TWI504347B - Anti-mosquito microcapsule composition, anti-mosquito microcapsule, anti-mosquito spray and anti-mosquito emulsion - Google Patents

Description

Anti-mosquito microcapsule composition, anti-mosquito microcapsule, anti-mosquito spray and anti-mosquito emulsion

The invention relates to a mosquito repellent liquid, in particular to an anti-mosquito microcapsule comprising a component for forming a microcapsule, a hydrophilic solvent, a polyoxyethylene sorbitan monooleate compound and an anti-mosquito oil component. A composition for a material, wherein the component for forming a microcapsule comprises chitosan, alginate, hyaluronic acid, and a curing agent.

Anti-mosquito liquid is divided into two types that cannot be directly used on the skin and can be directly applied to the skin. The main component of the former is diethyltoluamide (DEET). After being absorbed by the skin, it is toxic to the nervous system and blood vessels in the body, and it may cause death due to misuse. Therefore, it is not convenient to use, and It is dangerous. The main components of the latter are mainly plant essential oils, such as lemongrass, geranium or eucalyptus. These plant essential oils are often characterized by deworming properties. Although the anti-mosquito effective time of these plant essential oils is shorter than that of B-tolerance, the safety is higher than that of B. Therefore, the use of plant essential oils as anti-mosquito liquids has become the mainstream in the market. However, although the use of plant essential oils has better safety, the anti-mosquito effective time is not good, and it needs to be replenished frequently during use, which is not convenient in use.

In view of the above, providing a mosquito repellent liquid having long-lasting anti-mosquito properties is a subject that can be further broken by those skilled in the art.

Accordingly, a first object of the present invention is to provide a composition for an anti-mosquito microcapsule. Anti-mosquito microcapsule formed by the composition for anti-mosquito microcapsules The material has long-lasting anti-mosquito properties and can improve the skin's moisture retention, and at the same time, it has structural stability. When used, the anti-mosquito microcapsules will slowly break the capsule due to external pressure, temperature or natural diffusion, and then slowly release the anti-mosquito essential oil component to achieve long-lasting anti-mosquito properties.

Therefore, the composition for anti-mosquito microcapsules of the present invention comprises: a component for forming a microcapsule; a hydrophilic solvent; a polyoxyethylene sorbitan monooleate compound; and an anti-mosquito essential oil component Wherein the microcapsule forming component comprises chitosan, alginate, 1 wt% to 2 wt% hyaluronic acid, and a curing agent; the anti moth essential oil component comprises a main agent essential oil and a subsidiary essential oil, the main agent essential oil It is selected from peppermint essential oil or eucalyptus essential oil, and the auxiliary oil includes citronella essential oil, lemon essential oil and acid slag tree oil.

A second object of the present invention is to provide an anti-mosquito microcapsule which has long-lasting anti-mosquito properties, can improve skin moisturization and has good structural stability.

The anti-mosquito microcapsule of the present invention comprises: an anti-mosquito microcapsule; and a hydrophilic solvent; wherein the anti-mosquito microcapsule comprises a microcapsule body defining an accommodating space; and a disposing space is disposed in the accommodating space a mosquito-resistant essential oil component; and a polyoxyethylene sorbitan monooleate compound; and the microcapsule body is composed of a microcapsule group comprising chitosan, alginate, hyaluronic acid and a curing agent Formed by the portion; the anti-mosquito essential oil component includes the main agent essential oil and the auxiliary agent The oil, the main essential oil is selected from peppermint essential oil or eucalyptus essential oil, and the auxiliary oil includes citronella essential oil, lemon essential oil and acid slag tree oil.

A third object of the present invention is to provide an anti-mosquito spray which has long-lasting anti-mosquito properties and can improve the moisturizing property of the skin.

The anti-mosquito spray of the present invention comprises the anti-mosquito microcapsule material described above.

A fourth object of the present invention is to provide an anti-mosquito lotion which has long-lasting anti-mosquito properties and can improve the moisturizing property of the skin.

The anti-mosquito emulsion of the present invention comprises the anti-mosquito microcapsule material described above.

The invention has the advantages that the composition for forming the microcapsules of the invention can make the anti-mosquito microcapsules formed subsequently have long-lasting anti-mosquito properties and can improve the moisturizing property of the skin, and at the same time, have structural stability. When used, the anti-mosquito microcapsules will slowly break the capsule due to external pressure, temperature or natural diffusion, and then slowly release the anti-mosquito essential oil component to achieve long-lasting anti-mosquito properties.

The composition for anti-mosquito microcapsules of the present invention comprises: a component for forming a microcapsule; a hydrophilic solvent; a polyoxyethylene sorbitan monooleate compound; and an anti-mosquito essential oil component, wherein The microcapsule forming component comprises chitosan, alginate, 1 wt% to 2 wt% hyaluronic acid, and a curing agent; the anti moth essential oil component comprises a main ingredient essential oil and Auxiliary essential oil, the essential oil is selected from peppermint or oli of lemon Eucalyptus), and the auxiliary oil includes citronella oil, lemon essential oil and andiroba oil.

The hydrophilic solvent is intended to dissolve chitosan, alginate, hyaluronic acid and a curing agent to enable subsequent treatment in a homogeneous phase. The hydrophilic solvent may be used singly or in combination, and the hydrophilic solvent may be, but not limited to, water. Preferably, the polyoxyethylene sorbitan monooleate compound is contained in an amount ranging from 0.3% by weight to 0.6% by weight based on 100% by weight of the total of the composition for the mosquito-proof microcapsule material. The polyoxyethylene sorbitan monooleate compound is not particularly limited as long as the anti-mosquito microcapsules formed later can have structural stability without causing a problem of rupture. The polyoxyethylene sorbitan monooleate compound may be used singly or in combination, and the polyoxyethylene sorbitan monooleate compound may be, but not limited to, tween 80.

Preferably, the curing agent is contained in an amount ranging from 1% by weight to 2% by weight based on 100% by weight of the total of the components for forming the microcapsules. Preferably, the curing agent is calcium dichloride.

Preferably, the anti-mosquito essential oil component is contained in an amount ranging from 0.3% by weight to 0.6% by weight based on 100% by weight of the total of the composition for the mosquito-proof microcapsule material. Preferably, the main component essential oil is contained in an amount ranging from 30% by weight to 60% by weight based on 100% by weight of the total of the anti-mosquito essential oil component. Preferably, the content of the citronella essential oil ranges from 15% by weight to 255% by weight based on the total amount of the auxiliary essential oil, and the content of the lemon essential oil ranges from 20% by weight to 40% by weight, and the acid slag oil The content ranges from 40% by weight to 60% by weight.

The anti-mosquito microcapsule of the invention comprises: An anti-mosquito microcapsule; and a hydrophilic solvent; wherein the anti-mosquito microcapsule comprises a microcapsule body defining an accommodating space; an anti-mosquito oil component disposed in the accommodating space; and a polyoxygen An ethylene sorbitan monooleate compound; and the microcapsule body is formed of a microcapsule-forming component comprising chitosan, alginate, hyaluronic acid and a curing agent; the anti-mosquito essential oil component The main essential oil and the auxiliary oil are selected from the essential oils of peppermint essential oil or eucalyptus oil, and the essential oils include citronella essential oil, lemon essential oil and acid residue oil.

Preferably, the mosquito microcapsules have an average particle diameter ranging from 1 μm to 5 μm. The anti-mosquito microcapsule has an average particle diameter of less than 1 μm, is easily absorbed by a portion contacted by a user, and cannot exert an anti-mosquito effect, and the anti-mosquito microcapsule has an average particle diameter of more than 5 μm, which is liable to have a problem of breaking the capsule. produce.

The preparation method of the anti-mosquito microcapsule material of the invention can adopt the conventional method, as long as the microcapsule body can effectively coat the anti-mosquito essential oil component, and the anti-mosquito microcapsule does not cause the problem of breaking the capsule, for example, The microcapsule-forming component and the hydrophilic solvent in the composition for anti-mosquito microcapsules are mixed by a coacervation method, and then a polyoxyethylene sorbitan monooleate compound aqueous solution is added. And the anti-mosquito essential oil component is emulsified, and then the curing agent is added and stirred and mixed. In order to make it easy to control the average particle diameter of the mosquito microcapsules to be 1 μm to 5 μm, preferably, when stirring with a high-speed homogenizer, the stirring speed ranges from 2,500 rpm to 3,000 rpm.

The anti-mosquito microcapsules of the present invention can be used in different dosage forms for subsequent applications. The dosage form can be, but is not limited to, an emulsion or a gel. , ointment, cream, patch, embrocation, aerosol, spray, lotion, serum, paste ), foam and drops. The preparation of the dosage form can be carried out by a conventional method, and therefore will not be described in detail.

The anti-mosquito spray of the present invention comprises the anti-mosquito microcapsule material described above.

The anti-mosquito emulsion of the present invention comprises the anti-mosquito microcapsule material described above.

The anti-mosquito spray or anti-mosquito emulsion further comprises a functional reagent. The functional reagent can be a functional additive previously used in cosmetics or skin care products. The functional agent may be used singly or in combination, and the functional agent may be, but not limited to, a solvent, an emulsifier, a suspending agent, a dispersant, a surfactant. , binding agent, excipient, stabilizing agent, chelating agent, diluent, diluent, cooling agent, preservative, thickener (viscosity- Increasing agent), a filler, a gelling agent, or a lubricant.

The invention is further described in the following examples, but it should be understood that these examples are for illustrative purposes only and are not to be construed as limiting.

<Examples> <Example 1> Anti-mosquito microcapsules

0.5 g of peppermint essential oil, 0.1 g of citronella essential oil, 0.1 g of lemon essential oil and 0.3 g of acid residue oil are mixed to form an anti-mosquito essential oil component.

200 g of a 2% by weight aqueous solution of sodium alginate (4 g of sodium alginate and 196 g of water), 0.1 g of hyaluronic acid and 2 g of chitosan were mixed and added Enter 1 gram of tween 80 to form a first mixture.

The anti-mosquito essential oil component was added to the first mixed liquid, stirred and mixed by a high-speed homogenizer, and stirred at a rotational speed of 2,500 rpm for 30 minutes to form a second mixed liquid. Next, 0.1 g of calcium dichloride was added to the second mixed solution, and stirred at a rotation speed of 2,500 rpm for 30 minutes to obtain an anti-mosquito microcapsule.

<Example 2 and Comparative Examples 1 to 4>

In Example 2 and Comparative Examples 1 to 4, the mosquito-repellent microcapsules were prepared in the same manner as in Example 1, except that the types and amounts of the raw materials were changed as shown in Table 1. These anti-mosquito microcapsules were evaluated for each test item, and the results obtained are shown in Table 1.

<Application Example 1> Anti-mosquito spray

100 g of Example 1, 5 g of sorbital-70 (label: Zhaoyuan Chemical Co., Ltd.; component: hexamethylene alcohol), 3 g of propylene glycol, 0.2 g of chlorophenyl glycol (label: W. Merveille; model: Eleatab CPN), 10 grams of ethanol and 77.2 grams of water were mixed and stirred at 2,500 rpm for 30 minutes to obtain an anti-mosquito spray.

<Application Example 2> Anti-mosquito emulsion

0.2 g of Nikkomulese w/o (label: Nikkol; composition: Cyclopentasiloxiane/PEG-10Di-methicone/Disteardimonium Hectorite), 2 g of Salcare SC-91 (label: O-Basf; composition: Sodium acrylates/Copolymer- Paraffium Liquidum/PPG-1 Trideceth-6), 3 grams of Tefose 2561 (label: Gattefosse; composition: PEG-6Stearate/Ceteth-20/Glyceryl stearate/Steareth-20), 2 grams Tween60 (model Crillet3 label: CRODA), 0.1 g Biosol (label: Osaka Chemical Co., Ltd.; composition: Isopropylmethylphenol), 5 g of Myritol GTEH (label: Baida Precision Chemical; composition: Triethylhexanoin), 0.2 g Sanxianjiao (KELTROL T label: DANISCO; composition: Xanthan gum), 0.5 g LG-95 (label: NNAGRAM; composition: Sodium Lauroyl glutamate), 1 gram of DC-1403 (label: Essenceplus; ingredients :Dimethicone), 1.5 g of Corum 2340 (label: CORUM; ingredient: Glyceryl monostearate), 0.5 g of Hostapon CT (label: Clariant; ingredient: Sodium Methylcocoyltaurate), 1.2 g of octadecanoic acid, 1 g of 1618 alcohol (label: P & G chemicals; composition: Cetearyl alcohol), 0.5 g of KL-340D (label: Clariant; composition: Trilaureth-4 phosphate), 0.8 g of Cutina PES (label: Cognis; composition: Pentaerythrityl distearate ), 3 grams of PMX-200Sil Fluid 100CS (label: Yiameter; composition: Dimethicone), 5 grams of mineral oil (model Drakeol 7 label: CALUMET; composition: Mineral oil), 1.2 grams of Cetil SB45 (label: CRM; Ingredients: Shea b Butter), 0.2 g of K-300 (label: Euxyl; composition: phenoxyethanol/methylparaben/ethylparaben/butylparaben/propylparaben/isobutylparaben) and 0.2 g of Carbopol-10 (label: Lubrizol; ingredient: Carbomer), then Warmed to 80 ° C and stirred at 2,500 rpm for 15 minutes, then cooled to 30 ° C, then 100 grams of the anti-mosquito microcapsule of Example 2 was added, and then stirred at 2,500 rpm for 10 minutes, then Get an anti-mosquito spray.

【Test items】 1. Yield:

The anti-mosquito microcapsules of Example 1, Example 2, and Comparative Examples 1 to 4 were subjected to concentration treatment, and then the concentrates were subjected to high-speed centrifugation at rpm for 10,000 rpm at 4 ° C for 60 minutes. solid. Next, the solid is subjected to a freezing treatment at -80 ° C, and then vacuum-dried at -20 ° C to obtain an anti-mosquito microcapsule, which is weighed separately (W1) and calculated by the following formula Yield (%) = W1 × 100 / W2W2 represents the theoretical weight of the anti-mosquito microcapsule: Example 1 and Example 2 were 8.2 g (with respect to the hydrophilic solvent weight); Comparative Example 1 and Comparative Example 2 were 8.1 g ( The hydrophilic solvent weight was subtracted); Comparative Example 3 and Comparative Example 4 were 6.1 g (weight of hydrophilic solvent was subtracted).

2. Average particle size and particle size distribution index (PDI value):

3 ml of the anti-mosquito microcapsules of Example 1, Example 2, and Comparative Examples 1 to 4 were respectively subjected to a particle size analyzer (label: Brookhaven Instruments Corporation, New York, USA; model: Nanoparticle Size Analyzer 90 Plus). The particle size analysis was repeated 10 times, and the measurement time was 10 minutes each time, and the average value was taken. The particle size distribution after 1 week and 9 weeks after standing was measured separately.

3. Moisture lifting rate:

Nine subjects with a history of skin health and no allergies between the ages of 20 and 40 were provided. Before the test, the subjects should wash the wrists of the hands to the inside of the elbows with pure water, and wait at the ambient temperature of 25±2 °C and relatively wet. The degree was 45 to 50% RH for 30 minutes, and then the wrist to the inside of the elbow was divided into six 3 cm x 3 cm size areas. The test was carried out with a skin moisturizing tester [label: Courage+Khazaka Electronic GmbH (C+K); model: CK MPA580), and the obtained water content was R1.

0.1 ml of the anti-mosquito microcapsules of Example 1, Example 2, and Comparative Examples 1 to 4 were applied to each of the six areas, and the skin moisturizing tester was tested after 1 week and 4 weeks. The resulting water content is R2. And calculated by the following formula: moisture retention rate (%) = [(R2-R1) × 100] / R1.

4. Anti-mosquito:

A box (30 cm x 21 cm x 21 cm) having openings of 15 cm in diameter on both sides was provided, and the openings were sealed with elastic stockings, and 100 mosquitoes were placed in the box.

To facilitate the description of the measurement process, the following description will be made with reference to Example 1. First, 2 ml of the anti-mosquito microcapsule of Example 1 was applied to a latex glove as an experimental group, and a latex glove to which no anti-mosquito microcapsules were applied was used as a control group.

The control group and the experimental group were placed in a box, left to stand for 1 minute, and the number of mosquitoes staying in the control group and the experimental group after 1 minute was counted and repeated three times, and the average value was taken, and the following formula was used. Evaluation: anti-mosquito (%) = [(number of mosquitoes in the experimental group - number of mosquitoes in the control group) × 100 / number of mosquitoes in the control group]; after that, the experimental group was allowed to stand for 4 hours, and the control group was allowed to stand for 4 hours. The subsequent experimental groups were placed in boxes and allowed to stand for 1 minute. The number of mosquitoes staying in the control group and the experimental group after 1 minute was counted and repeated three times, and the average value was taken and evaluated by the above formula.

5. Allergies:

Ten subjects (2 males and 8 females) with a history of skin health and no allergies between the ages of 20 and 60 were provided. Before the test, the subjects were cleaned with pure water on the inside of the upper arm and then dried. Then, the inside of the upper arm of each subject was divided into six areas of 3 cm × 3 cm.

0.1 ml of the anti-mosquito microcapsules of Example 1, Example 2, and Comparative Examples 1 to 4 were respectively applied to the six regions, and the Finn Chambers on Scanpor patch was attached, and after 24 hours, the subject was observed. The upper arm was continuously observed for 24 hours. The evaluation criteria were as follows: Grade 0: no irritation; Grade 1: mild irritation; Grade 2: moderately irritating; Grade 3: Strong irritant.

From the results of the experimental data in Table 1, it can be seen that the average particle diameter and the PDI value of the anti-mosquito microcapsules of Examples 1 and 2 are not significantly different from the measured values after 1 week, indicating that the mosquitoes of the present invention are different. The anti-mosquito microcapsules in the microcapsules have structural stability without breaking the capsule.

Moreover, the moisturizing property of the anti-mosquito microcapsule of Example 1 can be increased to 14.36% after one week of application, and can be increased to 18.31% after 4 weeks, indicating that the anti-mosquito microcapsule of the present invention can improve the skin after use. Moisturizing properties.

Furthermore, the anti-mosquito microcapsules of Examples 1 and 2 still had excellent anti-mosquito properties (90% or more) after 4 hours. Compared with Comparative Examples 1 and 2, not only the mosquito resistance was not good after 1 minute of use, but also the mosquito resistance was worse after 4 hours.

In summary, the design of the microcapsule component of the present invention enables the subsequent anti-mosquito microcapsule to have long-lasting anti-mosquito properties and improve skin moisturization, and at the same time, has structural stability and is used. At this time, the anti-mosquito microcapsules will slowly break the sac due to external pressure, temperature and or natural diffusion, and then slowly release the anti-mosquito essential oil component to achieve long-lasting anti-mosquito properties, so the object of the present invention can be achieved.

The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent.

Claims (4)

An anti-mosquito microcapsule composition comprising: a component for forming a microcapsule; a hydrophilic solvent; a polyoxyethylene sorbitan monooleate compound; and an anti-mosquito essential oil component, wherein The microcapsule forming component comprises chitosan, alginate, hyaluronic acid and a curing agent; the anti-mosquito essential oil component comprises a main agent essential oil and a subsidiary essential oil, and the main agent essential oil is selected from peppermint essential oil or Yuga Essential oil, and the auxiliary oil includes citronella essential oil, lemon essential oil and acid slag tree oil; the curing agent is calcium chloride and the content is 1.6 wt% based on the total amount of the components for forming the microcapsules: 100% by weight %, the content of the chitosan is 32.3 wt%, the content of the alginate is 64.5 wt%, and the content of the hyaluronic acid is 1.6 wt%; and the total amount of the anti-mosquito oil component is 100 wt%, The content of the essential oil is 50% by weight and the content of the essential oil is 50% by weight; the content of the citronella essential oil is 20% by weight based on the total amount of the essential oil of the auxiliary agent, and the content of the essential oil of the lemon The range is 20% by weight, and the content of the acid residue oil is in the range of 60% by weight; The total amount of the substance is 100% by weight, the content of the polyoxyethylene sorbitan monooleate compound is 0.49 wt%, and the content of the anti-mosquito essential oil component is 0.49 wt%, and the component for forming a microcapsule is used. The content is 3.04% by weight, and the content of the hydrophilic solvent It is 95.98 wt%. An anti-mosquito microcapsule comprising: an anti-mosquito microcapsule; and a hydrophilic solvent; wherein the anti-mosquito microcapsule comprises a microcapsule body defining an accommodating space; and an anti-mosquito space is disposed in the accommodating space a mosquito essential oil component; and a polyoxyethylene sorbitan monooleate compound; and the microcapsule body is composed of a microcapsule component comprising chitosan, alginate, hyaluronic acid and a curing agent Formed; the anti-mosquito essential oil component comprises a main agent essential oil and a secondary essential oil, the main essential oil is selected from peppermint essential oil or eucalyptus essential oil, and the auxiliary oil includes citronella essential oil, lemon essential oil and acid slag tree An oil; the curing agent is calcium chloride and the content is 1.6% by weight, and the content of the chitosan is 32.3 wt%, based on the total amount of the components for forming the microcapsules, the alginate The content is 64.5 wt%, and the content of the hyaluronic acid is 1.6 wt%; the total amount of the essential oil is 50 wt%, and the content of the essential oil is 50 wt%, based on the total amount of the anti-mosquito oil component. %; the content of the citronella essential oil is 20wt% based on the total amount of the auxiliary oil of 100% by weight %, the content of the lemon essential oil is 20% by weight, and the content of the acid residue oil is 60% by weight; and the content of the mosquito microcapsule is 4.02wt based on the total amount of the mosquito microcapsules being 100% by weight. % and the content of the hydrophilic solvent is 95.98 wt%, wherein the polyoxygen is contained in an amount of 4.02% by weight of the anti-mosquito microcapsule The content of the ethylene sorbitan monooleate compound was 0.49 wt%, the content of the anti-mosquito oil component was 0.49 wt%, and the content of the microcapsule-forming component was 3.04 wt%. An anti-mosquito spray comprising the anti-mosquito microcapsule of claim 2. An anti-mosquito emulsion comprising the anti-mosquito microcapsule of claim 2.