyoxyethylene alkyl ether phosphate, polyphosphate, gluconate, EDTA Those having a chelating effect such as are desirable.

  When the composition of the present invention is actually used, the concentration of the antibacterial metal salt when the composition is dispersed in water is preferably set to be 0.00005% by weight or more. When the concentration of the antibacterial metal salt is less than 0.00005% by weight, the bactericidal effect is not exhibited. Further, even if the concentration of the antibacterial metal salt exceeds 0.25% by weight, the bactericidal effect does not change and has no meaning, so it is preferably set to 0.25% by weight or less.

  Hereinafter, although the composition of this invention is demonstrated based on a specific example, this invention is not limited to these.

(Evaluation as a disinfectant)
Different amounts of silver and copper salts of N-stearoyl-L-glutamic acid (Sangi Co., Ltd .: SS-5) were dispersed in a predetermined amount of water, and three types of dispersions (0.0005%, 0.00013) were dispersed. % And 0.00005%). For comparison, a dispersion of a commercially available fungicide in which silver is supported on hydroxyapatite (0.01%), and a dispersion of a commercially available fungicide in which silver is supported on zirconia phosphate (0.01%). Was made.

As test bacteria, Candida albicans (IFM-47259) and mutans bacteria (Streptcoccus mutans, IFO-13955) were used. These bacteria were prepared in a bacterial solution having a concentration of 10 ⁷ cfu / mL.

  1 mL of each bacterial solution is added to 100 mL of each of the above bactericidal dispersions, and immediately after that (within 5 minutes), 15 minutes, and 30 minutes later, 1 mL of the bactericide dispersion is sampled and diluted with LP (Lecithin Polysorbate). 9 mL of a solution (manufactured by Wako Pure Chemical Industries, Ltd.) was added, and 1 mL of this solution was measured for the number of cells by the pour method (SCD agar for mutans bacteria, PDA agar for Gandida). For those in which no colonies were detected in the medium, it was judged that the bacteria had been killed, and evaluation was performed according to the following criteria. The results are shown in Table 1.

Evaluation Criteria: Bacteria died within 5 minutes: ◎
Bacteria killed within 15 minutes: ○
Bacteria killed within 30 minutes: △
What did not kill the bacteria within 30 minutes: ×

  As is apparent from Table 1, the silver and copper salts of N-stearoyl-L-glutamic acid according to the present invention have a bactericidal effect at a significantly lower concentration than silver-supported hydroxyapatite and silver-supported zirconia phosphate. It was confirmed. In addition, even when the dispersion of silver and copper salts of N-stearoyl-L-glutamic acid is 0.00005% in the dispersion, it is also shown that there is a problem in bactericidal activity. .

(Preparation of denture cleaning composition)
The components of Examples 1 to 5 and Comparative Examples 1 to 5 having different distribution amounts shown in Tables 2 and 3 below were uniformly mixed and compressed by a tableting machine to produce tablets. At this time, since the silver and copper salt of N-stearoyl-L-glutamic acid was an aqueous dispersion, it was premixed with magnesium aluminate metasilicate, and then powdered and then mixed with the other components.

  The prepared denture cleaners of Examples 1 to 5 and Comparative Examples 1 to 5 were dissolved in water to give a 2% dispersion, and this was compared by the same test method and evaluation criteria as those for the above-mentioned disinfectant. . The results are shown in Tables 4 and 5.

  As shown in Tables 4 and 5, the denture cleaners of Examples 1 to 5 were significantly more sterilized in a shorter time than the silver-supported hydroxyapatite of Comparative Example 3 and the silver-supported zirconia phosphate of Comparative Example 4. It was found to have excellent bactericidal power against power, especially against Gandida.

  As a result, it was found that the silver and copper salts of N-stearoyl-L-glutamic acid according to the present invention are excellent as a disinfectant for denture cleaning.

Claims (4)

  A denture cleaning composition comprising an antibacterial metal salt of N-stearoyl-L-glutamic acid in an amount exceeding 0.0025% by weight based on the total weight.   The denture cleaning composition according to claim 1, wherein the antibacterial metal is at least one selected from the group consisting of silver and copper. The denture cleaning composition according to claim 1 or 2, further comprising at least one of the following (A) to (D) and foaming:
(A) at least one bleach selected from the group consisting of sodium percarbonate, sodium perborate, sodium persulfate, potassium monohydrogen persulfate: 5% by weight;
(B) at least one anionic surfactant: 0.1 to 10% by weight;
(C) at least one organic acid: 1 to 60% by weight;
(D) At least one selected from the group consisting of alkali metal carbonates and alkali metal hydrogen carbonates: 1 to 60% by weight. The denture cleaning composition according to any one of claims 1 to 3, further comprising at least one selected from the group consisting of silicon dioxide, magnesium aluminate metasilicate and magnesium aluminate silicate.