TWI552776B - Blood purification device - Google Patents

Description

Blood purification device

The present invention relates to a blood purification device.

Conventionally, blood purification therapy for purifying blood of patients such as acute renal failure has been subjected to continuous hemodiafiltration (CHDF) treatment, and various blood purification treatments have been developed. Purification device (for example, refer to Patent Documents 1 and 2)

In addition, a new blood purification therapy called PDF (Plasma Dia-filtration) for the purpose of purifying the blood of patients with acute liver failure and the like is being designed, and the treatment is now being studied (for example, refer to the non-patent Document 1). In addition, the term "PDF" refers to the use of a plasma separator having a hollow fiber membrane having a predetermined sieve coefficient, while permeating a dialysate on the outside of the hollow fiber membrane while performing simple plasma exchange (Plasma Exchange: PE).

[Previous Technical Literature] [Patent Literature]

Patent Document 1: Japanese Patent Laid-Open Publication No. 2001-541

Patent Document 2: Japanese Patent Laid-Open Publication No. 2003-126247

[Non-patent literature]

Non-Patent Document 1: Yoshioka Fukuoka, 13 outside, "Plasma Dialysis of the effectiveness of Dia-filtration (PDF)-Selective plasma filtration with dialysis, ICU and CCU Centralized Therapeutic Medicine Vol.32 Supplement, 2008, p.93-96

However, when the PDF is actually performed, as described in FIG. 1 of Non-Patent Document 1, a blood purification device including a blood pump, a dialysate pump, a filtrate pump, and a rehydration pump is prepared (hereinafter referred to as "a well-known blood." At the same time as the purification device"), a pump device including an infusion pump for delivering the replacement fluid to the vein side circuit must be separately prepared. That is, since it is necessary to prepare two devices at a time, it is impossible to deny the complexity of the device preparation work.

Further, each of the pump and the replacement fluid infusion pump in the conventional blood purification device is configured to be separately incorporated into a different device, and the flow rate of the pump is also controlled separately. Therefore, when the flow rate of the infusion pump is set in accordance with the flow rate of a pump (for example, a blood pump) included in a conventional blood purification device, when the flow rate of the pump included in the conventional blood purification device changes, the infusion must be manually adjusted. Pump flow. It is assumed that if the flow rate adjustment operation of the infusion pump is manually performed next to the device, since the PDF is performed over a relatively long period of time (for example, 8 to 9 hours for one course of treatment), the burden on the user of the device becomes considerable. However, if the flow rate adjustment of the infusion pump is not performed, there is a possibility that the blood of the patient such as a decrease in serum protein concentration is impaired, and there is a fear that the result is unfavorable to the patient.

Accordingly, the present invention has been made in order to solve such a problem, and an object of the present invention is to provide a blood purification device which can eliminate the cumbersome preparation work of the device and can reduce the burden on the user of the device while ensuring the safety of the patient.

The blood purification device of the present invention is a user in a blood purification system, the blood purification system comprising: a blood purifier, the inside of which is divided into a blood flow path and other flow paths, and includes a first phase communicating with one end of the blood flow path a first inflow portion communicating with the other end of the blood flow path, a second inflow portion communicating with one end of the other flow path, and a second outflow portion communicating with the other end of the other flow path; an artery side a circuit connected to the first inflow portion; a vein side circuit connected to the first outflow portion; a dialysate circuit connected to the second inflow portion; and a waste liquid circuit connected to the second outflow portion And passing the waste liquid from the second outflow portion; the first circuit is connected to the vein side circuit and transmits the first liquid; and the second circuit is connected to the artery side circuit, the vein side circuit or The first circuit transmits the second liquid; the blood purification device includes a plurality of pumps and a control unit that controls driving of the plurality of pumps, and the plurality of pumps includes a blood pump. And a dialysate pump for delivering the dialysate on the dialysate circuit to the blood purifier; and a waste pump for using the above The waste liquid on the waste liquid circuit is sent out; the first pump is configured to transport the first liquid on the first circuit to the vein side circuit; and the second pump is used The second liquid on the second circuit is supplied to the artery side circuit, the vein side circuit, or the first circuit; and the control unit controls the flow rate of the first pump and the flow rate of the second pump in conjunction with each other.

Therefore, the blood purification device according to the present invention is configured such that the above five pumps are incorporated in the device, and the first pump or the second pump can function as an infusion pump. Therefore, it is not necessary to specially prepare a pump device including an infusion pump. .

Further, according to the blood purification apparatus of the present invention, since the control unit controls the flow rate of the first pump and the flow rate of the second pump in conjunction with each other, the flow rate adjustment of the second pump accompanying the flow rate fluctuation of the first pump can be automatically performed (or accompanying The flow rate of the first pump in which the flow rate of the second pump fluctuates). In other words, it is not necessary to wait for the flow rate adjustment operation to wait for the device, and since the flow rate adjustment of the first pump and the second pump can be accurately performed, the safety of the patient can be sufficiently ensured.

Therefore, the blood purification device of the present invention is a blood purification device which can eliminate the cumbersome preparation work of the device and can reduce the burden on the user of the device while ensuring the safety of the patient.

In this specification, the "first liquid" means a liquid different from the blood of the patient, and the "second liquid" means a liquid different from the blood of the patient and the first liquid.

In the blood purification device of the present invention, preferably, the control unit controls the flow rate of at least one of the first pump and the second pump and the flow rate of the waste liquid pump in conjunction with each other.

By being configured in this manner, the flow rate of the waste liquid pump can be automatically changed. The flow rate adjustment of the first pump and the second pump is performed.

In the blood purification device of the present invention, preferably, the control unit controls the flow rate of at least one of the first pump and the second pump and the flow rate of the blood pump in conjunction with each other.

According to this configuration, the flow rate adjustment of the first pump and the second pump can be automatically performed in accordance with the flow rate fluctuation of the blood pump.

Preferably, the blood purification device according to the present invention further includes a setting input unit for setting a flow rate input to each of the pumps, and the control unit adjusts a flow rate of each pump based on a set value input by the setting input unit.

According to this configuration, for example, the flow rate of the second pump (that is, the change in the flow ratio between the first pump and the second pump) can be changed while the flow rate of the first pump is fixed, or all the pumps can be made. When the flow rate ratio is the same, the amount of blood flowing through the blood purifier or the like is changed, and the blood purification device is excellent in that it can be widely used for the purpose of the user.

According to the blood purification device of the present invention, since the first pump or the second pump can function as an infusion pump, it is not necessary to specially prepare a pump device including the infusion pump. Further, since the control unit controls the flow rate of the first pump and the flow rate of the second pump in conjunction with each other, the flow rate adjustment of the second pump accompanying the flow rate fluctuation of the first pump can be automatically performed (or the flow rate accompanying the flow rate of the second pump) 1 pump flow adjustment). As a result, the complexity of the device preparation work can be eliminated, and the burden on the device user can be reduced on the basis of ensuring the safety of the patient.

Hereinafter, the blood purification device of the present invention will be described based on the embodiment shown in the drawings.

[Embodiment]

First, the configuration of the blood purification system 1 for performing blood purification will be described with reference to Figs. 1 to 3 .

Fig. 1 is a view showing the configuration of a blood purification system 1 including a blood purification device 80 according to an embodiment of the present invention.

2(a) and 2(b) are views showing the blood purifier 10. 2(a) is a side view of the blood purifier 10, and FIG. 2(b) is a conceptual view showing the internal structure of the blood purifier 10. In addition, in FIG. 2(b), in order to make the invention easy to understand, only one of the plurality of selective separation membranes 12, which is originally disposed in the blood purifier 10, is schematically illustrated.

FIG. 3 is a block diagram showing the electrical configuration of the blood purification device 80.

As shown in FIG. 1, FIG. 2(a) and FIG. 2(b), the blood purification system 1 includes a blood purifier 10, an arterial side circuit 20 connected to the first inflow portion 15 of the blood purifier 10, and a vein. The side circuit 30 is connected to the first outflow portion 16 of the blood purifier 10; the dialysate circuit 40 is connected to the second inflow portion 17 of the blood purifier 10; the dialysate storage container 42 is capable of storing dialysate; The liquid circuit 50 is connected to the second outflow portion 18 of the blood purifier 10 and transmits the waste liquid from the second outflow portion 18; the first circuit 60 is connected to the vein side circuit 30 and serves as the first liquid. Replenishing solution a storage container 62 for storing a replenishing liquid; a second circuit 70 connected to the vein side circuit 30 and transmitting a replacement liquid as a second liquid; a replacement liquid storage container 72 for storing a replacement liquid; and a blood purification device 80.

As shown in Fig. 2 (a) and Fig. 2 (b), the blood purifier 10 includes a cylindrical casing portion 11 and a selective separation membrane 12 disposed inside the casing portion 11 and a first inflow portion. 15 . The first inflow portion 16 is disposed at one end of the housing portion 11 , and the second inflow portion 17 is disposed between the side surfaces of the housing portion 11 . The position of the outflow portion 16 and the second outflow portion 18 are provided at a position close to the first inflow portion 15 of the side surface of the casing portion 11.

The selective separation membrane 12 includes, for example, a hollow fiber membrane. Although not shown in the drawings, a plurality of selective separation films 12 are arranged to extend in the longitudinal direction of the casing portion 11 inside the casing portion 11.

The inside of the blood purifier 10 is divided into a blood flow path 13 and other flow paths 14 by the selective separation membrane 12 as shown in Fig. 2(b). That is, the inside of the selective separation membrane 12 serves as the blood flow path 13, and the outer side of the selective separation membrane 12 becomes the other flow path 14. The first inflow portion 15 and the first outflow portion 16 communicate with the blood flow path 13 , and the second inflow portion 17 and the second outflow portion 18 communicate with the other flow paths 14 . The blood purifier 10 is configured to reverse the flow direction of the blood flow path 13 (the direction of the black arrow in FIG. 2(b)) and the flow direction of the other flow path 14 (the direction of the hollow arrow in FIG. 2(b)) during blood purification. The way of direction (that is, the way to become a counterflow).

As the blood purifier 10, for example, Evacure EC-2A (having a sieve coefficient of blood protein of about 0.3, "Evacure" is a registered trademark of Chuancheng Chemical Industry Co., Ltd.) or the like can be preferably used. As the blood purifier, it is preferred to use a selective separation membrane having a sieve coefficient of blood protein of more than 0 and less than 1.

As shown in FIG. 1, an air trap 22 and a rolling tube portion 24 are provided in the middle of the artery side circuit 20. Further, although not described in FIG. 1, an anticoagulant injection line for introducing an anticoagulant into the circuit is connected in the middle of the artery side circuit 20, and is provided to sense the pressure in the artery side circuit 20. Pressure sensor.

A gas trap 32 is provided in the middle of the vein side circuit 30. Further, although not shown in FIG. 1, a bubble sensor is provided in the middle of the vein side circuit 30, and a venous pressure sensor is connected to the air trap 32.

The tube portions 44 and 54 are provided in the middle of the dialysate circuit 40 and the waste liquid circuit 50, respectively. Further, although not shown in FIG. 1, a pressure sensor for sensing the pressure in the waste liquid circuit 50 is provided in the middle of the waste liquid circuit 50.

The rolling pipe portions 64 and 74 are provided in the middle of the first circuit 60 and the second circuit 70, respectively. The end of the first circuit 60 is connected to the position of the vein side circuit 30 from the connection portion with the blood purifier 10 to the gas trap 32. The end of the second circuit 70 is connected to the gas trap 32 of the vein side circuit 30.

The dialysate storage container 42, the replenishing liquid storage container 62, and the replacement liquid storage container 72 are detachably and detachably attached to the end portions of the dialysate circuit 40, the first circuit 60, and the second circuit 70, respectively. Dialysate storage container 42, supplement The liquid storage container 62 and the replacement liquid storage container 72 are, for example, plastic storage bags. As the dialysate and the replenishing solution, for example, SubloodBS ("Sublood" is a registered trademark of Fuso Pharmaceutical Co., Ltd.) or the like can be preferably used. As the replacement liquid, for example, fresh frozen plasma (FFP) or a 5%, 20%, 25% blood protein solution or the like is preferably used. Further, as the dialysate, the replenisher, and the replacement solution, of course, those other than those exemplified herein may be used.

As shown in FIGS. 1 and 3, the blood purification device 80 includes a blood pump 81 for delivering blood on the arterial side circuit 20 to the blood purifier 10, and a dialysate pump 82 for purifying the blood. The device 10 delivers the dialysate on the dialysate circuit 40; the waste pump 83 is configured to deliver the waste liquid on the waste liquid circuit 50; and the first pump 84 is configured to deliver the first circuit to the vein side circuit 30. a replenishing liquid on 60; a second pump 85 for supplying a replacement liquid on the second circuit 70 to the vein side circuit 30; and a power supply unit 86 for supplying electric power to each part in the blood purification device 80; The input unit 87 is disposed on the outer surface of the blood purification device 80 and receives input from an operator. The display unit 88 is disposed on the outer surface of the blood purification device 80 and displays blood flowing in the circuit. Various information such as temperature information or venous pressure information measured by a venous pressure sensor; memory unit 89, performance data of a blood purifier used for memory; and control unit 90 for each of blood purification devices 80 Partially controlled.

Furthermore, in FIG. 1, the line extending from the control unit 90 to each of the pumps 81 to 85 is shown. Indicates the signal line.

The blood pump 81, the dialysate pump 82, the waste liquid pump 83, the first pump 84, and the second pump 85 are so-called roller pumps. Though the description of the illustration is omitted, the roller portion of the blood pump 81 is rotated in contact with the rolling tube portion 24 of the artery side circuit 20 (the drawn tube portion 24), so that the artery side circuit 20 can be placed. The liquid (blood) is supplied in a predetermined direction. The functions of the other pumps 82 to 85 are also the same as those of the blood pump 81.

Although the illustration is omitted, the setting input unit 87 is configured to be able to input the flow rate of each pump, the flow rate ratio of the pumps, and other set values. Further, the setting input unit 87 and the display unit 88 may be configured separately, or may be, for example, a touch panel type display in which an input portion and a display portion are integrated.

As shown in FIG. 3, the control unit 90 includes at least a pump drive control unit F1 that controls the driving of the five pumps 81 to 85, and a pump flow rate adjustment unit F2 that is based on the set value input to the setting input unit 87. The flow rate of each pump is adjusted; the first interlocking control unit F3 controls the flow rates of the first pump 84 and the second pump 85 in conjunction with the flow rate of the blood pump 81, and the second interlocking control unit F4 controls the first pump in conjunction with each other. The flow rate of the 84 and the second pump 85 and the flow rate of the waste pump 83; and the third interlocking control unit F5 control the flow rate of the first pump 84 and the flow rate of the second pump 85 in conjunction with each other.

The pump drive control unit F1 reads the flow rate information of the five pumps 81 to 85 stored in the memory unit 89, and controls the driving of the pumps 81 to 85 based on the information. That is, based on the settings of the pumps 81 to 85 previously stored in the memory unit 89. The flow rate is fixed, and the rotational driving of each of the pumps 81 to 85 is controlled.

The setting input unit 87 generates setting value information on the input setting value. The pump flow rate adjustment unit F2 receives the set value information generated by the setting input unit 87, and adjusts the flow rates of the pumps 81 to 85 based on the set value information.

The first interlocking control unit F3 controls the flow rate of at least one of the first pump 84 and the second pump 85 in conjunction with the adjustment of the flow rate of the blood pump 81.

For example, when a negative pressure is generated due to kinking of the tubular body or the like, and the pressure fluctuation of the arterial side circuit 20 is sensed by the pressure sensor provided in the arterial side circuit 20, the sensing information is transmitted to the pump drive control. Department F1. The pump drive control unit F1 reads the flow rate information stored in the memory unit 89, and based on the information, controls the drive of the blood pump 81 so that the blood pump 81 rotates at a safer flow rate. The first interlocking control unit F3 controls at least the first pump 84 and the second pump 85 in conjunction with each other in order to prevent the balance between the amount of blood which is caused by the blood flow of the blood pump 81 and the amount of blood to be replenished/replaced from collapsing. The flow of a pump.

When the flow rate of the blood pump 81 is adjusted by the pump flow rate adjusting unit F2, the first interlocking control unit F3 can control the flow rate of at least one of the first pump 84 and the second pump 85 in a coordinated manner. That is, the flow rate of the blood pump 81 is set only by setting the input unit 87, whereby the flow rates of the first pump 84 and the second pump 85 are also changed. An example of adjusting the flow rate of the blood pump 81 by the pump flow rate adjustment unit F2 is, for example, a case where the state of the patient is observed and it is desired to change the amount of blood discharge.

The second interlocking control unit F4 controls the flow rate of at least one of the first pump 84 and the second pump 85 in conjunction with the adjustment of the flow rate of the waste liquid pump 83.

For example, when the blood purifier is clogged, the pressure change of the waste liquid circuit 50 is sensed by the pressure sensor provided in the waste liquid circuit 50, and the sensed information is transmitted to the pump drive control portion F1. The pump drive control unit F1 reads the flow rate information stored in the storage unit 89, and based on the information, controls the drive of the waste liquid pump 83 so that the waste liquid pump 83 rotates at an appropriate flow rate. The second interlocking control unit F4 controls the flow rates of the first pump 84 and the second pump 85 in conjunction with each other in order to prevent the balance between the amount of the waste liquid and the amount of the liquid to be replenished/replaced from being collapsed by adjusting the flow rate of the waste liquid pump 83.

When the flow rate of the waste liquid pump 83 is adjusted by the pump flow rate adjusting unit F2, the second interlocking control unit F4 can control the flow rate of at least one of the first pump 84 and the second pump 85 in a coordinated manner. That is, the flow rate of the waste liquid pump 83 is set only by the setting input unit 87, whereby the flow rates of the first pump 84 and the second pump 85 are also changed. As an example of adjusting the flow rate of the waste liquid pump 83 by the pump flow rate adjustment unit F2, for example, it is desirable to change the amount of water removal due to a change in the condition such as a decrease in blood pressure of the patient.

The third interlocking control unit F5 adjusts the flow rate of one of the first pump 84 and the second pump 85 in cooperation with the pump flow rate adjusting unit F2, and controls the flow rate of the other pump in conjunction with each other.

According to the blood purification apparatus 80 of the embodiment configured as described above, the five pumps 81 to 85 are incorporated in the apparatus, and the second pump 85 can be incorporated. As a function of the infusion pump, there is no need to specially prepare a pump device including an infusion pump.

Further, according to the blood purification device 80 of the embodiment, the control unit 90 includes the third interlocking control unit F5, and the third interlocking control unit F5 controls the flow rate of the first pump 84 and the flow rate of the second pump 85 in conjunction with each other, thereby automatically The flow rate adjustment of the second pump 85 accompanying the flow rate fluctuation of the first pump 84 (or the flow rate adjustment of the first pump 84 accompanying the flow rate fluctuation of the second pump 85) is performed. In other words, it is not necessary to wait for the flow rate adjustment operation to wait for the device, and since the flow rate adjustment of the first pump 84 and the second pump 85 is accurately performed, the safety of the patient can be sufficiently ensured.

Therefore, the blood purification device 80 of the embodiment is a blood purification device that can eliminate the cumbersome preparation work of the device and can reduce the burden on the user of the device while ensuring the safety of the patient.

In the blood purification device 80 of the embodiment, the control unit 90 further includes the first and second interlocking control units F3 and F4, so that the first pump can be automatically performed in accordance with the flow rate fluctuation of the blood pump 81 or the waste liquid pump 83. 84 and the second pump 85 flow adjustment.

In the blood purification device 80 of the embodiment, the control unit 90 further includes the pump flow rate adjustment unit F2. Therefore, for example, the flow rate of the second pump 85 can be changed while the flow rate of the first pump 84 is fixed (that is, the first pump) The ratio of the flow rate of 84 to the second pump 85 is changed, or the amount of blood flowing through the blood purifier 10 can be changed in a state where the flow ratios of all the pumps 81 to 85 are matched, thereby It is an excellent blood purification device that can be widely used in accordance with the purpose of the user.

Here, the characteristics of the embodiment of the blood purification apparatus of the present invention described above are summarized as the following items i to iv.

[i] A blood purification device 80, which is a user of the blood purification system 1, which includes a blood purifier 10, the inside of which is divided into a blood flow path 13 and other flow paths 14, and includes and a first inflow portion 15 through which one end of the blood flow path 13 communicates, a first outflow portion 16 that communicates with the other end of the blood flow path 13, a second inflow portion 17 that communicates with one end of the other flow path 14, and other flow paths The second outflow portion 18 communicated with the other end of the 14; the artery side circuit 20 is connected to the first inflow portion 15; the vein side circuit 30 is connected to the first outflow portion 16; and the dialysate circuit 40 is connected to the second portion The inflow portion 17; the waste liquid circuit 50 is connected to the second outflow portion 18, and transmits the waste liquid from the second outflow portion 18; the first circuit 60 is connected to the vein side circuit 30, and transmits the first liquid. And a second circuit 70 connected to the artery side circuit 20, the vein side circuit 30, or the first circuit 60, and transmitting the second liquid; the blood purification device 80 is characterized by including a plurality of pumps and the plurality of pumps The control unit 90 for controlling the driving of the pump includes, as a plurality of pumps, a blood pump 81, which is used The blood on the arterial side circuit 20 is delivered to the blood purifier 10; the dialysate pump 82 is used to deliver the dialysate on the dialysate circuit 40 to the blood purifier 10; the waste liquid pump 83 is used to waste The waste liquid on the liquid circuit 50 is sent out; the first pump 84 is used The first liquid on the first circuit 60 is sent to the vein side circuit 30; and the second pump 85 is used to transport the second circuit 70 to the artery side circuit 20, the vein side circuit 30, or the first circuit 60. 2 liquid; and the control unit 90 controls the flow rate of the first pump 84 and the flow rate of the second pump 85 in conjunction with each other.

[ii] The blood purification device 80 of the above [i], wherein the control unit 90 further controls the flow rate of at least one of the first pump 84 and the second pump 85 and the flow rate of the waste liquid pump 83 in conjunction with each other.

[iii] The blood purification device 80 of the above [i] or [ii], wherein the control unit 90 further controls the flow rate of at least one of the first pump 84 and the second pump 85 and the flow rate of the blood pump 81 in conjunction with each other.

[IV] The blood purification device 80 according to any one of the above [i] to [iii], further comprising a setting input unit 87 for setting a flow rate input to each of the pumps 81 to 85, and the control unit 90 is based on the setting input unit 87. The set value input in the medium is adjusted for the flow rate of each of the pumps 81 to 85.

The blood purification device of the present invention has been described above based on the above-described embodiments. However, the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the spirit and scope of the invention.

(1) In the above embodiment, the case where the second circuit 70 is connected to the middle of the vein side circuit 30 (the gas trap 32) is exemplified and described, but the present invention is not limited thereto. The second circuit can be connected to the end portion of the first circuit 60 (the portion connected to the vein side circuit 30) to the rolling tube portion 64 (the arrangement position of the first pump 84) Any of the positions of the arterial side circuit 20 may be connected to any of the positions.

(2) In the above embodiment, a blood purifier having a selective separation membrane including a hollow fiber membrane is exemplified and described as a blood purifier, but the present invention is not limited thereto. For example, the present invention can also be applied to a blood purifier including a flat membrane (a laminate of a plurality of flat membranes) or a selective separation membrane other than a hollow fiber membrane such as a tubular membrane.

(3) In the above embodiment, the case where the dialysate storage container 42 and the replenishing liquid storage container 62 are separated is exemplified and described, but the present invention is not limited thereto as long as the contents of the dialysate storage container and the replenishing liquid storage container are provided. The contents are the same, and the two can be integrated.

(4) In the above embodiment, the case where the control unit 90 includes the pump drive control unit F1, the pump flow rate adjustment unit F2, and the first to third interlocking control units F3 to F5 is exemplified and described, but the present invention is not limited thereto. In addition to this, for example, the fourth interlocking control unit may be included, and the fourth interlocking control unit controls the flow rates of the first pump 84 and the second pump 85 and the flow rate of the dialysate pump 82 in conjunction with each other. In this case, the flow rate adjustment of the first pump and the second pump can be automatically performed in accordance with the flow rate fluctuation of the dialysate pump.

(5) In the above-described embodiment, the case where the so-called roller pump is used is exemplified and described as the respective pumps 81 to 85. However, the present invention is not limited thereto, and other well-known liquid supply means such as a syringe pump may be used. .

(6) In the above embodiment, it can also be configured as follows: The device is further provided with a container state sensing portion (for example, a weight meter or an ultrasonic sensor or the like) that senses a decrease in the amount of the storage container, and based on the sensing information obtained by the container state sensing portion, the liquid is made The pump of the reduced storage container is slow to drive. In this case, for example, when the amount of liquid in which the replenishing liquid storage container 62 or the replacement liquid storage container 72 is sensed is reduced, the pump (one pump) can be driven to slow down the storage of the liquid storage container based on the sensing information. And can drive the drive of another pump slower. Thereby, even if the amount of liquid in the storage container is reduced, the storage container can be made empty.

Furthermore, the container state sensing unit may be disposed in the blood purification system separately from the blood purification device.

(7) In the above embodiment, the blood purification device may be configured such that: a pressure sensing unit that measures a pressure at a predetermined position in the circuit; and an inter-membrane pressure difference calculation unit that is based on the pressure feeling The pressure difference between the membranes of the blood purifier (TMP, Trans Membrane Pressure) is calculated by measuring the measurement information of the measuring unit; when the calculated pressure difference between the membranes exceeds a predetermined value, the driving of the first pump 84 and the second pump 85 is changed. slow. The case where the pressure difference between the membranes exceeds a predetermined value implies that there is a possibility that the selective separation membrane of the blood purifier is clogged by protein or the like, and therefore, for example, either one of the replenishing liquid storage container 62 or the replacement liquid storage container 72 is advanced. When the liquid which is used to eliminate the clogging effect is filled, when the pressure difference between the membranes exceeds a predetermined value, the liquid which exhibits the clogging-eliminating effect can be transported into the circuit, thereby eliminating the clogging of the selective separation membrane.

Further, the pressure sensing unit and the inter-membrane pressure difference calculating unit may be disposed in the blood purification system separately from the blood purification device.

(8) In the above embodiment, the blood purification device may be configured to include an elapsed time measuring unit that measures the time from the start of the liquid supply from the storage container to the present; and the liquid feeding time The setting unit sets the time from the start of the liquid supply to the stop of the liquid supply (the liquid supply time), and reduces or stops the flow rate of the first pump 84 and the second pump 85 when the elapsed time of the measurement exceeds the liquid supply time. Alternatively, the blood purification device may be configured to: an actual amount measuring unit that measures a liquid supply amount (actual amount) from the start of liquid supply from the storage container to the present; and a reference amount setting unit The liquid supply amount (reference amount) from the start of liquid supply to the stop of liquid supply is set, and when the actual amount measured exceeds the reference amount, the flow rates of the first pump 84 and the second pump 85 are lowered or stopped. In this case, the liquid supply amount from the replenishing liquid storage container 62 or the replacement liquid storage container 72 can be adjusted in accordance with the elapsed time or the liquid supply amount.

Further, the elapsed time measuring unit, the liquid feeding time setting unit, the actual amount measuring unit, and the reference amount setting unit may be disposed separately from the blood purification device in the blood purification system.

The present invention has been described in detail with reference to the preferred embodiments of the invention. The present application is based on Japanese Patent Application No. 2011-173806, filed on Jan.

1‧‧‧Blood purification system

10‧‧‧ Blood Purifier

11‧‧‧Shell Department

12‧‧‧Selective separation membrane

13‧‧‧Blood flow

14‧‧‧Other flow paths

15‧‧‧1st inflow

16‧‧‧1st outflow

17‧‧‧2nd inflow

18‧‧‧2nd outflow

20‧‧‧Arterial side circuit

22, 32‧‧‧ gas trap

24, 44, 54, 64, 74‧ ‧ rolling department

30‧‧‧Vental side circuit

40‧‧‧ dialysate circuit

42‧‧‧ dialysate storage container

50‧‧‧ Waste circuit

60‧‧‧1st circuit

62‧‧‧Replenishing liquid storage container

70‧‧‧2nd circuit

72‧‧‧Replacement fluid storage container

80‧‧‧ blood purification device

81‧‧‧ blood pump

82‧‧‧ dialysate pump

83‧‧‧Waste pump

84‧‧‧First pump

85‧‧‧2nd pump

86‧‧‧Power Supply Department

87‧‧‧Setting input section

88‧‧‧Display Department

89‧‧‧Memory Department

90‧‧‧Control Department

F1‧‧‧Pump Drive Control Department

F2‧‧‧Pump Flow Adjustment Department

F3‧‧‧1st linkage control department

F4‧‧‧2nd linkage control department

F5‧‧‧3rd linkage control department

Fig. 1 is a view showing the configuration of a blood purification system 1 including a blood purification device 80 according to an embodiment of the present invention.

2(a) and 2(b) are views showing the blood purifier 10, Fig. 2(a) is a side view of the blood purifier 10, and Fig. 2(b) is a conceptual view showing the internal structure of the blood purifier 10.

FIG. 3 is a block diagram showing the electrical configuration of the blood purification device 80.

80‧‧‧ blood purification device

81‧‧‧ blood pump

82‧‧‧ dialysate pump

83‧‧‧Waste pump

84‧‧‧First pump

85‧‧‧2nd pump

86‧‧‧Power Supply Department

87‧‧‧Setting input section

88‧‧‧Display Department

89‧‧‧Memory Department

90‧‧‧Control Department

F1‧‧‧Pump Drive Control Department

F2‧‧‧Pump Flow Adjustment Department

F3‧‧‧1st linkage control department

F4‧‧‧2nd linkage control department

F5‧‧‧3rd linkage control department

Claims (2)

A blood purification device for use in a blood purification system, the blood purification system comprising: a blood purifier, the inside of which is divided into a blood flow path and other flow paths, and includes a communication with one end of the blood flow path a first inflow portion, a first outflow portion that communicates with the other end of the blood flow path, a second inflow portion that communicates with one end of the other flow path, and a second outflow portion that communicates with the other end of the other flow path; an artery a side circuit connected to the first inflow portion; a vein side circuit connected to the first outflow portion; a dialysate circuit connected to the second inflow portion; and a waste liquid circuit connected to the second outflow portion And passing the waste liquid from the second outflow portion; the first circuit is connected to the vein side circuit to transmit the first liquid; and the second circuit is connected to the artery side circuit and the vein side circuit Or the first circuit transmits the second liquid; the blood purification device includes a plurality of pumps and a control unit that controls driving of the plurality of pumps, and the plurality of pumps includes: Pump, which is based on for delivering the aforementioned arterial blood circuit to said blood purifier; dialysate pump that the dialysate line for delivering power to the blood purifiers a dialysate on the road; a waste liquid pump for sending the waste liquid on the waste liquid circuit; and a first pump for conveying the first liquid on the first circuit to the vein side circuit; And a second pump for transporting the second liquid on the second circuit to the artery side circuit, the vein side circuit, or the first circuit; and the control unit controls the flow rate of the first pump in conjunction with each other The flow rate of the second pump is further controlled by the control unit to control at least one of the flow rates of the first pump and the second pump and the flow rate of the blood pump and the flow rate of the waste liquid pump. The blood purification device according to claim 1, further comprising: a setting input unit for setting a flow rate input to each of the pumps, wherein the control unit is configured to flow the respective pumps based on the set value input by the setting input unit. Make adjustments.