TWI565476B - 基於肽之活體內ｓｉＲＮＡ傳遞系統 - Google Patents

基於肽之活體內ｓｉＲＮＡ傳遞系統 Download PDF

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Publication number
TWI565476B
TWI565476B TW101143327A TW101143327A TWI565476B TW I565476 B TWI565476 B TW I565476B TW 101143327 A TW101143327 A TW 101143327A TW 101143327 A TW101143327 A TW 101143327A TW I565476 B TWI565476 B TW I565476B
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TW
Taiwan
Prior art keywords
melittin
peptide
composition
seq
galactosamine
Prior art date
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TW101143327A
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English (en)
Chinese (zh)
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TW201325622A (zh
Inventor
大衛Ｂ 羅茲馬
戴倫Ｈ 維克菲爾德
大衛Ｌ 里維斯
瓊Ａ 沃夫
安卓Ｖ 布洛克辛
強納森Ｄ 賓森
傑福瑞Ｃ 卡爾森
菲力普 哈德維葛
艾瑞克Ａ 琪塔斯
托爾斯藤 霍夫曼
霍夫曼 琪爾斯丁 珍
彼得 摩爾
漢斯 馬丁 繆勒
古恩勒 歐特
印哥 羅爾
Original Assignee
愛羅海德麥迪森公司
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Priority claimed from US13/326,433 external-priority patent/US8501930B2/en
Application filed by 愛羅海德麥迪森公司 filed Critical 愛羅海德麥迪森公司
Publication of TW201325622A publication Critical patent/TW201325622A/zh
Application granted granted Critical
Publication of TWI565476B publication Critical patent/TWI565476B/zh

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW101143327A 2011-12-15 2012-11-20 基於肽之活體內ｓｉＲＮＡ傳遞系統 TWI565476B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/326,433 US8501930B2 (en) 2010-12-17 2011-12-15 Peptide-based in vivo siRNA delivery system

Publications (2)

Publication Number Publication Date
TW201325622A TW201325622A (zh) 2013-07-01
TWI565476B true TWI565476B (zh) 2017-01-11

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TW101143327A TWI565476B (zh) 2011-12-15 2012-11-20 基於肽之活體內ｓｉＲＮＡ傳遞系統

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AR (1) AR089244A1 (ar)
SA (1) SA112340077B1 (ar)
TW (1) TWI565476B (ar)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129672A1 (en) * 2009-05-05 2010-11-11 Miragen Therapeutics Lipophilic polynucleotide conjugates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129672A1 (en) * 2009-05-05 2010-11-11 Miragen Therapeutics Lipophilic polynucleotide conjugates

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEGENDRE, J. Y., et al. Dioleoylmelittin as a novel serum-insensitive reagent for efficient transfection of mammalian cells. Bioconjugate chemistry, 1997, 8.1: 57-63. *
WOLFRUM, Christian, et al. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature biotechnology, 2007, 25.10: 1149-1157. *

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Publication number Publication date
SA112340077B1 (ar) 2015-11-10
TW201325622A (zh) 2013-07-01
AR089244A1 (es) 2014-08-06

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