CZ19224U1 - Hydrophilic cream exhibiting antiphlogistic and abirritant activity for treating hands - Google Patents

Description

Hydrophilic hand cream with anti-inflammatory and soothing effect

Technical field

The object of the present invention is a hydrophilic hand cream composition for various types of work that has an anti-inflammatory and soothing effect.

BACKGROUND OF THE INVENTION Hand creams have been known for a long time in various types of work procedures. According to the state of the art, there is an increasing demand for the safety and efficacy of cosmetics, which also include this "working cosmetics",

Due to the development of the synthesis of new macromolecules and surfactants, the choice of excipients for the preparation of ointments and creams has increased in the last decades. Their selection should aim at enhancing the effect without adversely affecting the physiological functions of the skin.

Hydrophobic and hydrophilic ointments hitherto used, which contain paraffins, syn15 tetriacylglycerols, waxes as vehicles, may contain very small amounts of water, have moisturizing and emollient effects on the skin in the short term. In these vehicles, the hydropoiesis and osmotic activity cause removal of water to the skin, which is disadvantageous because it is necessary to establish a balance between the vehicle and the water taken from the epidermal cells, as reported in the publications, to release the substances from the vehicles and transfer them to the skin. Mandák M. et al .: "Pharmaceutical Forms Π"

2nd Edition, FaF UK Bratislava, 1990; Muller R.H., Hildebrand G .; 'Modeme Arzneiformen', Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1998; Milan Chalabala et al .: "Technology of Drugs", Galén 1997.

Hydrophilic creams are a complex of systems that contain several different surfactants, have a continuous aqueous phase, contain O / W emulsifiers, and these vehicles can serve to “reduce” the release of the ingredients to have a longer lasting effect on the skin.

(Katzung B.G .: "Basic and Clinical Pharmacology", H&H, 1994, p. 520).

The essence of the technical solution

The object of the invention is a hydrophilic hand cream having an anti-inflammatory and soothing effect, comprising as main components water, glycerol, bisabolol, sodium lactate and pyroglutamic acid sodium salt.

The composition of the hydrophilic cream according to the present invention is increasingly in compliance with these safety and efficacy requirements for cosmetics.

In particular, this cream composition complies with the test criteria for skin tolerance testing as prescribed

Cosmetic Product Test Guidelines for Human Skin Compatibility Assessment, COLIPA, Bruxelles, 1995. Tests were conducted in 2008 at an accredited workplace at the National Institute of Public Health in Prague. Zero irritation was subsequently confirmed by epicutaneous irritation tests in the toxicological screening laboratory at the Slovak Medical University in Bratislava.

The combination of two hydrates of sodium lactate and sodium pyroglutamic acid (PCA) in combination with glycerin has been shown to be important for achieving the desired effects. Further, the choice of a suitable surfactant and perfume so as not to contribute to irritability is important for the safety and efficacy.

The resulting emulsion then permeates the anti-inflammatory and soothing agent bisabolol below the skin surface also due to a suitably selected emollient, preferably octyldodecanol.

-1 CZ 19224 Ul

Preferably, the naturally-obtained bisabolol is used in the composition as a non-irritating chemically pure component of an otherwise complex and often allergic complex of substances contained in the camomile extract.

The hydrophilic cream of the present invention also contains a high amount of water. Its amount usually exceeds 50% by weight, glycerol is usually up to 5% by weight, bisabolol is in emulsion usually up to 1% by weight, sodium salts, i.e. sodium lactate and sodium PCA, less than 1% by weight. The weight percentages are based on the total weight of the cream.

Preferably, the hydrophilic cream comprises 65.5 to 79.0 wt. % water, 1 to 5 wt. % glycerol, 0.1 to 1 wt. % bisabolol, 0.2 to 1 wt. % sodium lactate and 0.2 to 1 wt. sodium salts

% PCA, the remainder being up to 100 wt. For example, stearic acid, PEG-5 glyceryl stearate, liquid paraffin, cetyl alcohol, a preservative and perfume, or an emolent, preferably octyldodecanol, are present in the cream compositions.

In a particularly preferred embodiment, the composition of the hydrophilic cream is by weight. % following:

Water 65.5 to 79.0 Glyceroi 85% 1.0 to 5.0 Stearic acid 5.0 PEG-5 glyceryl stearate 3.0 to 8.0 Octyldodecanol 3.0 to 5.0 Liquid paraffin 7.0 Sodium lactate 0.2 to 1.0 Bisabololum 0.1 to 1.0 Pyroglutamic acid sodium salt 0.2 to 1.0 Cetyl alcohol 1.0 Preservative 0.3 Perfume 0.2

A hydrophilic cream having an anti-inflammatory and soothing effect according to the present invention can be produced by a known process for the production of creams, i.e. an emulsion of an oil and an aqueous phase at a temperature of 70 ° C and subsequent homogenization of the resulting emulsion at the same temperature. This is followed by slow cooling of the emulsion under high vacuum and stirring. At a temperature of 30-35 ° C, the thermolabile ingredients are mixed into the emulsion and the emulsion is cooled under high vacuum and stirring.

The specific composition of the hydrophilic cream according to this invention is shown in the following 20 example.

Examples

Example

Name g in 100 g of the preparation Water 72.20 Glyceroi 85% 3.80 Stearic acid 5.00 PEG-5 glyceryl stearate 6.00 Octyldodecanol 3.00 Liquid paraffin 7.00 Bisabololum 0.50 Lactil * 1.00 Cetyl alcohol 1.00 Preservative 0.30 Perfume 0.20

-2GB 1V224 Ul. · *!

í | * Lactil: sodium lactate + sodium pyroglutamic acid + fructose + glycine + Inositol + <

lactic acid + urea + niacinamide + sodium benzoate. AND;

The hydrophilic cream was made by hot-emulsifying the oil and aqueous phases. After thorough homogenization and partially cooled, the other heat-sensitive ingredients were mixed into the emulsion, and the finished cream was further cooled. The cooled homogeneous cream was filled into tubes. J

Claims (7)

PROTECTION REQUIREMENTS Hydrophilic hand cream with an anti-inflammatory and soothing effect, characterized in that it contains as main components: water, glycerol, bisabolol, sodium lactate and sodium pyroglutamic acid. ío Hydrophilic cream according to claim 1, characterized in that the bisabolol is a natural bisabolol. The hydrophilic cream of claim 1 or 2, further comprising an emollient. j A hydrophilic cream according to claim 3, wherein the emolent is octyl, 15 dodecanol. | A hydrophilic cream according to any one of claims 1 to 4, further comprising stearic acid, PEG-5 glyceryl stearate, liquid paraffin, cetyl alcohol, a preservative and perfume. Hydrophilic cream according to any one of the preceding claims 1 to 5, characterized in that 20, containing by weight: 65.5 to 79.0% water; 1.0 to 5.0% glycerol 85%; 5.0% stearic acid; 3.0 to 8.0% PEG-5 glyceryl stearate; 25 3.0 to 5.0% octyldodecanol; 7.0% liquid paraffin; 0.2 to 1.0% sodium lactate; 0.1 to 1.0% natural bisabolol; 0.2 to 1.0% pyroglutamic acid sodium salt; 30 1.0% cetyl alcohol; 0.3% preservative; 0.2% perfume.