TWI608800B - Compound essential oil composition capable of inhibiting bacteria and repelling mosquitoes - Google Patents

Compound essential oil composition capable of inhibiting bacteria and repelling mosquitoes Download PDF

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TWI608800B
TWI608800B TW105113239A TW105113239A TWI608800B TW I608800 B TWI608800 B TW I608800B TW 105113239 A TW105113239 A TW 105113239A TW 105113239 A TW105113239 A TW 105113239A TW I608800 B TWI608800 B TW I608800B
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essential oil
compound essential
composition
oil composition
bacteriostatic
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TW201737800A (en
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Kun Jung Chen
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Kun Jung Chen
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Description

有香味可抑菌與驅蚊效果的複方精油組合物 Compound essential oil composition with scent inhibiting bacteria and mosquito repellent effect

本發明係一種以多種精油組成的複方精油以乳化劑、助溶劑與水均勻混合後形成水包油之透明水溶液再加入溫和的抗菌劑成份,成為一種具有特殊香氣並有殺菌抑菌及驅蚊效果的溶液。 The invention relates to a compound essential oil composed of a plurality of essential oils, which is uniformly mixed with an emulsifier, a co-solvent and water to form a transparent aqueous solution of oil-in-water and then added a mild antibacterial agent component, thereby becoming a special aroma with bactericidal and antibacterial and mosquito repellent The solution of the effect.

我國的中草藥傳承與歐美對於香草植物(Herbs)的應用到現在都已經有數千年的歷史,現代科學也已經能對中草藥或香草植物的藥理特性有確實的驗證,其中幾種香草值物如茶樹、尤加利、肉桂、百里香、檸檬草、迷迭香、廣藿香等精油萃取物對於殺菌、抑菌與驅蟲都經過科學驗證有很好效果。 The Chinese herbal medicine heritage in China and the application of Herbs in Europe and America have been used for thousands of years. Modern science has also proven the pharmacological properties of Chinese herbal medicines or vanilla plants. Several vanilla values such as tea trees, Essential oil extracts such as eucalyptus, cinnamon, thyme, lemongrass, rosemary, and patchouli have been scientifically proven to be effective in bactericidal, bacteriostatic and deworming.

目前許多流行疫病都是都過飛沫、蚊蟲來傳播,市面上已經有需多的殺菌抑菌產品,這類產品大致可分為使用酒精、次氯酸水、陽離子界面活性劑等幾種殺菌抑菌成份來達到防疫的效果,其中酒精、次氯酸水都是屬於短效型的產品接觸空氣後會很快揮發或是轉換成水,陽離子界面活性劑雖然比較長效但是對人體的刺激是比較大的,上述幾種產品大多沒有令人愉悅的香味且僅能殺菌抑菌並無驅蚊的效果。 At present, many epidemic diseases are spread by droplets and mosquitoes. There are already many antibacterial and antibacterial products on the market. These products can be roughly divided into several kinds of sterilizations such as alcohol, hypochlorous acid water and cationic surfactant. The components of the bacteria are used to achieve the effect of epidemic prevention. Among them, alcohol and hypochlorous acid are short-acting products which will quickly evaporate or convert into water after contact with air. Although the cationic surfactant is relatively long-lasting, the stimulation to the human body is Larger, most of the above products have no pleasant scent and can only sterilize and inhibit bacteria and have no mosquito repellent effect.

大部分使用精油來生產的抑菌產品需要稀釋後使用酒精或是乳化劑來達成精油分散的應用,產生水包油或是油包水的均勻液體來製成商品,使用高濃度的酒精來製成的產品有易燃的危險,存放於高溫處及 接近火源都容易產生危險,噴灑於皮膚上會將水分共同揮發造成皮膚乾燥產生不適感;使用乳化劑的產品型態多屬於乳白色液體,靜置一段時間也容易造成油水分離的現象,而本新型則是可以讓稀釋的精油產品穩定於透明清晰的液體狀態,也不會於靜置的過程後產生油水分離的狀態,在功能上可以達到抑菌殺菌與驅除蚊蟲的效果。 Most of the antibacterial products produced by using essential oils need to be diluted with alcohol or emulsifier to achieve the application of essential oil dispersion, producing a uniform liquid of oil-in-water or water-in-oil to make goods, using high concentration of alcohol to make The product is flammable and stored at high temperatures and It is easy to be dangerous when it is close to the fire source. Spraying on the skin will cause the water to volatilize together to cause dryness and discomfort. The product type using emulsifier is mostly milky white liquid. It is easy to cause oil and water separation after standing for a while. The new type can make the diluted essential oil product stable in a transparent and clear liquid state, and will not produce a state of separation of oil and water after the process of standing, and can achieve the effects of bacteriostatic sterilization and mosquito repelling in function.

本發明係為一種複方精油抑菌的組成物,包括:數種植物精油組成的複方精油;一種乳化劑,此乳化劑為親水疏水平衡值(HLB)大於10之聚氧乙烯山梨醇酐脂肪酸酯非離子界面活性劑;一種抑菌劑,此抑菌劑為Chlorhexidine Gluconate可增強複方精油的抑菌效果;一種助溶劑,為親水疏水平衡值(HLB)大於10之聚丙二醇月桂聚氧乙烯醚非離子界面活性劑;與水。其混合備製後可形成一種透明清澈淡黃色液體,具有特殊香氣並能用於殺菌抑菌及驅蚊效果的組合物。 The invention relates to a composition of a compound essential oil bacteriostatic, comprising: a compound essential oil composed of several plant essential oils; and an emulsifier, wherein the emulsifier is a polyoxyethylene sorbitan fatty acid having a hydrophilic hydrophobic equilibrium value (HLB) greater than 10. Ester nonionic surfactant; a bacteriostatic agent, Chlorhexidine Gluconate enhances the antibacterial effect of the compound essential oil; a co-solvent is a polypropylene glycol lauric ethoxylate having a hydrophilic hydrophobic equilibrium value (HLB) greater than 10. Nonionic surfactant; with water. The mixture can be prepared to form a transparent clear yellowish liquid, which has a special aroma and can be used for bactericidal and antibacterial effects.

其中複方精油選擇可以依照個人喜好的精油香氣來做調配,但若要達成殺菌抑菌與驅蚊的功效於本發明中選用茶樹精油與尤加利精油調配而成的基礎配方後再加入其他因應香味所需的精油配方,其中茶樹精油具有醇類架構主要成分為Terpinen-4-ol及α-Terpineol等可造成蛋白質變性破壞細胞膜及溶解脂質產生抑菌殺菌的效果,整體濃度於0.75%時對於金黃色葡萄球菌、化膿性鏈球菌、肺炎鏈球菌、噬血桿菌、大腸桿菌等都有良好的抑制性;尤加利精油含有p-menthane 3,8-diol(PMD)成分,為植物性的驅蚊成分,將此兩種精油調配成複方精油的基礎配方則可以達成抑菌殺菌與驅蚊的功效。 The essential oil selection can be formulated according to the preference of the individual's favorite essential oil, but if the antibacterial and anti-mosquito effect is to be achieved, the basic formula formulated by the tea tree oil and the eucalyptus oil is used in the present invention, and then other reactions are added. The essential oil formula required for the fragrance, wherein the tea tree essential oil has the main components of the alcohol structure, such as Terpinen-4-ol and α-Terpineol, which can cause the protein denaturation to destroy the cell membrane and dissolve the lipid to produce antibacterial and bactericidal effect. The overall concentration is 0.75%. Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus, Escherichia coli, etc. have good inhibition; Eucalyptus essential oil contains p-menthane 3,8-diol (PMD) component, which is vegetal Mosquito repellent ingredients, the basic formula of the two essential oils formulated into compound essential oils can achieve antibacterial sterilization and mosquito repellent effects.

其中聚氧乙烯山梨醇酐脂肪酸酯可以達成乳化精油成分的功效成為水包油成分的液體組成,但濃度過高時亦容易對皮膚產生刺激,所以必須控制於整體濃度10%以下可避免皮膚刺激,而其低濃度時對於皮膚、黏膜等神經末梢可產生麻醉作用,故能對於蚊蟲叮咬的搔癢感或疼痛感有舒緩的作用,此類成分也常見於具有舒緩功能的軟膏製品。 Among them, the polyoxyethylene sorbitan fatty acid ester can achieve the emulsified essential oil component and become a liquid component of the oil-in-water component. However, when the concentration is too high, it is easy to cause irritation to the skin, so it is necessary to control the skin concentration to be 10% or less to avoid skin. Stimulation, while at low concentrations, it can produce anesthetic effects on nerve endings such as skin and mucous membranes, so it can relieve the itching or pain of mosquito bites. Such ingredients are also commonly found in ointment products with soothing function.

其中助溶劑月桂醇類非離子界面活性劑(聚丙二醇月桂聚氧乙烯醚)可以維持組合物的穩定清澈透明狀態,若僅以乳化劑成分聚氧乙烯山梨醇酐脂肪酸酯僅能使組合液體型態為乳白色液體,並且靜置數日後會呈現油水分離的狀態。 The cosolvent lauryl alcohol nonionic surfactant (polypropylene glycol lauryl polyoxyethylene ether) can maintain the stable and transparent state of the composition, and if only the emulsifier component polyoxyethylene sorbitan fatty acid ester can only make the combined liquid The form is a milky white liquid, and after standing for a few days, the oil and water are separated.

其中抑菌劑Chlorhexidine Gluconate為安全溫和的抑菌成分,對於革蘭氏陽性菌、革蘭氏陰性菌與真菌均有殺滅與抑制的效果,經常應用於外科手術清潔液、傷口處理、抗菌漱口水、口腔護理產品中,為溫和有效的抗菌成份,我國法規限量為0.05%。 Among them, the bacteriostatic agent Chlorhexidine Gluconate is a safe and mild antibacterial ingredient. It has the effect of killing and inhibiting Gram-positive bacteria, Gram-negative bacteria and fungi. It is often used in surgical cleaning fluids, wound treatment, antibacterial agents. Among the saliva and oral care products, it is a mild and effective antibacterial ingredient, and the regulatory limit in China is 0.05%.

本發明之組合物對於生活上常見的金黃色葡萄球菌、大腸桿菌、綠膿桿菌與白色念珠菌都有卓越的殺滅與抑制效果,尤其是抑菌的時效性均能比酒精與次氯酸水的產品表現更佳,使用的乳化劑、助溶劑與抑菌劑都是屬於溫和不刺激的化妝品添加物,可以有效提高本組合物的安全使用範圍,除了抑菌安全有效外,複方的精油成分所產生的天然具有令人清新舒爽的香味,因含有p-menthane 3,8-diol(PMD)使本發明同時也具有驅蚊的效果。 The composition of the invention has excellent killing and inhibiting effects on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans which are common in life, especially the bacteriostatic time-effect is better than alcohol and hypochlorous acid. The water products perform better. The emulsifiers, cosolvents and bacteriostatic agents used are mild and non-irritating cosmetic additives, which can effectively improve the safe use range of the composition. In addition to the antibacterial safety and effectiveness, the compound essential oil The natural hyalinous fragrance produced by the ingredients has the effect of repelling mosquitoes by containing p-menthane 3,8-diol (PMD).

調配時須先將油相成分先行調配,以成品100公克為例:調配複方精油成分占總成分3.3%其中含:尤加利50%、天竺葵5%、茶樹35%、薄荷5%、廣藿香5%;調和乳化劑為HLB>10之聚氧乙烯山梨醇酐脂肪酸酯與精油比為2.5:1;調和助溶劑HLB>10之聚丙二醇月桂聚氧乙烯醚非離子界面活性劑為總比例1%;加入溫和抑菌劑Chlorhexidine Gluconate 250ppm後經高速攪拌機攪拌30分鐘均勻混合後添加無菌水至總重量為100公克再使用高速攪拌機攪拌60分鐘至液體呈現清澈透明琥珀色狀態即可。 When blending, the oil phase ingredients must be firstly formulated, taking 100 grams of finished product as an example: compound essential oil components account for 3.3% of the total composition, including: eucalyptus 50%, geranium 5%, tea tree 35%, mint 5%, 藿5% fragrance; blending emulsifier is HLB>10 polyoxyethylene sorbitan fatty acid ester and essential oil ratio of 2.5:1; blending cosolvent HLB>10 polypropylene glycol laurel polyoxyethylene ether nonionic surfactant for total The ratio was 1%; the mild bacteriostatic agent Chlorhexidine Gluconate 250 ppm was added, and the mixture was stirred for 30 minutes by a high-speed mixer, and then mixed with sterile water to a total weight of 100 g and stirred for 60 minutes using a high-speed mixer until the liquid was in a clear transparent amber state.

Claims (7)

一種有香味可抑菌與驅蚊效果的複方精油組合物,包括一複方精油佔總成分3.3%由尤加利50%、天竺葵5%、茶樹35%、薄荷5%、廣藿香5%組成;一種乳化劑為親水疏水平衡值(HLB)大於10非離子界面活性劑聚氧乙烯山梨醇酐脂肪酸酯與精油比為2.5:1,故為預訂調和總量8.25%;一種溫和抑菌劑Chlorhexidine Gluconate為預訂調和總量250ppm;一種助溶劑,為親水疏水平衡值(HLB)大於10之聚丙二醇月桂聚氧乙烯醚非離子界面活性劑為預訂調和總量1%;與水,其混合備製後可形成一種透明清澈淡黃色液體,具有特殊香氣並能用於殺菌抑菌及驅蚊效果的組合物。 A compound essential oil composition having aroma inhibiting and mosquito repellent effect, comprising a compound essential oil accounting for 3.3% of the total composition, consisting of eucalyptus 50%, geranium 5%, tea tree 35%, mint 5%, patchouli 5% An emulsifier having a hydrophilic hydrophobic equilibrium value (HLB) greater than 10 nonionic surfactants. The ratio of polyoxyethylene sorbitan fatty acid ester to essential oil is 2.5:1, so the total amount of the blend is 8.25%; a mild bacteriostatic agent Chlorhexidine Gluconate is a total of 250ppm for the preparation of a blend; a cosolvent, a polypropylene glycol urethane ether nonionic surfactant with a hydrophilic hydrophobic equilibrium (HLB) greater than 10 is 1% of the total amount of the blend; After the preparation, a transparent clear yellow liquid can be formed, which has a special aroma and can be used for bactericidal and antibacterial effects. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中該複方精油有茶樹與尤加利精油組成。 A compound essential oil composition having a scent-inhibiting and mosquito repellent effect according to the first aspect of the patent application, wherein the compound essential oil is composed of a tea tree and an eucalyptus essential oil. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中複方精油成分佔總成分3.3%其中含:尤加利50%、天竺葵5%、茶樹35%、薄荷5%、廣藿香5%。 According to the first application of the patent scope, the compound essential oil composition with bactericidal and anti-mosquito effect, wherein the compound essential oil component accounts for 3.3% of the total composition, including: eucalyptus 50%, geranium 5%, tea tree 35%, mint 5%, 5% of patchouli. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中該乳化劑為親水疏水平衡值(HLB)大於10聚氧乙烯山梨醇酐脂肪酸酯成分組成與精油比例為2.5:1。 The compound essential oil composition having the scent bacteriostatic and mosquito repellent effect according to the first aspect of the patent application, wherein the emulsifier has a hydrophilic hydrophobic equilibrium value (HLB) greater than 10 polyoxyethylene sorbitan fatty acid ester component composition and essential oil The ratio is 2.5:1. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中助溶劑(HLB)大於10之聚丙二醇月桂聚氧乙烯醚非離子界面活性劑組成為組合物比例1%。 A compound essential oil composition having a scent-inhibiting and mosquito repellent effect according to the first aspect of the patent application, wherein the polypropylene glycol laurel polyoxyethylene ether nonionic surfactant having a cosolvent (HLB) greater than 10 is composed of a composition ratio of 1 %. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中包含一種溫和抑菌劑Chlorhexidine Gluconate成分組成 濃度為250ppm。 A compound essential oil composition having a bactericidal and bacteriostatic effect according to the first application of the patent scope, which comprises a mild bacteriostatic agent Chlorhexidine Gluconate The concentration is 250 ppm. 根據申請專利範圍第1項之有香味可抑菌與驅蚊效果的複方精油組合物,其中功效可達成抑菌殺菌與驅蚊效果。 The compound essential oil composition having the scent bacteriostatic and mosquito repellent effect according to the first item of the patent application scope, wherein the efficacy can achieve bacteriostatic sterilization and mosquito repellent effect.
TW105113239A 2016-04-28 2016-04-28 Compound essential oil composition capable of inhibiting bacteria and repelling mosquitoes TWI608800B (en)

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CN102911788A (en) * 2012-09-25 2013-02-06 华南理工大学 Water-soluble tea tree oil and method for preparing same
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