TWI610694B - Dressing composition - Google Patents

Abstract

A wound dressing composition for forming a film layer on a surface of a wound, comprising: 55 to 73% by weight of a substrate, 17 to 35% of a water absorbing material, and 2 to 6% of a feeling Wet color changing molecules.

Description

Wound dressing composition

This invention relates to a wound dressing composition, and more particularly to a wound dressing composition having a warning replacement timing.

For the treatment of wounds such as abrasions, cuts, burns and the like on the skin, it is generally possible to cover a wound dressing with a conventional wound dressing to prevent the wound from being directly exposed to the air.

When the conventional wound dressing absorbs too much exudate but does not replace it in a timely manner, it may cause reinfection of the wound, so timely replacement of the conventional wound dressing is extremely important for wound healing.

Although the user can absorb the exudate (such as tissue fluid, blood, etc.) by the conventional wound dressing, the conventional wound dressing can not continue to absorb the exudate when the exudate absorbed by the conventional wound dressing reaches a certain amount. The fluid may ooze from the conventional wound dressing to the wound, and the user can thereby assess the timing of replacement of the conventional wound dressing. However, for the conventional wound dressing which covers the surface of the wound which is less visible to the user, it is not only easy for the injured person to observe the condition of the exudate outflow, so that the medical staff can easily neglect the replacement of the conventional wound dressing, which may cause repeated infection of the wound. Serious consequences. In view of this, the conventional wound dressings still have the need to improve.

In order to solve the above problems, the present invention provides a wound dressing composition which is useful for a user to evaluate the timing of replacing a wound dressing composition covering a wound surface.

A wound dressing composition of the present invention comprising: 55 to 73% of one substrate, 17 to 35% of one water absorbing material, and 2 to 6% of one of the moisture sensitive color molecules, the moisture sensitive color molecule containing 85% by weight of polyethylene glycol, 10% The hygroscopic molecule and 5% of the coloring molecules. Thus, the wound dressing composition of the present invention can be stably applied to the surface of the wound by the substrate to prevent the wound from being directly exposed to the air, and the exudate is absorbed by the absorbent material, so that the wound dressing composition can maintain the wound. In the wet state, the color of the exudate is perceived by the moist-staining color molecule, and the user can clearly understand the timing of the replacement of the wound dressing composition, which is the effect of the present invention.

The wound dressing composition of the present invention, wherein the hygroscopic molecule is calcium oxide, and the coloring molecule is phenolphthalein or curcumin; preferably, the polyethylene glycol comprises polyethylene glycol having molecular weights of 400, 700 and 1000, Polyethylene glycol having a molecular weight of 400, 700 and 1000 is mixed in an equal weight ratio. Thus, the calcium oxide reacts with the moisture absorbed by the water absorbing material to form calcium hydroxide to release hydroxide ions, and the hydroxide ions react with the phenolphthalein to convert the phenolphthalein from a colorless lactone structure to a red quinoid structure. Alternatively, the hydroxide ions released by the calcium oxide react with curcumin to convert the hygroscopic color-changing molecule from yellow to red, thereby allowing the wound dressing composition to exhibit a red color that is easily visible to the user.

The wound dressing composition of the present invention, wherein the substrate is a ruthenium gel; for example, the substrate comprises 60% by weight of polysorbate, 30% of ruthenium resin copolymer, 8% Polydimethyl methoxy oxane and 2% cross-linked polydimethyl methoxy oxane. In this embodiment, the substrate is obtained by a method comprising the steps of: uniformly dispersing a ruthenium resin copolymer in polydimethylene a sulfoxide to obtain a dispersion; a polysorbate and a cross-linked polydimethyl siloxane are sequentially added to the dispersion to obtain a solution to be formed; and the mixture is heated and stirred at 60 ° C. The solution to be formed was cooled at room temperature. Thus, the wound dressing composition can be stably applied to the wound surface by the high ductility, high conformability, high affinity and non-stickiness of the gel.

The wound dressing composition of the present invention, wherein the water absorbing material is carboxymethyl cellulose. Thus, carboxymethylcellulose is capable of absorbing moisture and thereby retaining moisture in the wound. Among the dressing compositions, and thus the wound dressing composition forms a film layer on the wound surface, the film layer maintains the wound in a wet state and has an effect of promoting wound healing.

The wound dressing composition of the present invention, wherein the wound dressing composition comprises from 8 to 25% by weight of one of the microbial indicators; preferably, the microbial indicator is a probe capable of specifically detecting microorganisms. Thus, by detecting the presence of the microorganism by the microbial indicator, the user can thereby assess whether the wound is infected.

〔this invention〕

1‧‧‧Wound dressing composition

11‧‧‧Substrate

12‧‧‧Water absorption material

13‧‧‧Damp-staining molecules

14‧‧‧Microbial indicator

W‧‧‧Wound surface

Fig. 1 is a schematic view showing a film layer formed on the wound surface by the wound dressing composition of the first and second embodiments of the present invention.

Fig. 2 is a schematic view showing a film layer formed on the wound surface by the wound dressing composition of the third embodiment of the present invention.

The above and other objects, features, and advantages of the present invention will become more apparent from the aspects of the appended claims. In one embodiment of the present invention, the wound dressing composition 1 may include: a substrate 11, a water absorbing material 12, and a moisture sensitive coloring molecule 13, so that when the wound dressing composition 1 is applied to the wound surface, Forming a film layer covering the wound completely on the wound surface W, and absorbing the exudate by the water absorbing material 12, and the sensible color changing molecule 13 can sense the amount of the oozing liquid and present a color, thereby facilitating the user's timelyness. The film layer formed by the wound dressing composition 1 is replaced.

In detail, the wound dressing composition 1 may comprise 55 to 73% by weight of the substrate 11 . For example, the substrate 11 may be a silica gel to be coagulated by ruthenium. The high flexibility of the glue, high conformability, high affinity and the tendency to leave the colloid on the wound surface W, and the wound dressing composition 1 can be firmly applied to the wound surface W.

In this embodiment, the substrate 11 may comprise 60% by weight of polysorbate, 30% of polysilicone-11, and 8% of polydimethyloxane. (polydimethylsiloxane, also known as eucalyptus oil) and 2% cross-linked polydimethylsiloxane; for example, it can be obtained by a method comprising the steps of: uniformly dispersing the polyoxyalkylene-11 in poly In a methyl oxane, a dispersion is obtained; a polysorbate and a cross-linked polydimethyl siloxane (particularly in a powder form) are sequentially added to the dispersion to obtain a solution to be formed; And the solution to be formed is heated and stirred at 60 ° C for 2 hours, and cooled at room temperature to make the solution to be formed into a gel state, that is, the substrate 11 can be obtained.

Further, the wound dressing composition 1 may comprise 17 to 35% by weight of the water absorbing material 12, for example, the water absorbing material 12 may be carboxymethyl cellulose (CMC), by carboxy Methylcellulose can indeed absorb exudates (such as tissue fluid, blood, etc.) secreted by the wound. In particular, carboxymethylcellulose can be added to the substrate 11 in the form of a fine powder, whereby when the wound dressing 1 is applied to the wound surface W in a gel form to form the film layer, Carboxymethylcellulose can exert the effect of better absorption of exudates, while also avoiding the adverse effects of biotoxicity of materials.

Next, the wound dressing composition 1 may further comprise 2 to 6% by weight percent of the hygroscopic discoloring molecule 13. In detail, the hygroscopic color-changing molecule 13 may comprise a hygroscopic molecule and a color-developing molecule, and the hygroscopic molecule is capable of reacting with the moisture absorbed by the water-absorbing material, thereby causing a color change of the color-developing molecule; For example, in the first embodiment, the moisture absorbing molecule is calcium oxide, and the coloring molecule is phenolphthalein. Thus, the calcium oxide can react with the water absorbed by the water absorbing material 12 to form hydrogen. Calcium hydroxide, calcium hydroxide can further release hydroxide ions, which react with phenolphthalein to convert phenolphthalein from a colorless lactone form to a red quinone structure. (phenolate form), so that the wound dressing composition 1 can be made red which can be easily seen by a user; in addition, in the second embodiment, the colored molecule can be ginger Curcumin, as such, the hydroxide ions formed by the action of calcium oxide can react with curcumin to convert the curcumin from yellow to red curcumin phenoxyl radicals, and Because curcumin is less toxic than phenolphthalein, it is more suitable as a coloring molecule in this embodiment to reduce the harm of biological toxicity to the human body.

Further, in order to enhance the mixing uniformity of the hygroscopic color-changing molecule 13 and the water-absorbing material 12 and further modify the toxic functional group carried by the moisture-absorbing molecule such as calcium oxide, the hygroscopic color-changing molecule 13 may further comprise polyethylene glycol. (polyethylene glycol), such as polyethylene glycol having a molecular weight of 400, 700 and 1000, and combinations thereof. In the present embodiment, the moisture-sensitive color-changing molecule 13 comprises polyethylene glycol (polyethylene glycol) in an amount of 80-90% by weight, hygroscopic molecules of 5 to 15%, and color molecules of 2 to 8%, and molecular weight. Polyethylene glycols of 400, 700 and 1000 are mixed in equal weight ratios.

Thus, the user can apply the wound dressing composition 1 to the wound surface W, so that the wound dressing composition 1 can form the film layer, and the water absorbing material 12 of the wound dressing composition 1 can absorb moisture in the liquid. When the water absorbing material 12 absorbs a sufficient amount of moisture, the color change of the sensible color changing molecule 13 of the wound dressing composition 1 is caused to make the film layer appear red, and the user can replace the wound dressing at a timely time. The film layer formed by the composition 1 is used to avoid problems such as infection caused by excessive bleeding.

In addition, as shown in FIG. 2, in the third embodiment of the present invention, the wound dressing composition 1 may further comprise 8 to 25% by weight of one of the microbial indicators 14, the microbial indicator. 14 may be a calibration body of a microorganism. For example, the substrate of the enzyme which can be produced by the microorganism can be calibrated on a fiber test piece, and the fiber test piece is cut into an appropriate size and added to the wound dressing 1. In particular, when the exudate absorbed by the wound dressing composition 1 contains a microorganism, the enzyme produced by the microorganism can perform a specific enzymatic conversion of the substance, and a colored color is formed in the wound dressing composition 1. Colonies. In this embodiment, glucopyranose can be labeled as a substrate on the fiber test piece. The β-glucosidase produced by the microorganism specifically converts the substrate to form a blue colony, thereby finding out whether there is a microbial infection, and immediately performing the wound dressing for the wound of the patient 1 Replacement.

Therefore, in the second embodiment of the present invention, the user can know the amount of exudate absorbed by the wound dressing composition 1 by the color change of the hygroscopic discoloring molecule 13 of the wound dressing composition 1. The signal released by the microbial indicator 14 can be used to know whether there is a specific microorganism in the exudate, so that the user can evaluate whether the wound has already raised a specific microorganism.

In summary, the wound dressing composition 1 of the present invention can be stably applied to the wound surface W by the substrate 11 to prevent the wound from being directly exposed to the air, and absorb the exudate by the water absorbing material 12 and match the moist color change. The molecule 13 senses the amount of the exudate and presents a color, which in turn allows the user to clearly understand the timing of the replacement of the wound dressing composition 1, which is an effect of the present invention.

Furthermore, since the wound dressing composition 1 of the present invention detects the presence of a specific microorganism by the microbial indicator 14, the user can thereby evaluate whether the wound breeds a specific microorganism, which is an effect of the present invention.

While the invention has been described in connection with the preferred embodiments described above, it is not intended to limit the scope of the invention. The technical scope of the invention is protected, and therefore the scope of the invention is defined by the scope of the appended claims.

1‧‧‧Wound dressing composition

11‧‧‧Substrate

12‧‧‧Water absorption material

13‧‧‧Damp-staining molecules

W‧‧‧Wound surface

Claims (11)

A wound dressing composition comprising: 55 to 73% by weight of a substrate, 17 to 35% of a water absorbing material, and 2 to 6% of one of the moisture sensitive color molecules, and the moisture sensitive color molecule comprises 85% by weight of polyethylene glycol, 10% of hygroscopic molecules and 5% of colored molecules. The wound dressing composition of claim 1, wherein the hygroscopic molecule is calcium oxide and the coloring molecule is phenolphthalein. The wound dressing composition of claim 1, wherein the hygroscopic molecule is calcium oxide and the coloring molecule is curcumin. The wound dressing composition of claim 1, wherein the polyethylene glycol comprises polyethylene glycol having a molecular weight of 400, 700 and 1000. The wound dressing composition of claim 4, wherein the polyethylene glycol having a molecular weight of 400, 700 and 1000 is mixed in an equal weight ratio. The wound dressing composition of claim 1, wherein the substrate is a ruthenium gel. The wound dressing composition of claim 6, wherein the substrate comprises 60% by weight of polysorbate, 30% of polyoxyalkylene-11, and 8% of polydimethylene. Alkoxyoxane and 2% crosslinked polydimethyloxane. The wound dressing composition according to claim 7, wherein the substrate is obtained by a method comprising the steps of: uniformly dispersing polyoxyalkylene-11 in polydimethyl siloxane to obtain a dispersion; a polysorbate and a cross-linked polydimethyl siloxane are sequentially added to the dispersion to obtain a solution to be formed; and the solution to be formed is heated and stirred at 60 ° C, and at room temperature Cool down. The wound dressing composition of claim 1, wherein the water absorbing material is carboxymethyl cellulose. The wound dressing composition of claim 1, wherein the wound dressing composition comprises from 8 to 25% by weight of the microbial indicator. The wound dressing composition of claim 10, wherein the microbial indicator is a calibrator capable of specifically detecting microorganisms.