JP6022846B2 - Blood purification apparatus and blood purification system - Google Patents

Description

  The present invention relates to a blood purification device and a blood purification system.

  Conventionally, treatment methods such as continuous hemodiafiltration (CHDF) have been performed as a blood purification therapy for purifying the blood of patients with acute renal failure, for example. Many blood purification apparatuses to be used have been developed (see, for example, Patent Documents 1 and 2). For example, in a conventional blood purification apparatus compatible with CHDF, four pumps (blood pump, dialysate pump, filtrate pump, and replenisher pump) are arranged.

JP 2001-541 A JP 2003-126247 A

  By the way, in the field where such a continuous blood purification therapy is performed, it may be desired to switch, for example, a replenisher or a replacement fluid to another type or a different concentration during the treatment.

  However, in the conventional blood purification apparatus, since only one pump for sending the replenisher is provided, in order to switch such a replenisher or replacement liquid, the apparatus is temporarily stopped. The storage bag containing the replenisher or replacement liquid must be removed from the circuit each time and replaced with a new one, which is very troublesome.

  In addition, it is not limited to the replacement of the replenisher or replacement solution, for example, even when it is desired to switch the dialysate to another type or a different concentration during the treatment, It is hard to say that conventional blood purification devices can easily cope with this. That is, the conventional blood purification apparatus is not suitable for switching the solution to be used.

  The problem of complication of the switching operation of the solution to be used is not limited to the CHDF-compatible blood purification device. For example, a continuous blood such as a blood purification device compatible with simple plasma exchange (PE). The same can occur in blood purification apparatuses used for blood purification therapy other than purification therapy.

  Therefore, the present invention has been made in view of the above circumstances, and provides a blood purification device and a blood purification system that can be handled relatively easily even when a solution to be used during treatment is to be switched. For the purpose.

  The blood purification apparatus (80) of the present invention is divided into a blood flow channel (13) and another flow channel (14), and a first inflow portion (15) communicating with one end of the blood flow channel (13). ), A blood purifier (10) having at least a first outflow part (16) communicating with the other end of the blood channel (13) and a second outflow part (18) communicating with the other channel (14); Connected to the arterial circuit (20) connected to the first inflow part (15), the venous circuit (30) connected to the first outflow part (16), and the second outflow part (18) A waste liquid circuit (50) through which the waste liquid from the second outflow part (18) passes, and a first circuit (60) connected to the vein side circuit (30) and through which the first liquid passes. , Connected to the arterial circuit (20), the venous circuit (30), or the first circuit (60) to allow the second fluid to pass therethrough. A blood purification device used in a blood purification system including at least a second circuit (70) that includes a plurality of pumps and a control unit (90) that controls driving of the plurality of pumps, and the plurality of pumps A blood pump (81) for sending blood on the artery side circuit (20) toward the blood purifier (10), and a waste liquid pump for sending out the waste liquid on the waste circuit (50) 83), a first pump (84) for delivering the first liquid on the first circuit (60) towards the venous circuit (30), and the above-mentioned on the second circuit (70) At least a second pump (85) for sending a second liquid toward the venous circuit (30) or the first circuit (60), and the control unit (90) includes the first pump Depending on whether (84) is driving Characterized in that it has a pump drive determining unit (F5) for determining whether the driving of the second pump (85).

  For this reason, according to the blood purification apparatus of the present invention, the first pump and the second pump described above are incorporated in the apparatus, and the control unit includes the pump drive determination unit described above. As long as a liquid of a different type (or different concentration) from the liquid is prepared as the second liquid and connected to the first circuit and the second circuit, respectively, it is set in the first pump and the second pump. When it is desired to switch the solution to be used during the treatment, a very smooth switching can be performed.

  Therefore, the blood purification apparatus of the present invention is a blood purification apparatus that can be handled relatively easily even when it is desired to switch the solution used during the treatment.

  In this specification, “first liquid” and “second liquid” refer to liquids different from the blood of a patient.

  In the blood purification apparatus (80) of the present invention, the pump drive determination unit stops the second pump (85) when the first pump (84) is in the drive state, and the first pump (84). When (84) is in a stopped state, it is preferable that the second pump (85) is in a driving state.

  With this configuration, when the first liquid is being sent by the first pump, the second liquid is not sent by the second pump, and the second liquid is being sent by the second pump. Sometimes, the liquid delivery of the first liquid by the first pump is stopped.

  In the blood purification apparatus of the present invention, the pump drive determination unit sets the second pump in the drive state when the first pump is in the drive state, and the pump drive determination unit when the first pump is in the stop state. The second pump is stopped, and the controller further controls the flow rates of the first pump and the second pump in conjunction with each other when both the first pump and the second pump are in the drive state. It is preferable.

  With this configuration, since the second liquid can be sent while the first liquid is being sent, for example, there is a request to send two types of solutions at a certain timing. However, the blood purification apparatus of the present invention can be handled relatively easily.

  In the blood purification apparatus (80) of the present invention, the control unit (90) further includes a flow rate of at least one of the first pump (84) and the second pump (85) in a driving state and the flow rate. It is preferable to control the flow rate of the waste liquid pump (83) in conjunction with each other.

  By comprising in this way, according to the flow volume fluctuation | variation of a waste liquid pump, it becomes possible to adjust the flow volume of a 1st pump and a 2nd pump automatically.

  In the blood purification apparatus (80) of the present invention, the control unit (90) further includes a flow rate of at least one of the first pump (84) and the second pump (85) in a driving state and the flow rate. It is preferable to control the flow rate of the blood pump (81) in conjunction with each other.

  With this configuration, it is possible to automatically adjust the flow rates of the first pump and the second pump in accordance with the flow rate fluctuation of the blood pump.

  The blood purification apparatus (80) of the present invention further includes a setting input unit (87) for setting and inputting the flow rate of each pump, and the control unit (90) is further connected to the setting input unit (87). It is preferable to adjust the flow rate of each pump based on the input set value.

  With this configuration, for example, the flow rate of the first pump can be kept constant while the flow rate of the second pump can be changed (that is, the flow rate ratio between the first pump and the second pump can be changed), or all pumps Thus, it is possible to change the amount of blood flowing through the blood purifier with the same flow rate ratio.

  The blood purification system (1) of the present invention is divided into a blood flow path (13) and another flow path (14), and a first inflow portion (15) communicating with one end of the blood flow path (13). ), A first outflow part (16) leading to the other end of the blood flow path (13), a second inflow part (17) leading to one end of the other flow path (14), and the other flow path (14). A blood purifier (10) having a second outflow portion (18) leading to the other end of the blood vessel, an arterial circuit (20) connected to the first inflow portion (15), and the first outflow portion (16). Connected to the venous side circuit (30) connected to the dialysis fluid circuit (40) connected to the second inflow part (17), the second outflow part (18), and the second outflow part ( 18) A waste liquid circuit (50) through which the waste liquid from the first liquid passage is passed, and a first time through which the first liquid is passed through the vein side circuit (30). (60) and the second circuit (70) connected to the arterial side circuit (20), the venous side circuit (30) or the first circuit (60) and through which the second fluid passes, and the present invention. Blood purification apparatus (80), and the blood purification apparatus (80) sends the dialysate on the dialysate circuit (40) toward the blood purifier (10). ).

  Therefore, according to the blood purification system of the present invention, since the above-described excellent blood purification apparatus is provided, CHDF, CHD (Continuous Hemodialysis), CHF (Continuous Hemofiltration), etc. In the case of carrying out the above, it becomes an excellent blood purification system capable of switching the replenisher or replacement liquid relatively easily.

  The blood purification system (2) of the present invention is divided into a blood flow path (213) and another flow path (214), and a first inflow portion (215) communicating with one end of the blood flow path (213). ), A blood purifier (210) having a first outflow part (216) communicating with the other end of the blood flow path (213) and a second outflow part (218) communicating with one end of the other flow path (214). The arterial circuit (20) connected to the first inflow part (215), the venous circuit (30) connected to the first outflow part (216), and the second outflow part (218). A waste liquid circuit (50) through which the waste liquid from the second outflow part (218) flows, and a first circuit (260) through which the first liquid flows through the vein circuit (30). And the artery side circuit (20), the vein side circuit (30), or the first circuit (260). Is connected to the second liquid is a second circuit (270) for passing liquid, characterized in that it comprises a blood purification apparatus of the present invention (280).

  For this reason, according to the blood purification system of the present invention, since the above-described excellent blood purification device is provided, the enforcement method of switching between two different replenishers or replacement fluids as necessary is performed relatively easily. It becomes an excellent blood purification system that can.

  The blood purification system (3) of the present invention is divided into a blood flow path (13) and another flow path (14), and a first inflow portion (15) communicating with one end of the blood flow path (13). ), A first outflow part (16) leading to the other end of the blood flow path (13), a second inflow part (17) leading to one end of the other flow path (14), and the other flow path (14). A blood purifier (10) having a second outflow portion (18) leading to the other end of the blood vessel, an arterial circuit (20) connected to the first inflow portion (15), and the first outflow portion (16). Connected to the venous side circuit (30) connected to the second inflow part (17), the first dialysate circuit (360) connected to the second inflow part (17), and the second outflow part (18). A waste liquid circuit (50) through which the waste liquid from the section (18) passes, and a second dialysate circuit connected to the first dialysate circuit (360) 370) and the blood purification device (380) of the present invention, and the first dialysate circuit (360) is configured to pass the first dialysate as the first liquid. The second dialysate circuit (370) is configured to pass a second dialysate as the second liquid, and the first pump (84) is configured to pass the first dialyzer. A pump for sending the first dialysate on the fluid circuit (360) to the blood purifier (10), wherein the second pump (85) is on the second dialysate circuit (370). The second dialysate is a pump for sending the second dialysate toward the first dialysate circuit (360).

  Therefore, according to the blood purification system of the present invention, since the above-described excellent blood purification device is provided, the dialysate can be switched relatively easily when performing CHDF, CHD, and the like. An excellent blood purification system.

  In addition, the reference numerals added in parentheses below the wording of each member, etc. described in the claims and in this column (column of means for solving the problems) are the contents described in the claims and this column. It is used for facilitating understanding of the present invention, and does not limit the contents described in the claims and in this section.

The figure which shows the structure of the blood purification system 1 which concerns on 1st Embodiment. The figure shown in order to demonstrate the blood purifier 10. FIG. The block diagram which shows the electrical constitution of the blood purification apparatus 80 which concerns on 1st Embodiment. The figure shown in order to demonstrate the pump drive control part F5 of the control part 90. FIG. The figure which shows the structure of the blood purification system 2 which concerns on 2nd Embodiment. The figure shown in order to demonstrate the blood purifier 210. The block diagram which shows the electrical constitution of the blood purification apparatus 280 which concerns on 2nd Embodiment. The figure which shows the structure of the blood purification system 3 which concerns on 3rd Embodiment. The block diagram which shows the electrical constitution of the blood purification apparatus 380 which concerns on 3rd Embodiment.

  Hereinafter, a blood purification device and a blood purification system of the present invention will be described based on the embodiments shown in the drawings.

[First Embodiment]
First, the structure of the blood purification system 1 for performing blood purification is demonstrated using FIGS. 1-3.

FIG. 1 is a diagram showing a configuration of a blood purification system 1 according to the first embodiment.
FIG. 2 is a view for explaining the blood purifier 10. FIG. 2A is a view for explaining the configuration of the blood purifier 10, and FIG. 2B is a conceptual diagram showing the internal structure of the blood purifier 10. In FIG. 2B, in order to facilitate understanding of the invention, only one selective separation membrane 12 is schematically shown among the selective separation membranes 12 originally arranged in the blood purifier 10. It is shown schematically.
FIG. 3 is a block diagram showing an electrical configuration of the blood purification apparatus 80 according to the first embodiment.

  As shown in FIG. 1, the blood purification system 1 according to the first embodiment includes a blood purification device 10, an artery side circuit 20 connected to the first inflow portion 15 of the blood purification device 10, and the blood purification device 10. A venous circuit 30 connected to the first outflow part 16, a dialysate circuit 40 connected to the second inflow part 17 of the blood purifier 10, a dialysate storage container 42 capable of storing dialysate, and blood purification A waste liquid circuit 50 connected to the second outflow part 18 of the vessel 10 and through which the waste liquid from the second outflow part 18 passes, and a first circuit 60 connected to the venous circuit 30 and through which the first liquid passes. The first storage container 62 that can store the first liquid, the second circuit 70 that is connected to the venous circuit 30 and allows the second liquid to flow therethrough, and the second storage container that can store the second liquid 72 and a blood purification device 80.

  As shown in FIG. 2, the blood purifier 10 includes a cylindrical housing part 11, a selective separation membrane 12 disposed inside the housing part 11, and a first provided at one end of the housing part 11. An inflow portion 15, a first outflow portion 16 provided at the other end of the housing portion 11, a second inflow portion 17 provided at a position near the first outflow portion 16 on the side surface of the housing portion 11, and a housing It has the 2nd outflow part 18 provided in the position near the 1st inflow part 15 among the side surfaces of the part 11. FIG.

  The selective separation membrane 12 is made of, for example, a hollow fiber membrane. Although not shown in the drawings, a plurality of selective separation membranes 12 are arranged in the housing portion 11 so as to extend along the longitudinal direction of the housing portion 11.

  As shown in FIG. 2B, the blood purifier 10 is partitioned into a blood channel 13 and another channel 14 by a selective separation membrane 12. That is, the inside of the selective separation membrane 12 becomes the blood flow path 13 and the outside of the selective separation membrane 12 becomes the other flow path 14. The first inflow portion 15 and the first outflow portion 16 communicate with the blood channel 13, and the second inflow portion 17 and the second outflow portion 18 communicate with the other channel 14. The blood purifier 10 has a direction in which the blood flow path 13 flows during the blood purification (indicated by the black arrow in FIG. 2B) and a direction in which the other flow path 14 flows (in the direction indicated by the hollow arrow in FIG. Are configured in the opposite direction (that is, in a counterflow).

  An air trap 22 and a rolling tube portion 24 are provided in the middle of the artery side circuit 20 as shown in FIG. Although not shown in FIG. 1, an anticoagulant injection line for introducing an anticoagulant into the circuit is connected to the middle of the artery side circuit 20, and the pressure in the artery side circuit 20 is There is provided a pressure detector for detecting.

  An air trap 32 is provided in the middle of the venous circuit 30. Although not shown in FIG. 1, a bubble detector is provided in the middle of the venous circuit 30, and a venous pressure sensor is connected to the air trap 32.

  Rolling tube portions 44 and 54 are provided in the middle of the dialysate circuit 40 and the waste liquid circuit 50, respectively. Although not shown in FIG. 1, a pressure detector for detecting the pressure in the waste liquid circuit 50 is provided in the middle of the waste liquid circuit 50.

  Rolling tube portions 64 and 74 are provided in the middle of the first circuit 60 and the second circuit 70, respectively. The end of the first circuit 60 is connected to a position from the connection portion with the blood purifier 10 to the air trap 32 in the venous circuit 30. The end of the second circuit 70 is connected to the air trap 32 of the vein side circuit 30.

  The dialysate storage container 42, the first storage container 62, and the second storage container 72 are detachably attached to the end portions of the dialysate circuit 40, the first circuit 60, and the second circuit 70, respectively. The dialysate storage container 42, the first storage container 62, and the second storage container 72 are, for example, plastic storage bags. As the dialysate stored in the dialysate storage container 42 and the first liquid stored in the first storage container 62, for example, sub-rad BS (“Sub-rad” is a registered trademark of Fuso Pharmaceutical Co., Ltd.) is preferably used. it can. As the second liquid stored in the second storage container 72, for example, bicarbon infusion (“Bicarbon” is a registered trademark of Ajinomoto Co., Inc.) can be suitably used. Needless to say, the dialysate, the first liquid, and the second liquid may be other than those exemplified here.

As shown in FIGS. 1 and 3, the blood purification device 80 blood purifies the blood pump 81 for sending the blood on the artery side circuit 20 toward the blood purifier 10 and the dialysate on the dialysate circuit 40. Dialysate pump 82 for sending to the vessel 10, waste pump 83 for sending the waste fluid on the waste circuit 50, and for sending the first fluid on the first circuit 60 toward the venous circuit 30. A first pump 84, a second pump 85 for sending the second liquid on the second circuit 70 toward the venous circuit 30, and a power supply unit 86 for supplying power to each part in the blood purification device 80. And a setting input unit 87 that is arranged on the outer surface of the blood purification device 80 and receives an input from an operator, and temperature information and veins of blood and the like that are arranged on the outer surface of the blood purification device 80 and flow in the circuit. Such as venous pressure information measured by pressure sensor A display unit 88 for displaying the seed information, a storage unit 89 for storing the performance data of the blood purifier to be used, etc., and a control unit 90 that collectively controls each unit in the blood purification apparatus 80.
In FIG. 1, a line extending from the control unit 90 to each of the pumps 81 to 85 represents a signal line.

  Blood pump 81, dialysate pump 82, waste liquid pump 83, first pump 84, and second pump 85 are so-called roller pumps. Although explanation by illustration is abbreviate | omitted, when the roller part of the blood pump 81 rotates in the state which contacted the rolling tube part 24 of the artery side circuit 20, the fluid in the artery side circuit 20 is rotated. (Blood) can be fed in a predetermined direction. The functions of the other pumps 82 to 85 are the same as those of the blood pump 81.

  The setting input unit 87 is configured to be able to input the flow rate of each pump, the flow rate interlocking ratio between pumps, and other set values, although the description by illustration is omitted. The setting input unit 87 and the display unit 88 may be configured as separate bodies, or may be a touch panel display in which an input part and a display part are integrated, for example.

  As shown in FIG. 3, the control unit 90 adjusts the flow rate of each pump based on the pump drive control unit F <b> 1 that controls driving of the five pumps 81 to 85 and the setting value input to the setting input unit 87. The pump flow rate adjustment unit F2, the first linkage control unit F3 that controls the flow rate of the first pump 84 or the second pump 85 and the flow rate of the blood pump 81 in conjunction, and the first pump 84 or the second pump 85. A second interlock control unit F4 that controls the flow rate and the flow rate of the waste liquid pump 83 in conjunction with each other, and a pump drive that determines whether the second pump 85 can be driven according to whether or not the first pump 84 is driven. And at least a determination unit F5.

  The pump drive control unit F1 reads the flow rate information of the five pumps 81 to 85 stored in the storage unit 89, and controls the drive of each pump 81 to 85 based on the information. That is, the rotational drive of each pump 81-85 is controlled based on the set flow rate of each pump 81-85 memorize | stored in the memory | storage part 89 previously.

  The setting input unit 87 generates setting value information related to the input setting value. The pump flow rate adjustment unit F2 receives the set value information generated by the setting input unit 87, and adjusts the flow rates of the pumps 81 to 85 based on the set value information.

The first interlock control unit F3 controls the flow rate of at least one of the first pump 84 and the second pump 85 in conjunction with the adjustment of the flow rate of the blood pump 81.
For example, when a negative pressure is generated by a kink of the tube or the like and a pressure fluctuation of the artery side circuit 20 is detected by a pressure detector provided in the artery side circuit 20, the detection information is sent to the pump drive control unit F1. . The pump drive control unit F1 reads the flow rate information stored in the storage unit 89, and controls the drive of the blood pump 81 based on the information so that the blood pump 81 rotates at a safer flow rate. In order to prevent the balance between the amount of blood to be removed and the amount of liquid to be replenished / replaced by adjusting the flow rate of the blood pump 81, the first interlock control unit F3 is configured by the first pump 84 or the second pump. The flow rate of the pump 85 is controlled in conjunction.
Also, when the flow rate of the blood pump 81 is adjusted by the pump flow rate adjusting unit F2, the first interlock control unit F3 can control the flow rate of the first pump 84 or the second pump 85 in conjunction with each other. That is, the flow rate of the first pump 84 or the second pump 85 is changed only by setting the flow rate of the blood pump 81 by the setting input unit 87. As a case where the flow rate of the blood pump 81 is adjusted by the pump flow rate adjustment unit F2, for example, when it is desired to change the blood removal amount by looking at the patient's condition.

The second interlock control unit F4 controls the flow rate of the first pump 84 or the second pump 85 in conjunction with the adjustment of the flow rate of the waste liquid pump 83.
For example, when the blood purifier is clogged and a pressure fluctuation in the waste liquid circuit 50 is detected by the pressure detector provided in the waste liquid circuit 50, the detection information is sent to the pump drive control unit F1. The pump drive control unit F1 reads the flow rate information stored in the storage unit 89, and controls the drive of the waste liquid pump 83 so that the waste liquid pump 83 rotates at a suitable flow rate based on the information. In order to prevent the balance between the amount of waste liquid and the amount of liquid to be replenished / replaced by adjusting the flow rate of the waste liquid pump 83, the second interlock control unit F4 controls the flow rate of the first pump 84 or the second pump 85. Are controlled in conjunction.
Also, when the flow rate of the waste liquid pump 83 is adjusted by the pump flow rate adjusting unit F2, the second interlock control unit F4 can control the flow rate of the first pump 84 or the second pump 85 in conjunction with each other. That is, the flow rate of the first pump 84 or the second pump 85 is changed only by setting the flow rate of the waste liquid pump 83 by the setting input unit 87. Examples of the case where the flow rate of the waste liquid pump 83 is adjusted by the pump flow rate adjusting unit F2 include a case where the water removal amount is desired to be changed due to a change in the condition such as a decrease in blood pressure of the patient.

  The pump drive determination unit F5 determines whether or not the second pump 85 can be driven according to whether or not the first pump 84 is driven. Specifically, the pump drive determination unit F5 stops the second pump 85 when the first pump 84 is in a drive state, and the second pump 85 when the first pump 84 is in a stop state. To the drive state.

  FIG. 4 is a diagram for explaining the pump drive control unit F5 of the control unit 90. In FIG. 4A, the flow of each circuit when the first pump 84 is in a driving state is indicated by an arrow, and in FIG. 4B, each circuit when the first pump 84 is in a stopped state. The flow is indicated by arrows.

  For example, as shown to Fig.4 (a), when the 1st pump 84 is a drive state, the pump drive determination part F5 makes the 2nd pump 85 a stop state. When the second pump 85 is stopped, the first liquid stored in the first storage container 62 is passed through the venous circuit 30.

  On the other hand, as shown in FIG. 4B, when the first pump 84 is in the stopped state, the pump drive determination unit F5 puts the second pump 85 in the drive state. When the second pump 85 is in a driving state, the second liquid stored in the second storage container 72 passes through the vein side circuit 30.

  According to the blood purification apparatus 80 according to the first embodiment configured as described above, the first pump 84 and the second pump 85 described above are incorporated in the apparatus, and the control unit 90 determines the pump drive determination unit described above. Since it has F5, a different type of liquid from the first liquid is prepared as the second liquid and connected to the first circuit 60 and the second circuit 70, respectively, and then the first pump 84 and the second liquid are connected. As long as the pump 85 is set, it is possible to perform a very smooth switching when it is desired to switch the solution used during the treatment.

  Therefore, the blood purification apparatus 80 according to the first embodiment is a blood purification apparatus that can be handled relatively easily even when it is desired to switch the solution used during the treatment.

  In the blood purification apparatus 80 according to the first embodiment, the pump drive determination unit F5 stops the second pump 85 when the first pump 84 is in a drive state, and the first pump 84 is in a stop state. In this case, the second pump 85 is set in a driving state. Thus, when the first liquid is being sent by the first pump 84, the second pump 85 stops sending the second liquid, and when the second pump 85 is sending the second liquid, the second liquid is being sent. The liquid supply of the first liquid by the one pump 84 is stopped.

  In the blood purification apparatus 80 according to the first embodiment, since the control unit 90 further includes the first and second interlocking control units F3 and F4 described above, according to the flow rate fluctuation of the blood pump 81 or the waste liquid pump 83, It becomes possible to automatically adjust the flow rates of the first pump 84 and the second pump 85.

  According to the blood purification system 1 according to the first embodiment, since the above-described excellent blood purification device 80 is provided, when performing CHDF, CHD, CHF, etc., switching of the replenisher or the replacement liquid is relatively performed. It is an excellent blood purification system that can be easily performed.

[Second Embodiment]
FIG. 5 is a diagram illustrating a configuration of the blood purification system 2 according to the second embodiment.
FIG. 6 is a view for explaining the blood purifier 210. FIG. 6A is a view for explaining the configuration of the blood purifier 210, and FIG. 6B is a conceptual diagram showing the internal structure of the blood purifier 210. In FIG. 6B, in order to facilitate understanding of the invention, only one selective separation membrane 212 is schematically illustrated among the selective separation membranes 212 originally arranged in the blood purifier 210. It is shown schematically.
FIG. 7 is a block diagram showing an electrical configuration of the blood purification apparatus 280 according to the second embodiment.
5 and 7, the same members as those in FIGS. 1 and 3 are denoted by the same reference numerals, and detailed description thereof is omitted.

  The blood purification system 2 according to the second embodiment basically has the same configuration as that of the blood purification system 1 according to the first embodiment, except that the configuration of the blood purification device and the dialysate circuit are not provided. This is different from the blood purification system 1 according to the first embodiment.

  That is, the blood purification system 2 according to the second embodiment includes a blood purification device 210, an artery side circuit 20 connected to the first inflow portion 215 of the blood purification device 210, and a blood purification device, as shown in FIG. A venous side circuit 30 connected to the first outflow portion 216 of 210, a effluent circuit 50 connected to the second outflow portion 218 of the blood purifier 210 and through which the effluent from the second outflow portion 218 passes, and a venous side A first circuit 260 that is connected to the circuit 30 and allows the first liquid to pass therethrough, a first storage container 262 that can store the first liquid, and a venous circuit 30 that is connected to the second liquid. And a second storage container 272 capable of storing the second liquid, and a blood purification device 280.

  As shown in FIG. 6, the blood purifier 210 includes a cylindrical housing portion 211, a selective separation membrane 212 disposed inside the housing portion 211, and a first portion provided at one end of the housing portion 211. An inflow portion 215, a first outflow portion 216 provided at the other end of the housing portion 211, a second inflow portion 217 provided near the first inflow portion 215 on the side surface of the housing portion 211, and a housing And a second outflow portion 218 provided at a position near the first outflow portion 216 in the side surface of the portion 211. The second inflow portion 217 of the blood purifier 210 is configured not to allow fluid to flow outside by plugging it.

  The selective separation membrane 212 is made of, for example, a hollow fiber membrane. Although not shown in the figure, a plurality of selective separation membranes 212 are arranged in the housing part 211 so as to extend along the longitudinal direction of the housing part 211.

  The inside of the blood purifier 210 is partitioned into a blood channel 213 and another channel 214 by a selective separation membrane 212 as shown in FIG. That is, the inside of the selective separation membrane 212 becomes the blood channel 213, and the outside of the selective separation membrane 212 becomes the other channel 214. The first inflow portion 215 and the first outflow portion 216 communicate with the blood channel 213, and the second inflow portion 217 and the second outflow portion 218 communicate with the other channel 214. At the time of blood purification, the blood sent from the artery side circuit 20 flows in the blood channel 213 in the direction of the black arrow in FIG. At this time, blood components passing through the selective separation membrane 212 in the blood flowing through the blood flow channel 213 are discharged from the second outflow portion 218 through the other flow channel 214 (see the white arrow in FIG. 6B). .)

  In the blood purification system 2 according to the second embodiment, the first liquid and the second liquid are solutions having different compositions.

  The blood purification apparatus 280 according to the second embodiment basically has the same configuration as the blood purification apparatus 80 according to the first embodiment (see FIG. 3) as shown in FIG. Is different from the blood purification apparatus 80 according to the first embodiment.

  As shown in FIG. 7, the control unit 290 has a pump drive control unit F <b> 1 that controls driving of the four pumps 81, 83 to 85, and a flow rate of each pump based on the set value input to the setting input unit 87. A pump flow rate adjusting unit F2 that adjusts the flow rate, a first interlock control unit F3 that controls the flow rate of the first pump 84 or the second pump 85 and the flow rate of the blood pump 81, and the first pump 84 or the second pump. Whether or not the second pump 85 can be driven is determined according to whether the first pump 84 is driven and the second interlock control unit F4 that controls the flow rate of 85 and the flow rate of the waste liquid pump 83 in conjunction with each other. And at least a pump drive determination unit F5.

  As described above, the blood purification device 280 according to the second embodiment differs from the blood purification device 80 according to the first embodiment in that the configuration of the blood purification device and the dialysate pump are not provided, but the first embodiment. As in the case of the blood purification apparatus 80 according to the first and second pumps 84 and 85, the first pump 84 and the second pump 85 are incorporated in the apparatus, and the control unit 290 includes the pump drive determination unit F5 described above. As long as a different type of liquid is prepared as the second liquid, connected to the first circuit 260 and the second circuit 270, respectively, and set in the first pump 84 and the second pump 85, When it is desired to switch the solution used during the treatment, a very smooth switching can be performed.

  Therefore, the blood purification apparatus 280 according to the second embodiment is a blood purification apparatus that can be handled relatively easily even when it is desired to switch the solution used during the treatment.

  The blood purification apparatus 280 according to the second embodiment has the same configuration as the blood purification apparatus 80 according to the first embodiment except that the blood purification apparatus 280 and the dialysate pump are not provided. It has the corresponding effect as it is among the effects of blood purification apparatus 80 according to the embodiment.

  According to the blood purification system 2 according to the second embodiment, since the above-described excellent blood purification device 280 is provided, the enforcement method of switching between two different replenishers or replacement fluids as necessary is relatively easy. It becomes an excellent blood purification system that can be performed in the future.

[Third Embodiment]
FIG. 8 is a diagram illustrating a configuration of the blood purification system 3 according to the third embodiment.
FIG. 9 is a block diagram showing an electrical configuration of blood purification apparatus 380 according to the third embodiment.
8 and 9, the same members as those in FIGS. 1 and 3 are denoted by the same reference numerals, and detailed description thereof is omitted.

  The blood purification system 3 according to the third embodiment basically has the same configuration as the blood purification system 1 according to the first embodiment, but a part of the circuit configuration is the blood purification system according to the first embodiment. Different from 1.

  That is, the blood purification system 3 according to the third embodiment is connected to the blood purifier 10, the artery side circuit 20 connected to the first inflow portion 15, and the first outflow portion 16, as shown in FIG. Connected to the venous circuit 30, the other circuit 340 connected to the venous circuit 30, the third storage container 342 capable of storing the third liquid flowing through the other circuit 340, and the second inflow portion 17. A first dialysate circuit 360, a first storage container 362 capable of storing the first dialysate, a waste liquid circuit 50 connected to the second outflow part 18 and through which the waste liquid from the second outflow part 18 flows. A second dialysate circuit 370 connected to the first dialysate circuit 360 and through which the second dialysate passes, a second storage container 372 capable of storing the second dialysate, and a blood purification device 380. Prepare.

  In the blood purification system 3 according to the third embodiment, the first dialysate as the first liquid, the second dialysate as the second liquid, and the third liquid are different types of solutions. . Various solutions can be used as the first dialysate, the second dialysate, and the third liquid depending on the purpose of treatment.

  The end of the second dialysate circuit 370 is connected to a position from the connection portion with the second inflow portion 17 to the rolling tube portion 364 in the first dialysate circuit 360.

  As shown in FIG. 9, the blood purification apparatus 380 according to the third embodiment has basically the same configuration as the blood purification apparatus 80 according to the first embodiment (see FIG. 3). The function and configuration of the pump are different from the blood purification device 80 according to the first embodiment.

  That is, the blood purification apparatus 380 according to the third embodiment includes, as five pumps, a blood pump 81 for sending the blood on the artery side circuit 20 toward the blood purification device 10 and a third on the other circuit 340. The other pump 382 for sending the liquid to the venous circuit 30, the waste liquid pump 83 for sending the waste liquid on the waste liquid circuit 50, and the first dialysate on the first dialysate circuit 360 for blood purification And a second pump 85 for sending the second dialysate on the second dialysate circuit 370 towards the first dialysate circuit 360.

  The other pump 382 is a so-called roller pump. Although description by illustration is abbreviate | omitted, when the roller part of the other pump 382 rotates in the state which contacted the rolling tube part 344 of the other circuit 340 (handles the rolling tube part 344), The third liquid can be fed in a predetermined direction.

  As shown in FIG. 9, the control unit 390 is configured to control each pump based on the pump drive control unit F <b> 1 that controls driving of the five pumps 81, 382, 83 to 85, and the setting value input to the setting input unit 87. A pump flow rate adjustment unit F2 that adjusts the flow rate of the first pump 84, a first interlock control unit F3 that controls the flow rate of the first pump 84 or the second pump 85 and the flow rate of the blood pump 81, and the first pump 84 or the second pump. Whether the second pump 85 can be driven or not depends on whether the first pump 84 is driven and the second interlocking control unit F4 that controls the flow rate of the two pumps 85 and the flow rate of the waste liquid pump 83 in conjunction with each other. And at least a pump drive determination unit F5 to be determined.

  Thus, the blood purification apparatus 380 according to the third embodiment differs from the blood purification apparatus 80 according to the first embodiment in the functions and configurations of some pumps, but the blood purification apparatus 80 according to the first embodiment. As in the case of the above, since the first pump 84 and the second pump 85 are incorporated in the apparatus, and the control unit 390 has the pump drive determination unit F5 described above, it is different from the first dialysate. As long as it is prepared as a second dialysate and connected to the first dialysate circuit 360 and the second dialysate circuit 370 and set to the first pump 84 and the second pump 85, respectively, When it is desired to switch dialysate during treatment, a very smooth switching can be performed.

  Therefore, the blood purification apparatus 380 according to the third embodiment is a blood purification apparatus that can be handled relatively easily even when it is desired to switch the dialysate during the treatment.

  The blood purification apparatus 380 according to the third embodiment has the same configuration as that of the blood purification apparatus 80 according to the first embodiment except that some pumps have different functions and configurations. Of the effects of the blood purification device 80, the corresponding effects are provided as they are.

  According to the third embodiment, since the above-described excellent blood purification apparatus 380 is provided, when performing CHDF, CHD, etc., excellent blood purification capable of switching dialysate relatively easily System.

  As mentioned above, although the blood purification apparatus and the blood purification system of this invention were demonstrated based on said embodiment, this invention is not limited to said embodiment, In various aspects in the range which does not deviate from the summary. For example, the following modifications are possible.

(1) In the first and second embodiments, the case where the second circuits 70 and 270 are connected to the middle of the venous circuit 30 (the air trap 32) has been described as an example. It is not limited to. The second circuit may be connected to any position from the end portion of the first circuit 60 (connection portion with the vein circuit 30) to the rolling tube portion 64 (position where the first pump 84 is disposed). However, it may be connected to any position of the artery side circuit 20.

(2) In each of the above embodiments, the blood purifier having a selective separation membrane made of a hollow fiber membrane has been exemplified and described as the blood purifier, but the present invention is not limited to this. For example, the present invention can also be applied to a blood purifier constituted by a selective separation membrane other than a hollow fiber membrane, such as a flat membrane (a laminate of a plurality of flat membranes) or a tubular membrane.

(3) In the second embodiment, the case where the second inflow portion 217 of the blood purifier 210 is configured to prevent passage through the outside by plugging the second inflow portion 217 has been described as an example. It is not limited to. For example, a blood purifier in which a mouth corresponding to the second inflow portion is not provided from the beginning may be used.

(4) In the said 1st Embodiment, although the case where the dialysate storage container 42 and the 1st storage container 62 were separated was demonstrated and demonstrated, this invention is not limited to this, dialysate storage If the contents of the container and the contents of the first storage container or the second storage container are the same, they may be integrated and used. Similarly, in the third embodiment, if the contents of the first storage container or the second storage container and the contents of the third storage container are the same, they may be integrated.

(5) In the above embodiment, the case where the types of the first liquid and the second liquid stored in the first storage container and the second storage container are different has been described as an example. It is not limited. As the first liquid and the second liquid, for example, the same type and different concentrations, or the same type and concentration may be used.

(6) In the above-described embodiment, a container state detection unit (for example, a weigh scale or an ultrasonic sensor) that detects that the storage container is empty is further provided in the blood purification device, and the container state detection unit Based on the detection information by, the drive of the empty storage container pump may be stopped. In this case, for example, when the same concentration and type are used as the first liquid and the second liquid, when the container state detection unit detects that the first storage container or the second storage container is empty, Based on the detection information, the driving of the pump (one pump) corresponding to the empty storage container is stopped. When the driving of the one pump is stopped, the other pump is shifted to a driving state by the pump driving determination function of the control unit, and the liquid is sent into the circuit from the non-empty storage container. That is, treatment can be continued while switching between the two storage containers, such as switching to the second storage container when the first storage container is empty and switching to the first storage container when the second storage container is empty. There is an effect that it is not necessary to use large-capacity containers as the first storage container and the second storage container. Similarly, even when the first liquid and the second liquid having different concentrations and types are used, the container state detection unit detects that one of the storage containers is empty, so that the other storage is performed. Since the container can be switched to the container, for example, the apparatus is convenient when it is desired to flow the liquid filled in the other storage container after the liquid filled in the one storage container is finished.
The container state detection unit described above may be disposed in the blood purification system as a separate body from the blood purification device.

(7) In the third embodiment, the pressure detector that measures the pressure at a predetermined position in the circuit, and the membrane that calculates the transmembrane pressure difference (TMP) of the blood purifier based on the measurement information of the pressure detector Even if the inter-pressure difference calculation unit is provided in the blood purification device and the calculated transmembrane pressure difference exceeds a predetermined value, the driving of the first pump or the second pump is stopped. Good. The fact that the transmembrane pressure difference exceeds a predetermined value means that the selective separation membrane of the blood purifier may be clogged with proteins or the like. For example, the first storage container or the second storage container If either one of them is pre-filled with a liquid that has a clogging-relieving effect, it can be sent into the circuit when the transmembrane pressure difference exceeds a predetermined value. The clogging of the selective separation membrane can be eliminated.
Note that the pressure detection unit and the transmembrane pressure difference calculation unit described above may be arranged in the blood purification system as a separate body from the blood purification device.

(8) In the above embodiment, an elapsed time measuring unit that measures the elapsed time from the start of liquid feeding from the storage container to the present time, and the time from the start of liquid feeding to the stop of liquid feeding (liquid feeding time) ) Is set in the blood purification device, and when the measured elapsed time exceeds the liquid feeding time, the driving of one of the pumps is stopped. Good. Or, the actual amount measurement unit that measures the amount (actual amount) of liquid delivered from the start of delivery from the storage container to the present, and the amount of liquid delivered (reference amount) from the start of delivery to the stop of delivery The blood purification apparatus may be configured to stop the driving of one of the pumps when the measured actual amount exceeds the reference amount. In this case, the liquid supply from the first storage container or the second storage container can be switched according to the elapsed time or the liquid supply amount.
The elapsed time measuring unit and the liquid feeding time setting unit or the actual amount measuring unit and the reference amount setting unit may be provided in the blood purification system as a separate body from the blood purification device.

(9) In the above-described embodiment, the rotational speed detection unit for detecting the rotational speed of each pump and the detected rotational speed of the pump are within a predetermined numerical range (for example, a range including the set value input to the setting input unit). The blood purification device is provided with a determination unit that determines whether or not the pump is within the range, and when it is determined that the detected rotational speed of each pump is not within the predetermined numerical range, You may be comprised so that the drive of 2 pumps may be stopped. If it is determined that the rotation speed of each detected pump is not within the predetermined numerical range, the pump may have failed, for example. In this case, if one of the pumps has failed However, it is possible to switch to the other pump that has not failed.
In addition, the above-mentioned rotation speed detection part and determination part may be arrange | positioned in the blood purification system as a different body from the blood purification apparatus.

(10) In the above-described embodiment, the blood purification device is provided with a pressure detection unit that measures the pressure at a predetermined position in the circuit, and when the measured in-circuit pressure exceeds a predetermined value, the first pump Or you may be comprised so that the drive of a 2nd pump may be stopped. If the pressure in the circuit exceeds the specified value, there may be a malfunction in the circuit, such as a tube being kinked. Even if a failure occurs, it is possible to switch to the other pump disposed in the circuit where the failure does not occur.
Note that the pressure detection unit described above may be disposed in the blood purification system as a separate body from the blood purification device.

(11) In the first embodiment, the control unit 90 includes a pump drive control unit F1, a pump flow rate adjustment unit F2, first and second interlock control units F3 and F4, and a pump drive determination unit F5. However, the present invention is not limited to this, and in addition, for example, a first control that controls the flow rates of the first pump 84 and the second pump 85 in conjunction with the flow rate of the dialysate pump 82. Three interlocking control units may be provided. In this case, it is possible to automatically adjust the flow rates of the first pump and the second pump in accordance with the flow rate fluctuation of the dialysate pump.

(12) In the above embodiment, the pump drive determining unit sets the second pump 85 to the stopped state when the first pump 84 is in the driven state, and the second when the first pump 84 is in the stopped state. Although the case where the pump 85 is set to the drive state has been described as an example, the present invention is not limited to this. For example, when the first pump is in the driving state, the second pump is in the driving state, and when the first pump is in the stopping state, the second pump is in the stopping state. When both the first pump and the second pump are in the drive state, the flow rates of the first pump and the second pump may be controlled in conjunction with each other. In this case, since the second liquid (second dialysate) can also be sent while the first liquid (first dialysate) is being sent, two types of solutions can be used at a certain timing, for example. Even if there is a request to send the blood, the blood purification device of the present invention can be handled relatively easily. In this case, the two kinds of solutions may be sent by sending two kinds of solutions from different routes, or from one route with two kinds of solutions mixed in a predetermined ratio. It may be sent.

(13) In the above embodiment, a case where a so-called roller pump is used as each pump has been described as an example. However, the present invention is not limited to this, and other known pumps such as a syringe pump can be used. A liquid feeding means may be used.

(14) In the above embodiment, the blood purification system including one blood purifier has been described as an example, but the present invention is not limited to this. For example, two or more blood purifiers, such as a blood purification system having two blood purifiers having a selective separation membrane, such as a blood purification system compatible with Double Filtration Plasmapheresis (DFPP) The present invention is also applicable to a blood purification system comprising

1,2,3 Blood purification systems 10,210 Blood purifiers 11,211 Housing parts 12,212 Selective separation membranes 13,213 Blood flow paths 14,214 Other flow paths 15,215 First inflow parts 16,216 First 1 outflow part 17,217 second inflow part 18,218 second outflow part 20 arterial circuit 22,32 air trap 24,44,54,64,74,264,274,344,364,374 rolling tube part 30 vein Side circuit 40 Dialysate circuit 42 Dialysate reservoir 50 Waste fluid circuit 60, 260 First circuit 62, 262, 362 First reservoir 70, 270 Second circuit 72, 272, 372 Second reservoir 80, 280, 380 Blood Purification device 81 Blood pump 82 Dialysate pump 83 Waste liquid pump 84 First pump 85 Second pump 86 Power supply unit 87 Setting input unit 88 Display 89 Storage unit 90, 290, 390 Control unit 219 Plug 340 Other circuit 342 Third storage container 360 First dialysate circuit 370 Second dialysate circuit 382 Other pump F1 Pump drive control unit F2 Pump flow rate adjustment unit F3 First Interlocking control unit F4 Second interlocking control unit F5 Pump drive determination unit

Claims (8)

The inside is partitioned into a blood flow path (13) and another flow path (14), the first inflow portion (15) leading to one end of the blood flow path (13), and other than the blood flow path (13) A blood purifier (10) having at least a first outflow part (16) leading to an end and a second outflow part (18) leading to the other flow path (14);
An arterial circuit (20) connected to the first inlet (15);
A venous circuit (30) connected to the first outlet (16);
A waste liquid circuit (50) connected to the second outflow part (18) and through which the waste liquid from the second outflow part (18) flows;
A first circuit (60) connected to the venous circuit (30) and through which a first liquid flows;
Used in a blood purification system comprising at least a second circuit (70) connected to the arterial circuit (20), the venous circuit (30), or the first circuit (60) and through which a second fluid passes. A blood purification device,
A plurality of pumps and a controller (90) for controlling driving of the plurality of pumps;
As the plurality of pumps,
A blood pump (81) for sending blood on the arterial circuit (20) toward the blood purifier (10);
A waste liquid pump (83) for delivering the waste liquid on the waste liquid circuit (50);
A first pump (84) for delivering the first liquid on the first circuit (60) towards the venous circuit (30);
At least a second pump (85) for delivering the second liquid on the second circuit (70) towards the venous circuit (30) or the first circuit (60);
Wherein the control unit (90), depending on whether the first pump (84) is driven, have a pump driving determination unit that determines whether the driving of the second pump (85) (F5) ,
The controller (90) further interlocks the flow rate of at least one of the first pump (84) and the second pump (85) in the drive state with the flow rate of the blood pump (81). A blood purification device (80) to control . The blood purification apparatus according to claim 1, wherein
The pump drive determination unit is
When the first pump (84) is in a driving state, the second pump (85) is stopped, and when the first pump (84) is in a stopping state, the second pump (85) is stopped. Blood purification device (80) to be in a driving state. The blood purification apparatus according to claim 1, wherein
The pump drive determination unit is
When the first pump is in a driving state, the second pump is driven, and when the first pump is in a stopping state, the second pump is stopped.
The control unit further controls the flow rate of the first pump and the second pump in conjunction with each other when both the first pump and the second pump are in a driving state. In the blood purification apparatus as described in any one of Claims 1-3,
The controller (90) further interlocks the flow rate of at least one of the first pump (84) and the second pump (85) in the drive state with the flow rate of the waste liquid pump (83). A blood purification device (80) to control. In the blood purification apparatus as described in any one of Claims 1-4 ,
A setting input unit (87) for setting and inputting the flow rate of each pump;
The control unit (90) further adjusts the flow rate of each pump based on the set value input to the setting input unit (87). The inside is partitioned into a blood flow path (13) and another flow path (14), the first inflow portion (15) leading to one end of the blood flow path (13), and other than the blood flow path (13) A first outflow part (16) leading to the end, a second inflow part (17) leading to one end of the other flow path (14), and a second outflow part (18) leading to the other end of the other flow path (14) A blood purifier (10) having
An arterial circuit (20) connected to the first inlet (15);
A venous circuit (30) connected to the first outlet (16);
A dialysate circuit (40) connected to the second inlet (17);
A waste liquid circuit (50) connected to the second outflow part (18) and through which the waste liquid from the second outflow part (18) flows;
A first circuit (60) connected to the venous circuit (30) and through which a first liquid flows;
A second circuit (70) connected to the arterial circuit (20), the venous circuit (30) or the first circuit (60) and through which a second fluid passes;
The blood purification apparatus (80) according to any one of claims 1 to 5 ,
The blood purification system (1), wherein the blood purification device (80) further comprises a dialysate pump (82) for sending dialysate on the dialysate circuit (40) toward the blood purifier (10). . The inside is partitioned into a blood flow path (213) and another flow path (214), and a first inflow portion (215) that communicates with one end of the blood flow path (213), in addition to the blood flow path (213) A blood purifier (210) having a first outflow portion (216) leading to an end and a second outflow portion (218) leading to one end of the other flow path (214);
An arterial circuit (20) connected to the first inflow part (215);
A venous circuit (30) connected to the first outlet (216);
A waste liquid circuit (50) connected to the second outflow part (218) and through which the waste liquid from the second outflow part (18) flows;
A first circuit (260) connected to the venous circuit (30) and through which a first liquid flows;
A second circuit (270) connected to the arterial circuit (20), the venous circuit (30) or the first circuit (260) and through which a second fluid passes;
A blood purification system (2) comprising the blood purification device (280) according to any one of claims 1 to 5 . The inside is partitioned into a blood flow path (13) and another flow path (14), the first inflow portion (15) leading to one end of the blood flow path (13), and other than the blood flow path (13) A first outflow part (16) leading to the end, a second inflow part (17) leading to one end of the other flow path (14), and a second outflow part (18) leading to the other end of the other flow path (14) A blood purifier (10) having
An arterial circuit (20) connected to the first inlet (15);
A venous circuit (30) connected to the first outlet (16);
A first dialysate circuit (360) connected to the second inlet (17);
A waste liquid circuit (50) connected to the second outflow part (18) and through which the waste liquid from the second outflow part (18) flows;
A second dialysate circuit (370) connected to the first dialysate circuit (360);
The blood purification apparatus (380) according to any one of claims 1 to 5 ,
The first dialysate circuit (360) is configured to pass the first dialysate as the first liquid,
The second dialysate circuit (370) is configured to pass a second dialysate as the second liquid,
The first pump (84) is a pump for sending the first dialysate on the first dialysate circuit (360) to the blood purifier (10);
A blood purification system (85), wherein the second pump (85) is a pump for sending the second dialysate on the second dialysate circuit (370) toward the first dialysate circuit (360). 3).