TWI451868B - 醫藥組成物之改良及相關之改良 - Google Patents
醫藥組成物之改良及相關之改良 Download PDFInfo
- Publication number
- TWI451868B TWI451868B TW097106779A TW97106779A TWI451868B TW I451868 B TWI451868 B TW I451868B TW 097106779 A TW097106779 A TW 097106779A TW 97106779 A TW97106779 A TW 97106779A TW I451868 B TWI451868 B TW I451868B
- Authority
- TW
- Taiwan
- Prior art keywords
- buprenorphine
- naloxone
- composition
- amount
- pain
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 37
- 229960001736 buprenorphine Drugs 0.000 claims description 54
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 54
- 229960004127 naloxone Drugs 0.000 claims description 39
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 39
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- 210000002200 mouth mucosa Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0703968A GB2447016A (en) | 2007-03-01 | 2007-03-01 | Buprenorphine/naloxone compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200843773A TW200843773A (en) | 2008-11-16 |
| TWI451868B true TWI451868B (zh) | 2014-09-11 |
Family
ID=37965735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW097106779A TWI451868B (zh) | 2007-03-01 | 2008-02-27 | 醫藥組成物之改良及相關之改良 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110046172A1 (enExample) |
| EP (1) | EP2129380A1 (enExample) |
| JP (2) | JP2010520186A (enExample) |
| KR (1) | KR20090117891A (enExample) |
| CN (1) | CN101626766B (enExample) |
| AR (1) | AR065579A1 (enExample) |
| AU (1) | AU2008220574A1 (enExample) |
| BR (1) | BRPI0807908A2 (enExample) |
| CA (1) | CA2678582A1 (enExample) |
| CL (1) | CL2008000606A1 (enExample) |
| GB (1) | GB2447016A (enExample) |
| MX (1) | MX2009009131A (enExample) |
| PE (1) | PE20090168A1 (enExample) |
| TW (1) | TWI451868B (enExample) |
| WO (1) | WO2008104738A1 (enExample) |
| ZA (1) | ZA200905664B (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US20110033542A1 (en) * | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US8663687B2 (en) | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| US8475832B2 (en) * | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
| US9277748B2 (en) * | 2010-03-12 | 2016-03-08 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Agonist/antagonist compositions and methods of use |
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| SG10202012743WA (en) * | 2011-12-21 | 2021-01-28 | Biodelivery Sciences Int Inc | Transmucosal drug delivery devices for use in chronic pain relief |
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| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| WO2023076281A1 (en) | 2021-10-25 | 2023-05-04 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060069113A1 (en) * | 1999-11-19 | 2006-03-30 | Reckitt Benckiser Healthcare (Uk) Limited, A United Kingdom Corporation | Analgesic compositions containing buprenorphine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332556D0 (en) * | 1983-12-06 | 1984-01-11 | Reckitt & Colmann Prod Ltd | Analgesic compositions |
| JPH1036265A (ja) * | 1996-07-19 | 1998-02-10 | Nitto Denko Corp | ブプレノルフィン経皮吸収製剤 |
| PT1526848E (pt) * | 2002-08-09 | 2007-08-08 | Gruenenthal Gmbh | Antagonistas dos receptores de opióides em sistemas transdérmicos contendo buprenorfina |
| US20050191340A1 (en) * | 2002-08-09 | 2005-09-01 | Gruenenthal Gmbh | Opioid-receptor antagonists in transdermal systems having buprenorphine |
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2007
- 2007-03-01 GB GB0703968A patent/GB2447016A/en not_active Withdrawn
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2008
- 2008-02-15 MX MX2009009131A patent/MX2009009131A/es not_active Application Discontinuation
- 2008-02-15 KR KR1020097018305A patent/KR20090117891A/ko not_active Ceased
- 2008-02-15 US US12/529,171 patent/US20110046172A1/en not_active Abandoned
- 2008-02-15 WO PCT/GB2008/000526 patent/WO2008104738A1/en not_active Ceased
- 2008-02-15 BR BRPI0807908-0A2A patent/BRPI0807908A2/pt not_active IP Right Cessation
- 2008-02-15 CA CA002678582A patent/CA2678582A1/en not_active Abandoned
- 2008-02-15 AU AU2008220574A patent/AU2008220574A1/en not_active Abandoned
- 2008-02-15 JP JP2009551256A patent/JP2010520186A/ja active Pending
- 2008-02-15 CN CN2008800068666A patent/CN101626766B/zh not_active Expired - Fee Related
- 2008-02-15 EP EP08709417A patent/EP2129380A1/en not_active Withdrawn
- 2008-02-27 TW TW097106779A patent/TWI451868B/zh not_active IP Right Cessation
- 2008-02-28 CL CL200800606A patent/CL2008000606A1/es unknown
- 2008-02-29 AR ARP080100880A patent/AR065579A1/es not_active Application Discontinuation
- 2008-02-29 PE PE2008000413A patent/PE20090168A1/es not_active Application Discontinuation
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2009
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- 2014-06-16 JP JP2014123827A patent/JP2014196325A/ja not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060069113A1 (en) * | 1999-11-19 | 2006-03-30 | Reckitt Benckiser Healthcare (Uk) Limited, A United Kingdom Corporation | Analgesic compositions containing buprenorphine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101626766A (zh) | 2010-01-13 |
| KR20090117891A (ko) | 2009-11-13 |
| CA2678582A1 (en) | 2008-09-04 |
| CL2008000606A1 (es) | 2008-10-03 |
| AR065579A1 (es) | 2009-06-17 |
| HK1139871A1 (en) | 2010-09-30 |
| US20110046172A1 (en) | 2011-02-24 |
| TW200843773A (en) | 2008-11-16 |
| ZA200905664B (en) | 2010-10-27 |
| WO2008104738A1 (en) | 2008-09-04 |
| GB0703968D0 (en) | 2007-04-11 |
| AU2008220574A1 (en) | 2008-09-04 |
| EP2129380A1 (en) | 2009-12-09 |
| CN101626766B (zh) | 2013-07-10 |
| JP2014196325A (ja) | 2014-10-16 |
| JP2010520186A (ja) | 2010-06-10 |
| PE20090168A1 (es) | 2009-03-19 |
| MX2009009131A (es) | 2009-09-03 |
| BRPI0807908A2 (pt) | 2014-06-17 |
| GB2447016A (en) | 2008-09-03 |
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